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Entry version 120 (18 Sep 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Nestin

Gene

Nes

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division (By similarity). Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nestin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nes
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:101784 Nes

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality with the neuroepithelium of developing neural tube exhibiting low numbers of neural stem cells and high levels of apoptosis. No effect on cytoskeletal integrity.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002858561 – 1864NestinAdd BLAST1864

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei312PhosphoserineBy similarity1
Modified residuei316PhosphothreonineBy similarity1
Modified residuei356PhosphoserineBy similarity1
Modified residuei359PhosphoserineBy similarity1
Modified residuei389PhosphothreonineBy similarity1
Modified residuei565PhosphoserineBy similarity1
Modified residuei575PhosphoserineBy similarity1
Modified residuei623PhosphoserineCombined sources1
Modified residuei688PhosphoserineBy similarity1
Modified residuei731PhosphoserineCombined sources1
Modified residuei775PhosphoserineCombined sources1
Modified residuei841PhosphoserineBy similarity1
Modified residuei862PhosphoserineCombined sources1
Modified residuei894PhosphoserineCombined sources1
Modified residuei963PhosphoserineCombined sources1
Modified residuei1010PhosphoserineBy similarity1
Modified residuei1021PhosphoserineCombined sources1
Modified residuei1106PhosphoserineBy similarity1
Modified residuei1127PhosphoserineBy similarity1
Modified residuei1177PhosphoserineBy similarity1
Modified residuei1188PhosphoserineBy similarity1
Modified residuei1195PhosphoserineBy similarity1
Modified residuei1216PhosphoserineCombined sources1
Modified residuei1290PhosphoserineBy similarity1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1565PhosphoserineCombined sources1
Modified residuei1656PhosphoserineBy similarity1
Modified residuei1665PhosphoserineBy similarity1
Modified residuei1745PhosphoserineBy similarity1
Modified residuei1747PhosphoserineBy similarity1
Modified residuei1837PhosphoserineCombined sources1
Modified residuei1860PhosphoserineBy similarity1
Modified residuei1861PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6P5H2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6P5H2

PeptideAtlas

More...
PeptideAtlasi
Q6P5H2

PRoteomics IDEntifications database

More...
PRIDEi
Q6P5H2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6P5H2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P5H2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000004891 Expressed in 271 organ(s), highest expression level in cerebral cortex

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6P5H2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, this protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%.

Interacts with FHOD3 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
201730, 7 interactors

Protein interaction database and analysis system

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IntActi
Q6P5H2, 9 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000088493

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6P5H2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 314IF rodPROSITE-ProRule annotationAdd BLAST307

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 7Head7
Regioni8 – 43Coil 1AAdd BLAST36
Regioni44 – 55Linker 1Add BLAST12
Regioni56 – 151Coil 1BAdd BLAST96
Regioni152 – 174Linker 12Add BLAST23
Regioni175 – 193Coil 2AAdd BLAST19
Regioni194 – 196Linker 23
Regioni197 – 314Coil 2BAdd BLAST118
Regioni315 – 1864TailAdd BLAST1550

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IRNV Eukaryota
ENOG410XZH4 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162240

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113766

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6P5H2

KEGG Orthology (KO)

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KOi
K07609

Identification of Orthologs from Complete Genome Data

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OMAi
RENQEPL

Database of Orthologous Groups

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OrthoDBi
127811at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6P5H2

