UniProtKB - Q6P9B6 (MEAK7_HUMAN)
Protein
MTOR-associated protein MEAK7
Gene
MEAK7
Organism
Homo sapiens (Human)
Status
Functioni
Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (PubMed:29750193). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (PubMed:29750193).1 Publication
GO - Biological processi
- negative regulation of oxidative stress-induced neuron death Source: Ensembl
- positive regulation of protein localization to lysosome Source: UniProtKB
- regulation of cell migration Source: UniProtKB
- regulation of cell population proliferation Source: UniProtKB
- response to amino acid Source: UniProtKB
- response to insulin Source: UniProtKB
- response to nutrient levels Source: UniProtKB
- TOR signaling Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q6P9B6 |
Names & Taxonomyi
Protein namesi | Recommended name: MTOR-associated protein MEAK7CuratedShort name: MEAK7Curated Alternative name(s): MTOR associated protein, eak-7 homologImported TBC/LysM-associated domain-containing protein 1 TLD domain-containing protein 1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29325, MEAK7 |
neXtProti | NX_Q6P9B6 |
VEuPathDBi | HostDB:ENSG00000140950.15 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Lysosome
- lysosomal membrane Source: UniProtKB
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Other locations
Keywords - Cellular componenti
Cytoplasm, Lysosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2 | G → A: Abolishes lysosomal location. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 57707 |
OpenTargetsi | ENSG00000140950 |
PharmGKBi | PA144596416 |
Miscellaneous databases
Pharosi | Q6P9B6, Tdark |
Genetic variation databases
BioMutai | TLDC1 |
DMDMi | 296434547 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000313640 | 2 – 456 | MTOR-associated protein MEAK7Add BLAST | 455 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine2 Publications | 1 |
Keywords - PTMi
Lipoprotein, MyristateProteomic databases
EPDi | Q6P9B6 |
jPOSTi | Q6P9B6 |
MassIVEi | Q6P9B6 |
MaxQBi | Q6P9B6 |
PaxDbi | Q6P9B6 |
PeptideAtlasi | Q6P9B6 |
PRIDEi | Q6P9B6 |
ProteomicsDBi | 67035 |
PTM databases
iPTMneti | Q6P9B6 |
MetOSitei | Q6P9B6 |
PhosphoSitePlusi | Q6P9B6 |
SwissPalmi | Q6P9B6 |
Expressioni
Inductioni
Addition of nutrients and insulin induces its expression (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000140950, Expressed in cervix squamous epithelium and 182 other tissues |
ExpressionAtlasi | Q6P9B6, baseline and differential |
Genevisiblei | Q6P9B6, HS |
Organism-specific databases
HPAi | ENSG00000140950, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via C-terminal domain) with MTOR and MLST8; the interaction with MTOR increases upon nutrient stimulation.
