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Protein

Cytochrome c oxidase assembly protein COX11, mitochondrial

Gene

Cox11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.By similarity

GO - Molecular functioni

GO - Biological processi

  • metal ion homeostasis Source: MGI
  • negative regulation of glucokinase activity Source: MGI

Keywordsi

LigandCopper

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX11, mitochondrial
Gene namesi
Name:Cox11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917052 Cox11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini? – 94Mitochondrial matrixBy similarity
Transmembranei95 – 113HelicalSequence analysisAdd BLAST19
Topological domaini114 – 275Mitochondrial intermembraneBy similarityAdd BLAST162

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000006081? – 275Cytochrome c oxidase assembly protein COX11, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiQ6P8I6
PaxDbiQ6P8I6
PeptideAtlasiQ6P8I6
PRIDEiQ6P8I6

PTM databases

PhosphoSitePlusiQ6P8I6

Expressioni

Gene expression databases

BgeeiENSMUSG00000020544
ExpressionAtlasiQ6P8I6 baseline and differential
GenevisibleiQ6P8I6 MM

Interactioni

Subunit structurei

Interacts with CNNM4/ACDP4.By similarity

Protein-protein interaction databases

BioGridi213688, 1 interactor
STRINGi10090.ENSMUSP00000020851

Structurei

3D structure databases

ProteinModelPortaliQ6P8I6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COX11/CtaG family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2540 Eukaryota
COG3175 LUCA
GeneTreeiENSGT00390000007512
HOGENOMiHOG000264965
HOVERGENiHBG051085
InParanoidiQ6P8I6
KOiK02258
OMAiNKLECFC
OrthoDBiEOG091G0J14
PhylomeDBiQ6P8I6
TreeFamiTF105072

Family and domain databases

Gene3Di2.60.370.10, 1 hit
HAMAPiMF_00155 CtaG, 1 hit
InterProiView protein in InterPro
IPR023471 CtaG/Cox11_dom_sf
IPR007533 Cyt_c_oxidase_assmbl_CtaG
PfamiView protein in Pfam
PF04442 CtaG_Cox11, 1 hit
SUPFAMiSSF110111 SSF110111, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P8I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGLWCPGWR LVASCGRGWR QPGWSGRTVV NAELVLRPGW DGLGGAERGL
60 70 80 90 100
RRLGTWKRPC GVRGPATQPP RRPRSSNPFQ RAQEDEWRRR NKTVLTYVAA
110 120 130 140 150
AAVGMLGASY AAVPLYRLYC QTTGLGGSAV AGHSSDQIEN MVPVKDRVIK
160 170 180 190 200
VTFNADVHAS LQWNFRPQQT EIYVVPGETA LAFYKAKNPT DKPVIGISTY
210 220 230 240 250
NVVPFEAGQY FNKIQCFCFE EQRLNPQEEV DMPVFFYIDP EFAEDPRMVN
260 270
VDLITLSYTF FEAKEGHKLP VPGYN
Length:275
Mass (Da):30,849
Last modified:July 5, 2004 - v1
Checksum:iF51774C9382CE8F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143937 mRNA Translation: BAE25618.1
AL646046, AL672199 Genomic DNA Translation: CAI23913.1
AL672199, AL646046 Genomic DNA Translation: CAI24239.1
BC061233 mRNA Translation: AAH61233.1
CCDSiCCDS25243.1
RefSeqiNP_950173.1, NM_199008.2
UniGeneiMm.151940

Genome annotation databases

EnsembliENSMUST00000020851; ENSMUSP00000020851; ENSMUSG00000020544
GeneIDi69802
KEGGimmu:69802
UCSCiuc007kwz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCOX11_MOUSE
AccessioniPrimary (citable) accession number: Q6P8I6
Secondary accession number(s): Q3UNX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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