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Protein

Glycine amidinotransferase, mitochondrial

Gene

gatm

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity).By similarity

Catalytic activityi

L-arginine + glycine = L-ornithine + guanidinoacetate.By similarity

Pathwayi: creatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes creatine from L-arginine and glycine.By similarity
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glycine amidinotransferase, mitochondrial (gatm)
  2. Guanidinoacetate N-methyltransferase (gamt)
This subpathway is part of the pathway creatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes creatine from L-arginine and glycine, the pathway creatine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei253By similarity1
Active sitei302By similarity1
Active sitei406Amidino-cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-XTR-71288 Creatine metabolism
UniPathwayiUPA00104; UER00579

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine amidinotransferase, mitochondrialBy similarity (EC:2.1.4.1By similarity)
Alternative name(s):
L-arginine:glycine amidinotransferaseBy similarity
TransamidinaseBy similarity
Gene namesi
Name:gatmImported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-974514 gatm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 37MitochondrionBy similarityAdd BLAST37
ChainiPRO_000039909838 – 422Glycine amidinotransferase, mitochondrialBy similarityAdd BLAST385

Proteomic databases

PaxDbiQ6P832

Expressioni

Gene expression databases

BgeeiENSXETG00000016109

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000035125

Structurei

3D structure databases

ProteinModelPortaliQ6P832
SMRiQ6P832
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amidinotransferase family.Sequence analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IFBR Eukaryota
ENOG410Y45M LUCA
GeneTreeiENSGT00390000011613
HOGENOMiHOG000231593
HOVERGENiHBG002492
InParanoidiQ6P832
KOiK00613
OMAiEEIEEMC
OrthoDBiEOG091G07LX
TreeFamiTF300256

Family and domain databases

InterProiView protein in InterPro
IPR033195 AmidinoTrfase
PANTHERiPTHR10488 PTHR10488, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P832-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVRCVRGG SRGAEAVHYI GSMLRKGFVG WVQRSFQSTQ AAAVSEKPCA
60 70 80 90 100
ADEKVSDTAV QECPVCSYNE WDPLEEVIVG RPENANVPPF SVEVKANTYE
110 120 130 140 150
KYWPFYQKHG GQSFPVEHVK KATEEIEEMC NVLRHEGVVV QRPEVIDWSV
160 170 180 190 200
KYKTPDFEST GMYAAMPRDI LLVVGNEIIE APMAWRARFF EYRAYRPLIK
210 220 230 240 250
DYFRRGAKWT TAPKPTMADE LYDQDYPIRT VEDRHKLAAM GKFVTTEFEP
260 270 280 290 300
CFDAADFMRA GRDIFAQRSQ VTNYLGIEWM RRHLAPDYKV HIISFKDPNP
310 320 330 340 350
MHIDATFNII GPGLVLSNPD RPCHQIELFK KAGWTVVTPP IPLIPDNHPL
360 370 380 390 400
WMSSKWLSMN VLMLDEKRVM VDANETSIQK MFEKLGISTI KVNIRHANSL
410 420
GGGFHCWTCD IRRRGTLQSY FS
Length:422
Mass (Da):48,424
Last modified:July 5, 2004 - v1
Checksum:iEF4EA3FDC393A67E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50A → T in CAJ82904 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR760875 mRNA Translation: CAJ82904.1
BC061399 mRNA Translation: AAH61399.1
RefSeqiNP_988971.1, NM_203640.1
UniGeneiStr.65067

Genome annotation databases

EnsembliENSXETT00000035125; ENSXETP00000035125; ENSXETG00000016109
GeneIDi394568
KEGGixtr:394568

Similar proteinsi

Entry informationi

Entry nameiGATM_XENTR
AccessioniPrimary (citable) accession number: Q6P832
Secondary accession number(s): Q28HI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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