1 PublicationBinary interactionsi
Q6P9B6
With | #Exp. | IntAct |
---|---|---|
TRIP13 [Q15645] | 4 | EBI-746504,EBI-358993 |
Protein-protein interaction databases
BioGRIDi | 121731, 28 interactors |
ELMi | Q6P9B6 |
IntActi | Q6P9B6, 10 interactors |
STRINGi | 9606.ENSP00000343635 |
Miscellaneous databases
RNActi | Q6P9B6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 244 – 412 | TLDcPROSITE-ProRule annotationAdd BLAST | 169 |
Phylogenomic databases
eggNOGi | KOG2557, Eukaryota |
GeneTreei | ENSGT00940000158087 |
HOGENOMi | CLU_036763_2_0_1 |
InParanoidi | Q6P9B6 |
OMAi | VIEDWVF |
OrthoDBi | 585082at2759 |
PhylomeDBi | Q6P9B6 |
TreeFami | TF316541 |
Family and domain databases
InterProi | View protein in InterPro IPR006571, TLDc_dom |
Pfami | View protein in Pfam PF07534, TLD, 1 hit |
SMARTi | View protein in SMART SM00584, TLDc, 1 hit |
PROSITEi | View protein in PROSITE PS51886, TLDC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q6P9B6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGNSRSRVGR SFCSQFLPEE QAEIDQLFDA LSSDKNSPNV SSKSFSLKAL
60 70 80 90 100
QNHVGEALPP EMVTRLYDGM RRVDLTGKAK GPSENVSQEQ FTASMSHLLK
110 120 130 140 150
GNSEEKSLMI MKMISATEGP VKAREVQKFT EDLVGSVVHV LSHRQELRGW
160 170 180 190 200
TGKEAPGPNP RVQVLAAQLL SDMKLQDGKR LLGPQWLDYD CDRAVIEDWV
210 220 230 240 250
FRVPHVAIFL SVVICKGFLI LCSSLDLTTL VPERQVDQGR GFESILDVLS
260 270 280 290 300
VMYINAQLPR EQRHRWCLLF SSELHGHSFS QLCGHITHRG PCVAVLEDHD
310 320 330 340 350
KHVFGGFASC SWEVKPQFQG DNRCFLFSIC PSMAVYTHTG YNDHYMYLNH
360 370 380 390 400
GQQTIPNGLG MGGQHNYFGL WVDVDFGKGH SRAKPTCTTY NSPQLSAQEN
410 420 430 440 450
FQFDKMEVWA VGDPSEEQLA KGNKSILDAD PEAQALLEIS GHSRHSEGLR
EVPDDE
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BPI4 | H3BPI4_HUMAN | MTOR-associated protein MEAK7 | MEAK7 | 57 | Annotation score: | ||
H3BM75 | H3BM75_HUMAN | MTOR-associated protein MEAK7 | MEAK7 | 193 | Annotation score: | ||
H3BTC5 | H3BTC5_HUMAN | MTOR-associated protein MEAK7 | MEAK7 | 83 | Annotation score: | ||
H3BQ13 | H3BQ13_HUMAN | MTOR-associated protein MEAK7 | MEAK7 | 45 | Annotation score: | ||
H3BUB0 | H3BUB0_HUMAN | MTOR-associated protein MEAK7 | MEAK7 | 148 | Annotation score: |
Sequence cautioni
The sequence BAB13435 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037675 | 10 | R → L. Corresponds to variant dbSNP:rs8046813EnsemblClinVar. | 1 | |
Natural variantiVAR_037676 | 97 | H → Q. Corresponds to variant dbSNP:rs8055536Ensembl. | 1 | |
Natural variantiVAR_037677 | 172 | D → E2 PublicationsCorresponds to variant dbSNP:rs436278Ensembl. | 1 | |
Natural variantiVAR_037678 | 220 | I → V3 PublicationsCorresponds to variant dbSNP:rs431818Ensembl. | 1 | |
Natural variantiVAR_037679 | 233 | E → D. Corresponds to variant dbSNP:rs34244563EnsemblClinVar. | 1 | |
Natural variantiVAR_037680 | 267 | C → R3 PublicationsCorresponds to variant dbSNP:rs422145Ensembl. | 1 | |
Natural variantiVAR_037681 | 443 | S → L. Corresponds to variant dbSNP:rs34628943Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB046829 mRNA Translation: BAB13435.1 Different initiation. AC022165 Genomic DNA No translation available. CH471114 Genomic DNA Translation: EAW95478.1 BC023251 mRNA Translation: AAH23251.1 BC060844 mRNA Translation: AAH60844.1 AL137316 mRNA Translation: CAB70693.1 |
