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Protein

Leiomodin-2

Gene

LMOD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:26370058, PubMed:25250574, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin monomer binding Source: UniProtKB
  • tropomyosin binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leiomodin-2
Alternative name(s):
Cardiac leiomodin
Short name:
C-LMOD
Leiomodin1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LMOD2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170807.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6648 LMOD2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608006 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P5Q4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi64F → D: Mildly impaired activity in promoting actin polymerization; when associated with D-69. 1 Publication1
Mutagenesisi69L → D: Mildly impaired activity in promoting actin polymerization; when associated with D-64. 1 Publication1
Mutagenesisi72 – 73YW → DD: Mildly impaired activity in promoting actin polymerization. 1 Publication2
Mutagenesisi284G → R: Strongly impaired activity in promoting actin polymerization. 1 Publication1
Mutagenesisi304H → G: Strongly impaired activity in promoting actin polymerization; when associated with G-334 and A-356. 1 Publication1
Mutagenesisi334H → G: Strongly impaired activity in promoting actin polymerization; when associated with G-304 and A-356. 1 Publication1
Mutagenesisi356R → A: Strongly impaired activity in promoting actin polymerization; when associated with G-304 and G-334. 1 Publication1
Mutagenesisi525 – 529LMEAI → AAEAA: Strongly impaired activity in promoting actin polymerization. 1 Publication5
Mutagenesisi537 – 540LKRV → AEEA: Strongly impaired activity in promoting actin polymerization. 1 Publication4

Organism-specific databases

DisGeNET

More...
DisGeNETi
442721

Open Targets

More...
OpenTargetsi
ENSG00000170807

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30414

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LMOD2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160395556

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003113401 – 547Leiomodin-2Add BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineBy similarity1
Modified residuei15PhosphoserineBy similarity1
Modified residuei24PhosphoserineBy similarity1
Modified residuei400PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P5Q4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P5Q4

PeptideAtlas

More...
PeptideAtlasi
Q6P5Q4

PRoteomics IDEntifications database

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PRIDEi
Q6P5Q4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66999
67000 [Q6P5Q4-2]
67001 [Q6P5Q4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P5Q4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P5Q4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in heart and skeletal muscles, with higher levels in heart (at protein level). Not expressed in other tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170807 Expressed in 93 organ(s), highest expression level in quadriceps femoris

CleanEx database of gene expression profiles

More...
CleanExi
HS_LMOD2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P5Q4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P5Q4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051039

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can bind at least three actin monomers and thereby provides a nucleus for actin filament formation (PubMed:18403713, PubMed:26417072). Interacts (via N-terminus) with tropomyosin alpha (TPM1) (via N-terminus) (PubMed:25250574, PubMed:26873245). May also interact with TPM2 (via N-terminus) (PubMed:25250574).4 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000411932

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1547
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q6P5Q4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P5Q4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini521 – 540WH2PROSITE-ProRule annotationAdd BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 161Interaction with actin 11 PublicationAdd BLAST161
Regioni1 – 47Interaction with tropomyosin alpha1 PublicationAdd BLAST47
Regioni162 – 497Interaction with actin 21 PublicationAdd BLAST336
Regioni521 – 540Interaction with actin 31 PublicationAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili16 – 41Sequence analysisAdd BLAST26
Coiled coili113 – 148Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 142Glu-richAdd BLAST129
Compositional biasi385 – 450Pro-richAdd BLAST66
Compositional biasi478 – 487Poly-Lys10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tropomodulin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3735 Eukaryota
ENOG410YAHM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156567

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261624

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056172

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P5Q4

KEGG Orthology (KO)

More...
KOi
K22030

Identification of Orthologs from Complete Genome Data

More...
OMAi
NTHADDN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0C3H

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P5Q4

TreeFam database of animal gene trees

More...
TreeFami
TF315841

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030132 LMOD2
IPR032675 LRR_dom_sf
IPR004934 TMOD
IPR003124 WH2_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10901 PTHR10901, 1 hit
PTHR10901:SF12 PTHR10901:SF12, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF03250 Tropomodulin, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51082 WH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P5Q4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTFGYRRGL SKYESIDEDE LLASLSAEEL KELERELEDI EPDRNLPVGL
60 70 80 90 100
RQKSLTEKTP TGTFSREALM AYWEKESQKL LEKERLGECG KVAEDKEESE
110 120 130 140 150
EELIFTESNS EVSEEVYTEE EEEESQEEEE EEDSDEEERT IETAKGINGT
160 170 180 190 200
VNYDSVNSDN SKPKIFKSQI ENINLTNGSN GRNTESPAAI HPCGNPTVIE
210 220 230 240 250
DALDKIKSND PDTTEVNLNN IENITTQTLT RFAEALKDNT VVKTFSLANT
260 270 280 290 300
HADDSAAMAI AEMLKVNEHI TNVNVESNFI TGKGILAIMR ALQHNTVLTE
310 320 330 340 350
LRFHNQRHIM GSQVEMEIVK LLKENTTLLR LGYHFELPGP RMSMTSILTR
360 370 380 390 400
NMDKQRQKRL QEQKQQEGYD GGPNLRTKVW QRGTPSSSPY VSPRHSPWSS
410 420 430 440 450
PKLPKKVQTV RSRPLSPVAT PPPPPPPPPP PPPSSQRLPP PPPPPPPPLP
460 470 480 490 500
EKKLITRNIA EVIKQQESAQ RALQNGQKKK KGKKVKKQPN SILKEIKNSL
510 520 530 540
RSVQEKKMED SSRPSTPQRS AHENLMEAIR GSSIKQLKRV EVPEALR
Length:547
Mass (Da):61,675
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i299A4C8F473E8A34
GO
Isoform 2 (identifier: Q6P5Q4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-138: SEVSEEVYTEEEEEESQEEEEEEDSDEEE → RRSPRRKRRKKTVTKRKEQLKLQKGLMEL
     139-547: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):16,239
Checksum:i41A59C70E0D97495
GO
Isoform 3 (identifier: Q6P5Q4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-129: QKLLEKERLG...EEEEESQEEE → LLLLPLLHSQ...KRSRNSQTVF
     130-547: Missing.

