UniProtKB - Q6P6J0 (ADAT2_MOUSE)
Protein
tRNA-specific adenosine deaminase 2
Gene
Adat2
Organism
Mus musculus (Mouse)
Status
Functioni
Probably participates in deamination of adenosine-34 to inosine in many tRNAs.By similarity
Catalytic activityi
- EC:3.5.4.33Curated
Cofactori
Zn2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 71 | Zinc; catalyticBy similarity | 1 | |
Active sitei | 73 | Proton donorBy similarity | 1 | |
Metal bindingi | 107 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 110 | Zinc; catalyticBy similarity | 1 |
GO - Molecular functioni
- tRNA-specific adenosine-34 deaminase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- tRNA wobble adenosine to inosine editing Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Biological process | tRNA processing |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA-specific adenosine deaminase 2 (EC:3.5.4.33Curated)Alternative name(s): Deaminase domain-containing protein 1 tRNA-specific adenosine-34 deaminase subunit ADAT2 |
Gene namesi | Name:Adat2 Synonyms:Deadc1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914007, Adat2 |
Subcellular locationi
Other locations
- tRNA-specific adenosine-34 deaminase complex Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287654 | 1 – 191 | tRNA-specific adenosine deaminase 2Add BLAST | 191 |
Proteomic databases
EPDi | Q6P6J0 |
MaxQBi | Q6P6J0 |
PaxDbi | Q6P6J0 |
PeptideAtlasi | Q6P6J0 |
PRIDEi | Q6P6J0 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000019808, Expressed in endocardial cushion and 199 other tissues |
Genevisiblei | Q6P6J0, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000019944 |
Miscellaneous databases
RNActi | Q6P6J0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 145 | CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST | 126 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1018, Eukaryota |
GeneTreei | ENSGT00390000000280 |
HOGENOMi | CLU_025810_8_1_1 |
InParanoidi | Q6P6J0 |
OMAi | LEPCQMC |
OrthoDBi | 1616309at2759 |
PhylomeDBi | Q6P6J0 |
TreeFami | TF313782 |
Family and domain databases
HAMAPi | MF_00972, tRNA_aden_deaminase, 1 hit |
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR002125, CMP_dCMP_dom IPR016193, Cytidine_deaminase-like IPR028883, tRNA_aden_deaminase |
Pfami | View protein in Pfam PF00383, dCMP_cyt_deam_1, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6P6J0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEKVESTTT PDGPCVVSVQ ETEKWMEEAM RMAKEALENI EVPVGCLMVY
60 70 80 90 100
NNEVVGKGRN EVNQTKNATR HAEMVAIDQV LDWCHQHGQS PSTVFEHTVL
110 120 130 140 150
YVTVEPCIMC AAALRLMKIP LVVYGCQNER FGGCGSVLNI ASADLPNTGR
160 170 180 190
PFQCIPGYRA EEAVELLKTF YKQENPNAPK SKVRKKDCQK S
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | D → H in BAB32363 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 30 | M → T in BAB32363 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 34 | K → N in BAB32363 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 59 | R → T in BAB32363 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK021291 mRNA Translation: BAB32363.2 BC062195 mRNA Translation: AAH62195.1 |
CCDSi | CCDS35847.1 |
RefSeqi | NP_080024.3, NM_025748.4 |
Genome annotation databases
Ensembli | ENSMUST00000019944; ENSMUSP00000019944; ENSMUSG00000019808 |
GeneIDi | 66757 |
KEGGi | mmu:66757 |
UCSCi | uc007ela.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK021291 mRNA Translation: BAB32363.2 BC062195 mRNA Translation: AAH62195.1 |
CCDSi | CCDS35847.1 |
RefSeqi | NP_080024.3, NM_025748.4 |
3D structure databases
SMRi | Q6P6J0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000019944 |
Proteomic databases
EPDi | Q6P6J0 |
MaxQBi | Q6P6J0 |
PaxDbi | Q6P6J0 |
PeptideAtlasi | Q6P6J0 |
PRIDEi | Q6P6J0 |
Protocols and materials databases
Antibodypediai | 33139, 58 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000019944; ENSMUSP00000019944; ENSMUSG00000019808 |
GeneIDi | 66757 |
KEGGi | mmu:66757 |
UCSCi | uc007ela.2, mouse |
Organism-specific databases
CTDi | 134637 |
MGIi | MGI:1914007, Adat2 |
Phylogenomic databases
eggNOGi | KOG1018, Eukaryota |
GeneTreei | ENSGT00390000000280 |
HOGENOMi | CLU_025810_8_1_1 |
InParanoidi | Q6P6J0 |
OMAi | LEPCQMC |
OrthoDBi | 1616309at2759 |
PhylomeDBi | Q6P6J0 |
TreeFami | TF313782 |
Miscellaneous databases
BioGRID-ORCSi | 66757, 8 hits in 19 CRISPR screens |
PROi | PR:Q6P6J0 |
RNActi | Q6P6J0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000019808, Expressed in endocardial cushion and 199 other tissues |
Genevisiblei | Q6P6J0, MM |
Family and domain databases
HAMAPi | MF_00972, tRNA_aden_deaminase, 1 hit |
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR002125, CMP_dCMP_dom IPR016193, Cytidine_deaminase-like IPR028883, tRNA_aden_deaminase |
Pfami | View protein in Pfam PF00383, dCMP_cyt_deam_1, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADAT2_MOUSE | |
Accessioni | Q6P6J0Primary (citable) accession number: Q6P6J0 Secondary accession number(s): Q9CX14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families