CCDSi | CCDS32498.1 |
PIRi | T46288 |
RefSeqi | NP_065998.3, NM_020947.3 XP_005256132.1, XM_005256075.2 XP_006721303.1, XM_006721240.2 XP_011521550.1, XM_011523248.2 XP_011521551.1, XM_011523249.2 XP_016878999.1, XM_017023510.1 XP_016879000.1, XM_017023511.1 |
Genome annotation databases
Ensembli | ENST00000343629; ENSP00000343635; ENSG00000140950 |
GeneIDi | 57707 |
KEGGi | hsa:57707 |
UCSCi | uc002fib.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB046829 mRNA Translation: BAB13435.1 Different initiation. AC022165 Genomic DNA No translation available. CH471114 Genomic DNA Translation: EAW95478.1 BC023251 mRNA Translation: AAH23251.1 BC060844 mRNA Translation: AAH60844.1 AL137316 mRNA Translation: CAB70693.1 |
CCDSi | CCDS32498.1 |
PIRi | T46288 |
RefSeqi | NP_065998.3, NM_020947.3 XP_005256132.1, XM_005256075.2 XP_006721303.1, XM_006721240.2 XP_011521550.1, XM_011523248.2 XP_011521551.1, XM_011523249.2 XP_016878999.1, XM_017023510.1 XP_016879000.1, XM_017023511.1 |
3D structure databases
SMRi | Q6P9B6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121731, 28 interactors |
ELMi | Q6P9B6 |
IntActi | Q6P9B6, 10 interactors |
STRINGi | 9606.ENSP00000343635 |
PTM databases
iPTMneti | Q6P9B6 |
MetOSitei | Q6P9B6 |
PhosphoSitePlusi | Q6P9B6 |
SwissPalmi | Q6P9B6 |
Genetic variation databases
BioMutai | TLDC1 |
DMDMi | 296434547 |
Proteomic databases
EPDi | Q6P9B6 |
jPOSTi | Q6P9B6 |
MassIVEi | Q6P9B6 |
MaxQBi | Q6P9B6 |
PaxDbi | Q6P9B6 |
PeptideAtlasi | Q6P9B6 |
PRIDEi | Q6P9B6 |
ProteomicsDBi | 67035 |
Protocols and materials databases
Antibodypediai | 48850, 209 antibodies |
DNASUi | 57707 |
Genome annotation databases
Ensembli | ENST00000343629; ENSP00000343635; ENSG00000140950 |
GeneIDi | 57707 |
KEGGi | hsa:57707 |
UCSCi | uc002fib.4, human |
Organism-specific databases
CTDi | 57707 |
DisGeNETi | 57707 |
GeneCardsi | MEAK7 |
HGNCi | HGNC:29325, MEAK7 |
HPAi | ENSG00000140950, Low tissue specificity |
neXtProti | NX_Q6P9B6 |
OpenTargetsi | ENSG00000140950 |
PharmGKBi | PA144596416 |
VEuPathDBi | HostDB:ENSG00000140950.15 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2557, Eukaryota |
GeneTreei | ENSGT00940000158087 |
HOGENOMi | CLU_036763_2_0_1 |
InParanoidi | Q6P9B6 |
OMAi | VIEDWVF |
OrthoDBi | 585082at2759 |
PhylomeDBi | Q6P9B6 |
TreeFami | TF316541 |
Enzyme and pathway databases
PathwayCommonsi | Q6P9B6 |
Miscellaneous databases
BioGRID-ORCSi | 57707, 14 hits in 995 CRISPR screens |
ChiTaRSi | TLDC1, human |
GenomeRNAii | 57707 |
Pharosi | Q6P9B6, Tdark |
PROi | PR:Q6P9B6 |
RNActi | Q6P9B6, protein |
Gene expression databases
Bgeei | ENSG00000140950, Expressed in cervix squamous epithelium and 182 other tissues |
ExpressionAtlasi | Q6P9B6, baseline and differential |
Genevisiblei | Q6P9B6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006571, TLDc_dom |
Pfami | View protein in Pfam PF07534, TLD, 1 hit |
SMARTi | View protein in SMART SM00584, TLDc, 1 hit |
PROSITEi | View protein in PROSITE PS51886, TLDC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MEAK7_HUMAN | |
Accessioni | Q6P9B6Primary (citable) accession number: Q6P9B6 Secondary accession number(s): Q8IZ64, Q9HCG3, Q9NTE8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports