Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate-rich protein 5

Gene

ERICH5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-rich protein 5
Gene namesi
Name:ERICH5
Synonyms:C8orf47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000177459.10
HGNCiHGNC:26823 ERICH5
neXtProtiNX_Q6P6B1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177459
PharmGKBiPA142672366

Polymorphism and mutation databases

BioMutaiC8orf47
DMDMi74737479

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002944331 – 374Glutamate-rich protein 5Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei169PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P6B1
MaxQBiQ6P6B1
PaxDbiQ6P6B1
PeptideAtlasiQ6P6B1
PRIDEiQ6P6B1
ProteomicsDBi67018

PTM databases

iPTMnetiQ6P6B1
PhosphoSitePlusiQ6P6B1

Expressioni

Gene expression databases

BgeeiENSG00000177459 Expressed in 132 organ(s), highest expression level in palpebral conjunctiva
CleanExiHS_C8orf47
GenevisibleiQ6P6B1 HS

Organism-specific databases

HPAiHPA025070
HPA025293
HPA027233

Interactioni

Protein-protein interaction databases

BioGridi128453, 22 interactors
IntActiQ6P6B1, 2 interactors
STRINGi9606.ENSP00000315614

Structurei

3D structure databases

ProteinModelPortaliQ6P6B1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi219 – 366Glu-richAdd BLAST148

Phylogenomic databases

eggNOGiENOG410IINR Eukaryota
ENOG410YP4B LUCA
GeneTreeiENSGT00390000010783
HOGENOMiHOG000111616
HOVERGENiHBG096287
InParanoidiQ6P6B1
OMAiQHIEGET
OrthoDBiEOG091G0H5J
PhylomeDBiQ6P6B1
TreeFamiTF337219

Family and domain databases

InterProiView protein in InterPro
IPR027856 DUF4573
PfamiView protein in Pfam
PF15140 DUF4573, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6P6B1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGCSSSALNK AGDSSRFPSV TSNEHFSTAE ESESCFAQPK PHALGRESTV
60 70 80 90 100
DGNVQRESRP PLQKLKVSAE PTANGVKPLQ EQPLAKDVAP GRDATDQSGS
110 120 130 140 150
TEKTQPGEGL EESGPPQPGG KEDAPAAEGK KKDAGAGTEA ESLKGNAEAQ
160 170 180 190 200
PLGPEAKGQP LQAAVEKDSL RAVEVTENPQ TAAEMKPLGT TENVLTLQIA
210 220 230 240 250
GELQPQGTVG KDEQAPLLET ISKENESPEI LEGSQFVETA EEQQLQATLG
260 270 280 290 300
KEEQPQLLER IPKENVTPEV LDRSQLVEKP VMNDPFHKTP EGPGNMEQIQ
310 320 330 340 350
PEGIVGSMEH PARNVEAGAY VEMIRNIHTN EEDQRIEGET GEKVETDMEN
360 370
EKVSEGAETK EEETGEVVDL SAAT
Length:374
Mass (Da):39,936
Last modified:July 5, 2004 - v1
Checksum:i78FEE6D3CEF9011A
GO
Isoform 2 (identifier: Q6P6B1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-337: Missing.

Note: No experimental confirmation available.
Show »
Length:56
Mass (Da):5,813
Checksum:iFF3E363C877E709C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti326N → S in BAC04880 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03317659R → H. Corresponds to variant dbSNP:rs7833473Ensembl.1
Natural variantiVAR_033177244Q → P. Corresponds to variant dbSNP:rs35368005Ensembl.1
Natural variantiVAR_033178287H → R. Corresponds to variant dbSNP:rs11994440Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04665020 – 337Missing in isoform 2. CuratedAdd BLAST318

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096872 mRNA Translation: BAC04880.1
AP003352 Genomic DNA No translation available.
AP003439 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91772.1
BC062359 mRNA Translation: AAH62359.1
CCDSiCCDS34929.1 [Q6P6B1-1]
CCDS55266.1 [Q6P6B1-2]
RefSeqiNP_001164277.1, NM_001170806.1 [Q6P6B1-2]
NP_775820.2, NM_173549.2 [Q6P6B1-1]
UniGeneiHs.171455

Genome annotation databases

EnsembliENST00000318528; ENSP00000315614; ENSG00000177459 [Q6P6B1-1]
ENST00000545282; ENSP00000440297; ENSG00000177459 [Q6P6B1-2]
GeneIDi203111
KEGGihsa:203111
UCSCiuc003yih.2 human [Q6P6B1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096872 mRNA Translation: BAC04880.1
AP003352 Genomic DNA No translation available.
AP003439 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91772.1
BC062359 mRNA Translation: AAH62359.1
CCDSiCCDS34929.1 [Q6P6B1-1]
CCDS55266.1 [Q6P6B1-2]
RefSeqiNP_001164277.1, NM_001170806.1 [Q6P6B1-2]
NP_775820.2, NM_173549.2 [Q6P6B1-1]
UniGeneiHs.171455

3D structure databases

ProteinModelPortaliQ6P6B1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128453, 22 interactors
IntActiQ6P6B1, 2 interactors
STRINGi9606.ENSP00000315614

PTM databases

iPTMnetiQ6P6B1
PhosphoSitePlusiQ6P6B1

Polymorphism and mutation databases

BioMutaiC8orf47
DMDMi74737479

Proteomic databases

EPDiQ6P6B1
MaxQBiQ6P6B1
PaxDbiQ6P6B1
PeptideAtlasiQ6P6B1
PRIDEiQ6P6B1
ProteomicsDBi67018

Protocols and materials databases

DNASUi203111
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318528; ENSP00000315614; ENSG00000177459 [Q6P6B1-1]
ENST00000545282; ENSP00000440297; ENSG00000177459 [Q6P6B1-2]
GeneIDi203111
KEGGihsa:203111
UCSCiuc003yih.2 human [Q6P6B1-1]

Organism-specific databases

CTDi203111
EuPathDBiHostDB:ENSG00000177459.10
GeneCardsiERICH5
HGNCiHGNC:26823 ERICH5
HPAiHPA025070
HPA025293
HPA027233
neXtProtiNX_Q6P6B1
OpenTargetsiENSG00000177459
PharmGKBiPA142672366
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IINR Eukaryota
ENOG410YP4B LUCA
GeneTreeiENSGT00390000010783
HOGENOMiHOG000111616
HOVERGENiHBG096287
InParanoidiQ6P6B1
OMAiQHIEGET
OrthoDBiEOG091G0H5J
PhylomeDBiQ6P6B1
TreeFamiTF337219

Miscellaneous databases

GenomeRNAii203111
PROiPR:Q6P6B1

Gene expression databases

BgeeiENSG00000177459 Expressed in 132 organ(s), highest expression level in palpebral conjunctiva
CleanExiHS_C8orf47
GenevisibleiQ6P6B1 HS

Family and domain databases

InterProiView protein in InterPro
IPR027856 DUF4573
PfamiView protein in Pfam
PF15140 DUF4573, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERIC5_HUMAN
AccessioniPrimary (citable) accession number: Q6P6B1
Secondary accession number(s): G3V1K4, Q8N1L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again