TreeFam database of animal gene trees

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TreeFami
TF336633

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR031211 Nestin

The PANTHER Classification System

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PANTHERi
PTHR47051 PTHR47051, 3 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF00038 Filament, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6P5H2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGCVGEESF QMWELNRRLE AYLTRVKTLE EQNQLLSAEL GGLRAQSGDA
60 70 80 90 100
SWRARADDEL AALRVLVDQR WREKHEAEVQ RDNLAEELES VAGRCQQVRL
110 120 130 140 150
ARERTIEEAA CSRRALEAEK NARGWLSTQA AELERELEAL RASHEEERAH
160 170 180 190 200
LNAQAACTPR RPPAPAHASP IRAPEVEELA RRLGEVWRGA VRDYQERVAH
210 220 230 240 250
MESSLGQARE RLGQAVRGAR ESRLEVQQLQ ADRDSLQERR EALEQRLEGR
260 270 280 290 300
WQDRLQATEK FQLAVEALEQ EKQGLQSQIA QILEGGQQLA HLKMSLSLEV
310 320 330 340 350
ATYRTLLEAE NSRLQTPGRS SQASLGFPDP KLKLHFLGIP EDQHLGSVLP
360 370 380 390 400
VLSPTSFSSP LPNTLETPVT AFLKTQEFLK ARTPTLASTP IPPMSEAPYP
410 420 430 440 450
KNAEVRAQDV PHSLLQGGRQ QAPEPLWAEA TVPSSTGVLP ELEEPGGEQP
460 470 480 490 500
DHFPDDPTSL APPLNPHHSI LEAKDRESSE SRVSSIFQEE EGQIWELVKK
510 520 530 540 550
EAATEVKVEN SLAQEIQESG LDTEEIQDSQ GPLQMETLEA LGDEPLMSLK
560 570 580 590 600
TQNHETPGKE NCNSSIEENS GTVKSPEKEK QTPLKSLEEK NVEAEKTLEN
610 620 630 640 650
GVLELSKPLG EEEPRMEDQE LMSPEHTLET VSFLGKENQE VVRSSEEQNL
660 670 680 690 700
ESLITFKEES QYPLGGPEAE DQMLERLVEK EDQRFPRSPE EDQQAFRPLE
710 720 730 740 750
KENQEPLRFE EAEDQVLERL IEKERQESLK SPEEEDQQAF RLLEKENQEP
760 770 780 790 800
LRFEDAEDQV LERLIEKERQ ESLKSPEEED QQAFRLLEKE NQEPLRFEEA
810 820 830 840 850
EDQVLERLVE KESQESLKSP EEEDQRTGKP LEKENQESLR SLDENQETIV
860 870 880 890 900
LLESKNQRPL RSLEVEEEEQ RIVKPLEKVS QVSLESLEKE NVQSPRYLEE
910 920 930 940 950
DDHMIKSLLE DKTHEILGSL EDRNGENFIP PENETQGSLR PPEEEDQRIV
960 970 980 990 1000
NHLEKESQEF LRSPEAEEEE EQVMVRSLEG ENHDPLSSVV KEEQMAESKL
1010 1020 1030 1040 1050
ENESQDSRKS LEDESQETFG SLEKENLESL RSLAGQDQEE QKLEQETQQP
1060 1070 1080 1090 1100
LRAVEDEQMT VNPPEKVDPE LPKPLRNDQE VVRSLDKENQ ESLVSLNEGG
1110 1120 1130 1140 1150
METVKSSETE NIESLETVGE CLGRRKSVDT QEPLWSTEVT SETIEPLEDE
1160 1170 1180 1190 1200
TQEPLGCVDE NQEVLTPLER ESQELRSLGK WNPETVESPG GVEDSQQCLE
1210 1220 1230 1240 1250
VEEGPEREQH QESLRSLGEV EWELPGSGSQ QRWEDVVEDG EGQEASLGAT
1260 1270 1280 1290 1300
GVETEDKAEL HLRGQGGEEK AVEEGELLQD AVGEAWSLGS SEPKEQRVPA
1310 1320 1330 1340 1350
EPLDDLEGQP EQTGTLEVPV AQGMPEATEQ DEDRAQAGEQ DSVEVTLGLE
1360 1370 1380 1390 1400
AARAGLELEQ EVVGLEDPRH FAREEAIHPS LGEESVKAKI DQGLEEPGKE
1410 1420 1430 1440 1450
PKEAGALDSG IPELPKTSSE TLECKGWEES GEGWGEEEAS LETSDHEGSH
1460 1470 1480 1490 1500
APQPRPPKTE EDEGLQAALT VPGPKLLEPC SPIPILTDAH ELQPQAEGIQ
1510 1520 1530 1540 1550
EAGWQPEAGT EALGRVEDEP EFGRGEIPEG LQDWEEGRED SEADELGETL
1560 1570 1580 1590 1600
PDSTPLGLYL KSPASPKWEQ AGEQRLFPQG EARKEGWSPA ALAAQGLSDP
1610 1620 1630 1640 1650
PEEEQQGHDS DLSSEEFEDL GTEASLLPGV PKEVSDHLGQ EPPVLQPACW
1660 1670 1680 1690 1700
DQGGESDGFA DEEESGEEGE EEDADEEEGA ESGTQWWGPG PSGGGVKVQD
1710 1720 1730 1740 1750
VTQRGDLEHE SVGDSGLWDD GLSGAAANVL VTALETVSQD SAEPSGSEGS
1760 1770 1780 1790 1800
ESASLEGEEG QAIDHLDAPQ EVTSVVPGAG DTFDISGQGP NLESEQVNGR
1810 1820 1830 1840 1850
MENGLEQAEG QVVLHGDEDQ GIPLQEQGTL KAPLVGSPVH LGPSQPLKFT
1860
LSGVDGDSWS SGED
Length:1,864
Mass (Da):207,124
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9DF21005D977983
GO
Isoform 2 (identifier: Q6P5H2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-793: Missing.

