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Entry version 128 (02 Jun 2021)
Sequence version 2 (13 Jun 2006)
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Protein

Coiled-coil domain-containing protein 62

Gene

CCDC62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6P9F0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 62
Alternative name(s):
Protein TSP-NY
Protein aaa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC62
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30723, CCDC62

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613481, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P9F0

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000130783.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi637 – 638LL → AA: Abrogates interaction with ESR1 and ESR2. 2 Publications2
Mutagenesisi653 – 654LL → AA: No effect on interaction with ESR1 or ESR2. 2 Publications2

Organism-specific databases

DisGeNET

More...
DisGeNETi
84660

Open Targets

More...
OpenTargetsi
ENSG00000130783

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485414

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P9F0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC62

Domain mapping of disease mutations (DMDM)

More...
DMDMi
108935965

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002402471 – 684Coiled-coil domain-containing protein 62Add BLAST684

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P9F0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P9F0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6P9F0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P9F0

PeptideAtlas

More...
PeptideAtlasi
Q6P9F0

PRoteomics IDEntifications database

More...
PRIDEi
Q6P9F0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67037 [Q6P9F0-1]
67038 [Q6P9F0-2]
67039 [Q6P9F0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P9F0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P9F0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in adult testis. Expressed in both prostate epithelial and stromal cells, with predominant expression in epithelial cells (at protein level) (PubMed:19126643). Not detected in prostate by RT-PCR (PubMed:19165854). Overexpressed in various cancers.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130783, Expressed in testis and 109 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P9F0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P9F0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000130783, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ESR1 and ESR2 in the presence of estradiol/E2. The interaction with ESR2 recruits CCDC62 to ER target genes, including cyclin-D1/CCND1 AP-1 promoter.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124180, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P9F0, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253079

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P9F0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P9F0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni579 – 603DisorderedSequence analysisAdd BLAST25
Regioni657 – 684DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili11 – 160Sequence analysisAdd BLAST150
Coiled coili199 – 322Sequence analysisAdd BLAST124

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi634 – 638LXXLL motif 15
Motifi650 – 654LXXLL motif 25

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RHSF, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00400000022269

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025504_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P9F0

Identification of Orthologs from Complete Genome Data

More...
OMAi
WMNIFKP

Database of Orthologous Groups

More...
OrthoDBi
397822at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P9F0

TreeFam database of animal gene trees

More...
TreeFami
TF329149

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P9F0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPPAAFLAG RQNIGSEVEI STIEKQRKEL QLLIGELKDR DKELNDMVAV
60 70 80 90 100
HQQQLLSWEE DRQKVLTLEE RCSKLEGELH KRTEIIRSLT KKVKALESNQ
110 120 130 140 150
MECQTALQKT QLQLQEMAQK ATHSSLLSED LEARNETLSN TLVELSAQVG
160 170 180 190 200
QLQAREQALT TMIKLKDKDI IEAVNHIADC SGKFKMLEHA LRDAKMAETC
210 220 230 240 250
IVKEKQDYKQ KLKALKIEVN KLKEDLNEKT TENNEQREEI IRLKQEKSCL
260 270 280 290 300
HDELLFTVER EKRKDELLNI AKSKQERTNS ELHNLRQIYV KQQSDLQFLN
310 320 330 340 350
FNVENSQELI QMYDSKMEES KALDSSRDMC LSDLENNHPK VDIKREKNQK
360 370 380 390 400
SLFKDQKFEA MLVQQNRSDK SSCDECKEKK QQIDTVFGEK SVITLSSIFT
410 420 430 440 450
KDLVEKHNLP WSLGGKTQIE PENKITLCKI HTKSPKCHGT GVQNEGKQPS
460 470 480 490 500
ETPTLSDEKQ WHDVSVYLGL TNCPSSKHPE KLDVECQDQM ERSEISCCQK
510 520 530 540 550
NEACLGESGM CDSKCCHPSN FIIEAPGHMS DVEWMSIFKP SKMQRIVRLK
560 570 580 590 600
SGCTCSESIC GTQHDSPASE LIAIQDSHSL GSSKSALRED ETESSSNKKN
610 620 630 640 650
SPTSLLIYKD APAFNEKASI VLPSQDDFSP TSKLQRLLAE SRQMVTDLEL
660 670 680
STLLPISHEN LTGSATNKSE VPEESAQKNT FVSY
Length:684
Mass (Da):77,748
Last modified:June 13, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i071DCEC789E4DF60
GO
Isoform 2 (identifier: Q6P9F0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     668-684: KSEVPEESAQKNTFVSY → ISHLCGRQKADTNTE

Show »
Length:682
Mass (Da):77,478
Checksum:i2F866192CA92507B
GO
Isoform 3 (identifier: Q6P9F0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-239: Missing.
     240-257: IIRLKQEKSCLHDELLFT → MPNSSPKDPTTASGNGSK

