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Protein

Exportin-1

Gene

Xpo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3769402 Deactivation of the beta-catenin transactivating complex
R-MMU-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-5687128 MAPK6/MAPK4 signaling
R-MMU-68877 Mitotic Prometaphase
R-MMU-69273 Cyclin A/B1/B2 associated events during G2/M transition

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-1
Short name:
Exp1
Alternative name(s):
Chromosome region maintenance 1 protein homolog
Gene namesi
Name:Xpo1
Synonyms:Crm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144013 Xpo1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047061 – 1071Exportin-1Add BLAST1071

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei391PhosphoserineBy similarity1
Modified residuei446N6-acetyllysineCombined sources1
Modified residuei448PhosphothreonineBy similarity1
Modified residuei450PhosphoserineBy similarity1
Modified residuei454PhosphotyrosineBy similarity1
Modified residuei693N6-acetyllysineBy similarity1
Modified residuei1031PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6P5F9
MaxQBiQ6P5F9
PaxDbiQ6P5F9
PeptideAtlasiQ6P5F9
PRIDEiQ6P5F9

PTM databases

iPTMnetiQ6P5F9
PhosphoSitePlusiQ6P5F9
SwissPalmiQ6P5F9

Expressioni

Gene expression databases

BgeeiENSMUSG00000020290 Expressed in 309 organ(s), highest expression level in metanephric loop of Henle
CleanExiMM_XPO1
ExpressionAtlasiQ6P5F9 baseline and differential
GenevisibleiQ6P5F9 MM

Interactioni

Subunit structurei

Found in a U snRNA export complex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA (PubMed:10786834). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214, RANBP3 and TERT. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at 'Lys-129'. Interacts with SERTAD2; the interaction translocates SERTAD2 out of the nucleus. Interacts with ATF2. Interacts with SLC35G1 and STIM1. Interacts with DCAF8 (By similarity). Interacts with DTNBP1 and the interaction translocates DTNBP1 out of the nucleus (PubMed:20921223). Interacts with CPEB3 (By similarity). Interacts with HAX1 (By similarity). Interacts with BOK; translocates to the cytoplasm (By similarity). Interacts with HSP90AB1 (By similarity).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222117, 19 interactors
DIPiDIP-48612N
IntActiQ6P5F9, 1784 interactors
STRINGi10090.ENSMUSP00000020538

Structurei

Secondary structure

11071
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6P5F9
SMRiQ6P5F9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6P5F9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 112Importin N-terminalPROSITE-ProRule annotationAdd BLAST67
Repeati217 – 240HEAT 1Add BLAST24
Repeati241 – 277HEAT 2Add BLAST37
Repeati354 – 472HEAT 3Add BLAST119
Repeati515 – 553HEAT 4Add BLAST39
Repeati560 – 597HEAT 5Add BLAST38
Repeati602 – 639HEAT 6Add BLAST38
Repeati775 – 813HEAT 7Add BLAST39
Repeati885 – 916HEAT 8Add BLAST32
Repeati917 – 954HEAT 9Add BLAST38
Repeati1002 – 1039HEAT 10Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni327 – 450Necessary for interaction with Ran and nuclear export complex formationBy similarityAdd BLAST124
Regioni411 – 481Necessary for interaction with RANBP3By similarityAdd BLAST71

Sequence similaritiesi

Belongs to the exportin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2020 Eukaryota
COG5101 LUCA
GeneTreeiENSGT00390000000572
HOGENOMiHOG000209012
HOVERGENiHBG052817
InParanoidiQ6P5F9
KOiK14290
OMAiSEYPEHR
OrthoDBiEOG091G013G
PhylomeDBiQ6P5F9
TreeFamiTF105695

