UniProtKB - Q6P9F5 (TRI40_HUMAN)
Protein
Tripartite motif-containing protein 40
Gene
TRIM40
Organism
Homo sapiens (Human)
Status
Functioni
May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 14 – 56 | RING-typePROSITE-ProRule annotationAdd BLAST | 43 | |
Zinc fingeri | 66 – 107 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- ubiquitin protein ligase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- innate immune response Source: GO_Central
- negative regulation of cell growth Source: Ensembl
- negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
- negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
- negative regulation of protein catabolic process Source: UniProtKB
- negative regulation of protein localization to nucleus Source: UniProtKB
- protein neddylation Source: UniProtKB
- protein ubiquitination Source: GO_Central
- regulation of gene expression Source: GO_Central
Keywordsi
Biological process | Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6P9F5 |
Names & Taxonomyi
Protein namesi | Recommended name: Tripartite motif-containing protein 40Alternative name(s): Probable E3 NEDD8-protein ligase RING finger protein 35 |
Gene namesi | Name:TRIM40 Synonyms:RNF35 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204614.8 |
HGNCi | HGNC:18736, TRIM40 |
MIMi | 616976, gene |
neXtProti | NX_Q6P9F5 |
Subcellular locationi
Cytosol
- IkappaB kinase complex Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 135644 |
OpenTargetsi | ENSG00000204614 |
PharmGKBi | PA38663 |
Miscellaneous databases
Pharosi | Q6P9F5, Tbio |
Polymorphism and mutation databases
BioMutai | TRIM40 |
DMDMi | 229463021 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056260 | 1 – 258 | Tripartite motif-containing protein 40Add BLAST | 258 |
Proteomic databases
MassIVEi | Q6P9F5 |
PeptideAtlasi | Q6P9F5 |
PRIDEi | Q6P9F5 |
ProteomicsDBi | 67040 [Q6P9F5-1] 67041 [Q6P9F5-2] |
PTM databases
iPTMneti | Q6P9F5 |
PhosphoSitePlusi | Q6P9F5 |
Expressioni
Tissue specificityi
Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract.1 Publication
Gene expression databases
Bgeei | ENSG00000204614, Expressed in duodenum and 39 other tissues |
ExpressionAtlasi | Q6P9F5, baseline and differential |
Genevisiblei | Q6P9F5, HS |
Organism-specific databases
HPAi | ENSG00000204614, Group enriched (intestine, placenta) |
Interactioni
Subunit structurei
Interacts with NEDD8.
1 PublicationProtein-protein interaction databases
BioGRIDi | 126432, 9 interactors |
IntActi | Q6P9F5, 1 interactor |
STRINGi | 9606.ENSP00000379826 |
Miscellaneous databases
RNActi | Q6P9F5, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 107 – 159 | Sequence analysisAdd BLAST | 53 |
Sequence similaritiesi
Belongs to the TRIM/RBCC family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 14 – 56 | RING-typePROSITE-ProRule annotationAdd BLAST | 43 | |
Zinc fingeri | 66 – 107 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00710000106875 |
HOGENOMi | CLU_013137_3_0_1 |
InParanoidi | Q6P9F5 |
OMAi | PEHVSHH |
OrthoDBi | 251004at2759 |
PhylomeDBi | Q6P9F5 |
TreeFami | TF333491 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR027370, Znf-RING_LisH IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13445, zf-RING_UBOX, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6P9F5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIPLQKDNQE EGVCPICQES LKEAVSTNCG HLFCRVCLTQ HVEKASASGV
60 70 80 90 100
FCCPLCRKPC SEEVLGTGYI CPNHQKRVCR FCEESRLLLC VECLVSPEHM
110 120 130 140 150
SHHELTIENA LSHYKERLNR RSRKLRKDIA ELQRLKAQQE KKLQALQFQV
160 170 180 190 200
DHGNHRLEAG PESQHQTREQ LGALPQQWLG QLEHMPAEAA RILDISRAVT
210 220 230 240 250
QLRSLVIDLE RTAKELDTNT LKNAGDLLNR SAPQKLEVIY PQLEKGVSEL
LLQPPQKL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JIV5 | A0A0G2JIV5_HUMAN | TRIM40 | TRIM40 | 258 | Annotation score: | ||
A0A0G2JMU7 | A0A0G2JMU7_HUMAN | TRIM40 | TRIM40 | 258 | Annotation score: | ||
A0A140T9D5 | A0A140T9D5_HUMAN | Tripartite motif-containing protein... | TRIM40 | 229 | Annotation score: | ||
