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Protein

Pancreatic triacylglycerol lipase

Gene

Pnlip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity).By similarity

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169NucleophileBy similarity1
Active sitei193Charge relay systemPROSITE-ProRule annotation1
Metal bindingi204Calcium; via carbonyl oxygenBy similarity1
Metal bindingi207Calcium; via carbonyl oxygenBy similarity1
Metal bindingi209CalciumBy similarity1
Metal bindingi212CalciumBy similarity1
Active sitei280Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

  • lipase activity Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • triglyceride lipase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-192456 Digestion of dietary lipid
R-MMU-975634 Retinoid metabolism and transport

Protein family/group databases

ESTHERimouse-1plip Pancreatic_lipase

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic triacylglycerol lipase (EC:3.1.1.3)
Short name:
PL
Short name:
PTL
Short name:
Pancreatic lipase
Gene namesi
Name:Pnlip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:97722 Pnlip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000040113917 – 465Pancreatic triacylglycerol lipaseAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 26PROSITE-ProRule annotation
Disulfide bondi107 ↔ 118PROSITE-ProRule annotation
Disulfide bondi254 ↔ 278PROSITE-ProRule annotation
Disulfide bondi302 ↔ 313PROSITE-ProRule annotation
Disulfide bondi316 ↔ 321PROSITE-ProRule annotation
Disulfide bondi449 ↔ 465PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ6P8U6
PaxDbiQ6P8U6
PRIDEiQ6P8U6

PTM databases

iPTMnetiQ6P8U6
PhosphoSitePlusiQ6P8U6

Expressioni

Tissue specificityi

Pancreas.1 Publication

Inductioni

By colipase/CLPS in the presence of bile salts.

Gene expression databases

BgeeiENSMUSG00000046008 Expressed in 56 organ(s), highest expression level in pancreas
GenevisibleiQ6P8U6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056377

Structurei

3D structure databases

ProteinModelPortaliQ6P8U6
SMRiQ6P8U6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini355 – 465PLATPROSITE-ProRule annotationAdd BLAST111

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHRX Eukaryota
ENOG410Y92X LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000038552
HOVERGENiHBG003243
InParanoidiQ6P8U6
KOiK14073
OMAiAGKEVCF
OrthoDBiEOG091G0DJ5
PhylomeDBiQ6P8U6
TreeFamiTF324997

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002331 Lipase_panc
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00823 PANCLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P8U6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLMLWTFAVL LGAVAGREVC FDKLGCFSDD APWSGTLDRP LKALPWSPAQ
60 70 80 90 100
INTRFLLYTN ENPDNYQLIT SDASNIRNSN FRTNRKTRII IHGFIDKGEE
110 120 130 140 150
NWLSDMCKNM FRVESVNCIC VDWKGGSRTT YTQATQNVRV VGAEVALLVN
160 170 180 190 200
VLQSDLGYSL NNVHLIGHSL GSHIAGEAGK RTFGAIGRIT GLDPAEPYFQ
210 220 230 240 250
GTPEEVRLDP TDAQFVDAIH TDAGPIIPNL GFGMSQTVGH LDFFPNGGIE
260 270 280 290 300
MPGCQKNILS QIVDIDGIWE GTRNFAACNH LRSYKFYTDS IVNPTGFAGF
310 320 330 340 350
SCSSYSLFTA NKCFPCGSGG CPQMGHYADR YPGKTSRLYQ TFYLNTGDKS
360 370 380 390 400
NFARWRYQVT VTLSGQKVTG HILVSLFGNG GNSKQYEVFK GSLQPGTSHV
410 420 430 440 450
NEFDSDVDVG DLQKVKFIWY NNVINPTLPK VGASRITVER NDGRVFNFCS
460
QETVREDVLL TLSPC
Length:465
Mass (Da):51,428
Last modified:July 5, 2004 - v1
Checksum:i5CD39E8ABDF43A64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY387690 mRNA Translation: AAQ90020.1
CH466585 Genomic DNA Translation: EDL01803.1
BC061061 mRNA Translation: AAH61061.1
CCDSiCCDS29930.1
RefSeqiNP_081201.2, NM_026925.3
UniGeneiMm.20407

Genome annotation databases

EnsembliENSMUST00000057270; ENSMUSP00000056377; ENSMUSG00000046008
GeneIDi69060
KEGGimmu:69060
UCSCiuc008iaq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY387690 mRNA Translation: AAQ90020.1
CH466585 Genomic DNA Translation: EDL01803.1
BC061061 mRNA Translation: AAH61061.1
CCDSiCCDS29930.1
RefSeqiNP_081201.2, NM_026925.3
UniGeneiMm.20407

3D structure databases

ProteinModelPortaliQ6P8U6
SMRiQ6P8U6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056377

Protein family/group databases

ESTHERimouse-1plip Pancreatic_lipase

PTM databases

iPTMnetiQ6P8U6
PhosphoSitePlusiQ6P8U6

Proteomic databases

MaxQBiQ6P8U6
PaxDbiQ6P8U6
PRIDEiQ6P8U6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057270; ENSMUSP00000056377; ENSMUSG00000046008
GeneIDi69060
KEGGimmu:69060
UCSCiuc008iaq.1 mouse

Organism-specific databases

CTDi5406
MGIiMGI:97722 Pnlip

Phylogenomic databases

eggNOGiENOG410IHRX Eukaryota
ENOG410Y92X LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000038552
HOVERGENiHBG003243
InParanoidiQ6P8U6
KOiK14073
OMAiAGKEVCF
OrthoDBiEOG091G0DJ5
PhylomeDBiQ6P8U6
TreeFamiTF324997

Enzyme and pathway databases

ReactomeiR-MMU-192456 Digestion of dietary lipid
R-MMU-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRSiPnlip mouse
PROiPR:Q6P8U6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046008 Expressed in 56 organ(s), highest expression level in pancreas
GenevisibleiQ6P8U6 MM

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002331 Lipase_panc
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00823 PANCLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIPP_MOUSE
AccessioniPrimary (citable) accession number: Q6P8U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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