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Entry version 127 (12 Aug 2020)
Sequence version 2 (14 Dec 2011)
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Protein

Neurexin-3

Gene

Nrxn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi304CalciumBy similarity1
Metal bindingi321Calcium; via carbonyl oxygenBy similarity1
Metal bindingi374Calcium; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6794361, Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurexin-3
Alternative name(s):
Neurexin III-alpha
Neurexin-3-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nrxn3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1096389, Nrxn3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 1496ExtracellularSequence analysisAdd BLAST1469
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1497 – 1517HelicalSequence analysisAdd BLAST21
Topological domaini1518 – 1571CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000041255728 – 1571Neurexin-3Add BLAST1544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi202 ↔ 213By similarity
Disulfide bondi207 ↔ 222By similarity
Disulfide bondi224 ↔ 234By similarity
Disulfide bondi404 ↔ 440By similarity
Disulfide bondi610 ↔ 639By similarity
Disulfide bondi647 ↔ 658By similarity
Disulfide bondi652 ↔ 667By similarity
Disulfide bondi669 ↔ 679By similarity
Glycosylationi757N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1018 ↔ 1046By similarity
Disulfide bondi1053 ↔ 1064By similarity
Disulfide bondi1058 ↔ 1073By similarity
Disulfide bondi1075 ↔ 1085By similarity
Glycosylationi1189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1331N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P9K9

PeptideAtlas

More...
PeptideAtlasi
Q6P9K9

PRoteomics IDEntifications database

More...
PRIDEi
Q6P9K9

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2541, 3 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6P9K9, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P9K9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P9K9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain and arteries (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000066392, Expressed in rostral migratory stream and 242 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P9K9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P9K9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The laminin G-like domain 2 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. The cytoplasmic C-terminal region binds to CASK (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
201853, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q6P9K9, 2 interactors

Molecular INTeraction database

More...
MINTi
Q6P9K9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000129678

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P9K9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11571
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P9K9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6P9K9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 202Laminin G-like 1PROSITE-ProRule annotationAdd BLAST175
Domaini198 – 235EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini258 – 440Laminin G-like 2PROSITE-ProRule annotationAdd BLAST183
Domaini447 – 639Laminin G-like 3PROSITE-ProRule annotationAdd BLAST193
Domaini643 – 680EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini685 – 857Laminin G-like 4PROSITE-ProRule annotationAdd BLAST173
Domaini871 – 1046Laminin G-like 5PROSITE-ProRule annotationAdd BLAST176
Domaini1049 – 1086EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini1090 – 1290Laminin G-like 6PROSITE-ProRule annotationAdd BLAST201

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1302 – 1328Thr-richAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3514, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154618

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001710_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P9K9

KEGG Orthology (KO)

More...
KOi
K07377

Database of Orthologous Groups

More...
OrthoDBi
35129at2759

TreeFam database of animal gene trees

More...
TreeFami
TF321302

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR001791, Laminin_G
IPR003585, Neurexin-like
IPR027789, Syndecan/Neurexin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 1 hit
PF02210, Laminin_G_2, 6 hits
PF01034, Syndecan, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00294, 4.1m, 1 hit
SM00181, EGF, 3 hits
SM00282, LamG, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS50026, EGF_3, 3 hits
PS50025, LAM_G_DOMAIN, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus.

