UniProtKB - Q6P9U7 (Q6P9U7_RAT)
Protein
L-lactate dehydrogenase
Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
- EC:1.1.1.27UniRule annotationARBA annotation
: pyruvate fermentation to lactate Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotationARBA annotationProteins known to be involved in this subpathway in this organism are:
- L-lactate dehydrogenase A chain (Ldha), L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldhal6b), L-lactate dehydrogenase B chain (Ldhb), L-lactate dehydrogenase C chain (Ldhc), L-lactate dehydrogenase, L-lactate dehydrogenase (Ldhc)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 44 | SubstrateUniRule annotation | 1 | |
Binding sitei | 76 | SubstrateUniRule annotation | 1 | |
Binding sitei | 107 | SubstrateUniRule annotation | 1 | |
Active sitei | 131 | Proton acceptorUniRule annotation | 1 |
GO - Molecular functioni
- L-lactate dehydrogenase activity Source: UniProtKB-EC
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- carboxylic acid metabolic process Source: InterPro
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Ligand | NADUniRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00554;UER00611 |
Names & Taxonomyi
Protein namesi | Recommended name: L-lactate dehydrogenaseUniRule annotationARBA annotation (EC:1.1.1.27UniRule annotationARBA annotation) |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Subcellular locationi
Other locations
- cytoplasm Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 98 | Ldh_1_NInterPro annotationAdd BLAST | 98 | |
Domaini | 102 – 262 | Ldh_1_CInterPro annotationAdd BLAST | 161 |
Sequence similaritiesi
Belongs to the LDH/MDH superfamily.UniRule annotation
Family and domain databases
Gene3Di | 3.90.110.10, 1 hit |
InterProi | View protein in InterPro IPR001557, L-lactate/malate_DH IPR011304, L-lactate_DH IPR018177, L-lactate_DH_AS IPR022383, Lactate/malate_DH_C IPR001236, Lactate/malate_DH_N IPR015955, Lactate_DH/Glyco_Ohase_4_C IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF02866, Ldh_1_C, 1 hit PF00056, Ldh_1_N, 1 hit |
PIRSFi | PIRSF000102, Lac_mal_DH, 1 hit |
PRINTSi | PR00086, LLDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF56327, SSF56327, 1 hit |
TIGRFAMsi | TIGR01771, L-LDH-NAD, 1 hit |
PROSITEi | View protein in PROSITE PS00064, L_LDH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6P9U7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLQHGSLFL KTPKIVSSKD YSVTANSKLV IITAGARQQE GESRLNLVQR
60 70 80 90 100
NVNIFKFIIP NVVKYSPQCK LLIVSNPVDI LTYVAWKISG FPKNRVIGSG
110 120 130 140 150
CNLDSARFRY LMGERLGVHP LSCHGWVLGE HGDSSVPVWS GVNVAGVSLK
160 170 180 190 200
SLNPQLGTDA DKEQWKDVHK QVVDSAYEVI KLKGYTSWAI GLSVADLAES
210 220 230 240 250
IMKNLRRVHP ISTMIKGLYG IKEDVFLSVP CILGQNGISD VVKVTLTPDE
260 270
EARLKKSADT LWGIQKELQF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC060587 mRNA Translation: AAH60587.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC060587 mRNA Translation: AAH60587.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | Q6P9U7 |
Enzyme and pathway databases
UniPathwayi | UPA00554;UER00611 |
Family and domain databases
Gene3Di | 3.90.110.10, 1 hit |
InterProi | View protein in InterPro IPR001557, L-lactate/malate_DH IPR011304, L-lactate_DH IPR018177, L-lactate_DH_AS IPR022383, Lactate/malate_DH_C IPR001236, Lactate/malate_DH_N IPR015955, Lactate_DH/Glyco_Ohase_4_C IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF02866, Ldh_1_C, 1 hit PF00056, Ldh_1_N, 1 hit |
PIRSFi | PIRSF000102, Lac_mal_DH, 1 hit |
PRINTSi | PR00086, LLDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF56327, SSF56327, 1 hit |
TIGRFAMsi | TIGR01771, L-LDH-NAD, 1 hit |
PROSITEi | View protein in PROSITE PS00064, L_LDH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6P9U7_RAT | |
Accessioni | Q6P9U7Primary (citable) accession number: Q6P9U7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |