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UniProtKB - Q6P9B6 (MEAK7_HUMAN)

Entry version 127 (12 Aug 2020)
Sequence version 2 (18 May 2010)
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Protein

MTOR-associated protein MEAK7

Gene

MEAK7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (PubMed:29750193). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (PubMed:29750193).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6P9B6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MTOR-associated protein MEAK7Curated
Short name:
MEAK7Curated
Alternative name(s):
MTOR associated protein, eak-7 homologImported
TBC/LysM-associated domain-containing protein 1
TLD domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEAK7Imported
Synonyms:KIAA1609, TLDC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000140950.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:29325, MEAK7

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6P9B6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2G → A: Abolishes lysosomal location. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		57707

Open Targets

More...OpenTargetsi		ENSG00000140950

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA144596416

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6P9B6, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TLDC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434547

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003136402 – 456MTOR-associated protein MEAK7Add BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine2 Publications1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6P9B6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6P9B6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6P9B6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6P9B6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6P9B6

PeptideAtlas

More...PeptideAtlasi		Q6P9B6

PRoteomics IDEntifications database

More...PRIDEi		Q6P9B6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67035

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6P9B6

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q6P9B6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6P9B6

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q6P9B6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Addition of nutrients and insulin induces its expression (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140950, Expressed in cervix squamous epithelium and 182 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6P9B6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6P9B6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140950, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminal domain) with MTOR and MLST8; the interaction with MTOR increases upon nutrient stimulation.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121731, 23 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q6P9B6

Protein interaction database and analysis system

More...IntActi		Q6P9B6, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000343635

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6P9B6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6P9B6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini244 – 412TLDcPROSITE-ProRule annotationAdd BLAST169

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2557, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158087

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_036763_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P9B6

Identification of Orthologs from Complete Genome Data

More...OMAi		VIEDWVF

Database of Orthologous Groups

More...OrthoDBi		585082at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6P9B6

TreeFam database of animal gene trees

More...TreeFami		TF316541

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006571, TLDc_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07534, TLD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00584, TLDc, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51886, TLDC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q6P9B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNSRSRVGR SFCSQFLPEE QAEIDQLFDA LSSDKNSPNV SSKSFSLKAL 
        60         70         80         90        100
QNHVGEALPP EMVTRLYDGM RRVDLTGKAK GPSENVSQEQ FTASMSHLLK 
       110        120        130        140        150
GNSEEKSLMI MKMISATEGP VKAREVQKFT EDLVGSVVHV LSHRQELRGW 
       160        170        180        190        200
TGKEAPGPNP RVQVLAAQLL SDMKLQDGKR LLGPQWLDYD CDRAVIEDWV 
       210        220        230        240        250
FRVPHVAIFL SVVICKGFLI LCSSLDLTTL VPERQVDQGR GFESILDVLS 
       260        270        280        290        300
VMYINAQLPR EQRHRWCLLF SSELHGHSFS QLCGHITHRG PCVAVLEDHD 
       310        320        330        340        350
KHVFGGFASC SWEVKPQFQG DNRCFLFSIC PSMAVYTHTG YNDHYMYLNH 
       360        370        380        390        400
GQQTIPNGLG MGGQHNYFGL WVDVDFGKGH SRAKPTCTTY NSPQLSAQEN 
       410        420        430        440        450
FQFDKMEVWA VGDPSEEQLA KGNKSILDAD PEAQALLEIS GHSRHSEGLR 

EVPDDE
Length:456
Mass (Da):50,994
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3237DF7BB9818667
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPI4H3BPI4_HUMAN
MTOR-associated protein MEAK7
MEAK7
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BM75H3BM75_HUMAN
MTOR-associated protein MEAK7
MEAK7
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTC5H3BTC5_HUMAN
MTOR-associated protein MEAK7
MEAK7
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQ13H3BQ13_HUMAN
MTOR-associated protein MEAK7
MEAK7
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUB0H3BUB0_HUMAN
MTOR-associated protein MEAK7
MEAK7
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB13435 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03767510R → L. Corresponds to variant dbSNP:rs8046813Ensembl.1
Natural variantiVAR_03767697H → Q. Corresponds to variant dbSNP:rs8055536Ensembl.1
Natural variantiVAR_037677172D → E2 PublicationsCorresponds to variant dbSNP:rs436278Ensembl.1
Natural variantiVAR_037678220I → V3 PublicationsCorresponds to variant dbSNP:rs431818Ensembl.1
Natural variantiVAR_037679233E → D. Corresponds to variant dbSNP:rs34244563Ensembl.1
Natural variantiVAR_037680267C → R3 PublicationsCorresponds to variant dbSNP:rs422145Ensembl.1
Natural variantiVAR_037681443S → L. Corresponds to variant dbSNP:rs34628943Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB046829 mRNA Translation: BAB13435.1 Different initiation.
AC022165 Genomic DNA No translation available.
CH471114 Genomic DNA Translation: EAW95478.1
BC023251 mRNA Translation: AAH23251.1
BC060844 mRNA Translation: AAH60844.1
AL137316 mRNA Translation: CAB70693.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32498.1