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1a (identifier: Q6P9K9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFTLHSVFF TLKVSIFLGS LVGLCLGLEF MGLPNQWARY LRWDASTRSD
60 70 80 90 100
LSFQFKTNVS TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETTVLS
110 120 130 140 150
NKQVNDSSWH FLMVSRDRVR TGLVIDGEGQ SGELRPQRPY MDVVSDLFLG
160 170 180 190 200
GVPADIRPSA LTLDGVQSMP GFKGLMLDLK YGNSEPRLLG SQSVQLEAEG
210 220 230 240 250
PCGERPCENG GICFLLDGHP TCDCSTTGYG GTLCSEDVSQ GPGLSHLMMS
260 270 280 290 300
EQAREENVAT FRGSEYLCYD LSQNPIQSSS DEITLSFKTW QRNGLILHTG
310 320 330 340 350
KSADYVNLAL KDGAVSLVIN LGSGAFEAIV EPVNGKFNDN AWHDVKVTRN
360 370 380 390 400
LRQVTISVDG ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN
410 420 430 440 450
FMGCLKEVVY KNNDIRLELS RLARIGDTKM KIYGEVVFKC ENVATLDPIN
460 470 480 490 500
FETPEAYISL PKWNTKRMGS ISFDFRTTEP NGLILFTHGK PQERKDVRSQ
510 520 530 540 550
KNTKVDFFAV ELLDGNLYLL LDMGSGTIKV KATQKKANDG EWYHVDIQRD
560 570 580 590 600
GRSGTISVNS RRTPFTASGE SEILDLEGDM YLGGLPENRA GLILPTELWT
610 620 630 640 650
AMLNYGYVGC IRDLFIDGRS KNIRQLAEMQ NAAGVKSSCS RMSAKQCDSY
660 670 680 690 700
PCKNNAVCKD GWNRFICDCT GTGYWGRTCE REASILSYDG SMYMKVIMPM
710 720 730 740 750
VMHTEAEDVS FRFMSQRAYG LLVATTSRDS ADTLRLELDG GRVKLMVNLD
760 770 780 790 800
CIRINCNSSK GPETLYAGQK LNDNEWHTVR VVRRGKSLKL TVDDDVAEGT
810 820 830 840 850
MVGDHTRLEF HNIETGIMTE KRYISVVPSS FIGHLQSLMF NGLLYIDLCK
860 870 880 890 900
NGDIDYCELK ARFGLRNIIA DPVTFKTKSS YLTLATLQAY TSMHLFFQFK
910 920 930 940 950
TTSADGFILF NSGDGNDFIA VELVKGYIHY VFDLGNGPNV IKGNSDRPLN
960 970 980 990 1000
DNQWHNVVIT RDSSNTHSLK VDTKVVTQVI NGAKNLDLKG DLYMAGLAQG
1010 1020 1030 1040 1050
MYSNLPKLVA SRDGFQGCLA SVDLNGRLPD LINDALHRSG QIERGCEGPS
1060 1070 1080 1090 1100
TTCQEDSCAN QGVCMQQWEG FTCDCSMTSY SGNQCNDPGA TYIFGKSGGL
1110 1120 1130 1140 1150
ILYTWPANDR PSTRSDRLAV GFSTTVKDGI LVRIDSAPGL GDFLQLHIEQ
1160 1170 1180 1190 1200
GKIGVVFNIG TVDISIKEER TPVNDGKYHV VRFTRNGGNA TLQVDNWPVN
1210 1220 1230 1240 1250
EHYPTGNTDN ERLQMVKQKI PFKYNRPVEE WLQEKGRQLT IFNTQAQIAI
1260 1270 1280 1290 1300
GGKDKGRLFQ GQLSGLYYDG LKVLNMAAEN NPNIKINGSV RLVGEVPSVS
1310 1320 1330 1340 1350
GTTQTTSMPP EMSTTVMETT TTMATTTTRK NRSTASIQPT SDDLVSSAEC
1360 1370 1380 1390 1400
SSDDEDFVEC EPSTDKSLST SIFEGGYKAH APKWESKDFR PNKVSETSRT
1410 1420 1430 1440 1450
TTTSLSPELI RFTASSSSGM VPKLPAGKMN NRDLKPQPDI VLLPLPTAYE
1460 1470 1480 1490 1500
LDSTKLKSPL ITSPMFRNVP TANPTEPGIR RVPGASEVIR ESSSTTGMVV
1510 1520 1530 1540 1550
GIVAAAALCI LILLYAMYKY RNRDEGSYQV DETRNYISNS AQSNGTLMKE
1560 1570
KQASSKSGHK KQKNKDKEYY V
Length:1,571
Mass (Da):173,428
Last modified:December 14, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98F989F5DD2B71AB
GO
Isoform 2a (identifier: Q6P9K9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-373: Missing.
     1047-1047: E → EVALTKADLQ
     1364-1470: Missing.

Note: Produced by alternative splicing.Curated
Show »
Length:1,100
Mass (Da):121,794
Checksum:iF2D6860CFAF3C8F0
GO
Isoform 1b (identifier: Q8C985-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q8C985.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:567
Mass (Da):62,376
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q3Q4E9Q3Q4_MOUSE
Neurexin-3-beta
Nrxn3
430Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8MPQ9A0A5F8MPQ9_MOUSE
Neurexin-3-beta
Nrxn3
635Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q2X2E9Q2X2_MOUSE
Neurexin-3-beta
Nrxn3
1,391Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WPQ9A0A087WPQ9_MOUSE
Neurexin-3-beta
Nrxn3
1,009Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH60719 differs from that shown. Contains an insert which is not supported by any other transcript and which does not match with the genome.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti390A → T in BAC27716 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0417101 – 373Missing in isoform 2a. 1 PublicationAdd BLAST373
Alternative sequenceiVSP_0417111047E → EVALTKADLQ in isoform 2a. 1 Publication1
Alternative sequenceiVSP_0417121364 – 1470Missing in isoform 2a. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK032126 mRNA Translation: BAC27716.1
AC115709 Genomic DNA No translation available.
AC115744 Genomic DNA No translation available.
AC115910 Genomic DNA No translation available.
AC120383 Genomic DNA No translation available.
AC154495 Genomic DNA No translation available.
AC155231 Genomic DNA No translation available.
AC155274 Genomic DNA No translation available.
AC156637 Genomic DNA No translation available.
AC161049 Genomic DNA No translation available.
AC171335 Genomic DNA No translation available.
CAAA01025627 Genomic DNA No translation available.
CR974428 Genomic DNA No translation available.
CR974583 Genomic DNA No translation available.
CT009613 Genomic DNA No translation available.
CT009725 Genomic DNA No translation available.
CT010588 Genomic DNA No translation available.
CU041252 Genomic DNA No translation available.
BC060719 mRNA Translation: AAH60719.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS49134.1 [Q6P9K9-2]
CCDS56856.1 [Q6P9K9-1]

