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Entry version 121 (16 Oct 2019)
Sequence version 2 (18 May 2010)
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Protein

MTOR-associated protein MEAK7

Gene

MEAK7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (PubMed:29750193). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (PubMed:29750193).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MTOR-associated protein MEAK7Curated
Short name:
MEAK7Curated
Alternative name(s):
MTOR associated protein, eak-7 homologImported
TBC/LysM-associated domain-containing protein 1
TLD domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEAK7Imported
Synonyms:KIAA1609, TLDC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29325 MEAK7

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P9B6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2G → A: Abolishes lysosomal location. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000140950

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596416

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P9B6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TLDC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434547

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003136402 – 456MTOR-associated protein MEAK7Add BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine2 Publications1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P9B6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P9B6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6P9B6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P9B6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P9B6

PeptideAtlas

More...
PeptideAtlasi
Q6P9B6

PRoteomics IDEntifications database

More...
PRIDEi
Q6P9B6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67035

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P9B6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P9B6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6P9B6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Addition of nutrients and insulin induces its expression (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140950 Expressed in 162 organ(s), highest expression level in cervix squamous epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P9B6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P9B6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041020

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminal domain) with MTOR and MLST8; the interaction with MTOR increases upon nutrient stimulation.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP13Q156453EBI-746504,EBI-358993

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121731, 19 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q6P9B6

Protein interaction database and analysis system

More...
IntActi
Q6P9B6, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000343635

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P9B6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini244 – 412TLDcPROSITE-ProRule annotationAdd BLAST169

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2557 Eukaryota
ENOG410XR8F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158087

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000031408

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P9B6

Identification of Orthologs from Complete Genome Data

More...
OMAi
DNRCFLF

Database of Orthologous Groups

More...
OrthoDBi
585082at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P9B6

TreeFam database of animal gene trees

More...
TreeFami
TF316541

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006571 TLDc_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07534 TLD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00584 TLDc, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51886 TLDC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q6P9B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNSRSRVGR SFCSQFLPEE QAEIDQLFDA LSSDKNSPNV SSKSFSLKAL
60 70 80 90 100
QNHVGEALPP EMVTRLYDGM RRVDLTGKAK GPSENVSQEQ FTASMSHLLK
110 120 130 140 150
GNSEEKSLMI MKMISATEGP VKAREVQKFT EDLVGSVVHV LSHRQELRGW
160 170 180 190 200
TGKEAPGPNP RVQVLAAQLL SDMKLQDGKR LLGPQWLDYD CDRAVIEDWV
210 220 230 240 250
FRVPHVAIFL SVVICKGFLI LCSSLDLTTL VPERQVDQGR GFESILDVLS
260 270 280 290 300
VMYINAQLPR EQRHRWCLLF SSELHGHSFS QLCGHITHRG PCVAVLEDHD
310 320 330 340 350
KHVFGGFASC SWEVKPQFQG DNRCFLFSIC PSMAVYTHTG YNDHYMYLNH
360 370 380 390 400
GQQTIPNGLG MGGQHNYFGL WVDVDFGKGH SRAKPTCTTY NSPQLSAQEN
410 420 430 440 450
FQFDKMEVWA VGDPSEEQLA KGNKSILDAD PEAQALLEIS GHSRHSEGLR

EVPDDE
Length:456
Mass (Da):50,994
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3237DF7BB9818667
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPI4H3BPI4_HUMAN
MTOR-associated protein MEAK7
MEAK7
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BM75H3BM75_HUMAN
MTOR-associated protein MEAK7
MEAK7
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQ13H3BQ13_HUMAN
MTOR-associated protein MEAK7
MEAK7
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTC5H3BTC5_HUMAN
MTOR-associated protein MEAK7
MEAK7
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUB0H3BUB0_HUMAN
MTOR-associated protein MEAK7
MEAK7
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB13435 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03767510R → L. Corresponds to variant dbSNP:rs8046813Ensembl.1
Natural variantiVAR_03767697H → Q. Corresponds to variant dbSNP:rs8055536Ensembl.1
Natural variantiVAR_037677172D → E2 PublicationsCorresponds to variant dbSNP:rs436278Ensembl.1
Natural variantiVAR_037678220I → V3 PublicationsCorresponds to variant dbSNP:rs431818Ensembl.1
Natural variantiVAR_037679233E → D. Corresponds to variant dbSNP:rs34244563Ensembl.1
Natural variantiVAR_037680267C → R3 PublicationsCorresponds to variant dbSNP:rs422145Ensembl.1
Natural variantiVAR_037681443S → L. Corresponds to variant dbSNP:rs34628943Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB046829 mRNA Translation: BAB13435.1 Different initiation.
AC022165 Genomic DNA No translation available.
CH471114 Genomic DNA Translation: EAW95478.1
BC023251 mRNA Translation: AAH23251.1
BC060844 mRNA Translation: AAH60844.1
AL137316 mRNA Translation: CAB70693.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32498.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T46288

