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Protein

Protein orai-3

Gene

Orai3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key regulator or component of store-operated Ca2+ channel and transcription factor NFAT nuclear import.By similarity

GO - Molecular functioni

  • store-operated calcium channel activity Source: GO_Central

GO - Biological processi

  • store-operated calcium entry Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Protein orai-3
Alternative name(s):
Transmembrane protein 142C
Gene namesi
Name:Orai3
Synonyms:Tmem142c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3039586 Orai3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei63 – 82HelicalSequence analysisAdd BLAST20
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002343961 – 290Protein orai-3Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6P8G8
PaxDbiQ6P8G8
PRIDEiQ6P8G8

PTM databases

iPTMnetiQ6P8G8
PhosphoSitePlusiQ6P8G8

Expressioni

Gene expression databases

BgeeiENSMUSG00000043964 Expressed in 183 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiQ6P8G8 baseline and differential
GenevisibleiQ6P8G8 MM

Interactioni

Subunit structurei

Interacts with CRACR2A/EFCAB4B.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050279

Structurei

3D structure databases

ProteinModelPortaliQ6P8G8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4298 Eukaryota
ENOG4110DSB LUCA
GeneTreeiENSGT00390000015354
HOGENOMiHOG000246925
HOVERGENiHBG081343
InParanoidiQ6P8G8
KOiK16058
OMAiMASTVIM
OrthoDBiEOG091G0E4P
PhylomeDBiQ6P8G8
TreeFamiTF313576

Family and domain databases

Gene3Di1.20.140.140, 2 hits
InterProiView protein in InterPro
IPR012446 CRAC_channel
IPR030032 Orai-3
IPR038350 Orai_sf
PANTHERiPTHR31501 PTHR31501, 1 hit
PTHR31501:SF6 PTHR31501:SF6, 1 hit
PfamiView protein in Pfam
PF07856 Orai-1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6P8G8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGGEGDTGE QAPLNPEVDS PAGSATYREF VHRGYLDLMG ASQHSLRALS
60 70 80 90 100
WRRLYLSRAK LKASSRTSAL LSGFAMVAMV EVQLENDHEY PPGLLVAFSA
110 120 130 140 150
CTTVLVAVHL FALMVSTCLL PHIEAVSNIH NLNSVHQSPH QRLHRYVELA
160 170 180 190 200
WGFSTALGTF LFLAEVVLVG WVKFVPIGAP MGKPAPVVPM SQVPPVTVSL
210 220 230 240 250
SLASNLTPSS ASITTSQQPS KACPPRQVCD SAHGPGWQAA MASTAIMVPV
260 270 280 290
GLVFMAFALH FYRSLVAHKT DRHKQELEEL SRLQGELQAV
Length:290
Mass (Da):31,358
Last modified:July 5, 2004 - v1
Checksum:iF702164F9F1EB44B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YX58D3YX58_MOUSE
Protein orai-3
Orai3
176Annotation score:
D3Z6X8D3Z6X8_MOUSE
Protein orai-3
Orai3
136Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136955 mRNA Translation: BAE23186.1
BC061259 mRNA Translation: AAH61259.1
CCDSiCCDS21878.1
RefSeqiNP_940816.1, NM_198424.3
UniGeneiMm.36852

Genome annotation databases

EnsembliENSMUST00000061587; ENSMUSP00000050279; ENSMUSG00000043964
GeneIDi269999
KEGGimmu:269999
UCSCiuc009jwr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136955 mRNA Translation: BAE23186.1
BC061259 mRNA Translation: AAH61259.1
CCDSiCCDS21878.1
RefSeqiNP_940816.1, NM_198424.3
UniGeneiMm.36852

3D structure databases

ProteinModelPortaliQ6P8G8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050279

PTM databases

iPTMnetiQ6P8G8
PhosphoSitePlusiQ6P8G8

Proteomic databases

MaxQBiQ6P8G8
PaxDbiQ6P8G8
PRIDEiQ6P8G8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061587; ENSMUSP00000050279; ENSMUSG00000043964
GeneIDi269999
KEGGimmu:269999
UCSCiuc009jwr.1 mouse

Organism-specific databases

CTDi93129
MGIiMGI:3039586 Orai3

Phylogenomic databases

eggNOGiKOG4298 Eukaryota
ENOG4110DSB LUCA
GeneTreeiENSGT00390000015354
HOGENOMiHOG000246925
HOVERGENiHBG081343
InParanoidiQ6P8G8
KOiK16058
OMAiMASTVIM
OrthoDBiEOG091G0E4P
PhylomeDBiQ6P8G8
TreeFamiTF313576

Miscellaneous databases

PROiPR:Q6P8G8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043964 Expressed in 183 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiQ6P8G8 baseline and differential
GenevisibleiQ6P8G8 MM

Family and domain databases

Gene3Di1.20.140.140, 2 hits
InterProiView protein in InterPro
IPR012446 CRAC_channel
IPR030032 Orai-3
IPR038350 Orai_sf
PANTHERiPTHR31501 PTHR31501, 1 hit
PTHR31501:SF6 PTHR31501:SF6, 1 hit
PfamiView protein in Pfam
PF07856 Orai-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiORAI3_MOUSE
AccessioniPrimary (citable) accession number: Q6P8G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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