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UniProtKB - Q6P5H2 (NEST_MOUSE)

Entry version 133 (25 May 2022)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Nestin

Gene

Nes

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division (By similarity).

Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nestin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:101784, Nes

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000004891

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Intermediate filament

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality with the neuroepithelium of developing neural tube exhibiting low numbers of neural stem cells and high levels of apoptosis. No effect on cytoskeletal integrity.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002858561 – 1864NestinAdd BLAST1864

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei312PhosphoserineBy similarity1
Modified residuei316PhosphothreonineBy similarity1
Modified residuei356PhosphoserineBy similarity1
Modified residuei359PhosphoserineBy similarity1
Modified residuei389PhosphothreonineBy similarity1
Modified residuei565PhosphoserineBy similarity1
Modified residuei575PhosphoserineBy similarity1
Modified residuei623PhosphoserineCombined sources1
Modified residuei688PhosphoserineBy similarity1
Modified residuei731PhosphoserineCombined sources1
Modified residuei775PhosphoserineCombined sources1
Modified residuei841PhosphoserineBy similarity1
Modified residuei862PhosphoserineCombined sources1
Modified residuei894PhosphoserineCombined sources1
Modified residuei963PhosphoserineCombined sources1
Modified residuei1010PhosphoserineBy similarity1
Modified residuei1021PhosphoserineCombined sources1
Modified residuei1106PhosphoserineBy similarity1
Modified residuei1127PhosphoserineBy similarity1
Modified residuei1177PhosphoserineBy similarity1
Modified residuei1188PhosphoserineBy similarity1
Modified residuei1195PhosphoserineBy similarity1
Modified residuei1216PhosphoserineCombined sources1
Modified residuei1290PhosphoserineBy similarity1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1565PhosphoserineCombined sources1
Modified residuei1656PhosphoserineBy similarity1
Modified residuei1665PhosphoserineBy similarity1
Modified residuei1745PhosphoserineBy similarity1
Modified residuei1747PhosphoserineBy similarity1
Modified residuei1837PhosphoserineCombined sources1
Modified residuei1860PhosphoserineBy similarity1
Modified residuei1861PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6P5H2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6P5H2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6P5H2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6P5H2

PeptideAtlas

More...PeptideAtlasi		Q6P5H2

PRoteomics IDEntifications database

More...PRIDEi		Q6P5H2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		252809 [Q6P5H2-1]
252810 [Q6P5H2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6P5H2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6P5H2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000004891, Expressed in cerebral cortex and 293 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6P5H2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, this protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%.

Interacts with FHOD3 (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		201730, 15 interactors

Protein interaction database and analysis system

More...IntActi		Q6P5H2, 9 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000088493

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6P5H2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q6P5H2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6P5H2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 314IF rodPROSITE-ProRule annotationAdd BLAST307

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 7Head7
Regioni8 – 43Coil 1AAdd BLAST36
Regioni44 – 55Linker 1Add BLAST12
Regioni56 – 151Coil 1BAdd BLAST96
Regioni152 – 174Linker 12Add BLAST23
Regioni175 – 193Coil 2AAdd BLAST19
Regioni194 – 196Linker 23
Regioni197 – 314Coil 2BAdd BLAST118
Regioni315 – 1864TailAdd BLAST1550
Regioni437 – 492DisorderedSequence analysisAdd BLAST56
Regioni515 – 625DisorderedSequence analysisAdd BLAST111
Regioni680 – 845DisorderedSequence analysisAdd BLAST166
Regioni916 – 1113DisorderedSequence analysisAdd BLAST198
Regioni1129 – 1158DisorderedSequence analysisAdd BLAST30
Regioni1175 – 1344DisorderedSequence analysisAdd BLAST170
Regioni1375 – 1722DisorderedSequence analysisAdd BLAST348
Regioni1735 – 1807DisorderedSequence analysisAdd BLAST73
Regioni1841 – 1864DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi469 – 484Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi515 – 534Polar residuesSequence analysisAdd BLAST20
Compositional biasi549 – 571Polar residuesSequence analysisAdd BLAST23
Compositional biasi572 – 597Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi606 – 624Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi680 – 841Basic and acidic residuesSequence analysisAdd BLAST162
Compositional biasi938 – 978Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi985 – 1021Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi1035 – 1051Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1059 – 1087Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi1088 – 1113Polar residuesSequence analysisAdd BLAST26
Compositional biasi1200 – 1217Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1254 – 1277Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1375 – 1403Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi1439 – 1462Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1512 – 1534Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1656 – 1680Acidic residuesSequence analysisAdd BLAST25
Compositional biasi1735 – 1754Polar residuesSequence analysisAdd BLAST20
Compositional biasi1787 – 1801Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RYFK, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162240

