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Entry version 131 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

MAGUK p55 subfamily member 4

Gene

Mpp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in retinal photoreceptors development.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MAGUK p55 subfamily member 4
Alternative name(s):
Discs large homolog 6
Short name:
mDLG6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mpp4
Synonyms:Dlg6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2386681 Mpp4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000945781 – 635MAGUK p55 subfamily member 4Add BLAST635

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P7F1

PRoteomics IDEntifications database

More...
PRIDEi
Q6P7F1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P7F1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P7F1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in the retina (at protein level). Highly enriched in the retina where it is mainly expressed by rod photoreceptors; detected in the inner segment of the photoreceptor layer and in the outer nuclear layer. Also detected at much lower levels in pineal gland, cerebellum, cortex, hippocampus, olfactory bulb, heart, liver and spleen. Expressed in the CA1-CA3 regions of pyramidal cell layers and in the granule cell layer of dentate gyrus in the hippocampus. In the cerebellum, expressed in Purkinje cells and throughout the granule cell layer. In the olfactory bulb, expressed in mitral cells.4 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed postnatally in the retina. The expression in the retina coincides with one of the photoreceptor specific genes. Expressed in forebrain of 9.5 dpc embryos and in whole brain of 11.5 dpc embryos.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000079550 Expressed in 84 organ(s), highest expression level in retina

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P7F1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P7F1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with GRIA2 (By similarity).

Interacts with MPDZ.

Forms a complex with CRB1 and MPP5.

Interacts with FASLG (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
230597, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q6P7F1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000109914

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 79L27 1PROSITE-ProRule annotationAdd BLAST57
Domaini86 – 136L27 2PROSITE-ProRule annotationAdd BLAST51
Domaini153 – 234PDZPROSITE-ProRule annotationAdd BLAST82
Domaini241 – 311SH3PROSITE-ProRule annotationAdd BLAST71
Domaini426 – 615Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST190

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili567 – 622Sequence analysisAdd BLAST56

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0609 Eukaryota
COG0194 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156444

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233034

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P7F1

KEGG Orthology (KO)

More...
KOi
K21109

Database of Orthologous Groups

More...
OrthoDBi
278124at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P7F1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12034 SH3_MPP4, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR035600 MPP4_SH3
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF02828 L27, 1 hit
PF00595 PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072 GuKc, 1 hit
SM00569 L27, 2 hits
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101288 SSF101288, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS51022 L27, 2 hits
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P7F1-1) [UniParc]FASTAAdd to basket
Also known as: mDLG6A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRQSDRGAEL TNEDRALPTP PDPENGLSGI LRLLLQELSL FYSRDVNGLC
60 70 80 90 100
LLYDLLHSPW LQALLKVYDC LQRFKEKKLV PDTTHAQILA CEVLELLPKA
110 120 130 140 150
SGSPEIQELR QVLQAPHCKA LLSAHDTVAQ KDFEPLLPPL PDNIPDSEEA
160 170 180 190 200
MRIVCLVKNQ QPLGATIKRH EITGDILVAR VIHGGLVERS GLLYAGDKLV
210 220 230 240 250
EVNGVSVEGL DPEQVIHILA MSCGTIMFKV IPVSAPPVSS QKMVYVRAMI
260 270 280 290 300
DYWPQEDPDI PCMDAGLPFL KGDILQIVDQ NDALWWQARK ISDLTICAGL
310 320 330 340 350
IPSNHLLKRK QREFWWSQPY QPHTCLKSTR ALSMEEEDSM KIDEKCVEAD
360 370 380 390 400
EETFESEELA EAKDEFVGDG QKFFIAGFRR SMRLCRRKSH FSQLHASLCC
410 420 430 440 450
SCSCYSAVGA PYEEVVRYQR QPADKHRLIV LVGPSGVGVN ELRRQLIGCN
460 470 480 490 500
PSCFQSAVPH TTRFPKSYEM DGREYHYVSR ETFESLMYGH KMLEYGEYKG
510 520 530 540 550
HLYGTSVNAV HAVLDEGKIC IMDLEPQDIQ SARTRDLKPY VIFIKPPNTS
560 570 580 590 600
SMRHSRKNAK ITTDYYVDMK FKDEDLQEME ELAQKMESQF GQFFDHVIVN
610 620 630
DNLQDACGQL LSAIQKAQEE LQWVPEAWVS PDTES
Length:635
Mass (Da):72,001
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8E08DDD122670C4
GO
Isoform 3 (identifier: Q6P7F1-3) [UniParc]FASTAAdd to basket
Also known as: mDLG6B

The sequence of this isoform differs from the canonical sequence as follows:
     331-336: Missing.

Show »
Length:629
Mass (Da):71,341
Checksum:i33F47923AA56BA30
GO
Isoform 4 (identifier: Q6P7F1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-150: Missing.
     331-336: Missing.
     350-354: DEETF → GNSSS
     355-635: Missing.