Show »
Length:445
Mass (Da):49,908
Checksum:i30D5CA8386F76AA1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A024RBT8A0A024RBT8_HUMAN
Coiled-coil domain containing 62, i...
CCDC62 hCG_2015662
497Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0F1F5H0F1_HUMAN
Coiled-coil domain-containing prote...
CCDC62
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG49396 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti486C → R in BAF85155 (PubMed:14702039).Curated1
Sequence conflicti651S → N in AAG49396 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03549831Q → E in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_061585141T → M. Corresponds to variant dbSNP:rs58131754Ensembl.1
Natural variantiVAR_026715394T → K1 PublicationCorresponds to variant dbSNP:rs17855031Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0193271 – 239Missing in isoform 3. 1 PublicationAdd BLAST239
Alternative sequenceiVSP_019328240 – 257IIRLK…ELLFT → MPNSSPKDPTTASGNGSK in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_019329668 – 684KSEVP…TFVSY → ISHLCGRQKADTNTE in isoform 2. 3 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY254201 mRNA Translation: AAP13075.1
AK097663 mRNA Translation: BAG53505.1
AK124633 mRNA Translation: BAC85909.1
AK292466 mRNA Translation: BAF85155.1
BC060796 mRNA Translation: AAH60796.1
AY009105 mRNA Translation: AAG49396.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9238.1 [Q6P9F0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_958843.2, NM_201435.4 [Q6P9F0-1]
XP_006719706.1, XM_006719643.1 [Q6P9F0-1]
XP_006719707.1, XM_006719644.1 [Q6P9F0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000253079; ENSP00000253079; ENSG00000130783 [Q6P9F0-1]
ENST00000341952; ENSP00000341471; ENSG00000130783 [Q6P9F0-2]
ENST00000392441; ENSP00000376236; ENSG00000130783 [Q6P9F0-2]
ENST00000537566; ENSP00000445045; ENSG00000130783 [Q6P9F0-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84660

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84660

UCSC genome browser

More...
UCSCi
uc001udc.4, human [Q6P9F0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY254201 mRNA Translation: AAP13075.1
AK097663 mRNA Translation: BAG53505.1
AK124633 mRNA Translation: BAC85909.1
AK292466 mRNA Translation: BAF85155.1
BC060796 mRNA Translation: AAH60796.1
AY009105 mRNA Translation: AAG49396.1 Different initiation.
CCDSiCCDS9238.1 [Q6P9F0-1]
RefSeqiNP_958843.2, NM_201435.4 [Q6P9F0-1]
XP_006719706.1, XM_006719643.1 [Q6P9F0-1]
XP_006719707.1, XM_006719644.1 [Q6P9F0-2]

3D structure databases

SMRiQ6P9F0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124180, 3 interactors
IntActiQ6P9F0, 4 interactors
STRINGi9606.ENSP00000253079

PTM databases

iPTMnetiQ6P9F0
PhosphoSitePlusiQ6P9F0

Genetic variation databases

BioMutaiCCDC62
DMDMi108935965

Proteomic databases

EPDiQ6P9F0
jPOSTiQ6P9F0
MassIVEiQ6P9F0
PaxDbiQ6P9F0
PeptideAtlasiQ6P9F0
PRIDEiQ6P9F0
ProteomicsDBi67037 [Q6P9F0-1]
67038 [Q6P9F0-2]
67039 [Q6P9F0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
52252, 67 antibodies

The DNASU plasmid repository

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DNASUi
84660

Genome annotation databases

EnsembliENST00000253079; ENSP00000253079; ENSG00000130783 [Q6P9F0-1]
ENST00000341952; ENSP00000341471; ENSG00000130783 [Q6P9F0-2]
ENST00000392441; ENSP00000376236; ENSG00000130783 [Q6P9F0-2]
ENST00000537566; ENSP00000445045; ENSG00000130783 [Q6P9F0-3]
GeneIDi84660
KEGGihsa:84660
UCSCiuc001udc.4, human [Q6P9F0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84660
DisGeNETi84660

GeneCards: human genes, protein and diseases

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GeneCardsi
CCDC62
HGNCiHGNC:30723, CCDC62
HPAiENSG00000130783, Tissue enriched (testis)
MIMi613481, gene
neXtProtiNX_Q6P9F0
OpenTargetsiENSG00000130783
PharmGKBiPA143485414
VEuPathDBiHostDB:ENSG00000130783.13

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502RHSF, Eukaryota
GeneTreeiENSGT00400000022269
HOGENOMiCLU_025504_0_0_1
InParanoidiQ6P9F0
OMAiWMNIFKP
OrthoDBi397822at2759
PhylomeDBiQ6P9F0
TreeFamiTF329149

Enzyme and pathway databases

PathwayCommonsiQ6P9F0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84660, 21 hits in 991 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CCDC62, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84660
PharosiQ6P9F0, Tbio

Protein Ontology

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PROi
PR:Q6P9F0
RNActiQ6P9F0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000130783, Expressed in testis and 109 other tissues
ExpressionAtlasiQ6P9F0, baseline and differential
GenevisibleiQ6P9F0, HS

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD62_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P9F0
Secondary accession number(s): A8K8V1
, B3KUP3, Q6ZVF2, Q86VJ0, Q9BYZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: June 2, 2021
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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