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Protein

TLD domain-containing protein 1

Gene

TLDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
TLD domain-containing protein 1
Alternative name(s):
TBC/LysM-associated domain-containing protein 1
Gene namesi
Name:TLDC1
Synonyms:KIAA1609
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140950.15
HGNCiHGNC:29325 TLDC1
neXtProtiNX_Q6P9B6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140950
PharmGKBiPA144596416

Polymorphism and mutation databases

BioMutaiTLDC1
DMDMi296434547

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00003136402 – 456TLD domain-containing protein 1Add BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine2 Publications1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ6P9B6
MaxQBiQ6P9B6
PaxDbiQ6P9B6
PeptideAtlasiQ6P9B6
PRIDEiQ6P9B6
ProteomicsDBi67035

PTM databases

iPTMnetiQ6P9B6
PhosphoSitePlusiQ6P9B6
SwissPalmiQ6P9B6

Expressioni

Gene expression databases

BgeeiENSG00000140950 Expressed in 162 organ(s), highest expression level in cervix squamous epithelium
CleanExiHS_KIAA1609
ExpressionAtlasiQ6P9B6 baseline and differential
GenevisibleiQ6P9B6 HS

Organism-specific databases

HPAiHPA041020

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP13Q156453EBI-746504,EBI-358993

Protein-protein interaction databases

BioGridi121731, 17 interactors
ELMiQ6P9B6
IntActiQ6P9B6, 1 interactor
STRINGi9606.ENSP00000343635

Structurei

3D structure databases

ProteinModelPortaliQ6P9B6
SMRiQ6P9B6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 412TLDAdd BLAST145

Phylogenomic databases

eggNOGiKOG2557 Eukaryota
ENOG410XR8F LUCA
GeneTreeiENSGT00410000025363
HOGENOMiHOG000031408
HOVERGENiHBG103322
InParanoidiQ6P9B6
OMAiKPQFQGD
OrthoDBiEOG091G0BIQ
PhylomeDBiQ6P9B6
TreeFamiTF316541

Family and domain databases

InterProiView protein in InterPro
IPR006571 TLDc_dom
PfamiView protein in Pfam
PF07534 TLD, 1 hit
SMARTiView protein in SMART
SM00584 TLDc, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q6P9B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNSRSRVGR SFCSQFLPEE QAEIDQLFDA LSSDKNSPNV SSKSFSLKAL
60 70 80 90 100
QNHVGEALPP EMVTRLYDGM RRVDLTGKAK GPSENVSQEQ FTASMSHLLK
110 120 130 140 150
GNSEEKSLMI MKMISATEGP VKAREVQKFT EDLVGSVVHV LSHRQELRGW
160 170 180 190 200
TGKEAPGPNP RVQVLAAQLL SDMKLQDGKR LLGPQWLDYD CDRAVIEDWV
210 220 230 240 250
FRVPHVAIFL SVVICKGFLI LCSSLDLTTL VPERQVDQGR GFESILDVLS
260 270 280 290 300
VMYINAQLPR EQRHRWCLLF SSELHGHSFS QLCGHITHRG PCVAVLEDHD
310 320 330 340 350
KHVFGGFASC SWEVKPQFQG DNRCFLFSIC PSMAVYTHTG YNDHYMYLNH
360 370 380 390 400
GQQTIPNGLG MGGQHNYFGL WVDVDFGKGH SRAKPTCTTY NSPQLSAQEN
410 420 430 440 450
FQFDKMEVWA VGDPSEEQLA KGNKSILDAD PEAQALLEIS GHSRHSEGLR

EVPDDE
Length:456
Mass (Da):50,994
Last modified:May 18, 2010 - v2
Checksum:i3237DF7BB9818667
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BM75H3BM75_HUMAN
MTOR-associated protein, eak-7 homo...
MEAK7
193Annotation score:
H3BUB0H3BUB0_HUMAN
MTOR-associated protein, eak-7 homo...
MEAK7
148Annotation score:
H3BPI4H3BPI4_HUMAN
MTOR-associated protein, eak-7 homo...
MEAK7
57Annotation score:
H3BQ13H3BQ13_HUMAN
MTOR-associated protein, eak-7 homo...
MEAK7
45Annotation score:
H3BTC5H3BTC5_HUMAN
MTOR-associated protein, eak-7 homo...
MEAK7
83Annotation score:

Sequence cautioni

The sequence BAB13435 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03767510R → L. Corresponds to variant dbSNP:rs8046813Ensembl.1
Natural variantiVAR_03767697H → Q. Corresponds to variant dbSNP:rs8055536Ensembl.1
Natural variantiVAR_037677172D → E2 PublicationsCorresponds to variant dbSNP:rs436278Ensembl.1
Natural variantiVAR_037678220I → V3 PublicationsCorresponds to variant dbSNP:rs431818Ensembl.1
Natural variantiVAR_037679233E → D. Corresponds to variant dbSNP:rs34244563Ensembl.1
Natural variantiVAR_037680267C → R3 PublicationsCorresponds to variant dbSNP:rs422145Ensembl.1
Natural variantiVAR_037681443S → L. Corresponds to variant dbSNP:rs34628943Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046829 mRNA Translation: BAB13435.1 Different initiation.
AC022165 Genomic DNA No translation available.
CH471114 Genomic DNA Translation: EAW95478.1
BC023251 mRNA Translation: AAH23251.1
BC060844 mRNA Translation: AAH60844.1
AL137316 mRNA Translation: CAB70693.1
CCDSiCCDS32498.1
PIRiT46288
RefSeqiNP_065998.3, NM_020947.3
XP_005256132.1, XM_005256075.2
XP_006721303.1, XM_006721240.2
XP_011521550.1, XM_011523248.2
XP_011521551.1, XM_011523249.2
XP_016878999.1, XM_017023510.1
XP_016879000.1, XM_017023511.1
UniGeneiHs.288274

Genome annotation databases

EnsembliENST00000343629; ENSP00000343635; ENSG00000140950
GeneIDi57707
KEGGihsa:57707
UCSCiuc002fib.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046829 mRNA Translation: BAB13435.1 Different initiation.
AC022165 Genomic DNA No translation available.
CH471114 Genomic DNA Translation: EAW95478.1
BC023251 mRNA Translation: AAH23251.1
BC060844 mRNA Translation: AAH60844.1
AL137316 mRNA Translation: CAB70693.1
CCDSiCCDS32498.1
PIRiT46288
RefSeqiNP_065998.3, NM_020947.3
XP_005256132.1, XM_005256075.2
XP_006721303.1, XM_006721240.2
XP_011521550.1, XM_011523248.2
XP_011521551.1, XM_011523249.2
XP_016878999.1, XM_017023510.1
XP_016879000.1, XM_017023511.1
UniGeneiHs.288274

3D structure databases

ProteinModelPortaliQ6P9B6
SMRiQ6P9B6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121731, 17 interactors
ELMiQ6P9B6
IntActiQ6P9B6, 1 interactor
STRINGi9606.ENSP00000343635

PTM databases

iPTMnetiQ6P9B6
PhosphoSitePlusiQ6P9B6
SwissPalmiQ6P9B6

Polymorphism and mutation databases

BioMutaiTLDC1
DMDMi296434547

Proteomic databases

EPDiQ6P9B6
MaxQBiQ6P9B6
PaxDbiQ6P9B6
PeptideAtlasiQ6P9B6
PRIDEiQ6P9B6
ProteomicsDBi67035

Protocols and materials databases

DNASUi57707
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343629; ENSP00000343635; ENSG00000140950
GeneIDi57707
KEGGihsa:57707
UCSCiuc002fib.4 human

Organism-specific databases

CTDi57707
EuPathDBiHostDB:ENSG00000140950.15
GeneCardsiTLDC1
HGNCiHGNC:29325 TLDC1
HPAiHPA041020
neXtProtiNX_Q6P9B6
OpenTargetsiENSG00000140950
PharmGKBiPA144596416
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2557 Eukaryota
ENOG410XR8F LUCA
GeneTreeiENSGT00410000025363
HOGENOMiHOG000031408
HOVERGENiHBG103322
InParanoidiQ6P9B6
OMAiKPQFQGD
OrthoDBiEOG091G0BIQ
PhylomeDBiQ6P9B6
TreeFamiTF316541

Miscellaneous databases

GenomeRNAii57707
PROiPR:Q6P9B6

Gene expression databases

BgeeiENSG00000140950 Expressed in 162 organ(s), highest expression level in cervix squamous epithelium
CleanExiHS_KIAA1609
ExpressionAtlasiQ6P9B6 baseline and differential
GenevisibleiQ6P9B6 HS

Family and domain databases

InterProiView protein in InterPro
IPR006571 TLDc_dom
PfamiView protein in Pfam
PF07534 TLD, 1 hit
SMARTiView protein in SMART
SM00584 TLDc, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTLDC1_HUMAN
AccessioniPrimary (citable) accession number: Q6P9B6
Secondary accession number(s): Q8IZ64, Q9HCG3, Q9NTE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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