NOTUM

Functionⁱ

Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).1 Publication

Caution

The molecular function of NOTUM has remained unclear for many years. It was initially thought to hydrolyze glycosaminoglycan (GAG) chains of glypicans, thereby affecting glypicans ability to interact with Wnt ligands. It was later reported to trigger glypican shedding, by mediating cleavage of their GPI-anchor. However, while NOTUM specifically inhibit the Wnt signaling pathway, more pleiotropic effects would be expected from an enzyme affecting glypicans. It was finally shown that it requires glypicans to suppress Wnt signaling, but does not cleave their GPI-anchor. It acts by mediating depalmitoleoylation of WNT proteins, impairing WNT binding to frizzled receptors (PubMed:25731175).1 Publication

Catalytic activityⁱ

[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine + H₂O = [Wnt]-L-serine + (9Z)-hexadec-9-enoate.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	232	Charge relay system1 Publication	1
Active siteⁱ	340	Charge relay system1 Publication	1
Active siteⁱ	389	Charge relay system1 Publication	1

GO - Molecular functionⁱ

palmitoleyl hydrolase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 25731175
phospholipase C activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein metabolic process Source: Reactome
negative regulation of canonical Wnt signaling pathway Source: GO_Central
negative regulation of Wnt signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 25731175
post-translational protein modification Source: Reactome
protein depalmitoleylation
Source: UniProtKB
Inferred from direct assayⁱ
- 25731175
Wnt signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Serine esterase
Biological process	Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5362798 Release of Hh-Np from the secreting cell R-HSA-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5362798 Release of Hh-Np from the secreting cell
R-HSA-8957275 Post-translational protein phosphorylation

Protein family/group databases

ESTHERⁱ	human-NOTUM Pectinacetylesterase-Notum

ESTHERⁱ

human-NOTUM Pectinacetylesterase-Notum

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Palmitoleoyl-protein carboxylesterase NOTUMCurated (EC:3.1.1.981 Publication) Alternative name(s): hNOTUM1 Publication
Gene namesⁱ	Name:NOTUMImported ORF Names:OK/SW-CL.301 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000185269.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:27106 NOTUM
MIMⁱ	609847 gene
neXtProtⁱ	NX_Q6P988

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	232	S → A: Abolishes enzyme activity. Unable to mediate serine depalmitoleoylation of WNT proteins. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	147111
Open Targets More...OpenTargetsⁱ	ENSG00000185269
PharmGKBⁱ	PA142671250

Chemistry databases

ChEMBLⁱ	CHEMBL3714531

ChEMBLⁱ

CHEMBL3714531

Polymorphism and mutation databases

BioMutaⁱ	NOTUM
DMDMⁱ	182628300

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000318755	20 – 496	Palmitoleoyl-protein carboxylesterase NOTUMAdd BLAST		477

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	81	Phosphoserine; by FAM20C1 Publication		1
Glycosylationⁱ	96	N-linked (GlcNAc...) asparagineCombined sources		1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P988
PaxDbⁱ	Q6P988
PeptideAtlas More...PeptideAtlasⁱ	Q6P988
PRIDEⁱ	Q6P988
ProteomicsDBⁱ	67025

PTM databases

iPTMnetⁱ	Q6P988
PhosphoSitePlusⁱ	Q6P988

Expressionⁱ

Tissue specificityⁱ

Rarely expressed in adult normal tissues.1 Publication

Inductionⁱ

Up-regulated in hepatocellular carcinoma (HCC) with high intracellular beta-catenin.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000185269 Expressed in 136 organ(s), highest expression level in placenta
CleanExⁱ	HS_NOTUM
ExpressionAtlasⁱ	Q6P988 baseline and differential
Genevisibleⁱ	Q6P988 HS

Interactionⁱ

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-61508N
IntActⁱ	Q6P988, 5 interactors
STRINGⁱ	9606.ENSP00000387310

Chemistry databases

BindingDBⁱ

Q6P988

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	85 – 87	Combined sources	3
Beta strandⁱ	89 – 93	Combined sources	5
Beta strandⁱ	95 – 98	Combined sources	4
Beta strandⁱ	104 – 106	Combined sources	3
Beta strandⁱ	108 – 112	Combined sources	5
Beta strandⁱ	119 – 124	Combined sources	6
Helixⁱ	133 – 142	Combined sources	10
Helixⁱ	144 – 146	Combined sources	3
Beta strandⁱ	154 – 156	Combined sources	3
Helixⁱ	160 – 162	Combined sources	3
Turnⁱ	166 – 168	Combined sources	3
Turnⁱ	170 – 174	Combined sources	5
Beta strandⁱ	175 – 180	Combined sources	6
Beta strandⁱ	184 – 186	Combined sources	3
Beta strandⁱ	196 – 200	Combined sources	5
Helixⁱ	204 – 215	Combined sources	12
Helixⁱ	216 – 218	Combined sources	3
Helixⁱ	220 – 222	Combined sources	3
Beta strandⁱ	224 – 231	Combined sources	8
Helixⁱ	233 – 251	Combined sources	19
Beta strandⁱ	258 – 265	Combined sources	8
Helixⁱ	282 – 285	Combined sources	4
Helixⁱ	287 – 298	Combined sources	12
Helixⁱ	304 – 310	Combined sources	7
Helixⁱ	315 – 319	Combined sources	5
Helixⁱ	321 – 324	Combined sources	4
Helixⁱ	325 – 327	Combined sources	3
Beta strandⁱ	332 – 335	Combined sources	4
Beta strandⁱ	338 – 340	Combined sources	3
Helixⁱ	341 – 346	Combined sources	6
Beta strandⁱ	352 – 354	Combined sources	3
Helixⁱ	358 – 375	Combined sources	18
Beta strandⁱ	379 – 383	Combined sources	5
Beta strandⁱ	385 – 388	Combined sources	4
Turnⁱ	395 – 398	Combined sources	4
Helixⁱ	407 – 417	Combined sources	11
Turnⁱ	428 – 431	Combined sources	4
Beta strandⁱ	435 – 437	Combined sources	3
Beta strandⁱ	441 – 444	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q6P988
SMRⁱ	Q6P988
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the pectinacetylesterase family. Notum subfamily.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG4287 Eukaryota ENOG410XQKD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015892
HOGENOMⁱ	HOG000113832
HOVERGENⁱ	HBG061551
InParanoidⁱ	Q6P988
KEGG Orthology (KO) More...KOⁱ	K19882
OMAⁱ	CFNKENC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04KM
PhylomeDBⁱ	Q6P988
TreeFamⁱ	TF324830

Family and domain databases

InterProⁱ	View protein in InterPro IPR004963 PAE/NOTUM
PANTHERⁱ	PTHR21562 PTHR21562, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03283 PAE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q6P988-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGRGVRVLLL LSLLHCAGGS EGRKTWRRRG QQPPPPPRTE AAPAAGQPVE 
        60         70         80         90        100
SFPLDFTAVE GNMDSFMAQV KSLAQSLYPC SAQQLNEDLR LHLLLNTSVT 
       110        120        130        140        150
CNDGSPAGYY LKESRGSRRW LLFLEGGWYC FNRENCDSRY DTMRRLMSSR 
       160        170        180        190        200
DWPRTRTGTG ILSSQPEENP YWWNANMVFI PYCSSDVWSG ASSKSEKNEY 
       210        220        230        240        250
AFMGALIIQE VVRELLGRGL SGAKVLLLAG SSAGGTGVLL NVDRVAEQLE 
       260        270        280        290        300
KLGYPAIQVR GLADSGWFLD NKQYRHTDCV DTITCAPTEA IRRGIRYWNG 
       310        320        330        340        350
VVPERCRRQF QEGEEWNCFF GYKVYPTLRC PVFVVQWLFD EAQLTVDNVH 
       360        370        380        390        400
LTGQPVQEGL RLYIQNLGRE LRHTLKDVPA SFAPACLSHE IIIRSHWTDV 
       410        420        430        440        450
QVKGTSLPRA LHCWDRSLHD SHKASKTPLK GCPVHLVDSC PWPHCNPSCP 
       460        470        480        490 
TVRDQFTGQE MNVAQFLMHM GFDMQTVAQP QGLEPSELLG MLSNGS

Length:496

Mass (Da):55,699

Last modified:February 26, 2008 - v2

Checksum:ⁱ00A7B3FB6436F544

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JYG8	C9JYG8_HUMAN	Palmitoleoyl-protein carboxylestera... Palmitoleoyl-protein carboxylesterase NOTUM	NOTUM	295	Annotation score:
K7EIG3	K7EIG3_HUMAN	Palmitoleoyl-protein carboxylestera... Palmitoleoyl-protein carboxylesterase NOTUM	NOTUM	197	Annotation score:

Sequence cautionⁱ

The sequence AAH36872 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH60882 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB93501 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	207	I → N in AAH36872 (PubMed:15489334).Curated		1
Sequence conflictⁱ	244	R → L in AAH36872 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC145207 Genomic DNA No translation available. BC036872 mRNA Translation: AAH36872.2 Different initiation. BC060882 mRNA Translation: AAH60882.1 Different initiation. AB062438 mRNA Translation: BAB93501.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32771.2
NCBI Reference Sequences More...RefSeqⁱ	NP_848588.3, NM_178493.5
UniGeneⁱ	Hs.106137

Genome annotation databases

Ensemblⁱ	ENST00000409678; ENSP00000387310; ENSG00000185269
GeneIDⁱ	147111
KEGGⁱ	hsa:147111
UCSC genome browser More...UCSCⁱ	uc010wvg.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6P988	Palmitoleoyl-protein carboxylesterase NOTUM (Fragment)		HUMAN		295	UniRef100_Q6P988
Palmitoleoyl-protein carboxylesterase NOTUM (Fragment)		HUMAN		197