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003317_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P5H2

Identification of Orthologs from Complete Genome Data

More...OMAi		RKEGWDP

Database of Orthologous Groups

More...OrthoDBi		127811at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6P5H2

TreeFam database of animal gene trees

More...TreeFami		TF336633

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR031211, Nestin

The PANTHER Classification System

More...PANTHERi		PTHR47051, PTHR47051, 4 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00038, Filament, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01391, Filament, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6P5H2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGCVGEESF QMWELNRRLE AYLTRVKTLE EQNQLLSAEL GGLRAQSGDA 
        60         70         80         90        100
SWRARADDEL AALRVLVDQR WREKHEAEVQ RDNLAEELES VAGRCQQVRL 
       110        120        130        140        150
ARERTIEEAA CSRRALEAEK NARGWLSTQA AELERELEAL RASHEEERAH 
       160        170        180        190        200
LNAQAACTPR RPPAPAHASP IRAPEVEELA RRLGEVWRGA VRDYQERVAH 
       210        220        230        240        250
MESSLGQARE RLGQAVRGAR ESRLEVQQLQ ADRDSLQERR EALEQRLEGR 
       260        270        280        290        300
WQDRLQATEK FQLAVEALEQ EKQGLQSQIA QILEGGQQLA HLKMSLSLEV 
       310        320        330        340        350
ATYRTLLEAE NSRLQTPGRS SQASLGFPDP KLKLHFLGIP EDQHLGSVLP 
       360        370        380        390        400
VLSPTSFSSP LPNTLETPVT AFLKTQEFLK ARTPTLASTP IPPMSEAPYP 
       410        420        430        440        450
KNAEVRAQDV PHSLLQGGRQ QAPEPLWAEA TVPSSTGVLP ELEEPGGEQP 
       460        470        480        490        500
DHFPDDPTSL APPLNPHHSI LEAKDRESSE SRVSSIFQEE EGQIWELVKK 
       510        520        530        540        550
EAATEVKVEN SLAQEIQESG LDTEEIQDSQ GPLQMETLEA LGDEPLMSLK 
       560        570        580        590        600
TQNHETPGKE NCNSSIEENS GTVKSPEKEK QTPLKSLEEK NVEAEKTLEN 
       610        620        630        640        650
GVLELSKPLG EEEPRMEDQE LMSPEHTLET VSFLGKENQE VVRSSEEQNL 
       660        670        680        690        700
ESLITFKEES QYPLGGPEAE DQMLERLVEK EDQRFPRSPE EDQQAFRPLE 
       710        720        730        740        750
KENQEPLRFE EAEDQVLERL IEKERQESLK SPEEEDQQAF RLLEKENQEP 
       760        770        780        790        800
LRFEDAEDQV LERLIEKERQ ESLKSPEEED QQAFRLLEKE NQEPLRFEEA 
       810        820        830        840        850
EDQVLERLVE KESQESLKSP EEEDQRTGKP LEKENQESLR SLDENQETIV 
       860        870        880        890        900
LLESKNQRPL RSLEVEEEEQ RIVKPLEKVS QVSLESLEKE NVQSPRYLEE 
       910        920        930        940        950
DDHMIKSLLE DKTHEILGSL EDRNGENFIP PENETQGSLR PPEEEDQRIV 
       960        970        980        990       1000
NHLEKESQEF LRSPEAEEEE EQVMVRSLEG ENHDPLSSVV KEEQMAESKL 
      1010       1020       1030       1040       1050
ENESQDSRKS LEDESQETFG SLEKENLESL RSLAGQDQEE QKLEQETQQP 
      1060       1070       1080       1090       1100
LRAVEDEQMT VNPPEKVDPE LPKPLRNDQE VVRSLDKENQ ESLVSLNEGG 
      1110       1120       1130       1140       1150
METVKSSETE NIESLETVGE CLGRRKSVDT QEPLWSTEVT SETIEPLEDE 
      1160       1170       1180       1190       1200
TQEPLGCVDE NQEVLTPLER ESQELRSLGK WNPETVESPG GVEDSQQCLE 
      1210       1220       1230       1240       1250
VEEGPEREQH QESLRSLGEV EWELPGSGSQ QRWEDVVEDG EGQEASLGAT 
      1260       1270       1280       1290       1300
GVETEDKAEL HLRGQGGEEK AVEEGELLQD AVGEAWSLGS SEPKEQRVPA 
      1310       1320       1330       1340       1350
EPLDDLEGQP EQTGTLEVPV AQGMPEATEQ DEDRAQAGEQ DSVEVTLGLE 
      1360       1370       1380       1390       1400
AARAGLELEQ EVVGLEDPRH FAREEAIHPS LGEESVKAKI DQGLEEPGKE 
      1410       1420       1430       1440       1450
PKEAGALDSG IPELPKTSSE TLECKGWEES GEGWGEEEAS LETSDHEGSH 
      1460       1470       1480       1490       1500
APQPRPPKTE EDEGLQAALT VPGPKLLEPC SPIPILTDAH ELQPQAEGIQ 
      1510       1520       1530       1540       1550
EAGWQPEAGT EALGRVEDEP EFGRGEIPEG LQDWEEGRED SEADELGETL 
      1560       1570       1580       1590       1600
PDSTPLGLYL KSPASPKWEQ AGEQRLFPQG EARKEGWSPA ALAAQGLSDP 
      1610       1620       1630       1640       1650
PEEEQQGHDS DLSSEEFEDL GTEASLLPGV PKEVSDHLGQ EPPVLQPACW 
      1660       1670       1680       1690       1700
DQGGESDGFA DEEESGEEGE EEDADEEEGA ESGTQWWGPG PSGGGVKVQD 
      1710       1720       1730       1740       1750
VTQRGDLEHE SVGDSGLWDD GLSGAAANVL VTALETVSQD SAEPSGSEGS 
      1760       1770       1780       1790       1800
ESASLEGEEG QAIDHLDAPQ EVTSVVPGAG DTFDISGQGP NLESEQVNGR 
      1810       1820       1830       1840       1850
MENGLEQAEG QVVLHGDEDQ GIPLQEQGTL KAPLVGSPVH LGPSQPLKFT 
      1860 
LSGVDGDSWS SGED
Length:1,864
Mass (Da):207,124
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9DF21005D977983
GO
Isoform 2 (identifier: Q6P5H2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-793: Missing.

Show »
Length:1,820
Mass (Da):201,770
Checksum:i270C501DACA10100
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti184G → C in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti257A → P in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti265V → L in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti319R → G in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti458T → S in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti535M → K in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti544E → K in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti558G → R in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti570S → L in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti587L → S in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti673M → I in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti704Q → L in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti734E → D in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti851L → P in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti855K → R in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti900E → D in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1008 – 1011RKSL → GKFF in AAF04456 (PubMed:10842089).Curated4
Sequence conflicti1021S → F in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1157C → S in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1241E → EV in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1382G → A in ABK96808 (Ref. 5) Curated1
Sequence conflicti1404A → T in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1410G → S in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1577F → S in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1586 – 1591GWSPAA → DWGPAV in AAF04456 (PubMed:10842089).Curated6
Sequence conflicti1684T → A in AAF04456 (PubMed:10842089).Curated1
Sequence conflicti1821G → D in AAF04456 (PubMed:10842089).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024923750 – 793Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF076623 mRNA Translation: AAF04456.2
BC060693 mRNA Translation: AAH60693.1
BC062893 mRNA Translation: AAH62893.1
AK009706 mRNA Translation: BAB26451.1
AK075690 mRNA Translation: BAC35892.1
S78708 mRNA Translation: AAP32014.1
EF101559 mRNA Translation: ABK96808.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS17461.1 [Q6P5H2-1]

NCBI Reference Sequences

More...RefSeqi		NP_057910.3, NM_016701.3 [Q6P5H2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000090973; ENSMUSP00000088493; ENSMUSG00000004891 [Q6P5H2-1]
ENSMUST00000160694; ENSMUSP00000125571; ENSMUSG00000004891 [Q6P5H2-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		18008

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:18008

UCSC genome browser

More...UCSCi		uc008ptm.1, mouse [Q6P5H2-2]
uc008ptn.1, mouse [Q6P5H2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076623 mRNA Translation: AAF04456.2
BC060693 mRNA Translation: AAH60693.1
BC062893 mRNA Translation: AAH62893.1
AK009706 mRNA Translation: BAB26451.1
AK075690 mRNA Translation: BAC35892.1
S78708 mRNA Translation: AAP32014.1
EF101559 mRNA Translation: ABK96808.1
CCDSiCCDS17461.1 [Q6P5H2-1]
RefSeqiNP_057910.3, NM_016701.3 [Q6P5H2-1]

3D structure databases

AlphaFoldDBiQ6P5H2
SMRiQ6P5H2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201730, 15 interactors
IntActiQ6P5H2, 9 interactors
STRINGi10090.ENSMUSP00000088493

PTM databases

iPTMnetiQ6P5H2
PhosphoSitePlusiQ6P5H2

Proteomic databases

EPDiQ6P5H2
jPOSTiQ6P5H2
MaxQBiQ6P5H2
PaxDbiQ6P5H2
PeptideAtlasiQ6P5H2
PRIDEiQ6P5H2
ProteomicsDBi252809 [Q6P5H2-1]
252810 [Q6P5H2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1658, 1099 antibodies from 49 providers

Genome annotation databases

EnsembliENSMUST00000090973; ENSMUSP00000088493; ENSMUSG00000004891 [Q6P5H2-1]
ENSMUST00000160694; ENSMUSP00000125571; ENSMUSG00000004891 [Q6P5H2-2]
GeneIDi18008
KEGGimmu:18008
UCSCiuc008ptm.1, mouse [Q6P5H2-2]
uc008ptn.1, mouse [Q6P5H2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10763
MGIiMGI:101784, Nes
VEuPathDBiHostDB:ENSMUSG00000004891

Phylogenomic databases

eggNOGiENOG502RYFK, Eukaryota
GeneTreeiENSGT00940000162240
HOGENOMiCLU_003317_0_0_1
InParanoidiQ6P5H2
OMAiRKEGWDP
OrthoDBi127811at2759
PhylomeDBiQ6P5H2
TreeFamiTF336633

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		18008, 4 hits in 72 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Nes, mouse

Protein Ontology

More...PROi		PR:Q6P5H2
RNActiQ6P5H2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000004891, Expressed in cerebral cortex and 293 other tissues
GenevisibleiQ6P5H2, MM

Family and domain databases

InterProiView protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR031211, Nestin
PANTHERiPTHR47051, PTHR47051, 4 hits
PfamiView protein in Pfam
PF00038, Filament, 1 hit
SMARTiView protein in SMART
SM01391, Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEST_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P5H2
Secondary accession number(s): A1E2I2
, Q80X00, Q8BPH7, Q9CV43, Q9R0C4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: May 25, 2022
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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