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Entry version 151 (22 Apr 2020)
Sequence version 2 (15 Mar 2005)
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Protein

Caskin-1

Gene

Caskin1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May link the scaffolding protein CASK to downstream intracellular effectors.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caskin-1
Alternative name(s):
CASK-interacting protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Caskin1
Synonyms:Kiaa1306
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442952 Caskin1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669811 – 1431Caskin-1Add BLAST1431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei253PhosphotyrosineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei398Omega-N-methylarginineBy similarity1
Modified residuei423PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Modified residuei650PhosphoserineCombined sources1
Modified residuei723PhosphoserineBy similarity1
Modified residuei728PhosphoserineCombined sources1
Modified residuei741PhosphothreonineBy similarity1
Modified residuei791PhosphoserineBy similarity1
Modified residuei891PhosphoserineBy similarity1
Modified residuei893PhosphoserineBy similarity1
Modified residuei989PhosphoserineCombined sources1
Modified residuei1067PhosphothreonineCombined sources1
Modified residuei1069PhosphoserineCombined sources1
Modified residuei1259PhosphoserineCombined sources1
Modified residuei1268PhosphothreonineCombined sources1
Modified residuei1363PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P9K8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P9K8

PeptideAtlas

More...
PeptideAtlasi
Q6P9K8

PRoteomics IDEntifications database

More...
PRIDEi
Q6P9K8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P9K8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P9K8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033597 Expressed in brain and 122 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P9K8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds the CaM kinase domain of CASK.

Forms a ternary complex with CASK and LIN7A, LIN7B or LIN7C. Competes with APBA1 that forms a similar complex with CASK and LIN7 proteins. The tripartite complex CASKIN1/CASK/LIN7(A/B/C) binds the cytoplasmic tail of NRXN1. Polymerizes, via the tandem SAM domains, to form long, 8 nM wide fibers, upon which other proteins can assemble (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
234580, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P9K8, 9 interactors

Molecular INTeraction database

More...
MINTi
Q6P9K8

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000024958

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P9K8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P9K8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati48 – 77ANK 1Add BLAST30
Repeati81 – 110ANK 2Add BLAST30
Repeati114 – 143ANK 3Add BLAST30
Repeati147 – 176ANK 4Add BLAST30
Repeati188 – 217ANK 5Add BLAST30
Repeati220 – 249ANK 6Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini281 – 347SH3PROSITE-ProRule annotationAdd BLAST67
Domaini476 – 539SAM 1PROSITE-ProRule annotationAdd BLAST64
Domaini545 – 609SAM 2PROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni375 – 471CASK-bindingBy similarityAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi761 – 878Pro-richAdd BLAST118
Compositional biasi1154 – 1356Pro-richAdd BLAST203

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INAR Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158025

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003619_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P9K8

KEGG Orthology (KO)

More...
KOi
K21952

Identification of Orthologs from Complete Genome Data

More...
OMAi
QEDGQGP

Database of Orthologous Groups

More...
OrthoDBi
75723at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P9K8