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):14,999
Checksum:i7657BE6C1608E942
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J8F4C9J8F4_HUMAN
Leiomodin-2
LMOD2
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH17911 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH62765 differs from that shown. Reason: Frameshift at position 99.Curated
The sequence AAH62765 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAL24334 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAL24335 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02952578 – 129QKLLE…SQEEE → LLLLPLLHSQRKSSLPETLQ KSSNNRRVPNGHYKMDKKRK KGKRSRNSQTVF in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_029526110 – 138SEVSE…SDEEE → RRSPRRKRRKKTVTKRKEQL KLQKGLMEL in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_029527130 – 547Missing in isoform 3. 1 PublicationAdd BLAST418
Alternative sequenceiVSP_029528139 – 547Missing in isoform 2. 1 PublicationAdd BLAST409

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH236947 Genomic DNA Translation: EAL24334.1 Sequence problems.
CH236947 Genomic DNA Translation: EAL24335.1 Sequence problems.
BC017911 mRNA Translation: AAH17911.1 Different initiation.
BC062765 mRNA Translation: AAH62765.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47693.1 [Q6P5Q4-1]

NCBI Reference Sequences

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RefSeqi
NP_997046.1, NM_207163.2 [Q6P5Q4-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.592260

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000458573; ENSP00000411932; ENSG00000170807 [Q6P5Q4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
442721

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:442721

UCSC genome browser

More...
UCSCi
uc003vky.3 human [Q6P5Q4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236947 Genomic DNA Translation: EAL24334.1 Sequence problems.
CH236947 Genomic DNA Translation: EAL24335.1 Sequence problems.
BC017911 mRNA Translation: AAH17911.1 Different initiation.
BC062765 mRNA Translation: AAH62765.1 Sequence problems.
CCDSiCCDS47693.1 [Q6P5Q4-1]
RefSeqiNP_997046.1, NM_207163.2 [Q6P5Q4-1]
UniGeneiHs.592260

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RWTX-ray2.98C/D1-547[»]
5WFNX-ray3.00C/D1-547[»]
ProteinModelPortaliQ6P5Q4
SMRiQ6P5Q4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000411932

PTM databases

iPTMnetiQ6P5Q4
PhosphoSitePlusiQ6P5Q4

Polymorphism and mutation databases

BioMutaiLMOD2
DMDMi160395556

Proteomic databases

EPDiQ6P5Q4
PaxDbiQ6P5Q4
PeptideAtlasiQ6P5Q4
PRIDEiQ6P5Q4
ProteomicsDBi66999
67000 [Q6P5Q4-2]
67001 [Q6P5Q4-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000458573; ENSP00000411932; ENSG00000170807 [Q6P5Q4-1]
GeneIDi442721
KEGGihsa:442721
UCSCiuc003vky.3 human [Q6P5Q4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
442721
DisGeNETi442721
EuPathDBiHostDB:ENSG00000170807.11

GeneCards: human genes, protein and diseases

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GeneCardsi
LMOD2
HGNCiHGNC:6648 LMOD2
HPAiHPA051039
MIMi608006 gene
neXtProtiNX_Q6P5Q4
OpenTargetsiENSG00000170807
PharmGKBiPA30414

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3735 Eukaryota
ENOG410YAHM LUCA
GeneTreeiENSGT00940000156567
HOGENOMiHOG000261624
HOVERGENiHBG056172
InParanoidiQ6P5Q4
KOiK22030
OMAiNTHADDN
OrthoDBiEOG091G0C3H
PhylomeDBiQ6P5Q4
TreeFamiTF315841

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
442721

Protein Ontology

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PROi
PR:Q6P5Q4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000170807 Expressed in 93 organ(s), highest expression level in quadriceps femoris
CleanExiHS_LMOD2
ExpressionAtlasiQ6P5Q4 baseline and differential
GenevisibleiQ6P5Q4 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR030132 LMOD2
IPR032675 LRR_dom_sf
IPR004934 TMOD
IPR003124 WH2_dom
PANTHERiPTHR10901 PTHR10901, 1 hit
PTHR10901:SF12 PTHR10901:SF12, 1 hit
PfamiView protein in Pfam
PF03250 Tropomodulin, 1 hit
PROSITEiView protein in PROSITE
PS51082 WH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLMOD2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P5Q4
Secondary accession number(s): A4D0W9, A4D0Y2, Q8WVJ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: December 5, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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