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Entry version 134 (13 Nov 2019)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Baculoviral IAP repeat-containing 2

Gene

Birc2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-111465 Apoptotic cleavage of cellular proteins
R-RNO-168638 NOD1/2 Signaling Pathway
R-RNO-5213460 RIPK1-mediated regulated necrosis
R-RNO-5357905 Regulation of TNFR1 signaling
R-RNO-5357956 TNFR1-induced NFkappaB signaling pathway
R-RNO-5668541 TNFR2 non-canonical NF-kB pathway
R-RNO-5675482 Regulation of necroptotic cell death
R-RNO-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
R-RNO-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I32.007

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Baculoviral IAP repeat-containing 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Birc2Imported
ORF Names:rCG_31679Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
620690 Birc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000010602 Expressed in 10 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000014560

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P6S1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini424 – 514CARDInterPro annotationAdd BLAST91
Domaini542 – 577RING-typeInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili398 – 425Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1101 Eukaryota
ENOG410YPNM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154175

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232059

KEGG Orthology (KO)

More...
KOi
K16060

Identification of Orthologs from Complete Genome Data

More...
OMAi
KVACFTC

Database of Orthologous Groups

More...
OrthoDBi
1340284at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105356

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00022 BIR, 3 hits
cd14394 UBA_BIRC2_3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001370 BIR_rpt
IPR041933 BIRC2/BIRC3_UBA
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR001841 Znf_RING

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00653 BIR, 3 hits
PF00619 CARD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00238 BIR, 3 hits
SM00114 CARD, 1 hit
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01282 BIR_REPEAT_1, 3 hits
PS50143 BIR_REPEAT_2, 3 hits
PS50209 CARD, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6P6S1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENSTVLSNW TKENKEKMKY DFSCELYRMS TYSAFPRGVP VSERSLARAG
60 70 80 90 100
FYYTGVNDKV KCFCCGLMLD NWKQGDSPTE KHRQFYPSCS FVQTLLSGGL
110 120 130 140 150
QSAAKNTSPA KSRFAHSLPL EQGGIHSSLP SNPLNSRAVE DFSLRMNPCS
160 170 180 190 200
YAMSTEEARF LSYSMWPLSF LSPAELAKAG FYYTGPGDRV ACFACGGKLS
210 220 230 240 250
NWEPNDDPLS EHRRHFPHCP FLENTSETQR FSVSNLSMQT HSARMRTFLY
260 270 280 290 300
WPSSVLVQPE QLASAGFYYV DHNDDVKCFC CDGGLRCWEP GDDPWIEHAK
310 320 330 340 350
WFPRCEFLIR MKGQEFVDEI QARYPHLLEQ LLSTSDTSEE ENADPPVVHL
360 370 380 390 400
GPGENWEDAV MMNTPVVKAA LDMGFSRSLV RQTVQRQILA TGENYRTVSD
410 420 430 440 450
IVSALLNAED ERREEEKERQ SEETASGDLS LIRKNRMALF QQLTCVIPIL
460 470 480 490 500
DDLLEASVLT KEEHDIIRQK TQIPLQAREL IDTILVKGNA AASVFKNSLK
510 520 530 540 550
EVDSTLYEHL FVEKTMKYIP TEDVSGLSLE EQLRRLQEER TCKVCMDREV
560 570 580
SIVFIPCGHL VVCRECAPSL RKCPICRGTI KGTVRTFLS
Length:589
Mass (Da):66,847
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i526ECBAA9052EF49
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07069022 Genomic DNA No translation available.
AABR07069023 Genomic DNA No translation available.
BC062055 mRNA Translation: AAH62055.1
CH473993 Genomic DNA Translation: EDL78522.1

NCBI Reference Sequences

More...
RefSeqi
NP_068520.2, NM_021752.2
XP_006242556.1, XM_006242494.3
XP_006242557.1, XM_006242495.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000014560; ENSRNOP00000014560; ENSRNOG00000010602

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
60371

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:60371

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069022 Genomic DNA No translation available.
AABR07069023 Genomic DNA No translation available.
BC062055 mRNA Translation: AAH62055.1
CH473993 Genomic DNA Translation: EDL78522.1
RefSeqiNP_068520.2, NM_021752.2
XP_006242556.1, XM_006242494.3
XP_006242557.1, XM_006242495.3

3D structure databases

SMRiQ6P6S1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014560

Protein family/group databases

MEROPSiI32.007

Genome annotation databases

EnsembliENSRNOT00000014560; ENSRNOP00000014560; ENSRNOG00000010602
GeneIDi60371
KEGGirno:60371

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
329
RGDi620690 Birc2

Phylogenomic databases

eggNOGiKOG1101 Eukaryota
ENOG410YPNM LUCA
GeneTreeiENSGT00940000154175
HOGENOMiHOG000232059
KOiK16060
OMAiKVACFTC
OrthoDBi1340284at2759
TreeFamiTF105356

Enzyme and pathway databases

ReactomeiR-RNO-111465 Apoptotic cleavage of cellular proteins
R-RNO-168638 NOD1/2 Signaling Pathway
R-RNO-5213460 RIPK1-mediated regulated necrosis
R-RNO-5357905 Regulation of TNFR1 signaling
R-RNO-5357956 TNFR1-induced NFkappaB signaling pathway
R-RNO-5668541 TNFR2 non-canonical NF-kB pathway
R-RNO-5675482 Regulation of necroptotic cell death
R-RNO-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
R-RNO-5689880 Ub-specific processing proteases

Gene expression databases

BgeeiENSRNOG00000010602 Expressed in 10 organ(s), highest expression level in liver

Family and domain databases

CDDicd00022 BIR, 3 hits
cd14394 UBA_BIRC2_3, 1 hit
InterProiView protein in InterPro
IPR001370 BIR_rpt
IPR041933 BIRC2/BIRC3_UBA
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR001841 Znf_RING
PfamiView protein in Pfam
PF00653 BIR, 3 hits
PF00619 CARD, 1 hit
SMARTiView protein in SMART
SM00238 BIR, 3 hits
SM00114 CARD, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS01282 BIR_REPEAT_1, 3 hits
PS50143 BIR_REPEAT_2, 3 hits
PS50209 CARD, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6P6S1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P6S1
Secondary accession number(s): F1M6X6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 13, 2019
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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