UniProtKB - Q6P9B6 (TLDC1_HUMAN)

BLAST

>sp|Q6P9B6|TLDC1_HUMAN TLD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TLDC1 PE=1 SV=2
MGNSRSRVGRSFCSQFLPEEQAEIDQLFDALSSDKNSPNVSSKSFSLKALQNHVGEALPP
EMVTRLYDGMRRVDLTGKAKGPSENVSQEQFTASMSHLLKGNSEEKSLMIMKMISATEGP
VKAREVQKFTEDLVGSVVHVLSHRQELRGWTGKEAPGPNPRVQVLAAQLLSDMKLQDGKR
LLGPQWLDYDCDRAVIEDWVFRVPHVAIFLSVVICKGFLILCSSLDLTTLVPERQVDQGR
GFESILDVLSVMYINAQLPREQRHRWCLLFSSELHGHSFSQLCGHITHRGPCVAVLEDHD
KHVFGGFASCSWEVKPQFQGDNRCFLFSICPSMAVYTHTGYNDHYMYLNHGQQTIPNGLG
MGGQHNYFGLWVDVDFGKGHSRAKPTCTTYNSPQLSAQENFQFDKMEVWAVGDPSEEQLA
KGNKSILDADPEAQALLEISGHSRHSEGLREVPDDE

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History
Entry version 113 (07 Nov 2018)
Sequence version 2 (18 May 2010)
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Protein

TLD domain-containing protein 1

Gene

TLDC1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Biological processⁱ

negative regulation of oxidative stress-induced neuron death Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TLD domain-containing protein 1 Alternative name(s): TBC/LysM-associated domain-containing protein 1
Gene namesⁱ	Name:TLDC1 Synonyms:KIAA1609
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140950.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29325 TLDC1
neXtProtⁱ	NX_Q6P9B6

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000140950
PharmGKBⁱ	PA144596416

Polymorphism and mutation databases

BioMutaⁱ	TLDC1
DMDMⁱ	296434547

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed
ChainⁱPRO_0000313640	2 – 456	TLD domain-containing protein 1Add BLAST		455

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	2	N-myristoyl glycine2 Publications		1

Keywords - PTMⁱ

Lipoprotein, Myristate

Proteomic databases

EPDⁱ	Q6P9B6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P9B6
PaxDbⁱ	Q6P9B6
PeptideAtlas More...PeptideAtlasⁱ	Q6P9B6
PRIDEⁱ	Q6P9B6
ProteomicsDBⁱ	67035

PTM databases

iPTMnetⁱ	Q6P9B6
PhosphoSitePlusⁱ	Q6P9B6
SwissPalmⁱ	Q6P9B6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000140950 Expressed in 162 organ(s), highest expression level in cervix squamous epithelium
CleanExⁱ	HS_KIAA1609
ExpressionAtlasⁱ	Q6P9B6 baseline and differential
Genevisibleⁱ	Q6P9B6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041020

HPAⁱ

HPA041020

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TRIP13	Q15645	3	EBI-746504,EBI-358993

With

Entry

#Exp.

IntAct

Notes

TRIP13

Q15645

EBI-746504,EBI-358993

Protein-protein interaction databases

BioGridⁱ	121731, 17 interactors
ELMⁱ	Q6P9B6
IntActⁱ	Q6P9B6, 1 interactor
STRINGⁱ	9606.ENSP00000343635

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6P9B6
SMRⁱ	Q6P9B6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	268 – 412	TLDAdd BLAST		145

Phylogenomic databases

eggNOGⁱ	KOG2557 Eukaryota ENOG410XR8F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00410000025363
HOGENOMⁱ	HOG000031408
HOVERGENⁱ	HBG103322
InParanoidⁱ	Q6P9B6
OMAⁱ	KPQFQGD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BIQ
PhylomeDBⁱ	Q6P9B6
TreeFamⁱ	TF316541

Family and domain databases

InterProⁱ	View protein in InterPro IPR006571 TLDc_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07534 TLD, 1 hit
SMARTⁱ	View protein in SMART SM00584 TLDc, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

