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Protein

Protein tyrosine phosphatase type IVA 2

Gene

Ptp4a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Activity regulationi

Inhibited by sodium orthovanadate and pentamidine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei69Proton donorBy similarity1
Active sitei101Phosphocysteine intermediateBy similarity1
Binding sitei107SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-RNO-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tyrosine phosphatase type IVA 2 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 4a2
Protein-tyrosine phosphatase of regenerating liver 2
Short name:
PRL-2
Gene namesi
Name:Ptp4a2
Synonyms:Prl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi619786 Ptp4a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947871 – 164Protein tyrosine phosphatase type IVA 2Add BLAST164
PropeptideiPRO_0000396733165 – 167Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 101By similarity
Modified residuei164Cysteine methyl esterBy similarity1
Lipidationi164S-farnesyl cysteineBy similarity1

Post-translational modificationi

Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ6P9X4
PRIDEiQ6P9X4

PTM databases

iPTMnetiQ6P9X4
PhosphoSitePlusiQ6P9X4

Expressioni

Tissue specificityi

Anterior pituitary, liver, brain, adrenal gland, kidney, testis and heart. Expression in the anterior pituitary is 3 fold higher in male as compared to female.1 Publication

Gene expression databases

BgeeiENSRNOG00000050044 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ6P9X4 RN

Interactioni

Subunit structurei

In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064832

Structurei

3D structure databases

ProteinModelPortaliQ6P9X4
SMRiQ6P9X4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 145Tyrosine-protein phosphataseAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 107Phosphate bindingBy similarity6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2836 Eukaryota
ENOG4111I7J LUCA
GeneTreeiENSGT00390000009788
HOVERGENiHBG071295
InParanoidiQ6P9X4
KOiK18041
OMAiAPIEKEG
OrthoDBiEOG091G0MYM
PhylomeDBiQ6P9X4

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
SMARTiView protein in SMART
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P9X4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRPAPVEIS YENMRFLITH NPTNATLNKF TEELKKYGVT TLVRVCDATY
60 70 80 90 100
DKAPVEKEGI HVLDWPFDDG APPPNQIVDD WLNLLKTKFR EEPGCCVAVH
110 120 130 140 150
CVAGLGRAPV LVALALIECG MKYEDAVQFI RQKRRGAFNS KQLLYLEKYR
160
PKMRLRFRDT NGHCCVQ
Length:167
Mass (Da):19,127
Last modified:July 5, 2004 - v1
Checksum:iE97B88BF87B87943
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23T → A in CAA07417 (PubMed:9805001).Curated1
Sequence conflicti157F → S in CAA07417 (PubMed:9805001).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007016 mRNA Translation: CAA07417.1
BC060549 mRNA Translation: AAH60549.1
RefSeqiNP_445927.1, NM_053475.1
XP_017449153.1, XM_017593664.1
XP_017449154.1, XM_017593665.1
UniGeneiRn.167750

Genome annotation databases

EnsembliENSRNOT00000074415; ENSRNOP00000064832; ENSRNOG00000050044
GeneIDi85237
KEGGirno:85237

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007016 mRNA Translation: CAA07417.1
BC060549 mRNA Translation: AAH60549.1
RefSeqiNP_445927.1, NM_053475.1
XP_017449153.1, XM_017593664.1
XP_017449154.1, XM_017593665.1
UniGeneiRn.167750

3D structure databases

ProteinModelPortaliQ6P9X4
SMRiQ6P9X4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064832

PTM databases

iPTMnetiQ6P9X4
PhosphoSitePlusiQ6P9X4

Proteomic databases

PaxDbiQ6P9X4
PRIDEiQ6P9X4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074415; ENSRNOP00000064832; ENSRNOG00000050044
GeneIDi85237
KEGGirno:85237

Organism-specific databases

CTDi8073
RGDi619786 Ptp4a2

Phylogenomic databases

eggNOGiKOG2836 Eukaryota
ENOG4111I7J LUCA
GeneTreeiENSGT00390000009788
HOVERGENiHBG071295
InParanoidiQ6P9X4
KOiK18041
OMAiAPIEKEG
OrthoDBiEOG091G0MYM
PhylomeDBiQ6P9X4

Enzyme and pathway databases

ReactomeiR-RNO-8873719 RAB geranylgeranylation

Miscellaneous databases

PROiPR:Q6P9X4

Gene expression databases

BgeeiENSRNOG00000050044 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ6P9X4 RN

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
SMARTiView protein in SMART
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTP4A2_RAT
AccessioniPrimary (citable) accession number: Q6P9X4
Secondary accession number(s): O88765
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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