UniProtKB - Q6P5X5 (CV039_HUMAN)
Protein
UPF0545 protein C22orf39
Gene
C22orf39
Organism
Homo sapiens (Human)
Status
Functioni
Caution
It is uncertain whether Met-1 or Met-38 is the initiator. Orthologous sequences cannot be extended.Curated
Enzyme and pathway databases
PathwayCommonsi | Q6P5X5 |
Names & Taxonomyi
Protein namesi | Recommended name: UPF0545 protein C22orf39 |
Gene namesi | Name:C22orf39 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000242259.8 |
HGNCi | HGNC:27012, C22orf39 |
neXtProti | NX_Q6P5X5 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 128977 |
OpenTargetsi | ENSG00000242259 |
PharmGKBi | PA162378995 |
Miscellaneous databases
Pharosi | Q6P5X5, Tdark |
Polymorphism and mutation databases
BioMutai | C22orf39 |
DMDMi | 510120816 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000326130 | 1 – 142 | UPF0545 protein C22orf39Add BLAST | 142 |
Proteomic databases
EPDi | Q6P5X5 |
MassIVEi | Q6P5X5 |
MaxQBi | Q6P5X5 |
PaxDbi | Q6P5X5 |
PeptideAtlasi | Q6P5X5 |
PRIDEi | Q6P5X5 |
ProteomicsDBi | 26215 67009 [Q6P5X5-1] |
PTM databases
iPTMneti | Q6P5X5 |
PhosphoSitePlusi | Q6P5X5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000242259, Expressed in gastrocnemius and 212 other tissues |
ExpressionAtlasi | Q6P5X5, baseline and differential |
Genevisiblei | Q6P5X5, HS |
Organism-specific databases
HPAi | ENSG00000242259, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ6P5X5
Protein-protein interaction databases
BioGRIDi | 126177, 45 interactors |
IntActi | Q6P5X5, 41 interactors |
MINTi | Q6P5X5 |
STRINGi | 9606.ENSP00000382474 |
Miscellaneous databases
RNActi | Q6P5X5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the UPF0545 family.Curated
Phylogenomic databases
eggNOGi | ENOG502S4W2, Eukaryota |
GeneTreei | ENSGT00390000002511 |
HOGENOMi | CLU_2164004_0_0_1 |
InParanoidi | Q6P5X5 |
OMAi | PRPCETY |
OrthoDBi | 1541651at2759 |
PhylomeDBi | Q6P5X5 |
TreeFami | TF324380 |
Family and domain databases
InterProi | View protein in InterPro IPR021475, DUF3128 |
PANTHERi | PTHR28052, PTHR28052, 1 hit |
Pfami | View protein in Pfam PF11326, DUF3128, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6P5X5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MCRCSLVLLS VDHEVPFSSF FIGWRTEGRA WRAGRPDMAD GSGWQPPRPC
60 70 80 90 100
EAYRAEWKLC RSARHFLHHY YVHGERPACE QWQRDLASCR DWEERRNAEA
110 120 130 140
QQSLCESERA RVRAARKHIL VWAPRQSPPP DWHLPLPQEK DE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE0CX16 | E0CX16_HUMAN | UPF0545 protein C22orf39 | C22orf39 | 92 | Annotation score: | ||
A0A0C4DH14 | A0A0C4DH14_HUMAN | UPF0545 protein C22orf39 | C22orf39 | 105 | Annotation score: | ||
A0A075B6P1 | A0A075B6P1_HUMAN | UPF0545 protein C22orf39 | C22orf39 | 80 | Annotation score: |
Sequence cautioni
The sequence AAH62599 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAF82762 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAG30225 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EAX03040 differs from that shown. Reason: Erroneous gene model prediction.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046502 | 102 – 142 | QSLCE…QEKDE → VLSVVAHTCNLSYLGG in isoform 2. CuratedAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290073 mRNA Translation: BAF82762.1 Different initiation. AC000068 Genomic DNA No translation available. AC000079 Genomic DNA No translation available. AC000085 Genomic DNA No translation available. AC000092 Genomic DNA No translation available. CH471176 Genomic DNA Translation: EAX03039.1 CH471176 Genomic DNA Translation: EAX03040.1 Sequence problems. CH471176 Genomic DNA Translation: EAX03041.1 BC062599 mRNA Translation: AAH62599.1 Different initiation. CR456339 mRNA Translation: CAG30225.1 Different initiation. |