Show »
Length:1,820
Mass (Da):201,770
Checksum:i270C501DACA10100
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti184G → C in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti257A → P in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti265V → L in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti319R → G in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti458T → S in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti535M → K in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti544E → K in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti558G → R in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti570S → L in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti587L → S in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti673M → I in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti704Q → L in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti734E → D in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti851L → P in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti855K → R in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti900E → D in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1008 – 1011RKSL → GKFF in AAF04456 (PubMed:10842089).Curated4
Sequence conflicti1021S → F in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1157C → S in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1241E → EV in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1382G → A in ABK96808 (Ref. 5) Curated1
Sequence conflicti1404A → T in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1410G → S in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1577F → S in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1586 – 1591GWSPAA → DWGPAV in AAF04456 (PubMed:10842089).Curated6
Sequence conflicti1684T → A in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1821G → D in AAF04456 (PubMed:10842089).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024923750 – 793Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF076623 mRNA Translation: AAF04456.2
BC060693 mRNA Translation: AAH60693.1
BC062893 mRNA Translation: AAH62893.1
AK009706 mRNA Translation: BAB26451.1
AK075690 mRNA Translation: BAC35892.1
S78708 mRNA Translation: AAP32014.1
EF101559 mRNA Translation: ABK96808.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS17461.1 [Q6P5H2-1]

NCBI Reference Sequences

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RefSeqi
NP_057910.3, NM_016701.3 [Q6P5H2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000090973; ENSMUSP00000088493; ENSMUSG00000004891 [Q6P5H2-1]
ENSMUST00000160694; ENSMUSP00000125571; ENSMUSG00000004891 [Q6P5H2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
18008

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:18008

UCSC genome browser

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UCSCi
uc008ptm.1 mouse [Q6P5H2-2]
uc008ptn.1 mouse [Q6P5H2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076623 mRNA Translation: AAF04456.2
BC060693 mRNA Translation: AAH60693.1
BC062893 mRNA Translation: AAH62893.1
AK009706 mRNA Translation: BAB26451.1
AK075690 mRNA Translation: BAC35892.1
S78708 mRNA Translation: AAP32014.1
EF101559 mRNA Translation: ABK96808.1
CCDSiCCDS17461.1 [Q6P5H2-1]
RefSeqiNP_057910.3, NM_016701.3 [Q6P5H2-1]

3D structure databases

SMRiQ6P5H2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi201730, 7 interactors
IntActiQ6P5H2, 9 interactors
STRINGi10090.ENSMUSP00000088493

PTM databases

iPTMnetiQ6P5H2
PhosphoSitePlusiQ6P5H2

Proteomic databases

jPOSTiQ6P5H2
PaxDbiQ6P5H2
PeptideAtlasiQ6P5H2
PRIDEiQ6P5H2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090973; ENSMUSP00000088493; ENSMUSG00000004891 [Q6P5H2-1]
ENSMUST00000160694; ENSMUSP00000125571; ENSMUSG00000004891 [Q6P5H2-2]
GeneIDi18008
KEGGimmu:18008
UCSCiuc008ptm.1 mouse [Q6P5H2-2]
uc008ptn.1 mouse [Q6P5H2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10763
MGIiMGI:101784 Nes

Phylogenomic databases

eggNOGiENOG410IRNV Eukaryota
ENOG410XZH4 LUCA
GeneTreeiENSGT00940000162240
HOGENOMiHOG000113766
InParanoidiQ6P5H2
KOiK07609
OMAiRENQEPL
OrthoDBi127811at2759
PhylomeDBiQ6P5H2
TreeFamiTF336633

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Nes mouse

Protein Ontology

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PROi
PR:Q6P5H2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000004891 Expressed in 271 organ(s), highest expression level in cerebral cortex
GenevisibleiQ6P5H2 MM

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR031211 Nestin
PANTHERiPTHR47051 PTHR47051, 3 hits
PfamiView protein in Pfam
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEST_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P5H2
Secondary accession number(s): A1E2I2
, Q80X00, Q8BPH7, Q9CV43, Q9R0C4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: September 18, 2019
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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