A0A0G2JK97 | A0A0G2JK97_HUMAN | Tripartite motif-containing protein... | TRIM40 | 229 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055309 | 142 | K → Q. Corresponds to variant dbSNP:rs12528473Ensembl. | 1 | |
Natural variantiVAR_055310 | 215 | E → K. Corresponds to variant dbSNP:rs757259Ensembl. | 1 | |
Natural variantiVAR_057222 | 244 | E → K. Corresponds to variant dbSNP:rs757259Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012131 | 148 – 176 | Missing in isoform 2. 1 PublicationAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF489517 mRNA Translation: AAM09503.1 AB110939 Genomic DNA Translation: BAD13705.1 AB110940 Genomic DNA Translation: BAD13706.1 AB202084 Genomic DNA Translation: BAE78604.1 AL669914 Genomic DNA No translation available. BX322644 Genomic DNA No translation available. AL671859 Genomic DNA No translation available. CR788282 Genomic DNA No translation available. BX927221 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03265.1 CH471081 Genomic DNA Translation: EAX03266.1 BC060785 mRNA Translation: AAH60785.1 |
CCDSi | CCDS4675.1 [Q6P9F5-2] CCDS69069.1 [Q6P9F5-1] |
RefSeqi | NP_001273562.1, NM_001286633.1 [Q6P9F5-1] NP_619645.1, NM_138700.4 [Q6P9F5-2] XP_011512607.1, XM_011514305.1 [Q6P9F5-1] XP_011512608.1, XM_011514306.1 [Q6P9F5-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF489517 mRNA Translation: AAM09503.1 AB110939 Genomic DNA Translation: BAD13705.1 AB110940 Genomic DNA Translation: BAD13706.1 AB202084 Genomic DNA Translation: BAE78604.1 AL669914 Genomic DNA No translation available. BX322644 Genomic DNA No translation available. AL671859 Genomic DNA No translation available. CR788282 Genomic DNA No translation available. BX927221 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03265.1 CH471081 Genomic DNA Translation: EAX03266.1 BC060785 mRNA Translation: AAH60785.1 |
CCDSi | CCDS4675.1 [Q6P9F5-2] CCDS69069.1 [Q6P9F5-1] |
RefSeqi | NP_001273562.1, NM_001286633.1 [Q6P9F5-1] NP_619645.1, NM_138700.4 [Q6P9F5-2] XP_011512607.1, XM_011514305.1 [Q6P9F5-1] XP_011512608.1, XM_011514306.1 [Q6P9F5-1] |
3D structure databases
SMRi | Q6P9F5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126432, 9 interactors |
IntActi | Q6P9F5, 1 interactor |
STRINGi | 9606.ENSP00000379826 |
PTM databases
iPTMneti | Q6P9F5 |
PhosphoSitePlusi | Q6P9F5 |
Polymorphism and mutation databases
BioMutai | TRIM40 |
DMDMi | 229463021 |
Proteomic databases
MassIVEi | Q6P9F5 |
PeptideAtlasi | Q6P9F5 |
PRIDEi | Q6P9F5 |
ProteomicsDBi | 67040 [Q6P9F5-1] 67041 [Q6P9F5-2] |
Protocols and materials databases
Antibodypediai | 26227, 84 antibodies |
DNASUi | 135644 |
Genome annotation databases
Organism-specific databases
CTDi | 135644 |
DisGeNETi | 135644 |
EuPathDBi | HostDB:ENSG00000204614.8 |
GeneCardsi | TRIM40 |
HGNCi | HGNC:18736, TRIM40 |
HPAi | ENSG00000204614, Group enriched (intestine, placenta) |
MIMi | 616976, gene |
neXtProti | NX_Q6P9F5 |
OpenTargetsi | ENSG00000204614 |
PharmGKBi | PA38663 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00710000106875 |
HOGENOMi | CLU_013137_3_0_1 |
InParanoidi | Q6P9F5 |
OMAi | PEHVSHH |
OrthoDBi | 251004at2759 |
PhylomeDBi | Q6P9F5 |
TreeFami | TF333491 |
Enzyme and pathway databases
PathwayCommonsi | Q6P9F5 |
Miscellaneous databases
BioGRID-ORCSi | 135644, 5 hits in 842 CRISPR screens |
ChiTaRSi | TRIM40, human |
GenomeRNAii | 135644 |
Pharosi | Q6P9F5, Tbio |
PROi | PR:Q6P9F5 |
RNActi | Q6P9F5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204614, Expressed in duodenum and 39 other tissues |
ExpressionAtlasi | Q6P9F5, baseline and differential |
Genevisiblei | Q6P9F5, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR027370, Znf-RING_LisH IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13445, zf-RING_UBOX, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRI40_HUMAN | |
Accessioni | Q6P9F5Primary (citable) accession number: Q6P9F5 Secondary accession number(s): Q5SRJ6, Q5SS36, Q8TD96 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | May 5, 2009 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations