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UniProtKB - Q6P9F7 (LRC8B_HUMAN)

Entry version 157 (23 Feb 2022)
Sequence version 2 (07 Feb 2006)
Previous versions | rss
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Protein

Volume-regulated anion channel subunit LRRC8B

Gene

LRRC8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731).

The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6P9F7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5223345, Miscellaneous transport and binding events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6P9F7

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.25.3.1, the gap junction-forming innexin (innexin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Volume-regulated anion channel subunit LRRC8BCurated
Alternative name(s):
Leucine-rich repeat-containing protein 8B1 Publication
T-cell activation leucine repeat-rich protein1 Publication
Short name:
TA-LRRP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC8B1 PublicationImported
Synonyms:KIAA02311 Publication
ORF Names:UNQ6413/PRO212071 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30692, LRRC8B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612888, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6P9F7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000197147

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 119ExtracellularSequence analysisAdd BLAST73
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 261CytoplasmicSequence analysisAdd BLAST121
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 307ExtracellularSequence analysisAdd BLAST25
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 803CytoplasmicSequence analysisAdd BLAST475

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000197147

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671535

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6P9F7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LRRC8B

Domain mapping of disease mutations (DMDM)

More...DMDMi		88911355

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000762451 – 803Volume-regulated anion channel subunit LRRC8BAdd BLAST803

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi55 ↔ 304By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 289By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei186PhosphoserineBy similarity1
Modified residuei196PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6P9F7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6P9F7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6P9F7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6P9F7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6P9F7

PeptideAtlas

More...PeptideAtlasi		Q6P9F7

PRoteomics IDEntifications database

More...PRIDEi		Q6P9F7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67042

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6P9F7, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6P9F7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6P9F7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197147, Expressed in primary visual cortex and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6P9F7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6P9F7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197147, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterohexamer (Probable). Oligomerizes with other LRRC8 proteins (LRRC8A, LRRC8C, LRRC8D and/or LRRC8E) to form a heterohexamer (PubMed:24790029, PubMed:26824658, PubMed:28193731). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (Probable).

Curated3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117054, 32 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q6P9F7

Database of interacting proteins

More...DIPi		DIP-61361N

Protein interaction database and analysis system

More...IntActi		Q6P9F7, 21 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000332674

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6P9F7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6P9F7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati464 – 486LRR 1Add BLAST23
Repeati488 – 509LRR 2Add BLAST22
Repeati511 – 532LRR 3Add BLAST22
Repeati539 – 559LRR 4Add BLAST21
Repeati562 – 582LRR 5Add BLAST21
Repeati586 – 607LRR 6Add BLAST22
Repeati609 – 630LRR 7Add BLAST22
Repeati634 – 655LRR 8Add BLAST22
Repeati657 – 678LRR 9Add BLAST22
Repeati680 – 701LRR 10Add BLAST22
Repeati703 – 724LRR 11Add BLAST22
Repeati726 – 747LRR 12Add BLAST22
Repeati749 – 771LRR 13Add BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LRRC8 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0619, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160703

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_019019_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P9F7

Identification of Orthologs from Complete Genome Data

More...OMAi		CSIDVQA

Database of Orthologous Groups

More...OrthoDBi		298712at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6P9F7

