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Protein

Tripartite motif-containing protein 40

Gene

TRIM40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 56RING-typePROSITE-ProRule annotationAdd BLAST43
Zinc fingeri66 – 107B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 40
Alternative name(s):
Probable E3 NEDD8-protein ligase
RING finger protein 35
Gene namesi
Name:TRIM40
Synonyms:RNF35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204614.8
HGNCiHGNC:18736 TRIM40
MIMi616976 gene
neXtProtiNX_Q6P9F5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi135644
OpenTargetsiENSG00000204614
PharmGKBiPA38663

Polymorphism and mutation databases

DMDMi229463021

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562601 – 258Tripartite motif-containing protein 40Add BLAST258

Proteomic databases

PeptideAtlasiQ6P9F5
PRIDEiQ6P9F5
ProteomicsDBi67040
67041 [Q6P9F5-2]

PTM databases

iPTMnetiQ6P9F5
PhosphoSitePlusiQ6P9F5

Expressioni

Tissue specificityi

Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract.1 Publication

Gene expression databases

BgeeiENSG00000204614 Expressed in 25 organ(s), highest expression level in chorionic villus
CleanExiHS_TRIM40
ExpressionAtlasiQ6P9F5 baseline and differential
GenevisibleiQ6P9F5 HS

Organism-specific databases

HPAiHPA043818

Interactioni

Subunit structurei

Interacts with NEDD8.1 Publication

Protein-protein interaction databases

BioGridi126432, 5 interactors
IntActiQ6P9F5, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ6P9F5
SMRiQ6P9F5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili107 – 159Sequence analysisAdd BLAST53

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 56RING-typePROSITE-ProRule annotationAdd BLAST43
Zinc fingeri66 – 107B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00710000106875
HOGENOMiHOG000060264
HOVERGENiHBG057956
InParanoidiQ6P9F5
KOiK12016
OMAiRVCLTQH
OrthoDBiEOG09370R60
PhylomeDBiQ6P9F5
TreeFamiTF333491

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000315 Znf_B-box
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00097 zf-C3HC4, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P9F5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPLQKDNQE EGVCPICQES LKEAVSTNCG HLFCRVCLTQ HVEKASASGV
60 70 80 90 100
FCCPLCRKPC SEEVLGTGYI CPNHQKRVCR FCEESRLLLC VECLVSPEHM
110 120 130 140 150
SHHELTIENA LSHYKERLNR RSRKLRKDIA ELQRLKAQQE KKLQALQFQV
160 170 180 190 200
DHGNHRLEAG PESQHQTREQ LGALPQQWLG QLEHMPAEAA RILDISRAVT
210 220 230 240 250
QLRSLVIDLE RTAKELDTNT LKNAGDLLNR SAPQKLEVIY PQLEKGVSEL

LLQPPQKL
Length:258
Mass (Da):29,336
Last modified:May 5, 2009 - v3
Checksum:iC360BECD4411F1DB
GO
Isoform 2 (identifier: Q6P9F5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-176: Missing.

Note: No experimental confirmation available.
Show »
Length:229
Mass (Da):26,073
Checksum:i48DA1F84FB6DE152
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JMU7A0A0G2JMU7_HUMAN
TRIM40
TRIM40
258Annotation score:
A0A0G2JIV5A0A0G2JIV5_HUMAN
TRIM40
TRIM40
258Annotation score:
A0A0G2JK97A0A0G2JK97_HUMAN
Tripartite motif-containing protein...
TRIM40
229Annotation score:
A0A140T9D5A0A140T9D5_HUMAN
Tripartite motif-containing protein...
TRIM40
229Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055309142K → Q. Corresponds to variant dbSNP:rs12528473Ensembl.1
Natural variantiVAR_055310215E → K. Corresponds to variant dbSNP:rs757259Ensembl.1
Natural variantiVAR_057222244E → K. Corresponds to variant dbSNP:rs757259Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012131148 – 176Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF489517 mRNA Translation: AAM09503.1
AB110939 Genomic DNA Translation: BAD13705.1
AB110940 Genomic DNA Translation: BAD13706.1
AB202084 Genomic DNA Translation: BAE78604.1
AL669914 Genomic DNA No translation available.
BX322644 Genomic DNA No translation available.
AL671859 Genomic DNA No translation available.
CR788282 Genomic DNA No translation available.
BX927221 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03265.1
CH471081 Genomic DNA Translation: EAX03266.1
BC060785 mRNA Translation: AAH60785.1
CCDSiCCDS4675.1 [Q6P9F5-2]
CCDS69069.1 [Q6P9F5-1]
RefSeqiNP_001273562.1, NM_001286633.1 [Q6P9F5-1]
NP_619645.1, NM_138700.4 [Q6P9F5-2]
XP_011512607.1, XM_011514305.1 [Q6P9F5-1]
XP_011512608.1, XM_011514306.1 [Q6P9F5-1]
UniGeneiHs.509439