Q6P9B6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGNSRSRVGR SFCSQFLPEE QAEIDQLFDA LSSDKNSPNV SSKSFSLKAL 
        60         70         80         90        100
QNHVGEALPP EMVTRLYDGM RRVDLTGKAK GPSENVSQEQ FTASMSHLLK 
       110        120        130        140        150
GNSEEKSLMI MKMISATEGP VKAREVQKFT EDLVGSVVHV LSHRQELRGW 
       160        170        180        190        200
TGKEAPGPNP RVQVLAAQLL SDMKLQDGKR LLGPQWLDYD CDRAVIEDWV 
       210        220        230        240        250
FRVPHVAIFL SVVICKGFLI LCSSLDLTTL VPERQVDQGR GFESILDVLS 
       260        270        280        290        300
VMYINAQLPR EQRHRWCLLF SSELHGHSFS QLCGHITHRG PCVAVLEDHD 
       310        320        330        340        350
KHVFGGFASC SWEVKPQFQG DNRCFLFSIC PSMAVYTHTG YNDHYMYLNH 
       360        370        380        390        400
GQQTIPNGLG MGGQHNYFGL WVDVDFGKGH SRAKPTCTTY NSPQLSAQEN 
       410        420        430        440        450
FQFDKMEVWA VGDPSEEQLA KGNKSILDAD PEAQALLEIS GHSRHSEGLR 

EVPDDE

Length:456

Mass (Da):50,994

Last modified:May 18, 2010 - v2

Checksum:ⁱ3237DF7BB9818667

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BM75	H3BM75_HUMAN	MTOR-associated protein, eak-7 homo... MTOR-associated protein, eak-7 homolog	MEAK7	193	Annotation score:
H3BUB0	H3BUB0_HUMAN	MTOR-associated protein, eak-7 homo... MTOR-associated protein, eak-7 homolog	MEAK7	148	Annotation score:
H3BPI4	H3BPI4_HUMAN	MTOR-associated protein, eak-7 homo... MTOR-associated protein, eak-7 homolog	MEAK7	57	Annotation score:
H3BQ13	H3BQ13_HUMAN	MTOR-associated protein, eak-7 homo... MTOR-associated protein, eak-7 homolog	MEAK7	45	Annotation score:
H3BTC5	H3BTC5_HUMAN	MTOR-associated protein, eak-7 homo... MTOR-associated protein, eak-7 homolog	MEAK7	83	Annotation score:

Sequence cautionⁱ

The sequence BAB13435 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_037675	10	R → L. Corresponds to variant dbSNP:rs8046813Ensembl.	1
Natural variantⁱVAR_037676	97	H → Q. Corresponds to variant dbSNP:rs8055536Ensembl.	1
Natural variantⁱVAR_037677	172	D → E2 PublicationsCorresponds to variant dbSNP:rs436278Ensembl.	1
Natural variantⁱVAR_037678	220	I → V3 PublicationsCorresponds to variant dbSNP:rs431818Ensembl.	1
Natural variantⁱVAR_037679	233	E → D. Corresponds to variant dbSNP:rs34244563Ensembl.	1
Natural variantⁱVAR_037680	267	C → R3 PublicationsCorresponds to variant dbSNP:rs422145Ensembl.	1
Natural variantⁱVAR_037681	443	S → L. Corresponds to variant dbSNP:rs34628943Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB046829 mRNA Translation: BAB13435.1 Different initiation. AC022165 Genomic DNA No translation available. CH471114 Genomic DNA Translation: EAW95478.1 BC023251 mRNA Translation: AAH23251.1 BC060844 mRNA Translation: AAH60844.1 AL137316 mRNA Translation: CAB70693.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32498.1
PIRⁱ	T46288
NCBI Reference Sequences More...RefSeqⁱ	NP_065998.3, NM_020947.3 XP_005256132.1, XM_005256075.2 XP_006721303.1, XM_006721240.2 XP_011521550.1, XM_011523248.2 XP_011521551.1, XM_011523249.2 XP_016878999.1, XM_017023510.1 XP_016879000.1, XM_017023511.1
UniGeneⁱ	Hs.288274

Genome annotation databases

Ensemblⁱ	ENST00000343629; ENSP00000343635; ENSG00000140950
GeneIDⁱ	57707
KEGGⁱ	hsa:57707
UCSC genome browser More...UCSCⁱ	uc002fib.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6P9B6	MTOR-associated protein, eak-7 homolog (Fragment)		HUMAN		148	UniRef100_Q6P9B6
MTOR-associated protein, eak-7 homolog (Fragment)		HUMAN		83
MTOR-associated protein, eak-7 homolog (Fragment)		HUMAN		45
cDNA FLJ50020		HUMAN		124
UPI000387BD1C		HUMAN		494

