UniProtKB - Q6P6Q2 (K2C5_RAT)
Protein
Keratin, type II cytoskeletal 5
Gene
Krt5
Organism
Rattus norvegicus (Rat)
Status
Functioni
Miscellaneous
There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 413 | StutterSequence analysis | 1 |
Enzyme and pathway databases
Reactomei | R-RNO-446107 Type I hemidesmosome assembly R-RNO-6805567 Keratinization R-RNO-6809371 Formation of the cornified envelope |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin, type II cytoskeletal 5Alternative name(s): Cytokeratin-5 Short name: CK-5 Keratin-5 Short name: K5 Type-II keratin Kb5 |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 727894 Krt5 |
Subcellular locationi
Cytoskeleton
- keratin filament Source: RGD
Keywords - Cellular componenti
Intermediate filament, KeratinPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000063729 | 1 – 576 | Keratin, type II cytoskeletal 5Add BLAST | 576 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 5 | PhosphoserineCombined sources | 1 | |
Modified residuei | 8 | PhosphoserineCombined sources | 1 | |
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 26 | PhosphoserineBy similarity | 1 | |
Modified residuei | 36 | PhosphoserineCombined sources | 1 | |
Modified residuei | 46 | PhosphoserineBy similarity | 1 | |
Modified residuei | 60 | PhosphoserineCombined sources | 1 | |
Modified residuei | 67 | PhosphoserineCombined sources | 1 | |
Modified residuei | 71 | PhosphoserineCombined sources | 1 | |
Modified residuei | 74 | PhosphoserineCombined sources | 1 | |
Modified residuei | 78 | PhosphoserineCombined sources | 1 | |
Modified residuei | 527 | Omega-N-methylarginineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
jPOSTi | Q6P6Q2 |
PaxDbi | Q6P6Q2 |
PRIDEi | Q6P6Q2 |
PTM databases
iPTMneti | Q6P6Q2 |
PhosphoSitePlusi | Q6P6Q2 |
Expressioni
Tissue specificityi
Expressed in the epidermis (at protein level) and testis (within pachytene spermatocytes).1 Publication
Interactioni
Subunit structurei
Heterodimer of a type I and a type II keratin. Heterodimer with type I keratin KRT25 leading to the formation of keratin intermediate filament (KIF) network. Heterodimer with KRT14.
Interacts with TCHP.
Interacts with EPPK1.
By similarityProtein-protein interaction databases
BioGridi | 266785, 2 interactors |
STRINGi | 10116.ENSRNOP00000011644 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 164 – 477 | IF rodPROSITE-ProRule annotationAdd BLAST | 314 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 163 | HeadSequence analysisAdd BLAST | 163 | |
Regioni | 164 – 199 | Coil 1ASequence analysisAdd BLAST | 36 | |
Regioni | 200 – 218 | Linker 1Sequence analysisAdd BLAST | 19 | |
Regioni | 219 – 311 | Coil 1BSequence analysisAdd BLAST | 93 | |
Regioni | 312 – 334 | Linker 12Sequence analysisAdd BLAST | 23 | |
Regioni | 335 – 473 | Coil 2Sequence analysisAdd BLAST | 139 | |
Regioni | 474 – 576 | TailSequence analysisAdd BLAST | 103 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 39 – 135 | Gly-richSequence analysisAdd BLAST | 97 | |
Compositional biasi | 532 – 576 | Ser-richSequence analysisAdd BLAST | 45 |
Sequence similaritiesi
Belongs to the intermediate filament family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
InParanoidi | Q6P6Q2 |
KOi | K07605 |
OrthoDBi | 824246at2759 |
PhylomeDBi | Q6P6Q2 |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR018039 IF_conserved IPR039008 IF_rod_dom IPR042180 IF_rod_dom_coil1B IPR032444 Keratin_2_head IPR003054 Keratin_II |
Pfami | View protein in Pfam PF00038 Filament, 1 hit PF16208 Keratin_2_head, 1 hit |
PRINTSi | PR01276 TYPE2KERATIN |
