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Entry version 109 (11 Dec 2019)
Sequence version 3 (27 Jul 2011)
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Protein

Sentrin-specific protease 6

Gene

Senp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei785By similarity1
Active sitei936By similarity1
Active sitei1049By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00886

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C48.004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sentrin-specific protease 6 (EC:3.4.22.-)
Alternative name(s):
SUMO-1-specific protease 1
Sentrin/SUMO-specific protease SENP6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Senp6
Synonyms:Kiaa0797, Susp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1922075 Senp6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002676081 – 1132Sentrin-specific protease 6Add BLAST1132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei41PhosphoserineBy similarity1
Modified residuei355PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei371PhosphoserineBy similarity1
Modified residuei373PhosphoserineBy similarity1
Modified residuei436PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki648Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei938PhosphoserineBy similarity1
Modified residuei1131PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P7W0

PeptideAtlas

More...
PeptideAtlasi
Q6P7W0

PRoteomics IDEntifications database

More...
PRIDEi
Q6P7W0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P7W0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P7W0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034252 Expressed in 284 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P7W0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P7W0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RXRA.

Forms a complex with KAT5-TIP60 and UBE2I in response to UV irradiation.

Interacts with RPA1 to maintain it in hyposumoylated state during S phase preventing DNA repair initiation (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
229616, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P7W0, 2 interactors

Molecular INTeraction database

More...
MINTi
Q6P7W0

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000047220

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P7W0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P7W0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni686 – 1132ProteaseAdd BLAST447

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0779 Eukaryota
COG5160 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155724

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P7W0

KEGG Orthology (KO)

More...
KOi
K08595

Database of Orthologous Groups

More...
OrthoDBi
1241636at2759

TreeFam database of animal gene trees

More...
TreeFami
TF350136

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR003653 Peptidase_C48_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02902 Peptidase_C48, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50600 ULP_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P7W0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGKSGGSA GALFLKALDR SESKRDGGFK NNWSFDHEEE SEGDADKDGA
60 70 80 90 100
NLLSVEDEDS EISKGKKLNR RSEIVATSSG DFILKTYVRR SKTDGFKTLK
110 120 130 140 150
GNPIGLNMLS NNKKLSESTA GTALCSGTVV HGRRFHHAHS QTPGIRTAAQ
160 170 180 190 200
RKEYPPYVHK AENSPVMLSH GQGGDHIMKK TEESESYVES EIKRKVQQKR
210 220 230 240 250
HCSTYQLSPL SPASKKCLTH LEVSEQREYC PKCGKEKENQ TKCQSCGIVF
260 270 280 290 300
HNDLQRNCRQ AVTLNEPTGP LLRTSIHQNS GGQKSQNTGL TAKKFYGNSV
310 320 330 340 350
DKIPIDILVT CDDSRHNYIQ TNGKVILPGG KIPKLTNPKE RKISVSDLND
360 370 380 390 400
PIILSSDDDD DDDDRTKRRE STSPKPADSA CSSPVPSTGK VEAALNADAC
410 420 430 440 450
RAEQEPRSSP AEPELNTIVI PRKARMKDQL GNSISTPLKR RKVNSHAAFI
460 470 480 490 500
HPMSLSCQNF ESVILNCRSI RVGTLFRLLV EPVIFSLESI TIHLDGPESD
510 520 530 540 550
PVDIILNTSD LTKCEWCNVR KLPVVFLQAI PAVYQKLSMQ LQMSKEDKVW
560 570 580 590 600
NDCKGINRIT SLEEQYIILI FQTGLDHQAE VVFESIITDI GIRNNVPNFF
610 620 630 640 650
AKILFDEANS RLVACTRSYE ESIKGNCAQK ENKVKTVSFE SKIQLRSKQE
660 670 680 690 700
LQFFDDDEEA GESHTIFIGP VEKLIVYPPP PAKGGISVTN EDLHCLSEGE
710 720 730 740 750
FLNDVIIDFY LKYLVLEKLK KEDADRIHIF SSFFYKRLNQ RERRNPETTN
760 770 780 790 800
LSIQQKRHGR VKTWTRHVDI FEKDFIFVPL NEAAHWFLAV VCFPGLEKPK
810 820 830 840 850
YEPNPHYHEN AVMQKTPSAE DSCVSSASEM GACSQNSAAK PVIKKMLNRK
860 870 880 890 900
HCLAVTDSSA AQEESEPCYR RNAYSVKCSM KKKNHAINEN EEPSNGESTC
910 920 930 940 950
QDICDRTQSE NGLRDECFSS VHHPDALSKI RLNYGDQSAD GGKLLEDELI
960 970 980 990 1000
DFSEDQDDPD DSSDDGLLAD ENYSSEIGQW HLKPTVCKQP CILLMDSLRG
1010 1020 1030 1040 1050
PSRSNVVKIL REYLEVEWEV KKGSKRSFSK DVMKGSNPKV PQQNNFSDCG
1060 1070 1080 1090 1100
VYVLQYVESF FENPVLNFEL PMNLMNWFPP PRMKTKREEI RNIILKLQES
1110 1120 1130
QSKDKKLLKD SLAETSLGDG AEQYASASGG SE
Length:1,132
Mass (Da):127,013
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D9BE2AE1202ECFF
GO
Isoform 2 (identifier: Q6P7W0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.

