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Entry version 157 (25 May 2022)
Sequence version 1 (05 Jul 2004)
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Protein

Connector enhancer of kinase suppressor of ras 3

Gene

CNKSR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).

1 Publication

Caution

The gene name MAGI1, shown in this entry as a synonym, is an obsolete human gene nomenclature committee-approved name. It should be noted that MAGI1 currently is the official name for the unrelated membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6P9H4

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q6P9H4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Connector enhancer of kinase suppressor of ras 3
Short name:
Connector enhancer of KSR 3
Alternative name(s):
CNK homolog protein 3
Short name:
CNK3
CNKSR family member 3
Maguin-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNKSR3
Synonyms:MAGI1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23034, CNKSR3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617476, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P9H4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000153721

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
154043

Open Targets

More...
OpenTargetsi
ENSG00000153721

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134880153

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P9H4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CNKSR3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74758311

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003111051 – 555Connector enhancer of kinase suppressor of ras 3Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei381PhosphoserineBy similarity1
Modified residuei383PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P9H4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P9H4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6P9H4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P9H4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P9H4

PeptideAtlas

More...
PeptideAtlasi
Q6P9H4

PRoteomics IDEntifications database

More...
PRIDEi
Q6P9H4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67049
7862

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P9H4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P9H4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by aldosterone (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000153721, Expressed in tibia and 203 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P9H4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P9H4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000153721, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with epithelial sodium channel ENaC.

Interacts directly with SCNN1A (ENaC subunit alpha) and SCNN1B (ENaC subunit beta) C-terminal tails.

Interacts with ENaC regulatory proteins NEDD4L, RAF1 and SGK1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127531, 37 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P9H4, 19 interactors

Molecular INTeraction database

More...
MINTi
Q6P9H4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000475915

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P9H4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q6P9H4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P9H4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 72SAMPROSITE-ProRule annotationAdd BLAST66
Domaini80 – 174CRICPROSITE-ProRule annotationAdd BLAST95
Domaini211 – 293PDZPROSITE-ProRule annotationAdd BLAST83
Domaini325 – 546DUF1170Add BLAST222

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni309 – 334DisorderedSequence analysisAdd BLAST26
Regioni347 – 390DisorderedSequence analysisAdd BLAST44
Regioni517 – 537DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ domain is required for interaction with ENaC and SGK1, but not for interaction with NEDDL4 and RAF1.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CNKSR family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1738, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154428

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037920_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P9H4

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNSFLDH

Database of Orthologous Groups

More...
OrthoDBi
1121556at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P9H4

TreeFam database of animal gene trees

More...
TreeFami
TF326495

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010599, CNK2/3_dom
IPR017874, CRIC_domain
IPR001478, PDZ
IPR036034, PDZ_sf
IPR001660, SAM
IPR013761, SAM/pointed_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10534, CRIC_ras_sig, 1 hit
PF06663, DUF1170, 1 hit
PF00595, PDZ, 1 hit
PF00536, SAM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 1 hit
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51290, CRIC, 1 hit
PS50106, PDZ, 1 hit
PS50105, SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform CNK3 (identifier: Q6P9H4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPVTKWSPK QVVDWTRGLD DCLQQYVHKF EREKINGEQL LQISHQDLEE
60 70 80 90 100
LGVTRIGHQE LVLEAVDLLC ALNYGLETDN MKNLVLKLRA SSHNLQNYIS
110 120 130 140 150
SRRKSPAYDG NTSRKAPNEF LTSVVELIGA AKALLAWLDR APFTGITDFS
160 170 180 190 200
VTKNKIIQLC LDLTTTVQKD CFVAEMEDKV LTVVKVLNGI CDKTIRSTTD
210 220 230 240 250
PVMSQCACLE EVHLPNIKPG EGLGMYIKST YDGLHVITGT TENSPADRSQ
260 270 280 290 300
KIHAGDEVIQ VNQQTVVGWQ LKNLVKKLRE NPTGVVLLLK KRPTGSFNFT
310 320 330 340 350
PAPLKNLRWK PPLVQTSPPP ATTQSPESTM DTSLKKEKSA ILDLYIPPPP
360 370 380 390 400
AVPYSPRDEN GSFVYGGSSK CKQPLPGPKG SESPNSFLDQ ESRRRRFTIA
410 420 430 440 450
DSDQLPGYSV ETNILPTKMR EKTPSYGKPR PLSMPADGNW MGIVDPFARP
460 470 480 490 500
RGHGRKGEDA LCRYFSNERI PPIIEESSSP PYRFSRPTTE RHLVRGADYI
510 520 530 540 550
RGSRCYINSD LHSSATIPFQ EEGTKKKSGS SATKSSSTEP SLLVSWFTRL