RefSeqi | NP_001159714.1, NM_001166242.1 NP_776154.3, NM_173793.4 |
Genome annotation databases
Ensembli | ENST00000399562; ENSP00000382474; ENSG00000242259 [Q6P5X5-1] ENST00000542103; ENSP00000439212; ENSG00000242259 [Q6P5X5-2] ENST00000611555; ENSP00000479673; ENSG00000242259 [Q6P5X5-1] |
GeneIDi | 128977 |
KEGGi | hsa:128977 |
UCSCi | uc002zpi.4, human [Q6P5X5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290073 mRNA Translation: BAF82762.1 Different initiation. AC000068 Genomic DNA No translation available. AC000079 Genomic DNA No translation available. AC000085 Genomic DNA No translation available. AC000092 Genomic DNA No translation available. CH471176 Genomic DNA Translation: EAX03039.1 CH471176 Genomic DNA Translation: EAX03040.1 Sequence problems. CH471176 Genomic DNA Translation: EAX03041.1 BC062599 mRNA Translation: AAH62599.1 Different initiation. CR456339 mRNA Translation: CAG30225.1 Different initiation. |
RefSeqi | NP_001159714.1, NM_001166242.1 NP_776154.3, NM_173793.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126177, 45 interactors |
IntActi | Q6P5X5, 41 interactors |
MINTi | Q6P5X5 |
STRINGi | 9606.ENSP00000382474 |
PTM databases
iPTMneti | Q6P5X5 |
PhosphoSitePlusi | Q6P5X5 |
Polymorphism and mutation databases
BioMutai | C22orf39 |
DMDMi | 510120816 |
Proteomic databases
EPDi | Q6P5X5 |
MassIVEi | Q6P5X5 |
MaxQBi | Q6P5X5 |
PaxDbi | Q6P5X5 |
PeptideAtlasi | Q6P5X5 |
PRIDEi | Q6P5X5 |
ProteomicsDBi | 26215 67009 [Q6P5X5-1] |
Protocols and materials databases
Antibodypediai | 76439, 9 antibodies |
DNASUi | 128977 |
Genome annotation databases
Ensembli | ENST00000399562; ENSP00000382474; ENSG00000242259 [Q6P5X5-1] ENST00000542103; ENSP00000439212; ENSG00000242259 [Q6P5X5-2] ENST00000611555; ENSP00000479673; ENSG00000242259 [Q6P5X5-1] |
GeneIDi | 128977 |
KEGGi | hsa:128977 |
UCSCi | uc002zpi.4, human [Q6P5X5-1] |
Organism-specific databases
CTDi | 128977 |
DisGeNETi | 128977 |
EuPathDBi | HostDB:ENSG00000242259.8 |
GeneCardsi | C22orf39 |
HGNCi | HGNC:27012, C22orf39 |
HPAi | ENSG00000242259, Low tissue specificity |
neXtProti | NX_Q6P5X5 |
OpenTargetsi | ENSG00000242259 |
PharmGKBi | PA162378995 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S4W2, Eukaryota |
GeneTreei | ENSGT00390000002511 |
HOGENOMi | CLU_2164004_0_0_1 |
InParanoidi | Q6P5X5 |
OMAi | PRPCETY |
OrthoDBi | 1541651at2759 |
PhylomeDBi | Q6P5X5 |
TreeFami | TF324380 |
Enzyme and pathway databases
PathwayCommonsi | Q6P5X5 |
Miscellaneous databases
BioGRID-ORCSi | 128977, 7 hits in 834 CRISPR screens |
ChiTaRSi | C22orf39, human |
GenomeRNAii | 128977 |
Pharosi | Q6P5X5, Tdark |
PROi | PR:Q6P5X5 |
RNActi | Q6P5X5, protein |
Gene expression databases
Bgeei | ENSG00000242259, Expressed in gastrocnemius and 212 other tissues |
ExpressionAtlasi | Q6P5X5, baseline and differential |
Genevisiblei | Q6P5X5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR021475, DUF3128 |
PANTHERi | PTHR28052, PTHR28052, 1 hit |
Pfami | View protein in Pfam PF11326, DUF3128, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CV039_HUMAN | |
Accessioni | Q6P5X5Primary (citable) accession number: Q6P5X5 Secondary accession number(s): A8MTW6 J3KNP9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | May 29, 2013 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - SIMILARITY comments
Index of protein domains and families - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM