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Entry version 124 (13 Nov 2019)
Sequence version 2 (11 Sep 2007)
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Protein

FK506-binding protein 15

Gene

Fkbp15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement (By similarity). May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processEndocytosis, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FK506-binding protein 15
Short name:
FKBP-15
Alternative name(s):
133 kDa FK506-binding protein
Short name:
133 kDa FKBP
Short name:
FKBP-133
WASP and FKBP-like
Short name:
WAFL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fkbp15
Synonyms:Fkbp133, Kiaa0674
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444782 Fkbp15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Endosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002995571 – 1216FK506-binding protein 15Add BLAST1216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei91N6-acetyllysineBy similarity1
Modified residuei306PhosphoserineCombined sources1
Modified residuei310PhosphoserineCombined sources1
Modified residuei342PhosphoserineBy similarity1
Modified residuei344PhosphoserineCombined sources1
Modified residuei617PhosphoserineCombined sources1
Modified residuei948PhosphoserineBy similarity1
Modified residuei1018PhosphoserineBy similarity1
Modified residuei1050PhosphoserineCombined sources1
Modified residuei1091PhosphoserineCombined sources1
Modified residuei1093PhosphothreonineCombined sources1
Modified residuei1108PhosphoserineBy similarity1
Modified residuei1153PhosphoserineBy similarity1
Modified residuei1157PhosphoserineCombined sources1
Modified residuei1159PhosphoserineCombined sources1
Modified residuei1190PhosphoserineCombined sources1
Modified residuei1198PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P9Q6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P9Q6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P9Q6

PeptideAtlas

More...
PeptideAtlasi
Q6P9Q6

PRoteomics IDEntifications database

More...
PRIDEi
Q6P9Q6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P9Q6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P9Q6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6P9Q6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, with highest levels in the granular cell layer of cerebellum and in the granule cell layer of dentate gyrus.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Strongly expressed in the developing nervous system at 18.5 dpc. Present in brain, heart, lung, kidney and thymus at 18.5 dpc (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000066151 Expressed in 277 organ(s), highest expression level in stroma of bone marrow

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P9Q6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P9Q6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WIP and actin (By similarity).

Interacts with TBC1D23 (PubMed:29084197).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
237211, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P9Q6, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000081575

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P9Q6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini196 – 289PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni71 – 168Important for function in growth cone organizationAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili519 – 790Sequence analysisAdd BLAST272
Coiled coili820 – 865Sequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi929 – 941Glu-richAdd BLAST13
Compositional biasi944 – 1045Pro-richAdd BLAST102
Compositional biasi1203 – 1211Poly-Asp9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity.
The central coiled-coil region is responsible for association with early endosomes.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INYI Eukaryota
ENOG4112APP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064286

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112601

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P9Q6

KEGG Orthology (KO)

More...
KOi
K17478

Identification of Orthologs from Complete Genome Data

More...
OMAi
GQPMVTP

Database of Orthologous Groups

More...
OrthoDBi
239029at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P9Q6

TreeFam database of animal gene trees

More...
TreeFami
TF328592

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001179 PPIase_FKBP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00254 FKBP_C, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q6P9Q6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFGAGDEDDT DFLSPSGGAK LASLFGLDQA TMGHGNEFFQ YTAPKQPKKG
60 70 80 90 100
QGTAAGNQTA PKPAPATTGT SSVLFATAVH AYRYINGQYA KQGKFGAAVL
110 120 130 140 150
GNHTSREYRI LLYISQQQPV TVATIHLNFE LMVRPNNYST FYDDQRQNWS
160 170 180 190 200
IMFESEKAAV SFNKQVCVAK CNSISSLDAV LCQDLVAAEG PAVETGDSLE
210 220 230 240 250
VAYTGWLLQN HVLGQVFDST ANKDKPLRLK LGSGKVVKGL EDGLLGMKKG
260 270 280 290 300
GKRLIITPSA CAAGSEGVIG WTQPTDSILV FEVEVRRVKF ARDSGSDGHS
310 320 330 340 350
VSSRDSAAPS PIPASDSLSA DPVVTPLPLP LKPGEPGLRS KSNSLSEQLT
360 370 380 390 400
VNSNPDTVKA KLISRMAKMG QPMLPILPPQ LDSNDSETED ATVLRGAGQS
410 420 430 440 450
LVTPSIQPSL QPAHPVLPQM ASQAPQPSGS GLQTPSAALM QAVSLDSHSA
460 470 480 490 500
VSGNAQNFQP YAGVQAYAYP QTPSVTSQLQ PVRPLYPAPL SQAPHFQGSG
510 520 530 540 550
DMMSFLMTEA RQHNTEIRMA VNKVADKMDH LMTKVEELQK HSSGNSMLLP
560 570 580 590 600
SMSVTMETSM IMSNIQRIIQ ENERLKQELL EKSSRIEEQN DKISDLIERN
610 620 630 640 650
QRYVEQSNLM MEKRNNSLQT ATENTQARIL HAEQEKAKVT EELAAATAQV
660 670 680 690 700
SHLQLKMTAH QKKETELQLQ LTDNLKETDL LRGHVTRLQA DLSELREASE
710 720 730 740 750
QTQTKFKSEK QSRRQLELKV TSLEEELTDL RAEKTSLEKN LSERKKKSAQ
760 770 780 790 800
ERCQAEAEMD EIRKSHQEEL DRLRQLLKKA RVSTDQAAAE QLTLAQAELQ
810 820 830 840 850
SQWEAKCEQL LASARDEHLQ QYREVCAQRD AHQQKLALLQ DECLALQAQI
860 870 880 890 900
AAFTEQKEHM QRLEKTKSQA PAGRAAADPS EKVKKIMNQV FQSLRGEFEL
910 920 930 940 950
EESYDGGTIL RTIMHTIKMV TLQLLNHQEE EEEEEEEEEE EKKPLRPSLE
960 970 980 990 1000
QPGPATPGMP PAPPSGETQE APEVLPEQVV GETTPLPLQA LPTPENGAQT
1010 1020 1030 1040 1050
RKGEPAEAEV PSEIKDSSLP PQPAGIPAHR VLGPPTSIPP KPPGPVTMDS
1060 1070 1080 1090 1100
ESEEMLAADQ RTVQPNGLLG EEHVREVATD GLLQGNSRRL SLTPDPEKGE
1110 1120 1130 1140 1150
PPALDPESQG GEAQPPECKQ AEDVSSSGPR ETLLDTELAS AAAGTSLRHN
1160 1170 1180 1190 1200
QDSQHCSLSG DEEDELFKGA TLKVPRPTAQ PEEEDEDEVS MKGRPPPTPL
1210
FGDDDDDDDD DIGWLG
Length:1,216
Mass (Da):132,961
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F8130D5038122FF
GO
Isoform B (identifier: Q6P9Q6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1190-1216: SMKGRPPPTPLFGDDDDDDDDDIGWLG → VRRPQALLSP...DGDGQLPLYS

