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Entry version 125 (29 Sep 2021)
Sequence version 2 (29 Mar 2005)
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Protein

Protein LEG1 homolog

Gene

LEG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in early liver development.

By similarity

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6P5S2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein LEG1 homologBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LEG1By similarity
Synonyms:C6orf58Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20960, C6orf58

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P5S2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000184530

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
352999

Open Targets

More...
OpenTargetsi
ENSG00000184530

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134881952

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P5S2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C6orf58

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749125

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025238521 – 330Protein LEG1 homologAdd BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi69N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6P5S2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P5S2

PeptideAtlas

More...
PeptideAtlasi
Q6P5S2

PRoteomics IDEntifications database

More...
PRIDEi
Q6P5S2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67003

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6P5S2, 3 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P5S2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P5S2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in saliva and in hypomineralized dental enamel (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184530, Expressed in nasal cavity mucosa and 119 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P5S2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000184530, Group enriched (intestine, salivary gland, stomach, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131603, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P5S2, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000328069

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P5S2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P5S2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LEG1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVPP, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004904

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_071068_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P5S2

Identification of Orthologs from Complete Genome Data

More...
OMAi
DIEPPLW

Database of Orthologous Groups

More...
OrthoDBi
1401349at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P5S2

TreeFam database of animal gene trees

More...
TreeFami
TF332991

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008499, Leg1

The PANTHER Classification System

More...
PANTHERi
PTHR18820, PTHR18820, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05612, Leg1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P5S2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFLPSWVCV LVGSFSASLA GTSNLSETEP PLWKESPGQL SDYRVENSMY
60 70 80 90 100
IINPWVYLER MGMYKIILNQ TARYFAKFAP DNEQNILWGL PLQYGWQYRT
110 120 130 140 150
GRLADPTRRT NCGYESGDHM CISVDSWWAD LNYFLSSLPF LAAVDSGVMG
160 170 180 190 200
ISSDQVRLLP PPKNERKFCY DVSSCRSSFP ETMNKWNTFY QYLQSPFSKF
210 220 230 240 250
DDLLKYLWAA HTSTLADNIK SFEDRYDYYS KAEAHFERSW VLAVDHLAAV
260 270 280 290 300
LFPTTLIRSY KFQKGMPPRI LLNTDVAPFI SDFTAFQNVV LVLLNMLDNV
310 320 330
DKSIGYLCTE KSNVYRDHSE SSSRSYGNNS
Length:330
Mass (Da):37,926
Last modified:March 29, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75F8219FC2C76914
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033675308C → G. Corresponds to variant dbSNP:rs9491833Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK303850 mRNA Translation: BAG64792.1
AL583806 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48094.1
BC062712 mRNA Translation: AAH62712.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34533.1

NCBI Reference Sequences

More...
RefSeqi
NP_001010905.1, NM_001010905.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329722; ENSP00000328069; ENSG00000184530

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
352999

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:352999

UCSC genome browser

More...
UCSCi
uc003qbh.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303850 mRNA Translation: BAG64792.1
AL583806 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48094.1
BC062712 mRNA Translation: AAH62712.2
CCDSiCCDS34533.1
RefSeqiNP_001010905.1, NM_001010905.2

3D structure databases

SMRiQ6P5S2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131603, 6 interactors
IntActiQ6P5S2, 8 interactors
STRINGi9606.ENSP00000328069

PTM databases

GlyGeniQ6P5S2, 3 sites, 1 O-linked glycan (1 site)
iPTMnetiQ6P5S2
PhosphoSitePlusiQ6P5S2

Genetic variation databases

BioMutaiC6orf58
DMDMi74749125

Proteomic databases

MassIVEiQ6P5S2
PaxDbiQ6P5S2
PeptideAtlasiQ6P5S2
PRIDEiQ6P5S2
ProteomicsDBi67003

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49859, 160 antibodies

The DNASU plasmid repository

More...
DNASUi
352999

Genome annotation databases

EnsembliENST00000329722; ENSP00000328069; ENSG00000184530
GeneIDi352999
KEGGihsa:352999
UCSCiuc003qbh.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
352999
DisGeNETi352999

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C6orf58
HGNCiHGNC:20960, C6orf58
HPAiENSG00000184530, Group enriched (intestine, salivary gland, stomach, tongue)
neXtProtiNX_Q6P5S2
OpenTargetsiENSG00000184530
PharmGKBiPA134881952
VEuPathDBiHostDB:ENSG00000184530

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QVPP, Eukaryota
GeneTreeiENSGT00390000004904
HOGENOMiCLU_071068_0_0_1
InParanoidiQ6P5S2
OMAiDIEPPLW
OrthoDBi1401349at2759
PhylomeDBiQ6P5S2
TreeFamiTF332991

Enzyme and pathway databases

PathwayCommonsiQ6P5S2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
352999, 2 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C6orf58, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
C6orf58

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
352999
PharosiQ6P5S2, Tbio

Protein Ontology

More...
PROi
PR:Q6P5S2
RNActiQ6P5S2, protein

Gene expression databases

BgeeiENSG00000184530, Expressed in nasal cavity mucosa and 119 other tissues
GenevisibleiQ6P5S2, HS

Family and domain databases

InterProiView protein in InterPro
IPR008499, Leg1
PANTHERiPTHR18820, PTHR18820, 1 hit
PfamiView protein in Pfam
PF05612, Leg1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEG1H_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P5S2
Secondary accession number(s): B4E1I0, Q5VUP2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 29, 2005
Last modified: September 29, 2021
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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