NCBI Reference Sequences

More...
RefSeqi
NP_065998.3, NM_020947.3
XP_005256132.1, XM_005256075.2
XP_006721303.1, XM_006721240.2
XP_011521550.1, XM_011523248.2
XP_011521551.1, XM_011523249.2
XP_016878999.1, XM_017023510.1
XP_016879000.1, XM_017023511.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343629; ENSP00000343635; ENSG00000140950

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57707

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57707

UCSC genome browser

More...
UCSCi
uc002fib.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046829 mRNA Translation: BAB13435.1 Different initiation.
AC022165 Genomic DNA No translation available.
CH471114 Genomic DNA Translation: EAW95478.1
BC023251 mRNA Translation: AAH23251.1
BC060844 mRNA Translation: AAH60844.1
AL137316 mRNA Translation: CAB70693.1
CCDSiCCDS32498.1
PIRiT46288
RefSeqiNP_065998.3, NM_020947.3
XP_005256132.1, XM_005256075.2
XP_006721303.1, XM_006721240.2
XP_011521550.1, XM_011523248.2
XP_011521551.1, XM_011523249.2
XP_016878999.1, XM_017023510.1
XP_016879000.1, XM_017023511.1

3D structure databases

SMRiQ6P9B6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121731, 19 interactors
ELMiQ6P9B6
IntActiQ6P9B6, 7 interactors
STRINGi9606.ENSP00000343635

PTM databases

iPTMnetiQ6P9B6
PhosphoSitePlusiQ6P9B6
SwissPalmiQ6P9B6

Polymorphism and mutation databases

BioMutaiTLDC1
DMDMi296434547

Proteomic databases

EPDiQ6P9B6
jPOSTiQ6P9B6
MassIVEiQ6P9B6
MaxQBiQ6P9B6
PaxDbiQ6P9B6
PeptideAtlasiQ6P9B6
PRIDEiQ6P9B6
ProteomicsDBi67035

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57707

Genome annotation databases

EnsembliENST00000343629; ENSP00000343635; ENSG00000140950
GeneIDi57707
KEGGihsa:57707
UCSCiuc002fib.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57707

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MEAK7
HGNCiHGNC:29325 MEAK7
HPAiHPA041020
neXtProtiNX_Q6P9B6
OpenTargetsiENSG00000140950
PharmGKBiPA144596416

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2557 Eukaryota
ENOG410XR8F LUCA
GeneTreeiENSGT00940000158087
HOGENOMiHOG000031408
InParanoidiQ6P9B6
OMAiDNRCFLF
OrthoDBi585082at2759
PhylomeDBiQ6P9B6
TreeFamiTF316541

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TLDC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57707
PharosiQ6P9B6

Protein Ontology

More...
PROi
PR:Q6P9B6

Gene expression databases

BgeeiENSG00000140950 Expressed in 162 organ(s), highest expression level in cervix squamous epithelium
ExpressionAtlasiQ6P9B6 baseline and differential
GenevisibleiQ6P9B6 HS

Family and domain databases

InterProiView protein in InterPro
IPR006571 TLDc_dom
PfamiView protein in Pfam
PF07534 TLD, 1 hit
SMARTiView protein in SMART
SM00584 TLDc, 1 hit
PROSITEiView protein in PROSITE
PS51886 TLDC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEAK7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P9B6
Secondary accession number(s): Q8IZ64, Q9HCG3, Q9NTE8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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