TreeFam database of animal gene trees

More...TreeFami		TF331443

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR026906, LRR_5
IPR032675, LRR_dom_sf
IPR021040, LRRC8_Pannexin-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13306, LRR_5, 1 hit
PF13855, LRR_8, 1 hit
PF12534, Pannexin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00369, LRR_TYP, 8 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51450, LRR, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6P9F7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITLTELKCL ADAQSSYHIL KPWWDVFWYY ITLIMLLVAV LAGALQLTQS 
        60         70         80         90        100
RVLCCLPCKV EFDNHCAVPW DILKASMNTS SNPGTPLPLP LRIQNDLHRQ 
       110        120        130        140        150
QYSYIDAVCY EKQLHWFAKF FPYLVLLHTL IFAACSNFWL HYPSTSSRLE 
       160        170        180        190        200
HFVAILHKCF DSPWTTRALS ETVAEQSVRP LKLSKSKILL SSSGCSADID 
       210        220        230        240        250
SGKQSLPYPQ PGLESAGIES PTSSVLDKKE GEQAKAIFEK VKRFRMHVEQ 
       260        270        280        290        300
KDIIYRVYLK QIIVKVILFV LIITYVPYFL THITLEIDCS VDVQAFTGYK 
       310        320        330        340        350
RYQCVYSLAE IFKVLASFYV ILVILYGLTS SYSLWWMLRS SLKQYSFEAL 
       360        370        380        390        400
REKSNYSDIP DVKNDFAFIL HLADQYDPLY SKRFSIFLSE VSENKLKQIN 
       410        420        430        440        450
LNNEWTVEKL KSKLVKNAQD KIELHLFMLN GLPDNVFELT EMEVLSLELI 
       460        470        480        490        500
PEVKLPSAVS QLVNLKELRV YHSSLVVDHP ALAFLEENLK ILRLKFTEMG 
       510        520        530        540        550
KIPRWVFHLK NLKELYLSGC VLPEQLSTMQ LEGFQDLKNL RTLYLKSSLS 
       560        570        580        590        600
RIPQVVTDLL PSLQKLSLDN EGSKLVVLNN LKKMVNLKSL ELISCDLERI 
       610        620        630        640        650
PHSIFSLNNL HELDLRENNL KTVEEIISFQ HLQNLSCLKL WHNNIAYIPA 
       660        670        680        690        700
QIGALSNLEQ LSLDHNNIEN LPLQLFLCTK LHYLDLSYNH LTFIPEEIQY 
       710        720        730        740        750
LSNLQYFAVT NNNIEMLPDG LFQCKKLQCL LLGKNSLMNL SPHVGELSNL 
       760        770        780        790        800
THLELIGNYL ETLPPELEGC QSLKRNCLIV EENLLNTLPL PVTERLQTCL 

DKC
Length:803
Mass (Da):92,390
Last modified:February 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9006CE628F427EB9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A7I2RK03A0A7I2RK03_HUMAN
Volume-regulated anion channel subu...
LRRC8B
731Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JGJ7C9JGJ7_HUMAN
Volume-regulated anion channel subu...
LRRC8B
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13220 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti225V → G in AAQ88479 (PubMed:12975309).Curated1
Sequence conflicti626Missing in AAQ88479 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051126288D → N. Corresponds to variant dbSNP:rs17131746EnsemblClinVar.1
Natural variantiVAR_025275419Q → K1 PublicationCorresponds to variant dbSNP:rs17855025Ensembl.1
Natural variantiVAR_051127469R → H. Corresponds to variant dbSNP:rs3795832EnsemblClinVar.1
Natural variantiVAR_051128689N → S. Corresponds to variant dbSNP:rs12747447Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF385436 mRNA Translation: AAM43837.1
D86984 mRNA Translation: BAA13220.2 Different initiation.
AY358112 mRNA Translation: AAQ88479.1
CH471097 Genomic DNA Translation: EAW73137.1
CH471097 Genomic DNA Translation: EAW73138.1
BC030607 mRNA Translation: AAH30607.1
BC060782 mRNA Translation: AAH60782.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS724.1

NCBI Reference Sequences

More...RefSeqi		NP_001127948.1, NM_001134476.1
NP_056165.1, NM_015350.2
XP_005270758.1, XM_005270701.4
XP_005270759.1, XM_005270702.4
XP_005270760.1, XM_005270703.4
XP_011539445.1, XM_011541143.2
XP_011539446.1, XM_011541144.2
XP_011539447.1, XM_011541145.2
XP_011539448.1, XM_011541146.2
XP_016856372.1, XM_017000883.1
XP_016856373.1, XM_017000884.1
XP_016856374.1, XM_017000885.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000330947; ENSP00000332674; ENSG00000197147
ENST00000639264; ENSP00000492151; ENSG00000197147
ENST00000640258; ENSP00000491377; ENSG00000197147

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23507

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23507

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000330947.7; ENSP00000332674.2; NM_001369817.2; NP_001356746.1