Genome annotation databases

EnsembliENST00000307859; ENSP00000308310; ENSG00000204614 [Q6P9F5-2]
ENST00000376724; ENSP00000365914; ENSG00000204614 [Q6P9F5-1]
ENST00000383610; ENSP00000373105; ENSG00000172524 [Q6P9F5-1]
ENST00000396581; ENSP00000379826; ENSG00000204614 [Q6P9F5-1]
ENST00000400651; ENSP00000383492; ENSG00000172524 [Q6P9F5-2]
ENST00000421981; ENSP00000403025; ENSG00000237046 [Q6P9F5-2]
ENST00000429471; ENSP00000393674; ENSG00000228001 [Q6P9F5-2]
ENST00000433713; ENSP00000389607; ENSG00000224496 [Q6P9F5-1]
ENST00000434151; ENSP00000388460; ENSG00000237046 [Q6P9F5-1]
ENST00000436951; ENSP00000416663; ENSG00000224496 [Q6P9F5-2]
ENST00000437563; ENSP00000416950; ENSG00000228001 [Q6P9F5-1]
ENST00000547289; ENSP00000446663; ENSG00000172524 [Q6P9F5-1]
ENST00000549728; ENSP00000447016; ENSG00000237046 [Q6P9F5-1]
ENST00000552119; ENSP00000448967; ENSG00000228001 [Q6P9F5-1]
ENST00000616351; ENSP00000483120; ENSG00000224496 [Q6P9F5-1]
GeneIDi135644
KEGGihsa:135644
UCSCiuc003npk.2 human [Q6P9F5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF489517 mRNA Translation: AAM09503.1
AB110939 Genomic DNA Translation: BAD13705.1
AB110940 Genomic DNA Translation: BAD13706.1
AB202084 Genomic DNA Translation: BAE78604.1
AL669914 Genomic DNA No translation available.
BX322644 Genomic DNA No translation available.
AL671859 Genomic DNA No translation available.
CR788282 Genomic DNA No translation available.
BX927221 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03265.1
CH471081 Genomic DNA Translation: EAX03266.1
BC060785 mRNA Translation: AAH60785.1
CCDSiCCDS4675.1 [Q6P9F5-2]
CCDS69069.1 [Q6P9F5-1]
RefSeqiNP_001273562.1, NM_001286633.1 [Q6P9F5-1]
NP_619645.1, NM_138700.4 [Q6P9F5-2]
XP_011512607.1, XM_011514305.1 [Q6P9F5-1]
XP_011512608.1, XM_011514306.1 [Q6P9F5-1]
UniGeneiHs.509439

3D structure databases

ProteinModelPortaliQ6P9F5
SMRiQ6P9F5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126432, 5 interactors
IntActiQ6P9F5, 1 interactor

PTM databases

iPTMnetiQ6P9F5
PhosphoSitePlusiQ6P9F5

Polymorphism and mutation databases

DMDMi229463021

Proteomic databases

PeptideAtlasiQ6P9F5
PRIDEiQ6P9F5
ProteomicsDBi67040
67041 [Q6P9F5-2]

Protocols and materials databases

DNASUi135644
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307859; ENSP00000308310; ENSG00000204614 [Q6P9F5-2]
ENST00000376724; ENSP00000365914; ENSG00000204614 [Q6P9F5-1]
ENST00000383610; ENSP00000373105; ENSG00000172524 [Q6P9F5-1]
ENST00000396581; ENSP00000379826; ENSG00000204614 [Q6P9F5-1]
ENST00000400651; ENSP00000383492; ENSG00000172524 [Q6P9F5-2]
ENST00000421981; ENSP00000403025; ENSG00000237046 [Q6P9F5-2]
ENST00000429471; ENSP00000393674; ENSG00000228001 [Q6P9F5-2]
ENST00000433713; ENSP00000389607; ENSG00000224496 [Q6P9F5-1]
ENST00000434151; ENSP00000388460; ENSG00000237046 [Q6P9F5-1]
ENST00000436951; ENSP00000416663; ENSG00000224496 [Q6P9F5-2]
ENST00000437563; ENSP00000416950; ENSG00000228001 [Q6P9F5-1]
ENST00000547289; ENSP00000446663; ENSG00000172524 [Q6P9F5-1]
ENST00000549728; ENSP00000447016; ENSG00000237046 [Q6P9F5-1]
ENST00000552119; ENSP00000448967; ENSG00000228001 [Q6P9F5-1]
ENST00000616351; ENSP00000483120; ENSG00000224496 [Q6P9F5-1]
GeneIDi135644
KEGGihsa:135644
UCSCiuc003npk.2 human [Q6P9F5-1]

Organism-specific databases

CTDi135644
DisGeNETi135644
EuPathDBiHostDB:ENSG00000204614.8
GeneCardsiTRIM40
H-InvDBiHIX0166177
HIX0167220
HGNCiHGNC:18736 TRIM40
HPAiHPA043818
MIMi616976 gene
neXtProtiNX_Q6P9F5
OpenTargetsiENSG00000204614
PharmGKBiPA38663
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00710000106875
HOGENOMiHOG000060264
HOVERGENiHBG057956
InParanoidiQ6P9F5
KOiK12016
OMAiRVCLTQH
OrthoDBiEOG09370R60
PhylomeDBiQ6P9F5
TreeFamiTF333491

Miscellaneous databases

ChiTaRSiTRIM40 human
GenomeRNAii135644
PROiPR:Q6P9F5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204614 Expressed in 25 organ(s), highest expression level in chorionic villus
CleanExiHS_TRIM40
ExpressionAtlasiQ6P9F5 baseline and differential
GenevisibleiQ6P9F5 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000315 Znf_B-box
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00097 zf-C3HC4, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRI40_HUMAN
AccessioniPrimary (citable) accession number: Q6P9F5
Secondary accession number(s): Q5SRJ6, Q5SS36, Q8TD96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 5, 2009
Last modified: October 10, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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