Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 136 (11 Dec 2019)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

FH1/FH2 domain-containing protein 1

Gene

Fhod1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FH1/FH2 domain-containing protein 1
Alternative name(s):
Formin homolog overexpressed in spleen 1
Short name:
FHOS
Formin homology 2 domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fhod1
Synonyms:Fhos1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2679008 Fhod1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001949061 – 1197FH1/FH2 domain-containing protein 1Add BLAST1197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei370PhosphoserineCombined sources1
Modified residuei490PhosphoserineBy similarity1
Modified residuei499PhosphothreonineBy similarity1
Modified residuei502PhosphoserineBy similarity1
Modified residuei524PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Modified residuei722PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by ROCK1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P9Q4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P9Q4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P9Q4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P9Q4

PeptideAtlas

More...
PeptideAtlasi
Q6P9Q4

PRoteomics IDEntifications database

More...
PRIDEi
Q6P9Q4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P9Q4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P9Q4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000014778 Expressed in 167 organ(s), highest expression level in brain

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P9Q4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C-terminus (By similarity).

Interacts with ROCK1 in a Src-dependent manner (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
231560, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q6P9Q4, 3 interactors

Molecular INTeraction database

More...
MINTi
Q6P9Q4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000014922

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P9Q4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P9Q4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 462GBD/FH3PROSITE-ProRule annotationAdd BLAST410
Domaini491 – 647FH1Add BLAST157
Domaini648 – 1045FH2PROSITE-ProRule annotationAdd BLAST398
Domaini1085 – 1166DADAdd BLAST82

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni644 – 839Interaction with ROCK1By similarityAdd BLAST196

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi491 – 641Pro-richAdd BLAST151
Compositional biasi1028 – 1031Poly-Gln4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Regulated by intramolecular binding to a C-terminal auto-inhibitory domain. Effector binding abolishes this interaction and activates the protein (By similarity).By similarity
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the formin homology family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1925 Eukaryota
ENOG410XRBZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160212

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015130

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P9Q4

Identification of Orthologs from Complete Genome Data

More...
OMAi
KYENDAN

Database of Orthologous Groups

More...
OrthoDBi
148001at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P9Q4

TreeFam database of animal gene trees

More...
TreeFami
TF316268

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.2220, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR015425 FH2_Formin
IPR042201 FH2_Formin_sf
IPR027647 FHOD1
IPR041387 FHOD1_GBD_N
IPR014768 GBD/FH3_dom

The PANTHER Classification System

More...
PANTHERi
PTHR45920:SF2 PTHR45920:SF2, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02181 FH2, 1 hit
PF18382 Formin_GBD_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00498 FH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51444 FH2, 1 hit
PS51232 GBD_FH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6P9Q4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGEEERGDG DPVSVVTVRV QYLEDTDPFA CANFPEPRRA PTCSLDGALP
60 70 80 90 100
LSAQIPALHR LLGAPLKLED CALQVSPSGY YLDPELSLEE QREMLEGFYE
110 120 130 140 150
EISKGRKPTL ILRTQLSVRV NAILEKLYGS SGPELRRSLF SLKQIFQEDK
160 170 180 190 200
DLVPEFVHSE GLSCLIRVGA AADHNYQSYI LRALGQLMLF VDGMLGVVAH
210 220 230 240 250
SETVQWLYTL CASLSRLVVK TALKLLLVFV EYSENNAPLF IQAVNAVASA
260 270 280 290 300
TGTLPWANLV SILEEKNGAD AELLVYTVTL INKTLAALPD QDSFYDVTDA
310 320 330 340 350
LEQQGMEALV QRFLGTAGTD VDLRTQLTLY ESALRLEDGD MEEAAAAAAA
360 370 380 390 400
GGRRERRKPS SEEGKRSRRS LEGGGCPVRA PEPGSTGSAS PVGSTPSTGS
410 420 430 440 450
APPTNPAFSS TGPASGLLRT SVNLFPTISV GPSVDSSCER SVYKARFLEN
460 470 480 490 500
VAAAETEKQA ALAQGRAETL AGATVDDTDG SSGTRELWDS PEPASAPRTP
510 520 530 540 550
QSPVSRILLR TQRSLEPEPK KPVSPPSPKA EPIQEPPTCV PKLCIGDLDF
560 570 580 590 600
SDLGEDEDQD TLNVESVEAG KASPFLSSLS PSLSGGPPPP PPPPPPITGS
610 620 630 640 650
CPPPPPPPLP PPATGSCPPP PPPPPPPIIG SCPPPPPLAA PFTHSALDGP
660 670 680 690 700
RHPTKRKTVK LFWRELKLTG GPGCSRSRFG PCPTLWASLE PVSVDTARLE
710 720 730 740 750
HLFESRAKDV LPTKKAGEGR RTMTVVLDPK RSNAINIGLT TLPPVHVIKA
760 770 780 790 800
ALLNFDEFAV SKDGIEKLLT MMPTEEERQK IEEAQLANPD VPLGPAENFL
810 820 830 840 850
MTLASIGGLA ARLQLWAFKL DYESMEREIA EPLFDLKVGM EQLVHNATFR
860 870 880 890 900
CILATLLAVG NFLNGSQSSG FELSYLEKVS EVKDTVRRQS LLYHLCSLVL
910 920 930 940 950
QTRPDSSDLY SEIPALTRCA KVDFEQLTEN LGQLECRSQA AEDSLRSLAK
960 970 980 990 1000
HELSPALRAR LTHFLAQCTR RVAMLRVVHR RVCNRFHAFL LYLGYTPQAA
1010 1020 1030 1040 1050
RDVRIMQFCH TLREFALEYR TCRERVLQQQ QKRATYRERN KTRGRMITET
1060 1070 1080 1090 1100
EKFSGVAGEA PNNLSVPVAV GSGPGQGDTD NHASMKSLLT SRPEDATHSR
1110 1120 1130 1140 1150
RSRGMVQSSS PVSHTAVGPS AASPEETAAS GLPTDTSDEI MDLLVQSVTK
1160 1170 1180 1190
SGPRALAARE RKRSRGNRKS LRRTLKSGLG DDLVQALGLS KAPGLEV
Length:1,197
Mass (Da):129,600
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i162634FAB9715F01
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti323L → Q in BAC27106 (PubMed:16141072).Curated1
Sequence conflicti929E → K in BAC27106 (PubMed:16141072).Curated1
Sequence conflicti1196E → G in BAC27106 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB041045 mRNA Translation: BAE06182.1
AK030737 mRNA Translation: BAC27106.1
BC060654 mRNA Translation: AAH60654.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22600.1

NCBI Reference Sequences

More...
RefSeqi
NP_808367.2, NM_177699.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000014922; ENSMUSP00000014922; ENSMUSG00000014778

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
234686

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:234686

UCSC genome browser

More...
UCSCi
uc009nct.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041045 mRNA Translation: BAE06182.1
AK030737 mRNA Translation: BAC27106.1
BC060654 mRNA Translation: AAH60654.1
CCDSiCCDS22600.1
RefSeqiNP_808367.2, NM_177699.4

3D structure databases

SMRiQ6P9Q4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi231560, 1 interactor
IntActiQ6P9Q4, 3 interactors
MINTiQ6P9Q4
STRINGi10090.ENSMUSP00000014922

PTM databases

iPTMnetiQ6P9Q4
PhosphoSitePlusiQ6P9Q4

Proteomic databases

EPDiQ6P9Q4
jPOSTiQ6P9Q4
MaxQBiQ6P9Q4
PaxDbiQ6P9Q4
PeptideAtlasiQ6P9Q4
PRIDEiQ6P9Q4

Genome annotation databases

EnsembliENSMUST00000014922; ENSMUSP00000014922; ENSMUSG00000014778
GeneIDi234686
KEGGimmu:234686
UCSCiuc009nct.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29109
MGIiMGI:2679008 Fhod1

Phylogenomic databases

eggNOGiKOG1925 Eukaryota
ENOG410XRBZ LUCA
GeneTreeiENSGT00940000160212
HOGENOMiHOG000015130
InParanoidiQ6P9Q4
OMAiKYENDAN
OrthoDBi148001at2759
PhylomeDBiQ6P9Q4
TreeFamiTF316268

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Fhod1 mouse

Protein Ontology

More...
PROi
PR:Q6P9Q4
RNActiQ6P9Q4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000014778 Expressed in 167 organ(s), highest expression level in brain
GenevisibleiQ6P9Q4 MM

Family and domain databases

Gene3Di1.20.58.2220, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR015425 FH2_Formin
IPR042201 FH2_Formin_sf
IPR027647 FHOD1
IPR041387 FHOD1_GBD_N
IPR014768 GBD/FH3_dom
PANTHERiPTHR45920:SF2 PTHR45920:SF2, 3 hits
PfamiView protein in Pfam
PF02181 FH2, 1 hit
PF18382 Formin_GBD_N, 1 hit
SMARTiView protein in SMART
SM00498 FH2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51444 FH2, 1 hit
PS51232 GBD_FH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFHOD1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P9Q4
Secondary accession number(s): Q8BMK2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: December 11, 2019
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again