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Protein
Submitted name:

Transglutaminase 2, C polypeptide

Gene

Tgm2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Ca2+UniRule annotationNote: Binds 1 Ca2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei277UniRule annotation1
Active sitei335UniRule annotation1
Active sitei358UniRule annotation1
Metal bindingi398CalciumUniRule annotation1
Metal bindingi400CalciumUniRule annotation1
Metal bindingi447CalciumUniRule annotation1
Metal bindingi452CalciumUniRule annotation1

GO - Molecular functioni

  • enzyme binding Source: RGD
  • GTP binding Source: RGD
  • metal ion binding Source: UniProtKB-KW
  • protein domain specific binding Source: RGD
  • protein-glutamine gamma-glutamyltransferase activity Source: InterPro

GO - Biological processi

Keywordsi

LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Transglutaminase 2, C polypeptideImported
Gene namesi
Name:Tgm2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621081 Tgm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ6P6R6

PTM databases

iPTMnetiQ6P6R6

Expressioni

Gene expression databases

GenevisibleiQ6P6R6 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ6P6R6

Structurei

3D structure databases

ProteinModelPortaliQ6P6R6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini269 – 361TGcInterPro annotationAdd BLAST93

Phylogenomic databases

eggNOGiENOG410IFMV Eukaryota
ENOG410XQEZ LUCA
HOGENOMiHOG000231695
HOVERGENiHBG004342
KOiK05625

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR038765 Papain_like_cys_pep_sf
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PfamiView protein in Pfam
PF00927 Transglut_C, 2 hits
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF54001 SSF54001, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P6R6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEELNLERC DLEIQANGRD HHTADLCQEK LVLRRGQRFR LTLYFEGRGY
60 70 80 90 100
EASVDRLTFG AVTGPDPSEE AGTKARFSLS DDVEEGSWSA SVLDQQDNVL
110 120 130 140 150
SLQLCTPANA PVGQYRLSLE TSTGYQGSSF MLGHFILLFN AWCPADDVYL
160 170 180 190 200
DSEAERREYV LTQQGFIYQG SVKFIKSVPW NFGQFEDGIL DACLMLLDVN
210 220 230 240 250
PKFLKDRSRD CSRRSSPIYV GRVVSGMVNC NDDQGVLLGR WDNNYGDGIS
260 270 280 290 300
PMAWIGSVDI LRRWKEHGCQ QVKYGQCWVF AAVACTVLRC LGIPTRVVTN
310 320 330 340 350
YNSAHDQNSN LLIEYFRNEY GELESNKSEM IWNFHCWVES WMTRPDLQPG
360 370 380 390 400
YEGWQAIDPT PQEKSEGTYC CGPVSVRAIK EGDLSTKYDA SFVFAEVNAD
410 420 430 440 450
VVDWIRQSDG SVLKSINNSL VVGQKISTKS VGRDDREDIT YTYKYPEGSP
460 470 480 490 500
EEREVFTRAN HLNKLAEKEE TGVAMRIRVG DGMSLGNDFD VFAHIGNDTS
510 520 530 540 550
ESRECRLLLC ARTVSYNGVL GPECGTEDIN LTLDPYSENS IPLRILYEKY
560 570 580 590 600
SGCLTESNLI KVRGLLVEPA ANSYLLAERD LYLENPEIKI RILGEPKQNR
610 620 630 640 650
KLVAEVSLKN PLSDSLYDCV FTVEGAGLTK EQKSVEVSDP VPAGDAVKVR
660 670 680
VDLFPTDIGL HKLVVNFQCD KLKSVKGYRN IIIGPA
Length:686
Mass (Da):76,936
Last modified:July 5, 2004 - v1
Checksum:iB29FF3E396989EDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062062 mRNA Translation: AAH62062.1
RefSeqiNP_062259.2, NM_019386.2
UniGeneiRn.10

Genome annotation databases

GeneIDi56083
KEGGirno:56083

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062062 mRNA Translation: AAH62062.1
RefSeqiNP_062259.2, NM_019386.2
UniGeneiRn.10

3D structure databases

ProteinModelPortaliQ6P6R6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ6P6R6

PTM databases

iPTMnetiQ6P6R6

Proteomic databases

PRIDEiQ6P6R6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56083
KEGGirno:56083

Organism-specific databases

CTDi7052
RGDi621081 Tgm2

Phylogenomic databases

eggNOGiENOG410IFMV Eukaryota
ENOG410XQEZ LUCA
HOGENOMiHOG000231695
HOVERGENiHBG004342
KOiK05625

Gene expression databases

GenevisibleiQ6P6R6 RN

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR038765 Papain_like_cys_pep_sf
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PfamiView protein in Pfam
PF00927 Transglut_C, 2 hits
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF54001 SSF54001, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ6P6R6_RAT
AccessioniPrimary (citable) accession number: Q6P6R6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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