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Protein

H/ACA ribonucleoprotein complex subunit 2-like protein

Gene

nhp2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit 2-like protein
Alternative name(s):
Nucleolar protein family A member 2-like protein
snoRNP protein NHP2-like protein
Gene namesi
Name:nhp2
Synonyms:nola2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-973261 nhp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367681 – 149H/ACA ribonucleoprotein complex subunit 2-like proteinAdd BLAST149

Proteomic databases

PaxDbiQ6P8C4

Expressioni

Gene expression databases

BgeeiENSXETG00000006731

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs). Component of the telomerase holoenzyme complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000014709

Structurei

3D structure databases

ProteinModelPortaliQ6P8C4
SMRiQ6P8C4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3167 Eukaryota
COG1358 LUCA
GeneTreeiENSGT00550000074939
HOGENOMiHOG000055227
HOVERGENiHBG000328
InParanoidiQ6P8C4
KOiK11129
OMAiMENIMAI
OrthoDBiEOG091G0VZK
TreeFamiTF105839

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR002415 H/ACA_rnp_Nhp2_euk
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492 Ribosomal_L7Ae/L8/Nhp2
IPR004037 Ribosomal_L7Ae_CS
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
PRINTSiPR00881 L7ARS6FAMILY
PR00883 NUCLEARHMG
SUPFAMiSSF55315 SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01082 RIBOSOMAL_L7AE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P8C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKAKKEESE EVPETPSKSY DELLAYLNPI AKPLAGRKLT KKLYKCVKKA
60 70 80 90 100
IKQKNIRRGV KEVQKFINKG EKGIVVMAGD TLPIEVYCHI PVMCEDRGIP
110 120 130 140
YSYVPSKSDL GAAAGSKRPT CVILIKPHED YQEAYDECLE DVQALPLPY
Length:149
Mass (Da):16,729
Last modified:July 5, 2004 - v1
Checksum:i539B0E35FF06DE21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061305 mRNA Translation: AAH61305.1
RefSeqiNP_988989.1, NM_203658.1
UniGeneiStr.1896

Genome annotation databases

EnsembliENSXETT00000014709; ENSXETP00000014709; ENSXETG00000006731
GeneIDi394586
KEGGixtr:394586

Similar proteinsi

Entry informationi

Entry nameiNHP2_XENTR
AccessioniPrimary (citable) accession number: Q6P8C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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