TreeFam database of animal gene trees

More...
TreeFami
TF320582

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09497 SAM_caskin1_2_repeat1, 1 hit
cd09498 SAM_caskin1_2_repeat2, 1 hit
cd12062 SH3_Caskin1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 2 hits
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR027013 Caskin-1/2
IPR032232 Caskin1-CID
IPR035497 Caskin1/2_SAM_1
IPR035498 Caskin1/2_SAM_2
IPR035495 Caskin1_SH3
IPR032117 Caskin_C
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR24174:SF11 PTHR24174:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF16632 Caskin-tail, 1 hit
PF16600 Caskin1-CID, 1 hit
PF00536 SAM_1, 2 hits
PF07653 SH3_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM00454 SAM, 2 hits
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 2 hits
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50105 SAM_DOMAIN, 2 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6P9K8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKEQELVQA VKAEDVGTAQ RLLQRPRPGK AKLLGSTKKI NVNFQDPDGF
60 70 80 90 100
SALHHAALNG NTELISLLLE AQAAVDIKDN KGMRPLHYAA WQGRKEPMKL
110 120 130 140 150
VLKAGSAVNV PSDEGHIPLH LAAQHGHYDV SEMLLQHQSN PCMVDNSGKT
160 170 180 190 200
PLDLACEFGR VGVVQLLLSS NMCAALLEPR PGDTTDPNGT SPLHLAAKNG
210 220 230 240 250
HIDIIRLLLQ AGIDINRQTK SGTALHEAAL CGKTEVVRLL LDSGINAQVR
260 270 280 290 300
NTYSQTALDI VHQFTTSQAS KEIKQLLREA SAALQVRATK DYCNNYDLTS
310 320 330 340 350
LNVKAGDIIT VLEQHPDGRW KGCIHDNRTG NDRVGYFPSS LGEAIVKRAG
360 370 380 390 400
SRTGSEPSPP QGGGSLGPSA PPEEIWVLRK PFAGGDRSGS LSNVAGGRST
410 420 430 440 450
GGHALHAGSE GVKLLATVLS QKSVSESSPG DSPVKPPEGS SGAARSQPPA
460 470 480 490 500
AHAGQVYGEQ PPKKLESASA SASEGKSAEA VSQWLATFQL QLYAPNFTSA
510 520 530 540 550
GYDLPTISRM TPEDLTAIGV TKPGHRKKIT AEISGLNIPD WLPEHKPANL
560 570 580 590 600
AVWLSMIGLA QYYKVLVDNG YENIDFITDI TWEDLQEIGI TKLGHQKKLM
610 620 630 640 650
LAVRKLAELQ KAEYSKYEGG PLRRKTPQSL EMMAIESPPP SEPAAAECQS
660 670 680 690 700
PKMTTFQDSE LSGELQAALS GPAEAGAAAV EKSSNHLPPT PRTTSRESSL
710 720 730 740 750
SGRARHISSS QELLGDGPPG PGSPMSRSQE YLLDEGMAPG TPPKEVRSSR
760 770 780 790 800
HGHSVKRASV PPVPGKPRQV LPSGASHFTP PQTPTKAQPG SPQALGGPHG
810 820 830 840 850
PATAKVKPTP QLLPPTDRPM SPRSLPQSPT HRGFAYVLPQ PVEGEVGPPA
860 870 880 890 900
PGPAPPPVPA AVPTLCLPPE TDVEPGRPKK RAHSLNRYAA SDSEPERDEL
910 920 930 940 950
LVPAAAGPYA TVQRRVGRSH SVRAPAGTDK NVNRSQSFAV RPRKKGPPPP
960 970 980 990 1000
PPKRSSSAMA SANLADEPAP DVEAEDGRLG VRAQRRRASD LAGSVDTGSA
1010 1020 1030 1040 1050
GSVKSIAAML ELSSIGGGGR AIRRPPEGHP TPRPASPEPG RVATVLASVK
1060 1070 1080 1090 1100
HKEAIGPDGE VVNRRRTLSG PVTGLLATAR RGSGEPAEQS HFMEDGTARQ
1110 1120 1130 1140 1150
RLRGPAKGEA SAEGPPLARV EASATLKRRI RAKQSQQENV KFILTESDTV
1160 1170 1180 1190 1200
KRRPKAKEPD TGPEPPPPLS VYQNGTATVR RRPTSEQAGP PELPPPPPPA
1210 1220 1230 1240 1250
EPPPADLMQL PPLPLPDGNA RKPVKPPVSP KPILSQPVSK IQGSPTPASK
1260 1270 1280 1290 1300
KVPLPGPGSP EVKRAHGTPP PVSPKPPPPP TAPKPAKALA GLQSSSATPS
1310 1320 1330 1340 1350
PVPSPARQPP AALIKPASSP PSQSASPVKP PSPGTPALHV PAKPPRAAAS
1360 1370 1380 1390 1400
VVSGPPVASD CASPGDSARQ KLEETSACLA AALQAVEEKI RQEDGQGPRP
1410 1420 1430
SSIEEKSTGS ILEDIGSMFD DLADQLDAML E
Length:1,431
Mass (Da):150,495
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF89BFB1B2B8926EF
GO
Isoform 2 (identifier: Q6P9K8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     477-547: Missing.

Show »
Length:1,360
Mass (Da):142,692
Checksum:i7EBBA250B6F29330
GO
Isoform 3 (identifier: Q6P9K8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1284-1342: Missing.

Show »
Length:1,372
Mass (Da):144,832
Checksum:iB2BF82B42AD11E09
GO
Isoform 4 (identifier: Q6P9K8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-365: SRTGSEPSPPQGGGS → KSTPLWREASRGHSA
     366-1431: Missing.

Show »
Length:365
Mass (Da):39,617
Checksum:iEAF68EC7094EE9E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti274K → E in BAB29308 (PubMed:16141072).Curated1
Sequence conflicti969A → S in BAC34019 (PubMed:16141072).Curated1
Sequence conflicti1235S → A in BAC98137 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013121351 – 365SRTGS…QGGGS → KSTPLWREASRGHSA in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_013122366 – 1431Missing in isoform 4. 1 PublicationAdd BLAST1066
Alternative sequenceiVSP_013123477 – 547Missing in isoform 2. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_0131241284 – 1342Missing in isoform 3. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK014376 mRNA Translation: BAB29308.1
AK048449 mRNA Translation: BAC33340.1
AK049987 mRNA Translation: BAC34019.1
AK129327 mRNA Translation: BAC98137.1
BC060720 mRNA Translation: AAH60720.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50013.1 [Q6P9K8-1]
CCDS89007.1 [Q6P9K8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_082213.2, NM_027937.2 [Q6P9K8-1]
XP_006524378.1, XM_006524315.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000024958; ENSMUSP00000024958; ENSMUSG00000033597 [Q6P9K8-1]
ENSMUST00000234717; ENSMUSP00000157196; ENSMUSG00000033597 [Q6P9K8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
268932

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:268932

UCSC genome browser

More...
UCSCi
uc008awm.1 mouse [Q6P9K8-4]
uc008awo.1 mouse [Q6P9K8-2]
uc008awp.2 mouse [Q6P9K8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014376 mRNA Translation: BAB29308.1
AK048449 mRNA Translation: BAC33340.1
AK049987 mRNA Translation: BAC34019.1
AK129327 mRNA Translation: BAC98137.1
BC060720 mRNA Translation: AAH60720.1
CCDSiCCDS50013.1 [Q6P9K8-1]
CCDS89007.1 [Q6P9K8-2]
RefSeqiNP_082213.2, NM_027937.2 [Q6P9K8-1]
XP_006524378.1, XM_006524315.3

3D structure databases

SMRiQ6P9K8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi234580, 8 interactors
IntActiQ6P9K8, 9 interactors
MINTiQ6P9K8
STRINGi10090.ENSMUSP00000024958

PTM databases

iPTMnetiQ6P9K8
PhosphoSitePlusiQ6P9K8

Proteomic databases

jPOSTiQ6P9K8
PaxDbiQ6P9K8
PeptideAtlasiQ6P9K8
PRIDEiQ6P9K8

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
61351 25 antibodies

Genome annotation databases

EnsembliENSMUST00000024958; ENSMUSP00000024958; ENSMUSG00000033597 [Q6P9K8-1]
ENSMUST00000234717; ENSMUSP00000157196; ENSMUSG00000033597 [Q6P9K8-2]
GeneIDi268932
KEGGimmu:268932
UCSCiuc008awm.1 mouse [Q6P9K8-4]
uc008awo.1 mouse [Q6P9K8-2]
uc008awp.2 mouse [Q6P9K8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57524
MGIiMGI:2442952 Caskin1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiENOG410INAR Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000158025
HOGENOMiCLU_003619_1_1_1
InParanoidiQ6P9K8
KOiK21952
OMAiQEDGQGP
OrthoDBi75723at2759
PhylomeDBiQ6P9K8
TreeFamiTF320582

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Caskin1 mouse

Protein Ontology

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PROi
PR:Q6P9K8
RNActiQ6P9K8 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000033597 Expressed in brain and 122 other tissues
GenevisibleiQ6P9K8 MM

Family and domain databases

CDDicd09497 SAM_caskin1_2_repeat1, 1 hit
cd09498 SAM_caskin1_2_repeat2, 1 hit
cd12062 SH3_Caskin1, 1 hit
Gene3Di1.10.150.50, 2 hits
1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR027013 Caskin-1/2
IPR032232 Caskin1-CID
IPR035497 Caskin1/2_SAM_1
IPR035498 Caskin1/2_SAM_2
IPR035495 Caskin1_SH3
IPR032117 Caskin_C
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR24174:SF11 PTHR24174:SF11, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF16632 Caskin-tail, 1 hit
PF16600 Caskin1-CID, 1 hit
PF00536 SAM_1, 2 hits
PF07653 SH3_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00454 SAM, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 2 hits
SSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50105 SAM_DOMAIN, 2 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSKI1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P9K8
Secondary accession number(s): Q6ZPU2
, Q8BWU2, Q8BX99, Q9CXH0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 22, 2020
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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