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Entry version 142 (02 Dec 2020)
Sequence version 3 (05 May 2009)
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Protein

Tripartite motif-containing protein 40

Gene

TRIM40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri14 – 56RING-typePROSITE-ProRule annotationAdd BLAST43
Zinc fingeri66 – 107B box-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6P9F5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tripartite motif-containing protein 40
Alternative name(s):
Probable E3 NEDD8-protein ligase
RING finger protein 35
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM40
Synonyms:RNF35
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000204614.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18736, TRIM40

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616976, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P9F5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
135644

Open Targets

More...
OpenTargetsi
ENSG00000204614

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38663

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P9F5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIM40

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229463021

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562601 – 258Tripartite motif-containing protein 40Add BLAST258

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6P9F5

PeptideAtlas

More...
PeptideAtlasi
Q6P9F5

PRoteomics IDEntifications database

More...
PRIDEi
Q6P9F5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67040 [Q6P9F5-1]
67041 [Q6P9F5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P9F5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P9F5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204614, Expressed in duodenum and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P9F5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P9F5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000204614, Group enriched (intestine, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NEDD8.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126432, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P9F5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379826

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P9F5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P9F5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili107 – 159Sequence analysisAdd BLAST53

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 56RING-typePROSITE-ProRule annotationAdd BLAST43
Zinc fingeri66 – 107B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2177, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00710000106875

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013137_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P9F5

Identification of Orthologs from Complete Genome Data

More...
OMAi
PEHVSHH

Database of Orthologous Groups

More...
OrthoDBi
251004at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P9F5

TreeFam database of animal gene trees

More...
TreeFami
TF333491

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027370, Znf-RING_LisH
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13445, zf-RING_UBOX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184, RING, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P9F5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPLQKDNQE EGVCPICQES LKEAVSTNCG HLFCRVCLTQ HVEKASASGV
60 70 80 90 100
FCCPLCRKPC SEEVLGTGYI CPNHQKRVCR FCEESRLLLC VECLVSPEHM
110 120 130 140 150
SHHELTIENA LSHYKERLNR RSRKLRKDIA ELQRLKAQQE KKLQALQFQV
160 170 180 190 200
DHGNHRLEAG PESQHQTREQ LGALPQQWLG QLEHMPAEAA RILDISRAVT
210 220 230 240 250
QLRSLVIDLE RTAKELDTNT LKNAGDLLNR SAPQKLEVIY PQLEKGVSEL

LLQPPQKL
Length:258
Mass (Da):29,336
Last modified:May 5, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC360BECD4411F1DB
GO
Isoform 2 (identifier: Q6P9F5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-176: Missing.

Show »
Length:229
Mass (Da):26,073
Checksum:i48DA1F84FB6DE152
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JIV5A0A0G2JIV5_HUMAN
TRIM40
TRIM40
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMU7A0A0G2JMU7_HUMAN
TRIM40
TRIM40
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9D5A0A140T9D5_HUMAN
Tripartite motif-containing protein...
TRIM40
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JK97A0A0G2JK97_HUMAN
Tripartite motif-containing protein...
TRIM40
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055309142K → Q. Corresponds to variant dbSNP:rs12528473Ensembl.1
Natural variantiVAR_055310215E → K. Corresponds to variant dbSNP:rs757259Ensembl.1
Natural variantiVAR_057222244E → K. Corresponds to variant dbSNP:rs757259Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012131148 – 176Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF489517 mRNA Translation: AAM09503.1
AB110939 Genomic DNA Translation: BAD13705.1
AB110940 Genomic DNA Translation: BAD13706.1
AB202084 Genomic DNA Translation: BAE78604.1
AL669914 Genomic DNA No translation available.
BX322644 Genomic DNA No translation available.
AL671859 Genomic DNA No translation available.
CR788282 Genomic DNA No translation available.
BX927221 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03265.1
CH471081 Genomic DNA Translation: EAX03266.1
BC060785 mRNA Translation: AAH60785.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4675.1 [Q6P9F5-2]
CCDS69069.1 [Q6P9F5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001273562.1, NM_001286633.1 [Q6P9F5-1]
NP_619645.1, NM_138700.4 [Q6P9F5-2]
XP_011512607.1, XM_011514305.1 [Q6P9F5-1]
XP_011512608.1, XM_011514306.1 [Q6P9F5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307859; ENSP00000308310; ENSG00000204614 [Q6P9F5-2]
ENST00000376724; ENSP00000365914; ENSG00000204614 [Q6P9F5-1]
ENST00000383610; ENSP00000373105; ENSG00000172524 [Q6P9F5-1]
ENST00000396581; ENSP00000379826; ENSG00000204614 [Q6P9F5-1]
ENST00000400651; ENSP00000383492; ENSG00000172524 [Q6P9F5-2]
ENST00000421981; ENSP00000403025; ENSG00000237046 [Q6P9F5-2]
ENST00000429471; ENSP00000393674; ENSG00000228001 [Q6P9F5-2]
ENST00000433713; ENSP00000389607; ENSG00000224496 [Q6P9F5-1]
ENST00000434151; ENSP00000388460; ENSG00000237046 [Q6P9F5-1]
ENST00000436951; ENSP00000416663; ENSG00000224496 [Q6P9F5-2]
ENST00000437563; ENSP00000416950; ENSG00000228001 [Q6P9F5-1]
ENST00000547289; ENSP00000446663; ENSG00000172524 [Q6P9F5-1]
ENST00000549728; ENSP00000447016; ENSG00000237046 [Q6P9F5-1]
ENST00000552119; ENSP00000448967; ENSG00000228001 [Q6P9F5-1]
ENST00000616351; ENSP00000483120; ENSG00000224496 [Q6P9F5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
135644