SMARTi | View protein in SMART SM01391 Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q6P6Q2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRQSSVSFR SGGSRSFSAA SAITPSVSRT TFSSVSRSGG GGGRVSLGGA
60 70 80 90 100
YGAGGYGSRS LYNVGGSKRI SFSSGGGSFR NQFGAGAGGG YGFGGGAGSG
110 120 130 140 150
FGFGGGAGSG FGFGGGAGFG GGYGGAGFPV CPPGGIQEVT VNQNLLTPLN
160 170 180 190 200
LQIDPTIQRV RTEEREQIKT LNNKFASFID KVRFLEQQNK VLDTKWTLLQ
210 220 230 240 250
EQGTKTIKQN LDPLFEQYIN NLRRQLDGVM GERGRLDSEL RNMQDLVEDY
260 270 280 290 300
KNKYEDEINK RTTAENEFVM LKKDVDAAYM NKVELEAKVD ALMDEINFMK
310 320 330 340 350
MFFDAELSQM QTHVSDTSVV LSMDNNRSLD LDSIIAEVKA QYEDIANRSR
360 370 380 390 400
TEAESWYQTK YEELQQTAGR HGDDLRNTKH EISEMNRMIQ RLRSEIDNVK
410 420 430 440 450
KQCANLQNAI AEAEQRGELA LKDARNKLTE LEEALQKAKQ DMARLLREYQ
460 470 480 490 500
ELMNTKLALD VEIATYRKLL EGEECRLSGE GVGPVNISVV TNSLSSGYGG
510 520 530 540 550
RSNIGYGSGL GSGIGGFASD IGPLLNRRGL GSGLSVGGSG FSASSGQGGG
560 570
FSSGGGSSSS VKFVSTTSSS RRSFKS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K509 | A0A0G2K509_RAT | Keratin, type II cytoskeletal 5 | Krt5 LOC102551453 | 591 | Annotation score: | ||
F7FFV2 | F7FFV2_RAT | Keratin, type II cytoskeletal 5 | Krt5 | 395 | Annotation score: | ||
A0A0G2K1K9 | A0A0G2K1K9_RAT | Keratin, type II cytoskeletal 5 | Krt5 LOC102551453 | 181 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 114 | G → R in AAQ20893 (PubMed:14551252).Curated | 1 | |
Sequence conflicti | 473 | E → Q in AAQ20893 (PubMed:14551252).Curated | 1 | |
Sequence conflicti | 508 | S → F in AAQ20893 (PubMed:14551252).Curated | 1 | |
Sequence conflicti | 528 | R → L in AAQ20893 (PubMed:14551252).Curated | 1 | |
Sequence conflicti | 562 | K → Q in AAQ20893 (PubMed:14551252).Curated | 1 | |
Sequence conflicti | 575 | K → N in AAQ20893 (PubMed:14551252).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY342389 mRNA Translation: AAQ20893.1 BC062086 mRNA Translation: AAH62086.1 |
RefSeqi | NP_899162.1, NM_183333.1 |
Genome annotation databases
GeneIDi | 369017 |
KEGGi | rno:369017 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY342389 mRNA Translation: AAQ20893.1 BC062086 mRNA Translation: AAH62086.1 |
RefSeqi | NP_899162.1, NM_183333.1 |
3D structure databases
SMRi | Q6P6Q2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 266785, 2 interactors |
STRINGi | 10116.ENSRNOP00000011644 |
PTM databases
iPTMneti | Q6P6Q2 |
PhosphoSitePlusi | Q6P6Q2 |
Proteomic databases
jPOSTi | Q6P6Q2 |
PaxDbi | Q6P6Q2 |
PRIDEi | Q6P6Q2 |
Genome annotation databases
GeneIDi | 369017 |
KEGGi | rno:369017 |
Organism-specific databases
CTDi | 3852 |
RGDi | 727894 Krt5 |
Phylogenomic databases
InParanoidi | Q6P6Q2 |
KOi | K07605 |
OrthoDBi | 824246at2759 |
PhylomeDBi | Q6P6Q2 |
Enzyme and pathway databases
Reactomei | R-RNO-446107 Type I hemidesmosome assembly R-RNO-6805567 Keratinization R-RNO-6809371 Formation of the cornified envelope |
Miscellaneous databases
PROi | PR:Q6P6Q2 |
Family and domain databases
Gene3Di | 1.20.5.1160, 1 hit |
InterProi | View protein in InterPro IPR018039 IF_conserved IPR039008 IF_rod_dom IPR042180 IF_rod_dom_coil1B IPR032444 Keratin_2_head IPR003054 Keratin_II |
Pfami | View protein in Pfam PF00038 Filament, 1 hit PF16208 Keratin_2_head, 1 hit |
PRINTSi | PR01276 TYPE2KERATIN |
SMARTi | View protein in SMART SM01391 Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | K2C5_RAT | |
Accessioni | Q6P6Q2Primary (citable) accession number: Q6P6Q2 Secondary accession number(s): Q7TN97 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | September 18, 2019 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families