KLLTH
Length:555
Mass (Da):61,904
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i456E284566D5EFC8
GO
Isoform CNK3-IPCEF1-1 (identifier: G9CGD6-1) [UniParc]FASTAAdd to basket
Also known as: CNK3/IPCEF1 Long-1
The sequence of this isoform can be found in the external entry G9CGD6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:899
Mass (Da):100,365
GO
Isoform CNK3-IPCEF1-2 (identifier: G9CGD6-2) [UniParc]FASTAAdd to basket
Also known as: CNK3/IPCEF1 Long-2
The sequence of this isoform can be found in the external entry G9CGD6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:900
Mass (Da):100,493
GO
Isoform CNK3-IPCEF1-3 (identifier: G9CGD6-3) [UniParc]FASTAAdd to basket
Also known as: CNK3/IPCEF1 Short
The sequence of this isoform can be found in the external entry G9CGD6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:830
Mass (Da):92,057
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T4Y8Q5T4Y8_HUMAN
Connector enhancer of kinase suppre...
CNKSR3
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5H1ZRR2A0A5H1ZRR2_HUMAN
Connector enhancer of kinase suppre...
CNKSR3
475Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti259I → T in BAB71044 (PubMed:14702039).Curated1
Sequence conflicti334L → P in AAQ92306 (Ref. 1) Curated1
Sequence conflicti334L → P in AAQ92307 (Ref. 1) Curated1
Sequence conflicti334L → P in AAQ92308 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY328891 mRNA Translation: AAQ92306.1
AY328892 mRNA Translation: AAQ92307.1
AY328893 mRNA Translation: AAQ92308.1
AK055911 mRNA Translation: BAB71044.1
AL357075 Genomic DNA No translation available.
AL033376 Genomic DNA No translation available.
AL590401 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47699.1
BC060761 mRNA Translation: AAH60761.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5246.1 [Q6P9H4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_775786.2, NM_173515.3 [Q6P9H4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000607772.6; ENSP00000475915.1; ENSG00000153721.19

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
154043

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:154043

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000607772.6; ENSP00000475915.1; NM_173515.4; NP_775786.2

UCSC genome browser

More...
UCSCi
uc003qpy.4, human [Q6P9H4-1]
uc063skq.1, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY328891 mRNA Translation: AAQ92306.1
AY328892 mRNA Translation: AAQ92307.1
AY328893 mRNA Translation: AAQ92308.1
AK055911 mRNA Translation: BAB71044.1
AL357075 Genomic DNA No translation available.
AL033376 Genomic DNA No translation available.
AL590401 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47699.1
BC060761 mRNA Translation: AAH60761.1
CCDSiCCDS5246.1 [Q6P9H4-1]
RefSeqiNP_775786.2, NM_173515.3 [Q6P9H4-1]

3D structure databases

AlphaFoldDBiQ6P9H4
SMRiQ6P9H4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127531, 37 interactors
IntActiQ6P9H4, 19 interactors
MINTiQ6P9H4
STRINGi9606.ENSP00000475915

PTM databases

iPTMnetiQ6P9H4
PhosphoSitePlusiQ6P9H4

Genetic variation databases

BioMutaiCNKSR3
DMDMi74758311

Proteomic databases

EPDiQ6P9H4
jPOSTiQ6P9H4
MassIVEiQ6P9H4
MaxQBiQ6P9H4
PaxDbiQ6P9H4
PeptideAtlasiQ6P9H4
PRIDEiQ6P9H4
ProteomicsDBi67049
7862

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33402, 182 antibodies from 22 providers

The DNASU plasmid repository

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DNASUi
154043

Genome annotation databases

EnsembliENST00000607772.6; ENSP00000475915.1; ENSG00000153721.19
GeneIDi154043
KEGGihsa:154043
MANE-SelectiENST00000607772.6; ENSP00000475915.1; NM_173515.4; NP_775786.2
UCSCiuc003qpy.4, human [Q6P9H4-1]
uc063skq.1, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
154043
DisGeNETi154043

GeneCards: human genes, protein and diseases

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GeneCardsi
CNKSR3
HGNCiHGNC:23034, CNKSR3
HPAiENSG00000153721, Low tissue specificity
MIMi617476, gene
neXtProtiNX_Q6P9H4
OpenTargetsiENSG00000153721
PharmGKBiPA134880153
VEuPathDBiHostDB:ENSG00000153721

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1738, Eukaryota
GeneTreeiENSGT00940000154428
HOGENOMiCLU_037920_0_0_1
InParanoidiQ6P9H4
OMAiPNSFLDH
OrthoDBi1121556at2759
PhylomeDBiQ6P9H4
TreeFamiTF326495

Enzyme and pathway databases

PathwayCommonsiQ6P9H4
SignaLinkiQ6P9H4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
154043, 9 hits in 1079 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CNKSR3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
154043
PharosiQ6P9H4, Tbio

Protein Ontology

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PROi
PR:Q6P9H4
RNActiQ6P9H4, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000153721, Expressed in tibia and 203 other tissues
ExpressionAtlasiQ6P9H4, baseline and differential
GenevisibleiQ6P9H4, HS

Family and domain databases

Gene3Di1.10.150.50, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR010599, CNK2/3_dom
IPR017874, CRIC_domain
IPR001478, PDZ
IPR036034, PDZ_sf
IPR001660, SAM
IPR013761, SAM/pointed_sf
PfamiView protein in Pfam
PF10534, CRIC_ras_sig, 1 hit
PF06663, DUF1170, 1 hit
PF00595, PDZ, 1 hit
PF00536, SAM_1, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SM00454, SAM, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51290, CRIC, 1 hit
PS50106, PDZ, 1 hit
PS50105, SAM_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNKR3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P9H4
Secondary accession number(s): C9IZX4, Q5SGD5, Q96N65
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: May 25, 2022
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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