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Protein

Mid1-interacting protein 1

Gene

Mid1ip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity).By similarity1 Publication

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-200425 Import of palmitoyl-CoA into the mitochondrial matrix

Names & Taxonomyi

Protein namesi
Recommended name:
Mid1-interacting protein 1
Alternative name(s):
Gastrulation-specific G12-like protein
Mid1-interacting G12-like protein
Protein STRAIT11499 homolog
Spot 14-related protein
Short name:
S14R
Short name:
Spot 14-R
Gene namesi
Name:Mid1ip1By similarity
Synonyms:Mig12Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1303258 Mid1ip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001237791 – 183Mid1-interacting protein 1Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei72PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei79PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6P7D5

PTM databases

iPTMnetiQ6P7D5
PhosphoSitePlusiQ6P7D5

Expressioni

Gene expression databases

BgeeiENSRNOG00000003228
ExpressionAtlasiQ6P7D5 baseline and differential
GenevisibleiQ6P7D5 RN

Interactioni

Subunit structurei

Homodimer in the absence of THRSP. Heterodimer with THRSP. The homodimer interacts with ACACA and ACACB. Promotes polymerization of Acetyl-CoA carboxylase to form complexes that contain MID1IP1 and ACACA and/or ACACB. Interaction with THRSP interferes with ACACA binding (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004305

Structurei

3D structure databases

SMRiQ6P7D5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPOT14 family.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IGNP Eukaryota
ENOG4111NGS LUCA
GeneTreeiENSGT00500000044890
HOGENOMiHOG000001157
HOVERGENiHBG002528
InParanoidiQ6P7D5
OMAiIEWGVLQ
OrthoDBiEOG091G0Z4G
PhylomeDBiQ6P7D5
TreeFamiTF326826

Family and domain databases

InterProiView protein in InterPro
IPR009786 Spot_14
PANTHERiPTHR14315 PTHR14315, 1 hit
PfamiView protein in Pfam
PF07084 Spot_14, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P7D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQICDTYNQ KHSLFNAMNR FIGAVNNMDQ TVMVPSLLRD VPLSEPDLDN
60 70 80 90 100
EVSVEVGGSG SCLEERTTPA PSPGSANGSF FAPSRDMYSH YVLLKSIRND
110 120 130 140 150
IEWGVLHQPS SPPAGSEEGT WKPKDILVGL SHLESTDAGE EDLEQQFHYH
160 170 180
LRGLHTVLSK LTRKANILTN RYKQEIGFSN WGH
Length:183
Mass (Da):20,414
Last modified:July 5, 2004 - v1
Checksum:i0E987B0470CAB319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061715 mRNA Translation: AAH61715.1
RefSeqiNP_996833.1, NM_206950.1
XP_006256734.1, XM_006256672.3
XP_017457615.1, XM_017602126.1
UniGeneiRn.8267

Genome annotation databases

EnsembliENSRNOT00000004305; ENSRNOP00000004305; ENSRNOG00000003228
GeneIDi404280
KEGGirno:404280
UCSCiRGD:1303258 rat

Similar proteinsi

Entry informationi

Entry nameiM1IP1_RAT
AccessioniPrimary (citable) accession number: Q6P7D5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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