Note: No experimental confirmation available.
Show »
Length:198
Mass (Da):22,138
Checksum:iA54B9ED6526DE8C0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0G8D3Z0G8_MOUSE
MAGUK p55 subfamily member 4
Mpp4
654Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K3W4N9K3W4N9_MOUSE
MAGUK p55 subfamily member 4
Mpp4
635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WQU9A0A087WQU9_MOUSE
MAGUK p55 subfamily member 4
Mpp4
591Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH61694 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI16724 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB69494 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB69495 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC32031 differs from that shown. Reason: Frameshift.Curated
The sequence BAC40562 differs from that shown. Frameshifts and sequencing errors.Curated
The sequence BAC40562 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2R → I in BAB69494 (PubMed:12127943).Curated1
Sequence conflicti2R → I in BAB69495 (PubMed:12127943).Curated1
Sequence conflicti114Q → K in BAB69494 (PubMed:12127943).Curated1
Sequence conflicti114Q → K in BAB69495 (PubMed:12127943).Curated1
Sequence conflicti117H → N in BAB69494 (PubMed:12127943).Curated1
Sequence conflicti117H → N in BAB69495 (PubMed:12127943).Curated1
Sequence conflicti225T → M in BAC32031 (PubMed:16141072).Curated1
Sequence conflicti225T → M in BAC40562 (PubMed:16141072).Curated1
Sequence conflicti225T → M in AAI16724 (PubMed:15489334).Curated1
Sequence conflicti244V → G in BAB69494 (PubMed:12127943).Curated1
Sequence conflicti244V → G in BAB69495 (PubMed:12127943).Curated1
Sequence conflicti258P → H in BAC32031 (PubMed:16141072).Curated1
Sequence conflicti272G → A in BAC40562 (PubMed:16141072).Curated1
Sequence conflicti464F → S in BAB69494 (PubMed:12127943).Curated1
Sequence conflicti464F → S in BAB69495 (PubMed:12127943).Curated1
Sequence conflicti464F → S in BAC32031 (PubMed:16141072).Curated1
Sequence conflicti464F → S in AAI16724 (PubMed:15489334).Curated1
Sequence conflicti531S → L in BAB69494 (PubMed:12127943).Curated1
Sequence conflicti531S → L in BAB69495 (PubMed:12127943).Curated1
Sequence conflicti531S → L in BAC32031 (PubMed:16141072).Curated1
Sequence conflicti531S → L in AAI16724 (PubMed:15489334).Curated1
Sequence conflicti540Y → C in BAB69494 (PubMed:12127943).Curated1
Sequence conflicti540Y → C in BAB69495 (PubMed:12127943).Curated1
Sequence conflicti616K → R in BAB69494 (PubMed:12127943).Curated1
Sequence conflicti616K → R in BAB69495 (PubMed:12127943).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0139941 – 150Missing in isoform 4. 1 PublicationAdd BLAST150
Alternative sequenceiVSP_013995331 – 336Missing in isoform 3 and isoform 4. 2 Publications6
Alternative sequenceiVSP_013996350 – 354DEETF → GNSSS in isoform 4. 1 Publication5
Alternative sequenceiVSP_013997355 – 635Missing in isoform 4. 1 PublicationAdd BLAST281

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB059357 mRNA Translation: BAB69494.1 Different initiation.
AB059358 mRNA Translation: BAB69495.1 Different initiation.
AJ748820 mRNA Translation: CAG38657.1
AK044682 mRNA Translation: BAC32031.1 Frameshift.
AK088771 mRNA Translation: BAC40562.1 Sequence problems.
BC061694 mRNA Translation: AAH61694.2 Different initiation.
BC116723 mRNA Translation: AAI16724.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48271.1 [Q6P7F1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001158154.1, NM_001164682.1
NP_660125.2, NM_145143.3 [Q6P7F1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000078874; ENSMUSP00000077914; ENSMUSG00000079550 [Q6P7F1-1]
ENSMUST00000191200; ENSMUSP00000140957; ENSMUSG00000079550 [Q6P7F1-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
227157

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:227157

UCSC genome browser

More...
UCSCi
uc007bdh.1 mouse [Q6P7F1-3]
uc007bdi.2 mouse [Q6P7F1-1]
uc007bdj.1 mouse [Q6P7F1-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059357 mRNA Translation: BAB69494.1 Different initiation.
AB059358 mRNA Translation: BAB69495.1 Different initiation.
AJ748820 mRNA Translation: CAG38657.1
AK044682 mRNA Translation: BAC32031.1 Frameshift.
AK088771 mRNA Translation: BAC40562.1 Sequence problems.
BC061694 mRNA Translation: AAH61694.2 Different initiation.
BC116723 mRNA Translation: AAI16724.1 Different initiation.
CCDSiCCDS48271.1 [Q6P7F1-1]
RefSeqiNP_001158154.1, NM_001164682.1
NP_660125.2, NM_145143.3 [Q6P7F1-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi230597, 1 interactor
CORUMiQ6P7F1
STRINGi10090.ENSMUSP00000109914

PTM databases

iPTMnetiQ6P7F1
PhosphoSitePlusiQ6P7F1

Proteomic databases

PaxDbiQ6P7F1
PRIDEiQ6P7F1

Genome annotation databases

EnsembliENSMUST00000078874; ENSMUSP00000077914; ENSMUSG00000079550 [Q6P7F1-1]
ENSMUST00000191200; ENSMUSP00000140957; ENSMUSG00000079550 [Q6P7F1-3]
GeneIDi227157
KEGGimmu:227157
UCSCiuc007bdh.1 mouse [Q6P7F1-3]
uc007bdi.2 mouse [Q6P7F1-1]
uc007bdj.1 mouse [Q6P7F1-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
58538
MGIiMGI:2386681 Mpp4

Phylogenomic databases

eggNOGiKOG0609 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00940000156444
HOGENOMiHOG000233034
InParanoidiQ6P7F1
KOiK21109
OrthoDBi278124at2759
PhylomeDBiQ6P7F1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Mpp4 mouse

Protein Ontology

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PROi
PR:Q6P7F1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000079550 Expressed in 84 organ(s), highest expression level in retina
ExpressionAtlasiQ6P7F1 baseline and differential
GenevisibleiQ6P7F1 MM

Family and domain databases

CDDicd12034 SH3_MPP4, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR035600 MPP4_SH3
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF02828 L27, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00569 L27, 2 hits
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS51022 L27, 2 hits
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPP4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P7F1
Secondary accession number(s): Q0VG45
, Q8BTT3, Q8BXM5, Q920P7, Q920P8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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