UCSC genome browser

More...UCSCi		uc057ieo.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385436 mRNA Translation: AAM43837.1
D86984 mRNA Translation: BAA13220.2 Different initiation.
AY358112 mRNA Translation: AAQ88479.1
CH471097 Genomic DNA Translation: EAW73137.1
CH471097 Genomic DNA Translation: EAW73138.1
BC030607 mRNA Translation: AAH30607.1
BC060782 mRNA Translation: AAH60782.1
CCDSiCCDS724.1
RefSeqiNP_001127948.1, NM_001134476.1
NP_056165.1, NM_015350.2
XP_005270758.1, XM_005270701.4
XP_005270759.1, XM_005270702.4
XP_005270760.1, XM_005270703.4
XP_011539445.1, XM_011541143.2
XP_011539446.1, XM_011541144.2
XP_011539447.1, XM_011541145.2
XP_011539448.1, XM_011541146.2
XP_016856372.1, XM_017000883.1
XP_016856373.1, XM_017000884.1
XP_016856374.1, XM_017000885.1

3D structure databases

SMRiQ6P9F7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117054, 32 interactors
CORUMiQ6P9F7
DIPiDIP-61361N
IntActiQ6P9F7, 21 interactors
STRINGi9606.ENSP00000332674

Protein family/group databases

TCDBi1.A.25.3.1, the gap junction-forming innexin (innexin) family

PTM databases

GlyGeniQ6P9F7, 2 sites
iPTMnetiQ6P9F7
PhosphoSitePlusiQ6P9F7

Genetic variation databases

BioMutaiLRRC8B
DMDMi88911355

Proteomic databases

EPDiQ6P9F7
jPOSTiQ6P9F7
MassIVEiQ6P9F7
MaxQBiQ6P9F7
PaxDbiQ6P9F7
PeptideAtlasiQ6P9F7
PRIDEiQ6P9F7
ProteomicsDBi67042

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19852, 123 antibodies from 15 providers

The DNASU plasmid repository

More...DNASUi		23507

Genome annotation databases

EnsembliENST00000330947; ENSP00000332674; ENSG00000197147
ENST00000639264; ENSP00000492151; ENSG00000197147
ENST00000640258; ENSP00000491377; ENSG00000197147
GeneIDi23507
KEGGihsa:23507
MANE-SelectiENST00000330947.7; ENSP00000332674.2; NM_001369817.2; NP_001356746.1
UCSCiuc057ieo.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23507

GeneCards: human genes, protein and diseases

More...GeneCardsi		LRRC8B
HGNCiHGNC:30692, LRRC8B
HPAiENSG00000197147, Low tissue specificity
MIMi612888, gene
neXtProtiNX_Q6P9F7
OpenTargetsiENSG00000197147
PharmGKBiPA142671535
VEuPathDBiHostDB:ENSG00000197147

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
GeneTreeiENSGT00940000160703
HOGENOMiCLU_019019_0_0_1
InParanoidiQ6P9F7
OMAiCSIDVQA
OrthoDBi298712at2759
PhylomeDBiQ6P9F7
TreeFamiTF331443

Enzyme and pathway databases

PathwayCommonsiQ6P9F7
ReactomeiR-HSA-5223345, Miscellaneous transport and binding events
SignaLinkiQ6P9F7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23507, 6 hits in 1042 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LRRC8B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23507
PharosiQ6P9F7, Tbio

Protein Ontology

More...PROi		PR:Q6P9F7
RNActiQ6P9F7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197147, Expressed in primary visual cortex and 217 other tissues
ExpressionAtlasiQ6P9F7, baseline and differential
GenevisibleiQ6P9F7, HS

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR026906, LRR_5
IPR032675, LRR_dom_sf
IPR021040, LRRC8_Pannexin-like
PfamiView protein in Pfam
PF13306, LRR_5, 1 hit
PF13855, LRR_8, 1 hit
PF12534, Pannexin_like, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 8 hits
PROSITEiView protein in PROSITE
PS51450, LRR, 9 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC8B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P9F7
Secondary accession number(s): D3DT28
, Q6UY21, Q8N106, Q92627
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: February 23, 2022
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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