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Entry version 78 (11 Dec 2019)
Sequence version 2 (30 Aug 2005)
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Protein
Submitted name:

Family with sequence similarity 184, member A

Gene

FAM184A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Family with sequence similarity 184, member AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM184AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA164719768

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

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PeptideAtlasi
Q6P9G8

PRoteomics IDEntifications database

More...
PRIDEi
Q6P9G8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6P9G8 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q6P9G8, 3 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 231FAM184InterPro annotationAdd BLAST211

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1010 – 1095DisorderedSequence analysisAdd BLAST86

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili25 – 49Sequence analysisAdd BLAST25
Coiled coili154 – 174Sequence analysisAdd BLAST21
Coiled coili187 – 221Sequence analysisAdd BLAST35
Coiled coili290 – 317Sequence analysisAdd BLAST28
Coiled coili322 – 345Sequence analysisAdd BLAST24
Coiled coili367 – 452Sequence analysisAdd BLAST86
Coiled coili465 – 525Sequence analysisAdd BLAST61
Coiled coili533 – 595Sequence analysisAdd BLAST63
Coiled coili609 – 644Sequence analysisAdd BLAST36
Coiled coili650 – 717Sequence analysisAdd BLAST68
Coiled coili722 – 749Sequence analysisAdd BLAST28
Coiled coili836 – 870Sequence analysisAdd BLAST35
Coiled coili926 – 946Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFYF Eukaryota
ENOG410ZNZK LUCA

Database of Orthologous Groups

More...
OrthoDBi
170922at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029605 FAM184
IPR029607 FAM184A
IPR039478 FAM184A/B_N

The PANTHER Classification System

More...
PANTHERi
PTHR18870 PTHR18870, 1 hit
PTHR18870:SF7 PTHR18870:SF7, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF15665 FAM184, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6P9G8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYSQEMHLK LSKKIAQLTK VIYALNTKND EHESAIQALK DAHEEEIQQI
60 70 80 90 100
LAETREKILQ YKSKVTEELD LRRKIQVLES SLEDHIKMKQ QALTEFEAYK
110 120 130 140 150
HRVEDMQLCA EAQHVQRIVT MSREVEEIRR KFEEKLRSFG QLQVQFEKDK
160 170 180 190 200
RLALEDLQAA HRQEIQELLK SQQDHSASVN KGQEKAEELH RMEVESLNKM
210 220 230 240 250
LEELRLERKK LIEDYEGKLN KAQSFYEREL DTLKRSQLFT AESLQASKEK
260 270 280 290 300
EADLRKEFQG QEAILRKTIG KLKTELQMVQ DEAGSLLDKC QKLQTALAIA
310 320 330 340 350
ENNVQVLQKQ LDDAKEGEMA LLSKHKEVES ELAAARERLQ QQASDLVLKA
360 370 380 390 400
SHIGMLQATQ MTQEVTIKDL ESEKSRVNER LSQLEEERAF LRSKTQSLDE
410 420 430 440 450
EQKQQILELE KKVNEAKRTQ QEYYERELKN LQSRLEEEVT QLNEAHSKTL
460 470 480 490 500
EELAWKHHMA IEAVHSNAIR DKKKLQMDLE EQHNKDKLNL EEDKNQLQQE
510 520 530 540 550
LENLKEVLED KLNTANQEIG HLQDMVRKSE QGLGSAEGLI ASLQDSQERL
560 570 580 590 600
QNELDLTKDS LKETKDALLN VEGELEQERQ QHEETIAAMK EEEKLKVDKM
610 620 630 640 650
AHDLEIKWTE NLRQECSKLR EELRLQHEED KKSAMSQLLQ LKDREKNAAR
660 670 680 690 700
DSWQKKVEDL LNQISLLKQN LEIQLSQSQT SLQQLQAQFT QERQRLTQEL
710 720 730 740 750
EELEEQHQQR HKSLKEAHVL AFQTMEEEKE KEQRALENHL QQKHSAELQS
760 770 780 790 800
LKDAHRESME GFRIEMEQEL QTLRFELEDE GKAMLASLRS ELNHQHAAAI
810 820 830 840 850
DLLRHNHHQE LAAAKMELER SIDISRRQSK EHICRITDLQ EELRHREHHI
860 870 880 890 900
SELDKEVQHL HENISALTKE LEFKGKEILR IRSESNQQIR LHEQDLNKRL
910 920 930 940 950
EKELDVMTAD HLREKNIMRA DFNKTNELLK EINAALQVSL EEMEEKYLMR
960 970 980 990 1000
ESKPEDIQMI TELKAMLTER DQIIKKLIED NKFYQLELVN RETNFNKVFN
1010 1020 1030 1040 1050
SSPTVGVINP LAKQKKKNDK SPTNRFVSVP NLSALESGGV GNGHPNRLDP
1060 1070 1080 1090 1100
IPNSPVHDIE FNSSKPLPQP VPPKGPKTFL SPAQSEASPV ASPDPQRQEW

FARYFTF
Length:1,107
Mass (Da):129,529
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDEC385303918C732
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC060769 mRNA Translation: AAH60769.2

NCBI Reference Sequences

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RefSeqi
NP_001275505.1, NM_001288576.1
NP_078857.5, NM_024581.5

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
79632

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79632

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060769 mRNA Translation: AAH60769.2
RefSeqiNP_001275505.1, NM_001288576.1
NP_078857.5, NM_024581.5

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ6P9G8, 3 interactors

Proteomic databases

PeptideAtlasiQ6P9G8
PRIDEiQ6P9G8

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79632

Genome annotation databases

GeneIDi79632
KEGGihsa:79632

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79632
PharmGKBiPA164719768

Phylogenomic databases

eggNOGiENOG410IFYF Eukaryota
ENOG410ZNZK LUCA
OrthoDBi170922at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM184A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79632

Gene expression databases

GenevisibleiQ6P9G8 HS

Family and domain databases

InterProiView protein in InterPro
IPR029605 FAM184
IPR029607 FAM184A
IPR039478 FAM184A/B_N
PANTHERiPTHR18870 PTHR18870, 1 hit
PTHR18870:SF7 PTHR18870:SF7, 1 hit
PfamiView protein in Pfam
PF15665 FAM184, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6P9G8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P9G8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: August 30, 2005
Last modified: December 11, 2019
This is version 78 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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