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Entry version 166 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Serine/threonine-protein kinase N3

Gene

PKN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to invasiveness in malignant prostate cancer.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Two specific sites, Thr-718 (activation loop of the kinase domain) and Thr-860 (turn motif), need to be phosphorylated for its full activation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei588ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei684Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi565 – 573ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6P5Z2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5625740, RHO GTPases activate PKNs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q6P5Z2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase N3 (EC:2.7.11.13)
Alternative name(s):
Protein kinase PKN-beta
Protein-kinase C-related kinase 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PKN3
Synonyms:PKNBETA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160447.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17999, PKN3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610714, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P5Z2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi588K → E: Abolishes autophosphorylation and catalytic activity. 2 Publications1
Mutagenesisi588K → R: Abolishes catalytic activity. 2 Publications1
Mutagenesisi718T → A: Abolishes phosphorylation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
29941

Open Targets

More...
OpenTargetsi
ENSG00000160447

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134919098

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P5Z2, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3627581

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PKN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749130

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000557251 – 889Serine/threonine-protein kinase N3Add BLAST889

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei171PhosphoserineCombined sources1
Modified residuei544PhosphoserineCombined sources1
Modified residuei548PhosphoserineCombined sources1
Modified residuei718Phosphothreonine1 Publication1
Modified residuei722PhosphothreonineCombined sources1
Modified residuei860PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6P5Z2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6P5Z2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6P5Z2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P5Z2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P5Z2

PeptideAtlas

More...
PeptideAtlasi
Q6P5Z2

PRoteomics IDEntifications database

More...
PRIDEi
Q6P5Z2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67014

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P5Z2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P5Z2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160447, Expressed in apex of heart and 144 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6P5Z2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6P5Z2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000160447, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
118978, 99 interactors

Protein interaction database and analysis system

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IntActi
Q6P5Z2, 58 interactors

Molecular INTeraction database

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MINTi
Q6P5Z2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000291906

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q6P5Z2

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P5Z2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P5Z2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 80REM-1 1PROSITE-ProRule annotationAdd BLAST76
Domaini93 – 163REM-1 2PROSITE-ProRule annotationAdd BLAST71
Domaini165 – 245REM-1 3PROSITE-ProRule annotationAdd BLAST81
Domaini559 – 818Protein kinasePROSITE-ProRule annotationAdd BLAST260
Domaini819 – 889AGC-kinase C-terminalAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi463 – 554Pro-richAdd BLAST92

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C1 domain does not bind the diacylglycerol (DAG).

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0694, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161818

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_132_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P5Z2

KEGG Orthology (KO)

More...
KOi
K23692

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNPVIER

Database of Orthologous Groups

More...
OrthoDBi
520651at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P5Z2

TreeFam database of animal gene trees

More...
TreeFami
TF102005

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11622, HR1_PKN_1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961, AGC-kinase_C
IPR011072, HR1_rho-bd
IPR036274, HR1_rpt_sf
IPR011009, Kinase-like_dom_sf
IPR017892, Pkinase_C
IPR037313, PKN_HR1_1
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02185, HR1, 3 hits
PF00069, Pkinase, 1 hit
PF00433, Pkinase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00742, Hr1, 3 hits
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46585, SSF46585, 3 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS51860, REM_1, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6P5Z2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEGAPRQPG PSQWPPEDEK EVIRRAIQKE LKIKEGVENL RRVATDRRHL
60 70 80 90 100
GHVQQLLRSS NRRLEQLHGE LRELHARILL PGPGPGPAEP VASGPRPWAE
110 120 130 140 150
QLRARHLEAL RRQLHVELKV KQGAENMTHT CASGTPKERK LLAAAQQMLR
160 170 180 190 200
DSQLKVALLR MKISSLEASG SPEPGPELLA EELQHRLHVE AAVAEGAKNV
210 220 230 240 250
VKLLSSRRTQ DRKALAEAQA QLQESSQKLD LLRLALEQLL EQLPPAHPLR
260 270 280 290 300
SRVTRELRAA VPGYPQPSGT PVKPTALTGT LQVRLLGCEQ LLTAVPGRSP
310 320 330 340 350
AAALASSPSE GWLRTKAKHQ RGRGELASEV LAVLKVDNRV VGQTGWGQVA
360 370 380 390 400
EQSWDQTFVI PLERARELEI GVHWRDWRQL CGVAFLRLED FLDNACHQLS
410 420 430 440 450
LSLVPQGLLF AQVTFCDPVI ERRPRLQRQE RIFSKRRGQD FLRASQMNLG
460 470 480 490 500
MAAWGRLVMN LLPPCSSPST ISPPKGCPRT PTTLREASDP ATPSNFLPKK
510 520 530 540 550
TPLGEEMTPP PKPPRLYLPQ EPTSEETPRT KRPHMEPRTR RGPSPPASPT
560 570 580 590 600
RKPPRLQDFR CLAVLGRGHF GKVLLVQFKG TGKYYAIKAL KKQEVLSRDE
610 620 630 640 650
IESLYCEKRI LEAVGCTGHP FLLSLLACFQ TSSHACFVTE FVPGGDLMMQ
660 670 680 690 700
IHEDVFPEPQ ARFYVACVVL GLQFLHEKKI IYRDLKLDNL LLDAQGFLKI
710 720 730 740 750
ADFGLCKEGI GFGDRTSTFC GTPEFLAPEV LTQEAYTRAV DWWGLGVLLY
760 770 780 790 800
EMLVGECPFP GDTEEEVFDC IVNMDAPYPG FLSVQGLEFI QKLLQKCPEK
810 820 830 840 850
RLGAGEQDAE EIKVQPFFRT TNWQALLART IQPPFVPTLC GPADLRYFEG
860 870 880
EFTGLPPALT PPAPHSLLTA RQQAAFRDFD FVSERFLEP
Length:889
Mass (Da):99,421
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3891DA1420DF54E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti444A → R in BAA85625 (PubMed:10441506).Curated1
Sequence conflicti627A → V in BAA85625 (PubMed:10441506).Curated1
Sequence conflicti636C → R in BAA85625 (PubMed:10441506).Curated1
Sequence conflicti738R → Q in BAA85625 (PubMed:10441506).Curated1
Sequence conflicti744G → A in BAA85625 (PubMed:10441506).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042346180A → E1 PublicationCorresponds to variant dbSNP:rs56251280Ensembl.1
Natural variantiVAR_050565404V → L. Corresponds to variant dbSNP:rs12932Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB019692 mRNA Translation: BAA85625.1
AL441992 Genomic DNA No translation available.
BC062558 mRNA Translation: AAH62558.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6908.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7083

NCBI Reference Sequences

More...
RefSeqi
NP_037487.2, NM_013355.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291906; ENSP00000291906; ENSG00000160447

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29941

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29941

UCSC genome browser

More...
UCSCi
uc004bvw.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019692 mRNA Translation: BAA85625.1
AL441992 Genomic DNA No translation available.
BC062558 mRNA Translation: AAH62558.1
CCDSiCCDS6908.1
PIRiJC7083
RefSeqiNP_037487.2, NM_013355.4

3D structure databases

SMRiQ6P5Z2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118978, 99 interactors
IntActiQ6P5Z2, 58 interactors
MINTiQ6P5Z2
STRINGi9606.ENSP00000291906

Chemistry databases

BindingDBiQ6P5Z2
ChEMBLiCHEMBL3627581

PTM databases

iPTMnetiQ6P5Z2
PhosphoSitePlusiQ6P5Z2

Polymorphism and mutation databases

BioMutaiPKN3
DMDMi74749130

Proteomic databases

EPDiQ6P5Z2
jPOSTiQ6P5Z2
MassIVEiQ6P5Z2
MaxQBiQ6P5Z2
PaxDbiQ6P5Z2
PeptideAtlasiQ6P5Z2
PRIDEiQ6P5Z2
ProteomicsDBi67014

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31249, 174 antibodies

The DNASU plasmid repository

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DNASUi
29941

Genome annotation databases

EnsembliENST00000291906; ENSP00000291906; ENSG00000160447
GeneIDi29941
KEGGihsa:29941
UCSCiuc004bvw.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29941
DisGeNETi29941
EuPathDBiHostDB:ENSG00000160447.6

GeneCards: human genes, protein and diseases

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GeneCardsi
PKN3
HGNCiHGNC:17999, PKN3
HPAiENSG00000160447, Low tissue specificity
MIMi610714, gene
neXtProtiNX_Q6P5Z2
OpenTargetsiENSG00000160447
PharmGKBiPA134919098

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0694, Eukaryota
GeneTreeiENSGT00940000161818
HOGENOMiCLU_000288_132_1_1
InParanoidiQ6P5Z2
KOiK23692
OMAiCNPVIER
OrthoDBi520651at2759
PhylomeDBiQ6P5Z2
TreeFamiTF102005

Enzyme and pathway databases

PathwayCommonsiQ6P5Z2
ReactomeiR-HSA-5625740, RHO GTPases activate PKNs
SignaLinkiQ6P5Z2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
29941, 12 hits in 902 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PKN3, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PKN3_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29941
PharosiQ6P5Z2, Tbio

Protein Ontology

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PROi
PR:Q6P5Z2
RNActiQ6P5Z2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160447, Expressed in apex of heart and 144 other tissues
ExpressionAtlasiQ6P5Z2, baseline and differential
GenevisibleiQ6P5Z2, HS

Family and domain databases

CDDicd11622, HR1_PKN_1, 1 hit
InterProiView protein in InterPro
IPR000961, AGC-kinase_C
IPR011072, HR1_rho-bd
IPR036274, HR1_rpt_sf
IPR011009, Kinase-like_dom_sf
IPR017892, Pkinase_C
IPR037313, PKN_HR1_1
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF02185, HR1, 3 hits
PF00069, Pkinase, 1 hit
PF00433, Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00742, Hr1, 3 hits
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF46585, SSF46585, 3 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS51860, REM_1, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKN3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P5Z2
Secondary accession number(s): Q9UM03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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