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UniProtKB - Q6P5L3 (RL19_DANRE)

Entry version 97 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
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Protein

60S ribosomal protein L19

Gene

rpl19

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • hemopoiesis Source: ZFIN
  • translation Source: InterPro
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-DRE-1799339, SRP-dependent cotranslational protein targeting to membrane
R-DRE-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-DRE-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-DRE-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DRE-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpl19
ORF Names:zgc:77733
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-040426-2290, rpl19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001311731 – 19660S ribosomal protein L19Add BLAST196

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6P5L3

PRoteomics IDEntifications database

More...PRIDEi		Q6P5L3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000013307, Expressed in embryo and 34 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000105649

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6P5L3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic ribosomal protein eL19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1696, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012628

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_083919_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P5L3

Identification of Orthologs from Complete Genome Data

More...OMAi		NRVWIDP

Database of Orthologous Groups

More...OrthoDBi		1437042at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6P5L3

TreeFam database of animal gene trees

More...TreeFami		TF313598

Family and domain databases

Conserved Domains Database

More...CDDi		cd01417, Ribosomal_L19e_E, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1650.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_01475, Ribosomal_L19e, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035970, 60S_ribosomal_L19/L19e_sf
IPR000196, Ribosomal_L19/L19e
IPR023638, Ribosomal_L19/L19e_CS
IPR015972, Ribosomal_L19/L19e_dom1
IPR033935, Ribosomal_L19_euka
IPR039547, RPL19

The PANTHER Classification System

More...PANTHERi		PTHR10722, PTHR10722, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01280, Ribosomal_L19e, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01416, Ribosomal_L19e, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48140, SSF48140, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00526, RIBOSOMAL_L19E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6P5L3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLVKDGLI 
        60         70         80         90        100
IKKPVTVHSR ARCRKNTLAR RKGRHMGVGK RKGTANARMP EKLCWMRRMR 
       110        120        130        140        150
ILRRLLRRYR EAKKIDRHMY HSLYLRAKGN VFKNKRILME HIHKLKADKA 
       160        170        180        190 
RKKLLADQAE ARRTKTREAR KRREERQQAK KEEIIKTLSK EDETKK
Length:196
Mass (Da):23,453
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8FB064826ACE2DF0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY648758 mRNA Translation: AAT68076.1
BC062844 mRNA Translation: AAH62844.1

NCBI Reference Sequences

More...RefSeqi		NP_998373.1, NM_213208.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000121728; ENSDARP00000105649; ENSDARG00000013307

Database of genes from NCBI RefSeq genomes

More...GeneIDi		406489

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:406489

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY648758 mRNA Translation: AAT68076.1
BC062844 mRNA Translation: AAH62844.1
RefSeqiNP_998373.1, NM_213208.1

3D structure databases

SMRiQ6P5L3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000105649

Proteomic databases

PaxDbiQ6P5L3
PRIDEiQ6P5L3

Genome annotation databases

EnsembliENSDART00000121728; ENSDARP00000105649; ENSDARG00000013307
GeneIDi406489
KEGGidre:406489

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6143
ZFINiZDB-GENE-040426-2290, rpl19

Phylogenomic databases

eggNOGiKOG1696, Eukaryota
GeneTreeiENSGT00390000012628
HOGENOMiCLU_083919_0_1_1
InParanoidiQ6P5L3
OMAiNRVWIDP
OrthoDBi1437042at2759
PhylomeDBiQ6P5L3
TreeFamiTF313598

Enzyme and pathway databases

ReactomeiR-DRE-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-DRE-1799339, SRP-dependent cotranslational protein targeting to membrane
R-DRE-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-DRE-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-DRE-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DRE-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q6P5L3

Gene expression databases

BgeeiENSDARG00000013307, Expressed in embryo and 34 other tissues

Family and domain databases

CDDicd01417, Ribosomal_L19e_E, 1 hit
Gene3Di1.10.1650.10, 1 hit
HAMAPiMF_01475, Ribosomal_L19e, 1 hit
InterProiView protein in InterPro
IPR035970, 60S_ribosomal_L19/L19e_sf
IPR000196, Ribosomal_L19/L19e
IPR023638, Ribosomal_L19/L19e_CS
IPR015972, Ribosomal_L19/L19e_dom1
IPR033935, Ribosomal_L19_euka
IPR039547, RPL19
PANTHERiPTHR10722, PTHR10722, 1 hit
PfamiView protein in Pfam
PF01280, Ribosomal_L19e, 1 hit
SMARTiView protein in SMART
SM01416, Ribosomal_L19e, 1 hit
SUPFAMiSSF48140, SSF48140, 1 hit
PROSITEiView protein in PROSITE
PS00526, RIBOSOMAL_L19E, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL19_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P5L3
Secondary accession number(s): Q6DRK1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
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