UniProtKB - Q6P6Z0 (DDB1_XENLA)
Protein
DNA damage-binding protein 1
Gene
ddb1
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. May play a role in the regulation of the circadian clock (By similarity).By similarity
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarityView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- DNA repair Source: UniProtKB-KW
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein ubiquitination Source: UniProtKB
- regulation of circadian rhythm Source: UniProtKB
- rhythmic process Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Biological rhythms, DNA damage, DNA repair, Ubl conjugation pathway |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: DNA damage-binding protein 1Alternative name(s): Damage-specific DNA-binding protein 1 |
Gene namesi | Name:ddb1 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-967911, ddb1.S |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB
Other locations
- Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
- Cul4A-RING E3 ubiquitin ligase complex Source: UniProtKB
- Cul4B-RING E3 ubiquitin ligase complex Source: UniProtKB
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000351085 | 1 – 1140 | DNA damage-binding protein 1Add BLAST | 1140 |
Proteomic databases
PRIDEi | Q6P6Z0 |
Interactioni
Subunit structurei
Component of the UV-DDB complex which includes ddb1 and ddb2 (By similarity).
Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which consist of a core of ddb1, cul4a or cul4b and rbx1, and a substrate receptor, such as CRBN (By similarity). DDB1 may recruit specific substrate targeting subunits to the DCX complex. These substrate targeting subunits are generally known as DCAF (DDB1- and CUL4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 100352, 3 interactors |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 13 – 356 | WD repeat beta-propeller ABy similarityAdd BLAST | 344 | |
Regioni | 391 – 708 | WD repeat beta-propeller B; Interaction with CUL4ABy similarityAdd BLAST | 318 | |
Regioni | 709 – 1043 | WD repeat beta-propeller CBy similarityAdd BLAST | 335 |
Domaini
The core of the protein consists of three WD40 beta-propeller domains.By similarity
Sequence similaritiesi
Belongs to the DDB1 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
OMAi | GDGSMYY |
OrthoDBi | 146622at2759 |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR004871, Cleavage/polyA-sp_fac_asu_C IPR018846, Cleavage/polyA-sp_fac_asu_N IPR031297, DDB1 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10644:SF3, PTHR10644:SF3, 1 hit |
Pfami | View protein in Pfam PF03178, CPSF_A, 1 hit PF10433, MMS1_N, 1 hit |
SUPFAMi | SSF50978, SSF50978, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6P6Z0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSYNYVVTAQ KPTAVNACVT GHFTSEDDLN LLIAKNTRLE IYVVTPEGLR
60 70 80 90 100
PVKEVGMYGK IAVMELFRPK GESKDLLFIL TAKYNACILE YKQSGDSIDI
110 120 130 140 150
ITRAHGNVQD RIGRPSETGI IGIIDPDCRM IGLRLYDGLF KVIPLERDNK
160 170 180 190 200
ELKAFNIRLE ELHVIDVKFL YSCQAPTICF VYQDPQGRHV KTYEVSLREK
210 220 230 240 250
EFSKGPWKQE NVEAEASMVI AVPEPFGGAI IIGQESITYH NGDKYLAIAP
260 270 280 290 300
PIIKQSTIVC HNRVDVNGSR YLLGDMEGRL FMLLLEKEEQ MDGSVTLKDL
310 320 330 340 350
RVELLGETSI AECLTYLDNG VVFVGSRLGD SQLVKLTTES NEQGSYVVVM
360 370 380 390 400
ETFTNLGPIV DMCVVDLERQ GQGQLVTCSG AFKEGSLRII RNGIGIHEHA
410 420 430 440 450
SIDLPGIKGL WPLRVAADRD TDDTLVLSFV GQTRVLTLTG EEVEETDLAG
460 470 480 490 500
FVDDQQTFFC GNVAHQQLIQ ITSASVRLVS QNPQNLVSEW KEPQGRKVSV
510 520 530 540 550
CSCNSRQVLL AVGRVLYYLE IHPGELRQTS CTEMEHEVAC LDVTPLGGND
560 570 580 590 600
TLSSLCAIGL WTDISARILS LPGFQLLHKE MLGGEIIPRS ILMTSFESSH
610 620 630 640 650
YLLCALGDGA LFYFSLNTDT GLLSDRKKVT LGTQPTVLRT FRSLSTTNVF
660 670 680 690 700
ACSDRPTVIY SSNHKLVFSN VNLKEVNYMC PLNSEGYPDS LALANNSTLT
710 720 730 740 750
IGTIDEIQKL HIRTVPLFES PRKICYQEVS QCFGVLSSRI EVQDASGGSS
760 770 780 790 800
PLRPSASTQA LSSSVSCSKL FSGSTSPHET SFGEEVEVHN LLIIDQHTFE
810 820 830 840 850
VLHTHQFLQN EYTLSLVSCK LGKDPTTYFV VGTAMVYPDE AEPKQGRIVV
860 870 880 890 900
FQYNDGKLQT VAEKEVKGAV YSMVEFNGKL LASINSTVRL YEWTAEKELR
910 920 930 940 950
TECNHYNNIM ALYLKTKGDF ILVGDLMRSV LLLAYKPMEG NFEEIARDFN
960 970 980 990 1000
PNWMSAVEIL DDDNFLGAEN AFNLFVCQKD SAATTDEERQ HLQEVGLFHL
1010 1020 1030 1040 1050
GEFVNVFCHG SLVMQNLGET SPPTQGSVLF GTVNGMIGLV TSLSESWYNL
1060 1070 1080 1090 1100
LLDVQNRLNK VIKSVGKIEH SFWRSFHTER KTEPATGFID GDLIESFLDI
1110 1120 1130 1140
SRPKMQEVIA NLQIDDGSGM KRETTVDDLI KVVEELTRIH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC061946 mRNA Translation: AAH61946.1 |
RefSeqi | NP_001083624.1, NM_001090155.1 |
Genome annotation databases
GeneIDi | 399026 |
KEGGi | xla:399026 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC061946 mRNA Translation: AAH61946.1 |
RefSeqi | NP_001083624.1, NM_001090155.1 |
3D structure databases
SMRi | Q6P6Z0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 100352, 3 interactors |
Proteomic databases
PRIDEi | Q6P6Z0 |
Genome annotation databases
GeneIDi | 399026 |
KEGGi | xla:399026 |
Organism-specific databases
CTDi | 399026 |
Xenbasei | XB-GENE-967911, ddb1.S |
Phylogenomic databases
OMAi | GDGSMYY |
OrthoDBi | 146622at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR004871, Cleavage/polyA-sp_fac_asu_C IPR018846, Cleavage/polyA-sp_fac_asu_N IPR031297, DDB1 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10644:SF3, PTHR10644:SF3, 1 hit |
Pfami | View protein in Pfam PF03178, CPSF_A, 1 hit PF10433, MMS1_N, 1 hit |
SUPFAMi | SSF50978, SSF50978, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DDB1_XENLA | |
Accessioni | Q6P6Z0Primary (citable) accession number: Q6P6Z0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 23, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families