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
IPR014877 XPO1_C_dom
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM01102 CRM1_C, 1 hit
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6P5F9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAIMTMLAD HAARQLLDFS QKLDINLLDN VVNCLYHGEG AQQRMAQEVL
60 70 80 90 100
THLKEHPDAW TRVDTILEFS QNMNTKYYGL QILENVIKTR WKILPRNQCE
110 120 130 140 150
GIKKYVVGLI IKTSSDPTCV EKEKVYIGKL NMILVQILKQ EWPKHWPTFI
160 170 180 190 200
SDIVGASRTS ESLCQNNMVI LKLLSEEVFD FSSGQITQVK AKHLKDSMCN
210 220 230 240 250
EFSQIFQLCQ FVMENSQNAP LVHATLETLL RFLNWIPLGY IFETKLISTL
260 270 280 290 300
IYKFLNVPMF RNVSLKCLTE IAGVSVSQYE EQFETLFTLT MMQLKQMLPL
310 320 330 340 350
NTNIRLAYSN GKDDEQNFIQ NLSLFLCTFL KEHGQLLEKR LNLREALMEA
360 370 380 390 400
LHYMLLVSEV EETEIFKICL EYWNHLAAEL YRESPFSTSA SPLLSGSQHF
410 420 430 440 450
DIPPRRQLYL TVLSKVRLLM VSRMAKPEEV LVVENDQGEV VREFMKDTDS
460 470 480 490 500
INLYKNMRET LVYLTHLDYV DTEIIMTKKL QNQVNGTEWS WKNLNTLCWA
510 520 530 540 550
IGSISGAMHE EDEKRFLVTV IKDLLGLCEQ KRGKDNKAII ASNIMYIVGQ
560 570 580 590 600
YPRFLRAHWK FLKTVVNKLF EFMHETHDGV QDMACDTFIK IAQKCRRHFV
610 620 630 640 650
QVQVGEVMPF IDEILNNINT IICDLQPQQV HTFYEAVGYM IGAQTDQTVQ
660 670 680 690 700
EHLIEKYMLL PNQVWDSIIQ QATKNVDILK DPETVKQLGS ILKTNVRACK
710 720 730 740 750
AVGHPFVIQL GRIYLDMLNV YKCLSENISA AIQANGEMVT KQPLIRSMRT
760 770 780 790 800
VKRETLKLIS GWVSRSNDPQ MVAENFVPPL LDAVLIDYQR NVPAAREPEV
810 820 830 840 850
LSTMAIIVNK LGGHITAEIP QIFDAVFECT LNMINKDFEE YPEHRTNFFL
860 870 880 890 900
LLQAVNSHCF PAFLAIPPAQ FKLVLDSIIW AFKHTMRNVA DTGLQILFTL
910 920 930 940 950
LQNVAQEEAA AQSFYQTYFC DILQHIFSVV TDTSHTAGLT MHASILAYMF
960 970 980 990 1000
NLVEEGKIST PLNPGNPVNN QMFIQDYVAN LLKSAFPHLQ DAQVKLFVTG
1010 1020 1030 1040 1050
LFSLNQDIPA FKEHLRDFLV QIKEFAGEDT SDLFLEERET ALRQAQEEKH
1060 1070
KLQMSVPGIL NPHEIPEEMC D
Length:1,071
Mass (Da):123,093
Last modified:July 5, 2004 - v1
Checksum:iB451A19780024562
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AKT6A2AKT6_MOUSE
Exportin-1
Xpo1
59Annotation score:
F6YA11F6YA11_MOUSE
Exportin-1
Xpo1
233Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062912 mRNA Translation: AAH62912.1
CCDSiCCDS24475.1
RefSeqiNP_001030303.1, NM_001035226.1
NP_598775.2, NM_134014.3
XP_006514493.1, XM_006514430.2
UniGeneiMm.217547

Genome annotation databases

EnsembliENSMUST00000020538; ENSMUSP00000020538; ENSMUSG00000020290
ENSMUST00000102869; ENSMUSP00000099933; ENSMUSG00000020290
ENSMUST00000102870; ENSMUSP00000099934; ENSMUSG00000020290
ENSMUST00000109551; ENSMUSP00000105178; ENSMUSG00000020290
GeneIDi103573
KEGGimmu:103573
UCSCiuc007iet.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062912 mRNA Translation: AAH62912.1
CCDSiCCDS24475.1
RefSeqiNP_001030303.1, NM_001035226.1
NP_598775.2, NM_134014.3
XP_006514493.1, XM_006514430.2
UniGeneiMm.217547

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GJXX-ray2.50A/D1-1071[»]
3NBYX-ray3.42A/D1-1071[»]
3NBZX-ray2.80A/D1-1071[»]
3NC0X-ray2.90A/D1-1071[»]
3NC1X-ray3.35A1-1071[»]
ProteinModelPortaliQ6P5F9
SMRiQ6P5F9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222117, 19 interactors
DIPiDIP-48612N
IntActiQ6P5F9, 1784 interactors
STRINGi10090.ENSMUSP00000020538

PTM databases

iPTMnetiQ6P5F9
PhosphoSitePlusiQ6P5F9
SwissPalmiQ6P5F9

Proteomic databases

EPDiQ6P5F9
MaxQBiQ6P5F9
PaxDbiQ6P5F9
PeptideAtlasiQ6P5F9
PRIDEiQ6P5F9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020538; ENSMUSP00000020538; ENSMUSG00000020290
ENSMUST00000102869; ENSMUSP00000099933; ENSMUSG00000020290
ENSMUST00000102870; ENSMUSP00000099934; ENSMUSG00000020290
ENSMUST00000109551; ENSMUSP00000105178; ENSMUSG00000020290
GeneIDi103573
KEGGimmu:103573
UCSCiuc007iet.1 mouse

Organism-specific databases

CTDi7514
MGIiMGI:2144013 Xpo1

Phylogenomic databases

eggNOGiKOG2020 Eukaryota
COG5101 LUCA
GeneTreeiENSGT00390000000572
HOGENOMiHOG000209012
HOVERGENiHBG052817
InParanoidiQ6P5F9
KOiK14290
OMAiSEYPEHR
OrthoDBiEOG091G013G
PhylomeDBiQ6P5F9
TreeFamiTF105695

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3769402 Deactivation of the beta-catenin transactivating complex
R-MMU-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-5687128 MAPK6/MAPK4 signaling
R-MMU-68877 Mitotic Prometaphase
R-MMU-69273 Cyclin A/B1/B2 associated events during G2/M transition

Miscellaneous databases

ChiTaRSiXpo1 mouse
EvolutionaryTraceiQ6P5F9
PROiPR:Q6P5F9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020290 Expressed in 309 organ(s), highest expression level in metanephric loop of Henle
CleanExiMM_XPO1
ExpressionAtlasiQ6P5F9 baseline and differential
GenevisibleiQ6P5F9 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
IPR014877 XPO1_C_dom
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM01102 CRM1_C, 1 hit
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXPO1_MOUSE
AccessioniPrimary (citable) accession number: Q6P5F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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