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:135644

UCSC genome browser

More...
UCSCi
uc003npk.2, human [Q6P9F5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF489517 mRNA Translation: AAM09503.1
AB110939 Genomic DNA Translation: BAD13705.1
AB110940 Genomic DNA Translation: BAD13706.1
AB202084 Genomic DNA Translation: BAE78604.1
AL669914 Genomic DNA No translation available.
BX322644 Genomic DNA No translation available.
AL671859 Genomic DNA No translation available.
CR788282 Genomic DNA No translation available.
BX927221 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03265.1
CH471081 Genomic DNA Translation: EAX03266.1
BC060785 mRNA Translation: AAH60785.1
CCDSiCCDS4675.1 [Q6P9F5-2]
CCDS69069.1 [Q6P9F5-1]
RefSeqiNP_001273562.1, NM_001286633.1 [Q6P9F5-1]
NP_619645.1, NM_138700.4 [Q6P9F5-2]
XP_011512607.1, XM_011514305.1 [Q6P9F5-1]
XP_011512608.1, XM_011514306.1 [Q6P9F5-1]

3D structure databases

SMRiQ6P9F5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126432, 9 interactors
IntActiQ6P9F5, 1 interactor
STRINGi9606.ENSP00000379826

PTM databases

iPTMnetiQ6P9F5
PhosphoSitePlusiQ6P9F5

Polymorphism and mutation databases

BioMutaiTRIM40
DMDMi229463021

Proteomic databases

MassIVEiQ6P9F5
PeptideAtlasiQ6P9F5
PRIDEiQ6P9F5
ProteomicsDBi67040 [Q6P9F5-1]
67041 [Q6P9F5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26227, 84 antibodies

The DNASU plasmid repository

More...
DNASUi
135644

Genome annotation databases

EnsembliENST00000307859; ENSP00000308310; ENSG00000204614 [Q6P9F5-2]
ENST00000376724; ENSP00000365914; ENSG00000204614 [Q6P9F5-1]
ENST00000383610; ENSP00000373105; ENSG00000172524 [Q6P9F5-1]
ENST00000396581; ENSP00000379826; ENSG00000204614 [Q6P9F5-1]
ENST00000400651; ENSP00000383492; ENSG00000172524 [Q6P9F5-2]
ENST00000421981; ENSP00000403025; ENSG00000237046 [Q6P9F5-2]
ENST00000429471; ENSP00000393674; ENSG00000228001 [Q6P9F5-2]
ENST00000433713; ENSP00000389607; ENSG00000224496 [Q6P9F5-1]
ENST00000434151; ENSP00000388460; ENSG00000237046 [Q6P9F5-1]
ENST00000436951; ENSP00000416663; ENSG00000224496 [Q6P9F5-2]
ENST00000437563; ENSP00000416950; ENSG00000228001 [Q6P9F5-1]
ENST00000547289; ENSP00000446663; ENSG00000172524 [Q6P9F5-1]
ENST00000549728; ENSP00000447016; ENSG00000237046 [Q6P9F5-1]
ENST00000552119; ENSP00000448967; ENSG00000228001 [Q6P9F5-1]
ENST00000616351; ENSP00000483120; ENSG00000224496 [Q6P9F5-1]
GeneIDi135644
KEGGihsa:135644
UCSCiuc003npk.2, human [Q6P9F5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
135644
DisGeNETi135644
EuPathDBiHostDB:ENSG00000204614.8

GeneCards: human genes, protein and diseases

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GeneCardsi
TRIM40
HGNCiHGNC:18736, TRIM40
HPAiENSG00000204614, Group enriched (intestine, placenta)
MIMi616976, gene
neXtProtiNX_Q6P9F5
OpenTargetsiENSG00000204614
PharmGKBiPA38663

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2177, Eukaryota
GeneTreeiENSGT00710000106875
HOGENOMiCLU_013137_3_0_1
InParanoidiQ6P9F5
OMAiPEHVSHH
OrthoDBi251004at2759
PhylomeDBiQ6P9F5
TreeFamiTF333491

Enzyme and pathway databases

PathwayCommonsiQ6P9F5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
135644, 5 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRIM40, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
135644
PharosiQ6P9F5, Tbio

Protein Ontology

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PROi
PR:Q6P9F5
RNActiQ6P9F5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000204614, Expressed in duodenum and 39 other tissues
ExpressionAtlasiQ6P9F5, baseline and differential
GenevisibleiQ6P9F5, HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR027370, Znf-RING_LisH
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PfamiView protein in Pfam
PF13445, zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00184, RING, 1 hit
PROSITEiView protein in PROSITE
PS50119, ZF_BBOX, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI40_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P9F5
Secondary accession number(s): Q5SRJ6, Q5SS36, Q8TD96
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 5, 2009
Last modified: December 2, 2020
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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