Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein B-Myc

Gene

Mycb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to act as an inhibitor of cellular proliferation.1 Publication

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Protein B-Myc
Gene namesi
Name:Mycb
Synonyms:Bmyc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88184 Bmyc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi60S → A: Loss of phosphorylation. 1 Publication1
Mutagenesisi68S → A: Loss of phosphorylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273391 – 170Protein B-MycAdd BLAST170

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60Phosphoserine1 Publication1
Modified residuei68Phosphoserine1 Publication1

Post-translational modificationi

Rapidly degraded via the ubiquitin-proteasome pathway.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6P8Z1
PRIDEiQ6P8Z1

PTM databases

iPTMnetiQ6P8Z1
PhosphoSitePlusiQ6P8Z1

Expressioni

Tissue specificityi

Highly expressed in epididymis. Also expressed in hypothalamus, pituitary, uterus and ovary. Low expression in testis. Not detected in heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000049086 Expressed in 237 organ(s), highest expression level in CA1 field of hippocampus
CleanExiMM_BMYC
ExpressionAtlasiQ6P8Z1 baseline and differential
GenevisibleiQ6P8Z1 MM

Interactioni

Protein-protein interaction databases

IntActiQ6P8Z1, 3 interactors
MINTiQ6P8Z1
STRINGi10090.ENSMUSP00000097885

Structurei

3D structure databases

DisProtiDP00564
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00510000046414
HOGENOMiHOG000041253
HOVERGENiHBG079592
InParanoidiQ6P8Z1
KOiK09111
OMAiWNGFSAS
OrthoDBiEOG091G0ZJQ
PhylomeDBiQ6P8Z1

Family and domain databases

InterProiView protein in InterPro
IPR002418 Tscrpt_reg_Myc
IPR012682 Tscrpt_reg_Myc_N
PfamiView protein in Pfam
PF01056 Myc_N, 1 hit
PRINTSiPR00044 LEUZIPPRMYC

Sequencei

Sequence statusi: Complete.

Q6P8Z1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLHVSLANG NRDLDYDSVQ PYFMCDDEEE DVHHQQPPQP PAPSEDIWKK
60 70 80 90 100
FELLPTPRPS PGHAGLYSPP CEAVAVSFAP RDHDGDSFSI ADLPELPGGD
110 120 130 140 150
AVKQSFVCDP DDETFVKNII LQDCMWNGFS ASAKLVSKLD PYQAVRKEGT
160 170
GVSLAADVEP ATPPDCTCNT
Length:170
Mass (Da):18,526
Last modified:July 5, 2004 - v1
Checksum:iEF3BD10DD793C2D4
GO

Sequence cautioni

The sequence BAB28992 differs from that shown. Reason: Frameshift at position 161.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012810 mRNA Translation: BAE43234.1
AK013780 mRNA Translation: BAB28992.1 Frameshift.
AK158603 mRNA Translation: BAE34577.1
BC061001 mRNA Translation: AAH61001.1
CCDSiCCDS15789.1
RefSeqiNP_075815.2, NM_023326.2
UniGeneiMm.330057

Genome annotation databases

EnsembliENSMUST00000061483; ENSMUSP00000097885; ENSMUSG00000049086
GeneIDi107771
KEGGimmu:107771
UCSCiuc008itg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012810 mRNA Translation: BAE43234.1
AK013780 mRNA Translation: BAB28992.1 Frameshift.
AK158603 mRNA Translation: BAE34577.1
BC061001 mRNA Translation: AAH61001.1
CCDSiCCDS15789.1
RefSeqiNP_075815.2, NM_023326.2
UniGeneiMm.330057

3D structure databases

DisProtiDP00564
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P8Z1, 3 interactors
MINTiQ6P8Z1
STRINGi10090.ENSMUSP00000097885

PTM databases

iPTMnetiQ6P8Z1
PhosphoSitePlusiQ6P8Z1

Proteomic databases

PaxDbiQ6P8Z1
PRIDEiQ6P8Z1

Protocols and materials databases

DNASUi107771
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061483; ENSMUSP00000097885; ENSMUSG00000049086
GeneIDi107771
KEGGimmu:107771
UCSCiuc008itg.1 mouse

Organism-specific databases

CTDi107771
MGIiMGI:88184 Bmyc

Phylogenomic databases

GeneTreeiENSGT00510000046414
HOGENOMiHOG000041253
HOVERGENiHBG079592
InParanoidiQ6P8Z1
KOiK09111
OMAiWNGFSAS
OrthoDBiEOG091G0ZJQ
PhylomeDBiQ6P8Z1

Miscellaneous databases

ChiTaRSiBmyc mouse
PROiPR:Q6P8Z1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049086 Expressed in 237 organ(s), highest expression level in CA1 field of hippocampus
CleanExiMM_BMYC
ExpressionAtlasiQ6P8Z1 baseline and differential
GenevisibleiQ6P8Z1 MM

Family and domain databases

InterProiView protein in InterPro
IPR002418 Tscrpt_reg_Myc
IPR012682 Tscrpt_reg_Myc_N
PfamiView protein in Pfam
PF01056 Myc_N, 1 hit
PRINTSiPR00044 LEUZIPPRMYC
ProtoNetiSearch...

Entry informationi

Entry nameiMYCB_MOUSE
AccessioniPrimary (citable) accession number: Q6P8Z1
Secondary accession number(s): Q9D6E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again