Show »
Length:1,255
Mass (Da):137,156
Checksum:i5146F31FFB4CEEC4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80YW6Q80YW6_MOUSE
Peptidylprolyl isomerase
Fkbp15
650Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q80YW9Q80YW9_MOUSE
Peptidylprolyl isomerase
Fkbp15
756Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q80YW7Q80YW7_MOUSE
Peptidylprolyl isomerase
Fkbp15
644Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti652H → R in BAE36541 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0277591190 – 1216SMKGR…IGWLG → VRRPQALLSPHTTTWGLFPA GSETRKGVCWWLVSWTLCTG PCGSKLGAQSGQLCKHDGDG QLPLYS in isoform B. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL683829 Genomic DNA No translation available.
AL732548 Genomic DNA No translation available.
BC060651 mRNA Translation: AAH60651.1
AK161705 mRNA Translation: BAE36541.1
AK122343 mRNA Translation: BAC65625.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51201.1 [Q6P9Q6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001038993.1, NM_001045528.1 [Q6P9Q6-1]
XP_006538097.1, XM_006538034.3 [Q6P9Q6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000084527; ENSMUSP00000081575; ENSMUSG00000066151 [Q6P9Q6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
338355

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:338355

UCSC genome browser

More...
UCSCi
uc008teh.2 mouse [Q6P9Q6-1]
uc008tei.1 mouse [Q6P9Q6-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL683829 Genomic DNA No translation available.
AL732548 Genomic DNA No translation available.
BC060651 mRNA Translation: AAH60651.1
AK161705 mRNA Translation: BAE36541.1
AK122343 mRNA Translation: BAC65625.1
CCDSiCCDS51201.1 [Q6P9Q6-1]
RefSeqiNP_001038993.1, NM_001045528.1 [Q6P9Q6-1]
XP_006538097.1, XM_006538034.3 [Q6P9Q6-2]

3D structure databases

SMRiQ6P9Q6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi237211, 3 interactors
IntActiQ6P9Q6, 2 interactors
STRINGi10090.ENSMUSP00000081575

PTM databases

iPTMnetiQ6P9Q6
PhosphoSitePlusiQ6P9Q6
SwissPalmiQ6P9Q6

Proteomic databases

EPDiQ6P9Q6
jPOSTiQ6P9Q6
PaxDbiQ6P9Q6
PeptideAtlasiQ6P9Q6
PRIDEiQ6P9Q6

Genome annotation databases

EnsembliENSMUST00000084527; ENSMUSP00000081575; ENSMUSG00000066151 [Q6P9Q6-1]
GeneIDi338355
KEGGimmu:338355
UCSCiuc008teh.2 mouse [Q6P9Q6-1]
uc008tei.1 mouse [Q6P9Q6-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23307
MGIiMGI:2444782 Fkbp15

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiENOG410INYI Eukaryota
ENOG4112APP LUCA
GeneTreeiENSGT00530000064286
HOGENOMiHOG000112601
InParanoidiQ6P9Q6
KOiK17478
OMAiGQPMVTP
OrthoDBi239029at2759
PhylomeDBiQ6P9Q6
TreeFamiTF328592

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Fkbp15 mouse

Protein Ontology

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PROi
PR:Q6P9Q6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000066151 Expressed in 277 organ(s), highest expression level in stroma of bone marrow
ExpressionAtlasiQ6P9Q6 baseline and differential
GenevisibleiQ6P9Q6 MM

Family and domain databases

InterProiView protein in InterPro
IPR001179 PPIase_FKBP_dom
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFKB15_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P9Q6
Secondary accession number(s): Q3TSY4, Q5SQG3, Q80TU5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 13, 2019
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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