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Entry version 121 (08 May 2019)
Sequence version 3 (10 Oct 2018)
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Protein

Rho guanine nucleotide exchange factor 18

Gene

Arhgef18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri347 – 372C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgef18
Synonyms:Kiaa0521
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2142567 Arhgef18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003414161 – 1405Rho guanine nucleotide exchange factor 18Add BLAST1405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei952PhosphothreonineCombined sources1
Modified residuei961PhosphoserineCombined sources1
Modified residuei1336PhosphoserineCombined sources1
Modified residuei1338PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P9R4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P9R4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P9R4

PeptideAtlas

More...
PeptideAtlasi
Q6P9R4

PRoteomics IDEntifications database

More...
PRIDEi
Q6P9R4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P9R4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P9R4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000004568 Expressed in 264 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P9R4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6P9R4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SEPT9; interaction may inhibit GEF activity.

Interacts with Gbetagamma subunits GNB1 and GNG2 (By similarity).

Interacts with EPB41L4B.

Interacts with PATJ (via C-terminus).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
221794, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P9R4, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000004684

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11405
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P9R4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini485 – 682DHPROSITE-ProRule annotationAdd BLAST198
Domaini723 – 825PHPROSITE-ProRule annotationAdd BLAST103

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1084 – 1181Sequence analysisAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1031 – 1155Gln-richPROSITE-ProRule annotationAdd BLAST125
Compositional biasi1080 – 1180Arg-richPROSITE-ProRule annotationAdd BLAST101

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri347 – 372C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3520 Eukaryota
COG5422 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157375

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236361

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P9R4

KEGG Orthology (KO)

More...
KOi
K21066

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMLCWKT

TreeFam database of animal gene trees

More...
TreeFami
TF325887

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15794 PH_ARHGEF18, 1 hit
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037744 ARHGEF18_PH
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR041020 PH_16
IPR001849 PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17838 PH_16, 1 hit
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P9R4-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSEPKPYAQ PLDSAAAAST TKGSCGPRKP ENPDFFSTVE DEQEDGFLRH
60 70 80 90 100
LSESTEDFSL DMGALQGSEY LRDLGLGAPS DLHQSEVIMD PETHRQEARR
110 120 130 140 150
ESSHTSCEGA SALPQRRSWE RSRSCSGSCR RLSLDASTVD KGACLPRTLA
160 170 180 190 200
SLALNLSGNG QKIWTQGCLP VSGTPAPSSK ECSSPEKRLR SKSVPVSCEI
210 220 230 240 250
SCMELASDSD VCTSPVQGLE PPVLECLEKD HVEPEHVLIV QQVLQELRQY
260 270 280 290 300
HGARQRARMS TSPGGAHSNL TWFEFLSESE DGACKIEKPG KSTRVKRSLS
310 320 330 340 350
SLRSRVTRQK EKGKSPAHLK DKTQDLPGKR ECVNGHQLMR GTFSGHSSCP
360 370 380 390 400
LCGEPLLNSA SLKEHPRTTL LSDGSSPAPS RNVGMTISQK GGLQPTPSPA
410 420 430 440 450
GSGVRLGPIA GDMDEADSVF LKLKQTADDS LSLTSSNAES VFIEDPYIAS
460 470 480 490 500
LRCEIESDAH EFEAESWSLS VDLAYAKKQK KEVVKRQDVL YELMQTEAHH
510 520 530 540 550
VRTLKIMLKV YSRALQEELQ FSGQAVSRLF PCADDLLDMH SHFLARLKER
560 570 580 590 600
RQEFLEEGSD RNYVIQKIGD VLVQQFSGET GERMKEKYAV FCSGHNDAVG
610 620 630 640 650
QYKLLLQQSK KFQNLIKKIG NFSIVRRLGV QECILLVTQR ITKYPVLVER
660 670 680 690 700
IIQNTEAGTE DYKDLSQALS LIKDIISQVD AKVSEYEKDQ RLKEIAAKTD
710 720 730 740 750
QKSSGKLKNG LTFRKEDMLQ QRQLHLEGAL CWKSTSGRLK DVLAVLLTDV
760 770 780 790 800
LLLLQEKDQK YVFASVDSKP PVISLQKLIV REVANEEKAM FLISASMQGP
810 820 830 840 850
EMYEMYTSSK EDRNIWMAHI RRAVESCPDE EEDVFSEAEE KKIAEARTMK
860 870 880 890 900
LQEFQERLSL KDQLIAQSLL EKQQIYLEMA QLSGLEESAQ NRGLFRGGGD
910 920 930 940 950
PSETLRGEQI LRSAMSEIEG IQSLICQRHL GSTSSQVEEG SVSAGLPRRA
960 970 980 990 1000
ETFGGYDSVG SPSKGGSFKR KVSNSDLRPQ DWQGPASSPD SRPCDNSAPS
1010 1020 1030 1040 1050
GCCEESPQAV EMPSTESLPT VLELELVHRV QTLSQLLLSL QAVIAQQDSY
1060 1070 1080 1090 1100
VEMQRTAIQE REKQFRLQST RGNLLLEQER QRNFEKQREE RAGVEKLQSQ
1110 1120 1130 1140 1150
LRQEQQRWER ERARQQQELE LAGARLQERE GEARQMRQRL DQERTELERQ
1160 1170 1180 1190 1200
RQAYQHDLER LREAQRAVDR ERERLELLRR FKKQNTVPGA LPPEVLAEAQ
1210 1220 1230 1240 1250
PASHPPSFNG DGLEGHSAPA KAPGTQGSAM LHGTGPDNVE RPEVARWDSA
1260 1270 1280 1290 1300
PPESRPAKSD VPIQLLSATN QIQRQTAVQQ QIPTKLAAST KGGKEKGSKS
1310 1320 1330 1340 1350
RGSQRWESSA SFDLKQQLLL SKFIGKDESA SRNRRSLSPV LPAAHGSAPA
1360 1370 1380 1390 1400
SDPCFPAPSP APAATPPEAF KFGGTSLPPV SPASSLPTTP LATTDEVSKE

DVIFF
Length:1,405
Mass (Da):155,982
Last modified:October 10, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD2ACACC62F31FEE
GO
Isoform 2 (identifier: Q6P9R4-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-384: Missing.

Show »
Length:1,021
Mass (Da):114,336
Checksum:iC62C35875FE1FA89
GO
Isoform 3 (identifier: Q6P9R4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-384: Missing.
     1310-1405: ASFDLKQQLL...EVSKEDVIFF → GELHPTPTTQ...QLHFCCDKIP

Note: No experimental confirmation available.
Show »
Length:983
Mass (Da):111,026
Checksum:i1F8C1006BAF352C3
GO
Isoform 4 (identifier: Q6P9R4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-384: Missing.
     918-1405: IEGIQSLICQ...EVSKEDVIFF → SKLASPLSYA...SGVGGGGDKA

Note: No experimental confirmation available.
Show »
Length:618
Mass (Da):69,228
Checksum:iA0B550CC80D6FE32
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YWI3D3YWI3_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef18
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti217Q → H in AAH60639 (PubMed:15489334).1
Sequence conflicti437N → S in BAC30940 (PubMed:16141072).1
Sequence conflicti1351S → P in AAH34512 (PubMed:15489334).1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0598781 – 384Missing in isoform 2, isoform 3 and isoform 4. CuratedAdd BLAST384
Alternative sequenceiVSP_059879918 – 1405IEGIQ…DVIFF → SKLASPLSYAMIFQGGLPGG PKPGSVLYCSPRTTVILLFF IIQGMESSMCNGSTAELYPN PLSTYSTNAPWVTLCSGVGG GGDKA in isoform 4. CuratedAdd BLAST488
Alternative sequenceiVSP_0598801310 – 1405ASFDL…DVIFF → GELHPTPTTQRSCTPLPVDL SQQHIWNADREADRQAPVCA RRQRGSLFQLHFCCDKIP in isoform 3. CuratedAdd BLAST96

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK041423 mRNA Translation: BAC30940.1
AC169677 Genomic DNA No translation available.
BC034512 mRNA Translation: AAH34512.1
BC060639 mRNA Translation: AAH60639.1
AK172963 mRNA Translation: BAD32241.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22060.1 [Q6P9R4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_598723.3, NM_133962.3 [Q6P9R4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000004684; ENSMUSP00000004684; ENSMUSG00000004568 [Q6P9R4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
102098

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:102098

UCSC genome browser

More...
UCSCi
uc009kri.1 mouse [Q6P9R4-3]
uc009krj.1 mouse [Q6P9R4-4]
uc009krk.1 mouse [Q6P9R4-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041423 mRNA Translation: BAC30940.1
AC169677 Genomic DNA No translation available.
BC034512 mRNA Translation: AAH34512.1
BC060639 mRNA Translation: AAH60639.1
AK172963 mRNA Translation: BAD32241.1
CCDSiCCDS22060.1 [Q6P9R4-1]
RefSeqiNP_598723.3, NM_133962.3 [Q6P9R4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6BCBX-ray1.40A686-828[»]
SMRiQ6P9R4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi221794, 4 interactors
IntActiQ6P9R4, 4 interactors
STRINGi10090.ENSMUSP00000004684

PTM databases

iPTMnetiQ6P9R4
PhosphoSitePlusiQ6P9R4

Proteomic databases

EPDiQ6P9R4
jPOSTiQ6P9R4
PaxDbiQ6P9R4
PeptideAtlasiQ6P9R4
PRIDEiQ6P9R4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004684; ENSMUSP00000004684; ENSMUSG00000004568 [Q6P9R4-1]
GeneIDi102098
KEGGimmu:102098
UCSCiuc009kri.1 mouse [Q6P9R4-3]
uc009krj.1 mouse [Q6P9R4-4]
uc009krk.1 mouse [Q6P9R4-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23370
MGIiMGI:2142567 Arhgef18

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG3520 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00940000157375
HOGENOMiHOG000236361
InParanoidiQ6P9R4
KOiK21066
OMAiGMLCWKT
TreeFamiTF325887

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Arhgef18 mouse

Protein Ontology

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PROi
PR:Q6P9R4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000004568 Expressed in 264 organ(s), highest expression level in blood
ExpressionAtlasiQ6P9R4 baseline and differential
GenevisibleiQ6P9R4 MM

Family and domain databases

CDDicd15794 PH_ARHGEF18, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037744 ARHGEF18_PH
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR041020 PH_16
IPR001849 PH_domain
PfamiView protein in Pfam
PF17838 PH_16, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARHGI_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P9R4
Secondary accession number(s): E9QK59
, Q6A055, Q8BYA4, Q8K227
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 10, 2018
Last modified: May 8, 2019
This is version 121 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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