UniProtKB - Q6P7C7 (GPNMB_RAT)
Protein
Transmembrane glycoprotein NMB
Gene
Gpnmb
Organism
Rattus norvegicus (Rat)
Status
Functioni
Could be a melanogenic enzyme.By similarity
GO - Molecular functioni
- heparin binding Source: RGD
- integrin binding Source: RGD
- receptor ligand activity Source: RGD
- syndecan binding Source: RGD
GO - Biological processi
- bone mineralization Source: RGD
- cell adhesion Source: RGD
- cell-cell signaling Source: RGD
- negative regulation of cytokine production Source: RGD
- negative regulation of G1/S transition of mitotic cell cycle Source: RGD
- negative regulation of neuron death Source: RGD
- negative regulation of T cell activation Source: RGD
- negative regulation of T cell proliferation Source: RGD
- negative regulation of tumor necrosis factor production Source: RGD
- osteoblast differentiation Source: RGD
- positive regulation of cell migration Source: RGD
- positive regulation of ERK1 and ERK2 cascade Source: RGD
- positive regulation of protein autophosphorylation Source: RGD
- positive regulation of protein phosphorylation Source: RGD
- regulation of tissue remodeling Source: RGD
- signal transduction Source: RGD
Enzyme and pathway databases
Reactomei | R-RNO-8857538, PTK6 promotes HIF1A stabilization |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane glycoprotein NMB |
Gene namesi | Name:Gpnmb |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 71008, Gpnmb |
Subcellular locationi
Plasma membrane
- Cell membrane ; Single-pass type I membrane protein By similarity
Endosome
- Early endosome membrane ; Single-pass type I membrane protein By similarity
Other locations
- Melanosome membrane ; Single-pass type I membrane protein By similarity
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.By similarity
Endosome
- early endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: RGD
Other locations
- cytoplasmic vesicle Source: RGD
- integral component of membrane Source: RGD
- melanosome membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 500 | ExtracellularSequence analysisAdd BLAST | 478 | |
Transmembranei | 501 – 521 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 522 – 572 | CytoplasmicSequence analysisAdd BLAST | 51 |
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000024711 | 23 – 572 | Transmembrane glycoprotein NMBAdd BLAST | 550 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 93 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 134 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 200 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 249 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 275 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 296 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 300 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 306 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 312 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 461 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 469 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 544 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q6P7C7 |
PRIDEi | Q6P7C7 |
PTM databases
GlyGeni | Q6P7C7, 11 sites |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000008816, Expressed in lung and 22 other tissues |
Genevisiblei | Q6P7C7, RN |
Interactioni
GO - Molecular functioni
- integrin binding Source: RGD
- receptor ligand activity Source: RGD
- syndecan binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000011945 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 251 – 338 | PKDPROSITE-ProRule annotationAdd BLAST | 88 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 556 – 558 | Cell attachment siteSequence analysis | 3 |
Sequence similaritiesi
Belongs to the PMEL/NMB family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QVWX, Eukaryota |
GeneTreei | ENSGT00950000183188 |
HOGENOMi | CLU_017264_1_0_1 |
InParanoidi | Q6P7C7 |
OMAi | CWKGGRV |
PhylomeDBi | Q6P7C7 |
TreeFami | TF334865 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR022409, PKD/Chitinase_dom IPR000601, PKD_dom IPR035986, PKD_dom_sf |
Pfami | View protein in Pfam PF00801, PKD, 1 hit |
SMARTi | View protein in SMART SM00089, PKD, 1 hit |
SUPFAMi | SSF49299, SSF49299, 1 hit |
PROSITEi | View protein in PROSITE PS50093, PKD, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6P7C7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESLCGVLVF LLLAAGLPLQ AAKRFRDVLG HEQYPDHMRE NNQLRGWSSD
60 70 80 90 100
ENEWDEQLYP VWRRGEGRWK DSWEGGRVQA ALTSDSPALV GSNITFVVNL
110 120 130 140 150
VFPRCQKEDA NGNIVYERNC RSDLELASDP YVYNWTTGAD DEDWEDSTSQ
160 170 180 190 200
GQHLRFPDGK PFPRPHGRKK WNFVYVFHTL GQYFQKLGRC SARVSINTVN
210 220 230 240 250
LTVGPQVMEV IVFRRHGRAY IPISKVKDVY VITDQIPIFV TMYQKNDRNS
260 270 280 290 300
SDETFLRDLP IFFDVLIHDP SHFLNYSAIS YKWNFGDNTG LFVSNNHTLN
310 320 330 340 350
HTYVLNGTFN FNLTVQTAVP GPCPSPTPSP SSSTSPSPAS SPSPTLSTPS
360 370 380 390 400
PSLMPTGHKS MELSDISNEN CRINRYGYFR ATITIVDGIL EVNIIQVADV
410 420 430 440 450
PIPTPQPDNS LMDFIVTCKG ATPTEACTII SDPTCQIAQN RVCSPVAVDE
460 470 480 490 500
LCLLSVRRAF NGSGTYCVNF TLGDDASLAL TSALISIPGK DLGSPLRTVN
510 520 530 540 550
GVLISIGCLA MFVTMVTILL YKKHKTYKPI GNCTRNVVKG KGLSVFLSHA
560 570
KAPFSRGDRE KDPLLQDKPW ML
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC061725 mRNA Translation: AAH61725.1 |
Genome annotation databases
Ensembli | ENSRNOT00000011945; ENSRNOP00000011945; ENSRNOG00000008816 |
UCSCi | RGD:71008, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC061725 mRNA Translation: AAH61725.1 |
3D structure databases
SMRi | Q6P7C7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000011945 |
PTM databases
GlyGeni | Q6P7C7, 11 sites |
Proteomic databases
PaxDbi | Q6P7C7 |
PRIDEi | Q6P7C7 |
Genome annotation databases
Ensembli | ENSRNOT00000011945; ENSRNOP00000011945; ENSRNOG00000008816 |
UCSCi | RGD:71008, rat |
Organism-specific databases
RGDi | 71008, Gpnmb |
Phylogenomic databases
eggNOGi | ENOG502QVWX, Eukaryota |
GeneTreei | ENSGT00950000183188 |
HOGENOMi | CLU_017264_1_0_1 |
InParanoidi | Q6P7C7 |
OMAi | CWKGGRV |
PhylomeDBi | Q6P7C7 |
TreeFami | TF334865 |
Enzyme and pathway databases
Reactomei | R-RNO-8857538, PTK6 promotes HIF1A stabilization |
Miscellaneous databases
PROi | PR:Q6P7C7 |
Gene expression databases
Bgeei | ENSRNOG00000008816, Expressed in lung and 22 other tissues |
Genevisiblei | Q6P7C7, RN |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR022409, PKD/Chitinase_dom IPR000601, PKD_dom IPR035986, PKD_dom_sf |
Pfami | View protein in Pfam PF00801, PKD, 1 hit |
SMARTi | View protein in SMART SM00089, PKD, 1 hit |
SUPFAMi | SSF49299, SSF49299, 1 hit |
PROSITEi | View protein in PROSITE PS50093, PKD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPNMB_RAT | |
Accessioni | Q6P7C7Primary (citable) accession number: Q6P7C7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | August 12, 2020 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families