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Protein

DNA-directed RNA polymerase II subunit GRINL1A

Gene

Polr2m

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Isoform 1 appears to be stable component of the Pol II(G) complex form of RNA polymerase II. Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in Mediator-dependent regulation of transcription activation. Isoform 1 acts in vitro as negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • maintenance of ER location Source: UniProtKB

Keywordsi

Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit GRINL1A
Alternative name(s):
DNA-directed RNA polymerase II subunit M
Glutamate receptor-like protein 1A
Gene namesi
Name:Polr2m
Synonyms:Grinl1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107282 Polr2m

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003262301 – 366DNA-directed RNA polymerase II subunit GRINL1AAdd BLAST366

Proteomic databases

EPDiQ6P6I6
PaxDbiQ6P6I6
PeptideAtlasiQ6P6I6
PRIDEiQ6P6I6

PTM databases

iPTMnetiQ6P6I6
PhosphoSitePlusiQ6P6I6

Expressioni

Gene expression databases

BgeeiENSMUSG00000032199 Expressed in 54 organ(s), highest expression level in heart
ExpressionAtlasiQ6P6I6 baseline and differential
GenevisibleiQ6P6I6 MM

Interactioni

Subunit structurei

Isoform 1 is a component of the Pol II(G) complex, which contains the RNA polymerase II (Pol II) core complex subunits and Polr2m isoform 1 and appears to be an abundant form of Pol II.

Protein-protein interaction databases

IntActiQ6P6I6, 1 interactor
MINTiQ6P6I6
STRINGi10090.ENSMUSP00000034720

Structurei

3D structure databases

ProteinModelPortaliQ6P6I6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili15 – 39Sequence analysisAdd BLAST25
Coiled coili299 – 333Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the GRINL1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IVF6 Eukaryota
ENOG410ZKMZ LUCA
GeneTreeiENSGT00530000063232
HOGENOMiHOG000112815
HOVERGENiHBG098324
InParanoidiQ6P6I6
KOiK21987
OMAiHYMTVLE
OrthoDBiEOG091G0HQJ
PhylomeDBiQ6P6I6
TreeFamiTF332945

Family and domain databases

InterProiView protein in InterPro
IPR026213 GRINL1
PfamiView protein in Pfam
PF15328 GCOM2, 1 hit
PRINTSiPR02085 POLR2GRINL1

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P6I6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSLPRGFEP PAPEDLGRQS SAELRERLRR QERLLRNEKF ICKLPDKGKK
60 70 80 90 100
ISDTVAKLKA AISEREEVRG RSELFHPVSV DCKLRQKATT RADTDVDKAQ
110 120 130 140 150
SSDLMLDTSS LDPDCSSIDI KSSKSTSETQ GPTHLTHRGN EETLEAGYTV
160 170 180 190 200
NSSPAAHIRA RAPSSEVKEH LPQHSVSSQE EEISSSIDSL FITKLQKITI
210 220 230 240 250
ADQSEPSEEN TSTENFPELQ SETPKKPHYM KVLEMRARNP VPPPHKFKTN
260 270 280 290 300
VLPTQQSDSP SHCQRGQSPA SSEEQRRRAR QHLDDITAAR LLPLHHLPAQ
310 320 330 340 350
LLSIEESLAL QREQKQNYEE MQAKLAAQKL AERLNIKMQS YNPEGESSGR
360
YREVRDEADA QSSDEC
Length:366
Mass (Da):41,237
Last modified:March 18, 2008 - v2
Checksum:i1115E39921CF3561
GO
Isoform 2 (identifier: Q6P6I6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.

Show »
Length:262
Mass (Da):29,375
Checksum:iD0C18B770AC37397
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PZ03E9PZ03_MOUSE
DNA-directed RNA polymerase II subu...
Polr2m
39Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112D → V in AAH62199 (PubMed:15489334).Curated1
Sequence conflicti275Q → R in AAH62199 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0326231 – 104Missing in isoform 2. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002571 mRNA Translation: BAB22196.1
AK014316 mRNA Translation: BAB29267.1
AK051868 mRNA Translation: BAC34793.1
AK052037 mRNA Translation: BAC34836.1
AK079119 mRNA Translation: BAC37548.1
AK159924 mRNA Translation: BAE35486.1
AK166738 mRNA Translation: BAE38981.1
BC018502 mRNA Translation: AAH18502.1
BC062199 mRNA Translation: AAH62199.1
AH012404 Genomic DNA Translation: AAO15648.1
CCDSiCCDS23326.1 [Q6P6I6-1]
CCDS52853.1 [Q6P6I6-2]
RefSeqiNP_001158265.1, NM_001164793.1 [Q6P6I6-2]
NP_848717.1, NM_178602.3 [Q6P6I6-1]
UniGeneiMm.21094

Genome annotation databases

EnsembliENSMUST00000034720; ENSMUSP00000034720; ENSMUSG00000032199 [Q6P6I6-1]
ENSMUST00000163972; ENSMUSP00000132335; ENSMUSG00000032199 [Q6P6I6-2]
GeneIDi28015
KEGGimmu:28015
UCSCiuc009qoy.2 mouse [Q6P6I6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002571 mRNA Translation: BAB22196.1
AK014316 mRNA Translation: BAB29267.1
AK051868 mRNA Translation: BAC34793.1
AK052037 mRNA Translation: BAC34836.1
AK079119 mRNA Translation: BAC37548.1
AK159924 mRNA Translation: BAE35486.1
AK166738 mRNA Translation: BAE38981.1
BC018502 mRNA Translation: AAH18502.1
BC062199 mRNA Translation: AAH62199.1
AH012404 Genomic DNA Translation: AAO15648.1
CCDSiCCDS23326.1 [Q6P6I6-1]
CCDS52853.1 [Q6P6I6-2]
RefSeqiNP_001158265.1, NM_001164793.1 [Q6P6I6-2]
NP_848717.1, NM_178602.3 [Q6P6I6-1]
UniGeneiMm.21094

3D structure databases

ProteinModelPortaliQ6P6I6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P6I6, 1 interactor
MINTiQ6P6I6
STRINGi10090.ENSMUSP00000034720

PTM databases

iPTMnetiQ6P6I6
PhosphoSitePlusiQ6P6I6

Proteomic databases

EPDiQ6P6I6
PaxDbiQ6P6I6
PeptideAtlasiQ6P6I6
PRIDEiQ6P6I6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034720; ENSMUSP00000034720; ENSMUSG00000032199 [Q6P6I6-1]
ENSMUST00000163972; ENSMUSP00000132335; ENSMUSG00000032199 [Q6P6I6-2]
GeneIDi28015
KEGGimmu:28015
UCSCiuc009qoy.2 mouse [Q6P6I6-1]

Organism-specific databases

CTDi81488
MGIiMGI:107282 Polr2m

Phylogenomic databases

eggNOGiENOG410IVF6 Eukaryota
ENOG410ZKMZ LUCA
GeneTreeiENSGT00530000063232
HOGENOMiHOG000112815
HOVERGENiHBG098324
InParanoidiQ6P6I6
KOiK21987
OMAiHYMTVLE
OrthoDBiEOG091G0HQJ
PhylomeDBiQ6P6I6
TreeFamiTF332945

Miscellaneous databases

ChiTaRSiPolr2m mouse
PROiPR:Q6P6I6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032199 Expressed in 54 organ(s), highest expression level in heart
ExpressionAtlasiQ6P6I6 baseline and differential
GenevisibleiQ6P6I6 MM

Family and domain databases

InterProiView protein in InterPro
IPR026213 GRINL1
PfamiView protein in Pfam
PF15328 GCOM2, 1 hit
PRINTSiPR02085 POLR2GRINL1
ProtoNetiSearch...

Entry informationi

Entry nameiGRL1A_MOUSE
AccessioniPrimary (citable) accession number: Q6P6I6
Secondary accession number(s): Q8CG13, Q9CXJ7, Q9DCQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 7, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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