Protein	Similar proteins		Species	Score	Length	Source
Q6P9B6	MTOR-associated protein, eak-7 homolog (Fragment)		HUMAN		148	UniRef90_Q6P9B6
Uncharacterized protein		PANPA		456
TLDC1 isoform 4 (Fragment)		PONAB		45
TLDC1 isoform 9 (Fragment)		PANTR		45
TLD domain-containing protein KIAA1609		CALJA		456
+29

Protein	Similar proteins		Species	Score	Length	Source
Q6P9B6	MTOR-associated protein, eak-7 homolog (Fragment)		HUMAN		148	UniRef50_Q6P9B6
TBC/LysM-associated domain containing 1		GORGO		456
Uncharacterized protein		NOMLE		456
TLD domain-containing protein KIAA1609		CALJA		456
Uncharacterized protein		AOTNA		456
+45

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB046829 mRNA Translation: BAB13435.1 Different initiation. AC022165 Genomic DNA No translation available. CH471114 Genomic DNA Translation: EAW95478.1 BC023251 mRNA Translation: AAH23251.1 BC060844 mRNA Translation: AAH60844.1 AL137316 mRNA Translation: CAB70693.1
CCDSⁱ	CCDS32498.1
PIRⁱ	T46288
RefSeqⁱ	NP_065998.3, NM_020947.3 XP_005256132.1, XM_005256075.2 XP_006721303.1, XM_006721240.2 XP_011521550.1, XM_011523248.2 XP_011521551.1, XM_011523249.2 XP_016878999.1, XM_017023510.1 XP_016879000.1, XM_017023511.1
UniGeneⁱ	Hs.288274

3D structure databases

ProteinModelPortalⁱ	Q6P9B6
SMRⁱ	Q6P9B6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121731, 17 interactors
ELMⁱ	Q6P9B6
IntActⁱ	Q6P9B6, 1 interactor
STRINGⁱ	9606.ENSP00000343635

PTM databases

iPTMnetⁱ	Q6P9B6
PhosphoSitePlusⁱ	Q6P9B6
SwissPalmⁱ	Q6P9B6

Polymorphism and mutation databases

BioMutaⁱ	TLDC1
DMDMⁱ	296434547

Proteomic databases

EPDⁱ	Q6P9B6
MaxQBⁱ	Q6P9B6
PaxDbⁱ	Q6P9B6
PeptideAtlasⁱ	Q6P9B6
PRIDEⁱ	Q6P9B6
ProteomicsDBⁱ	67035

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	57707
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000343629; ENSP00000343635; ENSG00000140950
GeneIDⁱ	57707
KEGGⁱ	hsa:57707
UCSCⁱ	uc002fib.4 human

Organism-specific databases

CTDⁱ	57707
EuPathDBⁱ	HostDB:ENSG00000140950.15
GeneCardsⁱ	TLDC1
HGNCⁱ	HGNC:29325 TLDC1
HPAⁱ	HPA041020
neXtProtⁱ	NX_Q6P9B6
OpenTargetsⁱ	ENSG00000140950
PharmGKBⁱ	PA144596416
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2557 Eukaryota ENOG410XR8F LUCA
GeneTreeⁱ	ENSGT00410000025363
HOGENOMⁱ	HOG000031408
HOVERGENⁱ	HBG103322
InParanoidⁱ	Q6P9B6
OMAⁱ	KPQFQGD
OrthoDBⁱ	EOG091G0BIQ
PhylomeDBⁱ	Q6P9B6
TreeFamⁱ	TF316541

Miscellaneous databases

GenomeRNAiⁱ	57707
Protein Ontology More...PROⁱ	PR:Q6P9B6

Gene expression databases

Bgeeⁱ	ENSG00000140950 Expressed in 162 organ(s), highest expression level in cervix squamous epithelium
CleanExⁱ	HS_KIAA1609
ExpressionAtlasⁱ	Q6P9B6 baseline and differential
Genevisibleⁱ	Q6P9B6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006571 TLDc_dom
Pfamⁱ	View protein in Pfam PF07534 TLD, 1 hit
SMARTⁱ	View protein in SMART SM00584 TLDc, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TLDC1_HUMAN
Accessionⁱ	Q6P9B6Primary (citable) accession number: Q6P9B6 Secondary accession number(s): Q8IZ64, Q9HCG3, Q9NTE8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q6P9B6 (TLDC1_HUMAN)

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TLD domain-containing protein 1

TLDC1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Lysosome

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