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Protein

60S ribosomal protein L22-like 1

Gene

RPL22L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiQ6P5R6

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L22-like 1
Alternative name(s):
Large ribosomal subunit protein eL22-like 1
Gene namesi
Name:RPL22L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163584.17
HGNCiHGNC:27610 RPL22L1
neXtProtiNX_Q6P5R6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi200916
OpenTargetsiENSG00000163584
PharmGKBiPA142671026

Polymorphism and mutation databases

BioMutaiRPL22L1
DMDMi109893176

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406321 – 12260S ribosomal protein L22-like 1Add BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P5R6
MaxQBiQ6P5R6
PaxDbiQ6P5R6
PeptideAtlasiQ6P5R6
PRIDEiQ6P5R6
ProteomicsDBi67002

PTM databases

iPTMnetiQ6P5R6
PhosphoSitePlusiQ6P5R6

Expressioni

Gene expression databases

BgeeiENSG00000163584
CleanExiHS_RPL22L1
ExpressionAtlasiQ6P5R6 baseline and differential
GenevisibleiQ6P5R6 HS

Organism-specific databases

HPAiHPA048060
HPA056207
HPA068294

Interactioni

Protein-protein interaction databases

BioGridi128356, 19 interactors
IntActiQ6P5R6, 5 interactors
STRINGi9606.ENSP00000346080

Structurei

3D structure databases

ProteinModelPortaliQ6P5R6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3434 Eukaryota
ENOG4111UVJ LUCA
GeneTreeiENSGT00390000003719
HOGENOMiHOG000198396
HOVERGENiHBG004373
InParanoidiQ6P5R6
KOiK02891
PhylomeDBiQ6P5R6
TreeFamiTF313018

Family and domain databases

Gene3Di3.30.1360.210, 1 hit
InterProiView protein in InterPro
IPR002671 Ribosomal_L22e
IPR038526 Ribosomal_L22e_sf
IPR028370 RPL22L1
PANTHERiPTHR10064 PTHR10064, 1 hit
PTHR10064:SF1 PTHR10064:SF1, 1 hit
PfamiView protein in Pfam
PF01776 Ribosomal_L22e, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P5R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPQKDRKPK RSTWRFNLDL THPVEDGIFD SGNFEQFLRE KVKVNGKTGN
60 70 80 90 100
LGNVVHIERF KNKITVVSEK QFSKRYLKYL TKKYLKKNNL RDWLRVVASD
110 120
KETYELRYFQ ISQDEDESES ED
Length:122
Mass (Da):14,607
Last modified:June 27, 2006 - v2
Checksum:i6C480CDD9FFAE761
GO

Sequence cautioni

The sequence AAH62731 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06177197V → F. Corresponds to variant dbSNP:rs13462Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062731 mRNA Translation: AAH62731.1 Different initiation.
BC107708 mRNA Translation: AAI07709.1
CCDSiCCDS46955.1
RefSeqiNP_001093115.1, NM_001099645.1
UniGeneiHs.380933

Genome annotation databases

EnsembliENST00000295830; ENSP00000346080; ENSG00000163584
GeneIDi200916
KEGGihsa:200916
UCSCiuc003fhc.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRL22L_HUMAN
AccessioniPrimary (citable) accession number: Q6P5R6
Secondary accession number(s): Q32Q77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: June 20, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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