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Protein

Zinc transporter ZIP10

Gene

Slc39a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a zinc-influx transporter.By similarity

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP10
Alternative name(s):
Solute carrier family 39 member 10
Zrt- and Irt-like protein 10
Short name:
ZIP-10
Gene namesi
Name:Slc39a10
Synonyms:Kiaa1265, Zip10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1914515 Slc39a10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21
Transmembranei689 – 709HelicalSequence analysisAdd BLAST21
Transmembranei734 – 754HelicalSequence analysisAdd BLAST21
Transmembranei761 – 781HelicalSequence analysisAdd BLAST21
Transmembranei803 – 823HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000029763326 – 833Zinc transporter ZIP10Add BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi218N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi341N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei538PhosphothreonineBy similarity1
Modified residuei555PhosphothreonineBy similarity1
Modified residuei593PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ6P5F6
MaxQBiQ6P5F6
PaxDbiQ6P5F6
PeptideAtlasiQ6P5F6
PRIDEiQ6P5F6

PTM databases

iPTMnetiQ6P5F6
PhosphoSitePlusiQ6P5F6

Expressioni

Gene expression databases

BgeeiENSMUSG00000025986 Expressed in 255 organ(s), highest expression level in brain blood vessel
ExpressionAtlasiQ6P5F6 baseline and differential
GenevisibleiQ6P5F6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027131

Structurei

3D structure databases

ProteinModelPortaliQ6P5F6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 40His-richAdd BLAST15
Compositional biasi101 – 294His-richAdd BLAST194
Compositional biasi460 – 485His-richAdd BLAST26
Compositional biasi609 – 658His-richAdd BLAST50

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693 Eukaryota
COG0428 LUCA
GeneTreeiENSGT00760000119115
HOGENOMiHOG000013093
HOVERGENiHBG055748
InParanoidiQ6P5F6
KOiK14716
OMAiDPGHGHQ
OrthoDBiEOG091G02WM
PhylomeDBiQ6P5F6
TreeFamiTF318470

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6P5F6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVHIHTKFC LICLLTFIFH HCNHCHEDHD HGPEELHRHH RGMTESESSK
60 70 80 90 100
FSVQDAENEK KYYIEKLFDR YGENGRLSFF GLEKLLTNLG LGEIKVVEIN
110 120 130 140 150
HEDLGHDHVS HLDILAVQEG KHFHSHTHQH FHNHLNAENH TTTSVTSKRN
160 170 180 190 200
HKCDPEKEAA ELPIKADDKH LHDRNHRFHH RHRLHHHLDH NTTRHVHNDS
210 220 230 240 250
VAHSEHGEPG HSPSPETNKT QEQSEVKSVK VRRKEKGKRK KENSEVNTPG
260 270 280 290 300
FLPNHDHSEQ YEHNRVHKLD RVHSPGHPHA HLPEHSGHEL GHGHQELDPD
310 320 330 340 350
NEGELRHTRK REAPHVRKSA IYSTPSHKDQ SEDDRQHECL NVTQLLKHFG
360 370 380 390 400
LGPNSPISPD LFTYLCPALL YQIDSRLCIE HFDKLLVEDL NKDKTLVPED
410 420 430 440 450
KTNIGASAWI CGIISITVIS LLSLLGVILV PIINQGCFKF LLTFLVALAV
460 470 480 490 500
GTMSGDALLH LLPHSQGGHD HSHQHTHGHG HSHGHESKEF LEEYDAVLKG
510 520 530 540 550
LVALGGIYLL FIIEHCIRMF KHYKQQRGKQ KWFMKQSTEE STIGRKLSDH
560 570 580 590 600
KLNSTPDADW LQLKPLAGTD DSVVSEDRLN ETELTDLEAQ QESPPKNYLG
610 620 630 640 650
VEEEKIMDHS HSDGLHTIHE HEVHVTSHNH HDEDKAVLRK HSHQWHHRHA
660 670 680 690 700
HHSHGPCHSG SDLKETGIAN IAWMVIMGDG IHNFSDGLAI GAAFSAGLTG
710 720 730 740 750
GISTSIAVFC HELPHELGDF AVLLKAGMTV KQAIVYNLLS AMMAYIGMLI
760 770 780 790 800
GTAVGQYANN ITLWIFAITA GMFLYVALVD MLPEMLHGDG DHEEHGFCPV
810 820 830
GQFILQNLGL LFGFAIMLVI ALYEDKIVFD IQF
Length:833
Mass (Da):94,394
Last modified:July 5, 2004 - v1
Checksum:iBA51B66A2296AFC2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WQF7A0A087WQF7_MOUSE
Zinc transporter ZIP10
Slc39a10
167Annotation score:
A0A087WRC8A0A087WRC8_MOUSE
Zinc transporter ZIP10
Slc39a10
144Annotation score:

Sequence cautioni

The sequence AAH59214 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC33542 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti346L → S in BAC65765 (PubMed:12693553).Curated1
Sequence conflicti676I → F in BAC27077 (PubMed:16141072).Curated1
Sequence conflicti829F → Y in BAC65765 (PubMed:12693553).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052880 mRNA Translation: AAH52880.1
BC059214 mRNA Translation: AAH59214.1 Different initiation.
BC062918 mRNA Translation: AAH62918.1
AK122483 mRNA Translation: BAC65765.1
AK030685 mRNA Translation: BAC27077.1
AK049099 mRNA Translation: BAC33542.1 Different initiation.
CCDSiCCDS14936.1
RefSeqiNP_766241.2, NM_172653.2
XP_006495996.1, XM_006495933.3
XP_006495997.1, XM_006495934.3
XP_006495998.1, XM_006495935.2
UniGeneiMm.233889
Mm.475398

Genome annotation databases

EnsembliENSMUST00000027131; ENSMUSP00000027131; ENSMUSG00000025986
GeneIDi227059
KEGGimmu:227059
UCSCiuc007axc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052880 mRNA Translation: AAH52880.1
BC059214 mRNA Translation: AAH59214.1 Different initiation.
BC062918 mRNA Translation: AAH62918.1
AK122483 mRNA Translation: BAC65765.1
AK030685 mRNA Translation: BAC27077.1
AK049099 mRNA Translation: BAC33542.1 Different initiation.
CCDSiCCDS14936.1
RefSeqiNP_766241.2, NM_172653.2
XP_006495996.1, XM_006495933.3
XP_006495997.1, XM_006495934.3
XP_006495998.1, XM_006495935.2
UniGeneiMm.233889
Mm.475398

3D structure databases

ProteinModelPortaliQ6P5F6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027131

PTM databases

iPTMnetiQ6P5F6
PhosphoSitePlusiQ6P5F6

Proteomic databases

EPDiQ6P5F6
MaxQBiQ6P5F6
PaxDbiQ6P5F6
PeptideAtlasiQ6P5F6
PRIDEiQ6P5F6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027131; ENSMUSP00000027131; ENSMUSG00000025986
GeneIDi227059
KEGGimmu:227059
UCSCiuc007axc.1 mouse

Organism-specific databases

CTDi57181
MGIiMGI:1914515 Slc39a10
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2693 Eukaryota
COG0428 LUCA
GeneTreeiENSGT00760000119115
HOGENOMiHOG000013093
HOVERGENiHBG055748
InParanoidiQ6P5F6
KOiK14716
OMAiDPGHGHQ
OrthoDBiEOG091G02WM
PhylomeDBiQ6P5F6
TreeFamiTF318470

Miscellaneous databases

ChiTaRSiSlc39a10 mouse
PROiPR:Q6P5F6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025986 Expressed in 255 organ(s), highest expression level in brain blood vessel
ExpressionAtlasiQ6P5F6 baseline and differential
GenevisibleiQ6P5F6 MM

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS39AA_MOUSE
AccessioniPrimary (citable) accession number: Q6P5F6
Secondary accession number(s): Q80TG2, Q8BX42, Q8C0L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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