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Protein

Zinc finger protein 82

Gene

Zfp82

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri168 – 190C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 82
Short name:
Zfp-82
Alternative name(s):
Zinc finger protein 545
Gene namesi
Name:Zfp82
Synonyms:Kiaa1948, Znf545
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1890753 Zfp82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331651 – 530Zinc finger protein 82Add BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ6P9Y7
PRIDEiQ6P9Y7

PTM databases

PhosphoSitePlusiQ6P9Y7

Expressioni

Gene expression databases

BgeeiENSMUSG00000098022 Expressed in 26 organ(s), highest expression level in embryonic stem cell
CleanExiMM_ZFP82
ExpressionAtlasiQ6P9Y7 baseline and differential
GenevisibleiQ6P9Y7 MM

Interactioni

Protein-protein interaction databases

BioGridi236978, 2 interactors
STRINGi10090.ENSMUSP00000079647

Structurei

3D structure databases

ProteinModelPortaliQ6P9Y7
SMRiQ6P9Y7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri168 – 190C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6P9Y7
KOiK09228
OMAiHQRIHFV
OrthoDBiEOG091G02KC
PhylomeDBiQ6P9Y7
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P9Y7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARVSVVFSD VSIAFSQEEW ESLDLEQRNL YKDVMMENYH NVASLGCFIS
60 70 80 90 100
KPDVISLLEQ GKEPWKVVRQ RKPCPDSETK DETNQVFSEN GIYEMNLSQW
110 120 130 140 150
KIMERIGNSG LKSLLLKNGW ESRRKQERQE DPQEGYLSQV RHTSERVSSY
160 170 180 190 200
EKRALTTRQR IHFVEKPYEC NECGKAFRVR QQLTFHHRIH TGEKPYECKE
210 220 230 240 250
CGMAFRQTAH LTRHQRLHSG EKLYECKECG QAFIYGPELR AHQKLHTGEK
260 270 280 290 300
PYTCRECGKA FRVRGQLTLH QRIHTGEKPY VCQECGKAFR QLAHLTRHQK
310 320 330 340 350
LNVVDRLYEC KECGKDFLCG SGLRVHHKLH TGEKPYECKD CGKAFRVRQQ
360 370 380 390 400
LTLHQRSHTG EKPYECTECG KTFSRGYHLI LHHRIHTGEK PYECKECWKA
410 420 430 440 450
FSRYSQLISH QSIHIGVKPY DCKDCGKAFR LLSQLTQHQS VHAGEKPYSC
460 470 480 490 500
KECGKSFRLR QKLALHQSIH TGEKPFECKE CRKAFRLNSS LIQHLRIHSG
510 520 530
EKPYECKECK KAFRQHSHLT HHLKVHTVKV
Note: No experimental confirmation available.
Length:530
Mass (Da):62,122
Last modified:July 5, 2004 - v1
Checksum:i87CFAFB2A3CF1BD6
GO
Isoform 2 (identifier: Q6P9Y7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-76: VRQRKPCPD → TMGDPGRTN

Note: No experimental confirmation available.
Show »
Length:530
Mass (Da):61,972
Checksum:i5CB02D4226254B11
GO
Isoform 3 (identifier: Q6P9Y7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-83: DSETKDET → ARRDGASL
     84-530: Missing.

Note: No experimental confirmation available.
Show »
Length:83
Mass (Da):9,530
Checksum:i177ED4713203FAFF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R1G9S4R1G9_MOUSE
Zinc finger protein 82
Zfp82
500Annotation score:
S4R2K1S4R2K1_MOUSE
Zinc finger protein 82
Zfp82
64Annotation score:
S4R2H1S4R2H1_MOUSE
Zinc finger protein 82
Zfp82
23Annotation score:

Sequence cautioni

The sequence BAC29755 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01808368 – 76VRQRKPCPD → TMGDPGRTN in isoform 2. 1 Publication9
Alternative sequenceiVSP_04623076 – 83DSETKDET → ARRDGASL in isoform 3. 1 Publication8
Alternative sequenceiVSP_04623184 – 530Missing in isoform 3. 1 PublicationAdd BLAST447

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037211 mRNA Translation: BAC29755.1 Sequence problems.
BC060530 mRNA Translation: AAH60530.1
AK129467 mRNA Translation: BAC98277.1
CCDSiCCDS39876.1 [Q6P9Y7-1]
CCDS59724.1 [Q6P9Y7-3]
RefSeqiNP_001239448.1, NM_001252519.1
NP_001240314.1, NM_001253385.1 [Q6P9Y7-3]
NP_808557.2, NM_177889.5 [Q6P9Y7-1]
UniGeneiMm.295906

Genome annotation databases

EnsembliENSMUST00000080834; ENSMUSP00000079647; ENSMUSG00000098022 [Q6P9Y7-1]
ENSMUST00000183190; ENSMUSP00000138469; ENSMUSG00000098022 [Q6P9Y7-3]
GeneIDi330502
KEGGimmu:330502
UCSCiuc009gcz.2 mouse [Q6P9Y7-1]
uc009gdc.2 mouse [Q6P9Y7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037211 mRNA Translation: BAC29755.1 Sequence problems.
BC060530 mRNA Translation: AAH60530.1
AK129467 mRNA Translation: BAC98277.1
CCDSiCCDS39876.1 [Q6P9Y7-1]
CCDS59724.1 [Q6P9Y7-3]
RefSeqiNP_001239448.1, NM_001252519.1
NP_001240314.1, NM_001253385.1 [Q6P9Y7-3]
NP_808557.2, NM_177889.5 [Q6P9Y7-1]
UniGeneiMm.295906

3D structure databases

ProteinModelPortaliQ6P9Y7
SMRiQ6P9Y7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236978, 2 interactors
STRINGi10090.ENSMUSP00000079647

PTM databases

PhosphoSitePlusiQ6P9Y7

Proteomic databases

PaxDbiQ6P9Y7
PRIDEiQ6P9Y7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080834; ENSMUSP00000079647; ENSMUSG00000098022 [Q6P9Y7-1]
ENSMUST00000183190; ENSMUSP00000138469; ENSMUSG00000098022 [Q6P9Y7-3]
GeneIDi330502
KEGGimmu:330502
UCSCiuc009gcz.2 mouse [Q6P9Y7-1]
uc009gdc.2 mouse [Q6P9Y7-3]

Organism-specific databases

CTDi284406
MGIiMGI:1890753 Zfp82
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6P9Y7
KOiK09228
OMAiHQRIHFV
OrthoDBiEOG091G02KC
PhylomeDBiQ6P9Y7
TreeFamiTF341817

Miscellaneous databases

PROiPR:Q6P9Y7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000098022 Expressed in 26 organ(s), highest expression level in embryonic stem cell
CleanExiMM_ZFP82
ExpressionAtlasiQ6P9Y7 baseline and differential
GenevisibleiQ6P9Y7 MM

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFP82_MOUSE
AccessioniPrimary (citable) accession number: Q6P9Y7
Secondary accession number(s): Q6ZPG0, Q8BIP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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