Show »
Length:966
Mass (Da):109,037
Checksum:iABA14523EB9875B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Z9A1F6Z9A1_MOUSE
Sentrin-specific protease 6
Senp6
1,139Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJS8H3BJS8_MOUSE
Sentrin-specific protease 6
Senp6
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKR4H3BKR4_MOUSE
Sentrin-specific protease 6
Senp6
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLA9H3BLA9_MOUSE
Sentrin-specific protease 6
Senp6
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BK20H3BK20_MOUSE
Sentrin-specific protease 6
Senp6
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKI2H3BKI2_MOUSE
Sentrin-specific protease 6
Senp6
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH61480 differs from that shown. Reason: Frameshift.Curated
The sequence BAC35583 differs from that shown. Probable cloning artifact.Curated
The sequence BAC98029 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti121G → A in AAH61480 (PubMed:15489334).Curated1
Sequence conflicti375K → Q in BAC98029 (PubMed:14621295).Curated1
Sequence conflicti375K → Q in AAH61480 (PubMed:15489334).Curated1
Sequence conflicti747E → D in BAC98029 (PubMed:14621295).Curated1
Sequence conflicti747E → D in AAH61480 (PubMed:15489334).Curated1
Sequence conflicti1075M → V in BAC98029 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0219431 – 166Missing in isoform 2. 1 PublicationAdd BLAST166

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK129219 mRNA Translation: BAC98029.1 Different initiation.
AC142111 Genomic DNA No translation available.
BC061480 mRNA Translation: AAH61480.1 Frameshift.
AK053904 mRNA Translation: BAC35583.1 Sequence problems.
AK083377 mRNA Translation: BAC38892.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40705.1 [Q6P7W0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001298039.1, NM_001311110.1
NP_666115.2, NM_146003.2 [Q6P7W0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000037484; ENSMUSP00000047220; ENSMUSG00000034252 [Q6P7W0-1]
ENSMUST00000164859; ENSMUSP00000128918; ENSMUSG00000034252 [Q6P7W0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
215351

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:215351

UCSC genome browser

More...
UCSCi
uc009qvb.1 mouse [Q6P7W0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129219 mRNA Translation: BAC98029.1 Different initiation.
AC142111 Genomic DNA No translation available.
BC061480 mRNA Translation: AAH61480.1 Frameshift.
AK053904 mRNA Translation: BAC35583.1 Sequence problems.
AK083377 mRNA Translation: BAC38892.2
CCDSiCCDS40705.1 [Q6P7W0-1]
RefSeqiNP_001298039.1, NM_001311110.1
NP_666115.2, NM_146003.2 [Q6P7W0-1]

3D structure databases

SMRiQ6P7W0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi229616, 2 interactors
IntActiQ6P7W0, 2 interactors
MINTiQ6P7W0
STRINGi10090.ENSMUSP00000047220

Protein family/group databases

MEROPSiC48.004

PTM databases

iPTMnetiQ6P7W0
PhosphoSitePlusiQ6P7W0

Proteomic databases

PaxDbiQ6P7W0
PeptideAtlasiQ6P7W0
PRIDEiQ6P7W0

Genome annotation databases

EnsembliENSMUST00000037484; ENSMUSP00000047220; ENSMUSG00000034252 [Q6P7W0-1]
ENSMUST00000164859; ENSMUSP00000128918; ENSMUSG00000034252 [Q6P7W0-2]
GeneIDi215351
KEGGimmu:215351
UCSCiuc009qvb.1 mouse [Q6P7W0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26054
MGIiMGI:1922075 Senp6

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG0779 Eukaryota
COG5160 LUCA
GeneTreeiENSGT00940000155724
InParanoidiQ6P7W0
KOiK08595
OrthoDBi1241636at2759
TreeFamiTF350136

Enzyme and pathway databases

UniPathwayiUPA00886

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Senp6 mouse

Protein Ontology

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PROi
PR:Q6P7W0
RNActiQ6P7W0 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000034252 Expressed in 284 organ(s), highest expression level in female gonad
ExpressionAtlasiQ6P7W0 baseline and differential
GenevisibleiQ6P7W0 MM

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR003653 Peptidase_C48_C
PfamiView protein in Pfam
PF02902 Peptidase_C48, 2 hits
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50600 ULP_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSENP6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P7W0
Secondary accession number(s): E9QN09
, Q6ZQ43, Q8BK94, Q8BUL4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 27, 2011
Last modified: December 11, 2019
This is version 109 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  4. Peptidase families
    Classification of peptidase families and list of entries
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