Krt5

Functionⁱ

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	413	StutterSequence analysis		1

GO - Molecular functionⁱ

structural molecule activity Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Keratin, type II cytoskeletal 5 Alternative name(s): Cytokeratin-5 Short name: CK-5 Keratin-5 Short name: K5 Type-II keratin Kb5
Gene namesⁱ	Name:Krt5By similarity Synonyms:Krt2-5Imported
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	727894 Krt5

RGDⁱ

727894 Krt5

Subcellular locationⁱ

GO - Cellular component

Keywords - Cellular componentⁱ

Intermediate filament, Keratin

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000063729	1 – 576	Keratin, type II cytoskeletal 5Add BLAST		576

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	5	PhosphoserineCombined sources	1
Modified residueⁱ	8	PhosphoserineCombined sources	1
Modified residueⁱ	16	PhosphoserineCombined sources	1
Modified residueⁱ	21	PhosphoserineCombined sources	1
Modified residueⁱ	26	PhosphoserineBy similarity	1
Modified residueⁱ	36	PhosphoserineCombined sources	1
Modified residueⁱ	46	PhosphoserineBy similarity	1
Modified residueⁱ	60	PhosphoserineCombined sources	1
Modified residueⁱ	67	PhosphoserineCombined sources	1
Modified residueⁱ	71	PhosphoserineCombined sources	1
Modified residueⁱ	74	PhosphoserineCombined sources	1
Modified residueⁱ	78	PhosphoserineCombined sources	1
Modified residueⁱ	527	Omega-N-methylarginineBy similarity	1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q6P6Q2
PRIDEⁱ	Q6P6Q2

PTM databases

iPTMnetⁱ	Q6P6Q2
PhosphoSitePlusⁱ	Q6P6Q2

Expressionⁱ

Tissue specificityⁱ

Expressed in the epidermis (at protein level) and testis (within pachytene spermatocytes).1 Publication

Interactionⁱ

Subunit structureⁱ

Heterodimer of a type I and a type II keratin. Heterodimer with type I keratin KRT25 leading to the formation of keratin intermediate filament (KIF) network. Heterodimer with KRT14. Interacts with TCHP. Interacts with EPPK1.By similarity

Protein-protein interaction databases

BioGridⁱ	266785, 1 interactor
STRINGⁱ	10116.ENSRNOP00000011644

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6P6Q2
SMRⁱ	Q6P6Q2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	164 – 477	IF rodPROSITE-ProRule annotationAdd BLAST		314

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 163	HeadSequence analysisAdd BLAST	163
Regionⁱ	164 – 199	Coil 1ASequence analysisAdd BLAST	36
Regionⁱ	200 – 218	Linker 1Sequence analysisAdd BLAST	19
Regionⁱ	219 – 311	Coil 1BSequence analysisAdd BLAST	93
Regionⁱ	312 – 334	Linker 12Sequence analysisAdd BLAST	23
Regionⁱ	335 – 473	Coil 2Sequence analysisAdd BLAST	139
Regionⁱ	474 – 576	TailSequence analysisAdd BLAST	103

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	39 – 135	Gly-richSequence analysisAdd BLAST		97
Compositional biasⁱ	532 – 576	Ser-richSequence analysisAdd BLAST		45

Sequence similaritiesⁱ

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

HOVERGENⁱ	HBG013015
InParanoidⁱ	Q6P6Q2
KEGG Orthology (KO) More...KOⁱ	K07605
PhylomeDBⁱ	Q6P6Q2

Family and domain databases

InterProⁱ	View protein in InterPro IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR032444 Keratin_2_head IPR003054 Keratin_II
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit PF16208 Keratin_2_head, 1 hit
PRINTSⁱ	PR01276 TYPE2KERATIN
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.ⁱShow all

Q6P6Q2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSRQSSVSFR SGGSRSFSAA SAITPSVSRT TFSSVSRSGG GGGRVSLGGA 
        60         70         80         90        100
YGAGGYGSRS LYNVGGSKRI SFSSGGGSFR NQFGAGAGGG YGFGGGAGSG 
       110        120        130        140        150
FGFGGGAGSG FGFGGGAGFG GGYGGAGFPV CPPGGIQEVT VNQNLLTPLN 
       160        170        180        190        200
LQIDPTIQRV RTEEREQIKT LNNKFASFID KVRFLEQQNK VLDTKWTLLQ 
       210        220        230        240        250
EQGTKTIKQN LDPLFEQYIN NLRRQLDGVM GERGRLDSEL RNMQDLVEDY 
       260        270        280        290        300
KNKYEDEINK RTTAENEFVM LKKDVDAAYM NKVELEAKVD ALMDEINFMK 
       310        320        330        340        350
MFFDAELSQM QTHVSDTSVV LSMDNNRSLD LDSIIAEVKA QYEDIANRSR 
       360        370        380        390        400
TEAESWYQTK YEELQQTAGR HGDDLRNTKH EISEMNRMIQ RLRSEIDNVK 
       410        420        430        440        450
KQCANLQNAI AEAEQRGELA LKDARNKLTE LEEALQKAKQ DMARLLREYQ 
       460        470        480        490        500
ELMNTKLALD VEIATYRKLL EGEECRLSGE GVGPVNISVV TNSLSSGYGG 
       510        520        530        540        550
RSNIGYGSGL GSGIGGFASD IGPLLNRRGL GSGLSVGGSG FSASSGQGGG 
       560        570 
FSSGGGSSSS VKFVSTTSSS RRSFKS

Length:576

Mass (Da):61,826

Last modified:July 5, 2004 - v1

Checksum:ⁱ23A1C2C47405EE3B

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
A0A0G2K509	A0A0G2K509_RAT	Keratin, type II cytoskeletal 5 Keratin, type II cytoskeletal 5	Krt5 LOC102551453	591	Annotation score:
F7FFV2	F7FFV2_RAT	Keratin, type II cytoskeletal 5 Keratin, type II cytoskeletal 5	Krt5	395	Annotation score:
A0A0G2K1K9	A0A0G2K1K9_RAT	Keratin, type II cytoskeletal 5 Keratin, type II cytoskeletal 5	Krt5 LOC102551453	181	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	114	G → R in AAQ20893 (PubMed:14551252).Curated	1
Sequence conflictⁱ	473	E → Q in AAQ20893 (PubMed:14551252).Curated	1
Sequence conflictⁱ	508	S → F in AAQ20893 (PubMed:14551252).Curated	1
Sequence conflictⁱ	528	R → L in AAQ20893 (PubMed:14551252).Curated	1
Sequence conflictⁱ	562	K → Q in AAQ20893 (PubMed:14551252).Curated	1
Sequence conflictⁱ	575	K → N in AAQ20893 (PubMed:14551252).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY342389 mRNA Translation: AAQ20893.1 BC062086 mRNA Translation: AAH62086.1
NCBI Reference Sequences More...RefSeqⁱ	NP_899162.1, NM_183333.1
UniGeneⁱ	Rn.129725 Rn.195318

Genome annotation databases

GeneIDⁱ	369017
KEGGⁱ	rno:369017

Protein	Similar proteins		Species	Score	Length	Source
Q6P6Q2	Keratin, type II cytoskeletal 5 (Fragment)		RAT		181	UniRef100_Q6P6Q2
Keratin, type II cytoskeletal 5 (Fragment)		RAT		395

Protein	Similar proteins		Species	Score	Length	Source
Q6P6Q2	Keratin, type II cytoskeletal 5		MOUSE		580	UniRef90_Q922U2
Keratin, type II cytoskeletal 5 (Fragment)		RAT		181
UPI000B4EABE6		MERUN		589
UPI000A304703		MUSPA		580
Keratin 5		MOUSE		580
+3

Protein	Similar proteins		Species	Score	Length	Source
Q6P6Q2	Keratin, type II cytoskeletal 73		HUMAN		540	UniRef50_Q86Y46
Keratin, type II cytoskeletal 5		MOUSE		580
Keratin, type II cytoskeletal 1		RAT		625
Keratin 73		AOTNA		541
Keratin 73		FELCA		540
+233

Entry informationⁱ

Entry nameⁱ	K2C5_RAT
Accessionⁱ	Q6P6Q2Primary (citable) accession number: Q6P6Q2 Secondary accession number(s): Q7TN97
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
	Last sequence update:	July 5, 2004
	Last modified:	May 23, 2018
	This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6P6Q2 (K2C5_RAT)

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Keratin, type II cytoskeletal 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi