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Protein

Keratin, type II cytoskeletal 5

Gene

Krt5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei413StutterSequence analysis1

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 5
Alternative name(s):
Cytokeratin-5
Short name:
CK-5
Keratin-5
Short name:
K5
Type-II keratin Kb5
Gene namesi
Name:Krt5By similarity
Synonyms:Krt2-5Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727894 Krt5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637291 – 576Keratin, type II cytoskeletal 5Add BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei26PhosphoserineBy similarity1
Modified residuei36PhosphoserineCombined sources1
Modified residuei46PhosphoserineBy similarity1
Modified residuei60PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei527Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ6P6Q2
PRIDEiQ6P6Q2

PTM databases

iPTMnetiQ6P6Q2
PhosphoSitePlusiQ6P6Q2

Expressioni

Tissue specificityi

Expressed in the epidermis (at protein level) and testis (within pachytene spermatocytes).1 Publication

Interactioni

Subunit structurei

Heterodimer of a type I and a type II keratin. Heterodimer with type I keratin KRT25 leading to the formation of keratin intermediate filament (KIF) network. Heterodimer with KRT14. Interacts with TCHP. Interacts with EPPK1.By similarity

Protein-protein interaction databases

BioGridi266785, 1 interactor
STRINGi10116.ENSRNOP00000011644

Structurei

3D structure databases

ProteinModelPortaliQ6P6Q2
SMRiQ6P6Q2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 477IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 163HeadSequence analysisAdd BLAST163
Regioni164 – 199Coil 1ASequence analysisAdd BLAST36
Regioni200 – 218Linker 1Sequence analysisAdd BLAST19
Regioni219 – 311Coil 1BSequence analysisAdd BLAST93
Regioni312 – 334Linker 12Sequence analysisAdd BLAST23
Regioni335 – 473Coil 2Sequence analysisAdd BLAST139
Regioni474 – 576TailSequence analysisAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 135Gly-richSequence analysisAdd BLAST97
Compositional biasi532 – 576Ser-richSequence analysisAdd BLAST45

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG013015
InParanoidiQ6P6Q2
KOiK07605
PhylomeDBiQ6P6Q2

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q6P6Q2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRQSSVSFR SGGSRSFSAA SAITPSVSRT TFSSVSRSGG GGGRVSLGGA
60 70 80 90 100
YGAGGYGSRS LYNVGGSKRI SFSSGGGSFR NQFGAGAGGG YGFGGGAGSG
110 120 130 140 150
FGFGGGAGSG FGFGGGAGFG GGYGGAGFPV CPPGGIQEVT VNQNLLTPLN
160 170 180 190 200
LQIDPTIQRV RTEEREQIKT LNNKFASFID KVRFLEQQNK VLDTKWTLLQ
210 220 230 240 250
EQGTKTIKQN LDPLFEQYIN NLRRQLDGVM GERGRLDSEL RNMQDLVEDY
260 270 280 290 300
KNKYEDEINK RTTAENEFVM LKKDVDAAYM NKVELEAKVD ALMDEINFMK
310 320 330 340 350
MFFDAELSQM QTHVSDTSVV LSMDNNRSLD LDSIIAEVKA QYEDIANRSR
360 370 380 390 400
TEAESWYQTK YEELQQTAGR HGDDLRNTKH EISEMNRMIQ RLRSEIDNVK
410 420 430 440 450
KQCANLQNAI AEAEQRGELA LKDARNKLTE LEEALQKAKQ DMARLLREYQ
460 470 480 490 500
ELMNTKLALD VEIATYRKLL EGEECRLSGE GVGPVNISVV TNSLSSGYGG
510 520 530 540 550
RSNIGYGSGL GSGIGGFASD IGPLLNRRGL GSGLSVGGSG FSASSGQGGG
560 570
FSSGGGSSSS VKFVSTTSSS RRSFKS
Length:576
Mass (Da):61,826
Last modified:July 5, 2004 - v1
Checksum:i23A1C2C47405EE3B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K509A0A0G2K509_RAT
Keratin, type II cytoskeletal 5
Krt5 LOC102551453
591Annotation score:
F7FFV2F7FFV2_RAT
Keratin, type II cytoskeletal 5
Krt5
395Annotation score:
A0A0G2K1K9A0A0G2K1K9_RAT
Keratin, type II cytoskeletal 5
Krt5 LOC102551453
181Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114G → R in AAQ20893 (PubMed:14551252).Curated1
Sequence conflicti473E → Q in AAQ20893 (PubMed:14551252).Curated1
Sequence conflicti508S → F in AAQ20893 (PubMed:14551252).Curated1
Sequence conflicti528R → L in AAQ20893 (PubMed:14551252).Curated1
Sequence conflicti562K → Q in AAQ20893 (PubMed:14551252).Curated1
Sequence conflicti575K → N in AAQ20893 (PubMed:14551252).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY342389 mRNA Translation: AAQ20893.1
BC062086 mRNA Translation: AAH62086.1
RefSeqiNP_899162.1, NM_183333.1
UniGeneiRn.129725
Rn.195318

Genome annotation databases

GeneIDi369017
KEGGirno:369017

Similar proteinsi

Entry informationi

Entry nameiK2C5_RAT
AccessioniPrimary (citable) accession number: Q6P6Q2
Secondary accession number(s): Q7TN97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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