Protein	Similar proteins		Species	Score	Length	Source
Q6P988	Palmitoleoyl-protein carboxylesterase NOTUM (Fragment)		HUMAN		295	UniRef90_Q6P988
palmitoleoyl-protein carboxylesterase NOTUM		DELLE		499
palmitoleoyl-protein carboxylesterase NOTUM		PHYCD		499
protein notum homolog		LIPVE		354
palmitoleoyl-protein carboxylesterase NOTUM		NEOSC		499
+42

Protein	Similar proteins		Species	Score	Length	Source
Q6P988	Palmitoleoyl-protein carboxylesterase notum1'		XENLA		488	UniRef50_Q6P988
Carboxylesterase notum2		DANRE		495
Palmitoleoyl-protein carboxylesterase NOTUM		MOUSE		503
Palmitoleoyl-protein carboxylesterase NOTUM (Fragment)		HUMAN		295
palmitoleoyl-protein carboxylesterase NOTUM		DELLE		499
+283

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

The art of biocuration - Issue 177 of March 2016

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC145207 Genomic DNA No translation available. BC036872 mRNA Translation: AAH36872.2 Different initiation. BC060882 mRNA Translation: AAH60882.1 Different initiation. AB062438 mRNA Translation: BAB93501.1 Different initiation.
CCDSⁱ	CCDS32771.2
RefSeqⁱ	NP_848588.3, NM_178493.5
UniGeneⁱ	Hs.106137

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4UYU	X-ray	2.30	A/B	81-451	[»]
	4UYW	X-ray	1.70	A/B	81-451	[»]
	4UYZ	X-ray	2.80	A/B/C/D	38-496	[»]
	4UZ1	X-ray	1.40	A	81-451	[»]
	4UZ5	X-ray	2.10	A	81-451	[»]
	4UZ6	X-ray	1.90	A/B	81-451	[»]
	4UZ7	X-ray	2.20	A/B	81-451	[»]
	4UZ9	X-ray	2.20	A	81-451	[»]
	4UZA	X-ray	2.40	A	81-451	[»]
	4UZL	X-ray	2.10	A/B	81-451	[»]
	4UZQ	X-ray	1.50	A	81-451	[»]
	4WBH	X-ray	2.20	A/B	38-496	[»]
ProteinModelPortalⁱ	Q6P988
SMRⁱ	Q6P988
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-61508N
IntActⁱ	Q6P988, 5 interactors
STRINGⁱ	9606.ENSP00000387310

Chemistry databases

BindingDBⁱ	Q6P988
ChEMBLⁱ	CHEMBL3714531

Protein family/group databases

ESTHERⁱ	human-NOTUM Pectinacetylesterase-Notum

ESTHERⁱ

human-NOTUM Pectinacetylesterase-Notum

PTM databases

iPTMnetⁱ	Q6P988
PhosphoSitePlusⁱ	Q6P988

Polymorphism and mutation databases

BioMutaⁱ	NOTUM
DMDMⁱ	182628300

Proteomic databases

MaxQBⁱ	Q6P988
PaxDbⁱ	Q6P988
PeptideAtlasⁱ	Q6P988
PRIDEⁱ	Q6P988
ProteomicsDBⁱ	67025

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	147111
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000409678; ENSP00000387310; ENSG00000185269
GeneIDⁱ	147111
KEGGⁱ	hsa:147111
UCSCⁱ	uc010wvg.3 human

Organism-specific databases

CTDⁱ	147111
DisGeNETⁱ	147111
EuPathDBⁱ	HostDB:ENSG00000185269.11
GeneCardsⁱ	NOTUM
HGNCⁱ	HGNC:27106 NOTUM
MIMⁱ	609847 gene
neXtProtⁱ	NX_Q6P988
OpenTargetsⁱ	ENSG00000185269
PharmGKBⁱ	PA142671250
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4287 Eukaryota ENOG410XQKD LUCA
GeneTreeⁱ	ENSGT00390000015892
HOGENOMⁱ	HOG000113832
HOVERGENⁱ	HBG061551
InParanoidⁱ	Q6P988
KOⁱ	K19882
OMAⁱ	CFNKENC
OrthoDBⁱ	EOG091G04KM
PhylomeDBⁱ	Q6P988
TreeFamⁱ	TF324830

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5362798 Release of Hh-Np from the secreting cell R-HSA-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5362798 Release of Hh-Np from the secreting cell
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

GenomeRNAiⁱ	147111
Protein Ontology More...PROⁱ	PR:Q6P988
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185269 Expressed in 136 organ(s), highest expression level in placenta
CleanExⁱ	HS_NOTUM
ExpressionAtlasⁱ	Q6P988 baseline and differential
Genevisibleⁱ	Q6P988 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004963 PAE/NOTUM
PANTHERⁱ	PTHR21562 PTHR21562, 1 hit
Pfamⁱ	View protein in Pfam PF03283 PAE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NOTUM_HUMAN
Accessionⁱ	Q6P988Primary (citable) accession number: Q6P988 Secondary accession number(s): Q8N410, Q8NI82
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	February 26, 2008
	Last modified:	September 12, 2018
	This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

UniProtKB

UniParc

Help

UniRef

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Supporting data

UniProtKB - Q6P988 (NOTUM_HUMAN)

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Palmitoleoyl-protein carboxylesterase NOTUM

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