Protein sequence database of the Protein Information Resource

More...PIRi		T46288

NCBI Reference Sequences

More...RefSeqi		NP_065998.3, NM_020947.3
XP_005256132.1, XM_005256075.2
XP_006721303.1, XM_006721240.2
XP_011521550.1, XM_011523248.2
XP_011521551.1, XM_011523249.2
XP_016878999.1, XM_017023510.1
XP_016879000.1, XM_017023511.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000343629; ENSP00000343635; ENSG00000140950

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57707

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57707

UCSC genome browser

More...UCSCi		uc002fib.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046829 mRNA Translation: BAB13435.1 Different initiation.
AC022165 Genomic DNA No translation available.
CH471114 Genomic DNA Translation: EAW95478.1
BC023251 mRNA Translation: AAH23251.1
BC060844 mRNA Translation: AAH60844.1
AL137316 mRNA Translation: CAB70693.1
CCDSiCCDS32498.1
PIRiT46288
RefSeqiNP_065998.3, NM_020947.3
XP_005256132.1, XM_005256075.2
XP_006721303.1, XM_006721240.2
XP_011521550.1, XM_011523248.2
XP_011521551.1, XM_011523249.2
XP_016878999.1, XM_017023510.1
XP_016879000.1, XM_017023511.1

3D structure databases

SMRiQ6P9B6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121731, 23 interactors
ELMiQ6P9B6
IntActiQ6P9B6, 7 interactors
STRINGi9606.ENSP00000343635

PTM databases

iPTMnetiQ6P9B6
MetOSiteiQ6P9B6
PhosphoSitePlusiQ6P9B6
SwissPalmiQ6P9B6

Polymorphism and mutation databases

BioMutaiTLDC1
DMDMi296434547

Proteomic databases

EPDiQ6P9B6
jPOSTiQ6P9B6
MassIVEiQ6P9B6
MaxQBiQ6P9B6
PaxDbiQ6P9B6
PeptideAtlasiQ6P9B6
PRIDEiQ6P9B6
ProteomicsDBi67035

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		48850, 209 antibodies

The DNASU plasmid repository

More...DNASUi		57707

Genome annotation databases

EnsembliENST00000343629; ENSP00000343635; ENSG00000140950
GeneIDi57707
KEGGihsa:57707
UCSCiuc002fib.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57707
DisGeNETi57707
EuPathDBiHostDB:ENSG00000140950.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		MEAK7
HGNCiHGNC:29325, MEAK7
HPAiENSG00000140950, Low tissue specificity
neXtProtiNX_Q6P9B6
OpenTargetsiENSG00000140950
PharmGKBiPA144596416

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2557, Eukaryota
GeneTreeiENSGT00940000158087
HOGENOMiCLU_036763_2_0_1
InParanoidiQ6P9B6
OMAiVIEDWVF
OrthoDBi585082at2759
PhylomeDBiQ6P9B6
TreeFamiTF316541

Enzyme and pathway databases

PathwayCommonsiQ6P9B6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57707, 11 hits in 877 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TLDC1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57707
PharosiQ6P9B6, Tdark

Protein Ontology

More...PROi		PR:Q6P9B6
RNActiQ6P9B6, protein

Gene expression databases

BgeeiENSG00000140950, Expressed in cervix squamous epithelium and 182 other tissues
ExpressionAtlasiQ6P9B6, baseline and differential
GenevisibleiQ6P9B6, HS

Family and domain databases

InterProiView protein in InterPro
IPR006571, TLDc_dom
PfamiView protein in Pfam
PF07534, TLD, 1 hit
SMARTiView protein in SMART
SM00584, TLDc, 1 hit
PROSITEiView protein in PROSITE
PS51886, TLDC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEAK7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P9B6
Secondary accession number(s): Q8IZ64, Q9HCG3, Q9NTE8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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