NCBI Reference Sequences

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RefSeqi
NP_001185516.2, NM_001198587.3 [Q6P9K9-1]
NP_766132.2, NM_172544.3 [Q6P9K9-2]
XP_006515620.1, XM_006515557.1 [Q6P9K9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000057634; ENSMUSP00000050075; ENSMUSG00000066392 [Q6P9K9-2]
ENSMUST00000163134; ENSMUSP00000129678; ENSMUSG00000066392 [Q6P9K9-1]
ENSMUST00000167887; ENSMUSP00000127926; ENSMUSG00000066392 [Q6P9K9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
18191

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:18191

UCSC genome browser

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UCSCi
uc007okc.2, mouse [Q6P9K9-2]
uc033ger.1, mouse [Q6P9K9-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032126 mRNA Translation: BAC27716.1
AC115709 Genomic DNA No translation available.
AC115744 Genomic DNA No translation available.
AC115910 Genomic DNA No translation available.
AC120383 Genomic DNA No translation available.
AC154495 Genomic DNA No translation available.
AC155231 Genomic DNA No translation available.
AC155274 Genomic DNA No translation available.
AC156637 Genomic DNA No translation available.
AC161049 Genomic DNA No translation available.
AC171335 Genomic DNA No translation available.
CAAA01025627 Genomic DNA No translation available.
CR974428 Genomic DNA No translation available.
CR974583 Genomic DNA No translation available.
CT009613 Genomic DNA No translation available.
CT009725 Genomic DNA No translation available.
CT010588 Genomic DNA No translation available.
CU041252 Genomic DNA No translation available.
BC060719 mRNA Translation: AAH60719.1 Sequence problems.
CCDSiCCDS49134.1 [Q6P9K9-2]
CCDS56856.1 [Q6P9K9-1]
RefSeqiNP_001185516.2, NM_001198587.3 [Q6P9K9-1]
NP_766132.2, NM_172544.3 [Q6P9K9-2]
XP_006515620.1, XM_006515557.1 [Q6P9K9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MW4X-ray2.00A/B/C1090-1293[»]
SMRiQ6P9K9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi201853, 1 interactor
IntActiQ6P9K9, 2 interactors
MINTiQ6P9K9
STRINGi10090.ENSMUSP00000129678

PTM databases

GlyConnecti2541, 3 N-Linked glycans (3 sites)
GlyGeniQ6P9K9, 6 sites
iPTMnetiQ6P9K9
PhosphoSitePlusiQ6P9K9

Proteomic databases

PaxDbiQ6P9K9
PeptideAtlasiQ6P9K9
PRIDEiQ6P9K9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
106, 231 antibodies

Genome annotation databases

EnsembliENSMUST00000057634; ENSMUSP00000050075; ENSMUSG00000066392 [Q6P9K9-2]
ENSMUST00000163134; ENSMUSP00000129678; ENSMUSG00000066392 [Q6P9K9-1]
ENSMUST00000167887; ENSMUSP00000127926; ENSMUSG00000066392 [Q6P9K9-2]
GeneIDi18191
KEGGimmu:18191
UCSCiuc007okc.2, mouse [Q6P9K9-2]
uc033ger.1, mouse [Q6P9K9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9369
MGIiMGI:1096389, Nrxn3

Phylogenomic databases

eggNOGiKOG3514, Eukaryota
GeneTreeiENSGT00940000154618
HOGENOMiCLU_001710_0_1_1
InParanoidiQ6P9K9
KOiK07377
OrthoDBi35129at2759
TreeFamiTF321302

Enzyme and pathway databases

ReactomeiR-MMU-6794361, Neurexins and neuroligins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
18191, 1 hit in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Nrxn3, mouse
EvolutionaryTraceiQ6P9K9
RNActiQ6P9K9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000066392, Expressed in rostral migratory stream and 242 other tissues
ExpressionAtlasiQ6P9K9, baseline and differential
GenevisibleiQ6P9K9, MM

Family and domain databases

InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR001791, Laminin_G
IPR003585, Neurexin-like
IPR027789, Syndecan/Neurexin_dom
PfamiView protein in Pfam
PF00008, EGF, 1 hit
PF02210, Laminin_G_2, 6 hits
PF01034, Syndecan, 1 hit
SMARTiView protein in SMART
SM00294, 4.1m, 1 hit
SM00181, EGF, 3 hits
SM00282, LamG, 6 hits
SUPFAMiSSF49899, SSF49899, 6 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS50026, EGF_3, 3 hits
PS50025, LAM_G_DOMAIN, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRX3A_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P9K9
Secondary accession number(s): E9PW93, E9Q466, Q8CCT8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: December 14, 2011
Last modified: August 12, 2020
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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