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Entry version 125 (31 Jul 2019)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Sal-like 1 (Drosophila)

Gene

Sall1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Sal-like 1 (Drosophila)Imported
Submitted name:
Sal-like protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sall1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1889585 Sall1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031665 Expressed in 318 organ(s), highest expression level in pineal body

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini450 – 477C2H2-typeInterPro annotationAdd BLAST28
Domaini478 – 505C2H2-typeInterPro annotationAdd BLAST28
Domaini705 – 732C2H2-typeInterPro annotationAdd BLAST28
Domaini733 – 760C2H2-typeInterPro annotationAdd BLAST28
Domaini765 – 792C2H2-typeInterPro annotationAdd BLAST28
Domaini1000 – 1027C2H2-typeInterPro annotationAdd BLAST28
Domaini1028 – 1055C2H2-typeInterPro annotationAdd BLAST28
Domaini1133 – 1160C2H2-typeInterPro annotationAdd BLAST28
Domaini1161 – 1188C2H2-typeInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 41DisorderedSequence analysisAdd BLAST41
Regioni79 – 128DisorderedSequence analysisAdd BLAST50
Regioni578 – 659DisorderedSequence analysisAdd BLAST82
Regioni789 – 855DisorderedSequence analysisAdd BLAST67
Regioni891 – 961DisorderedSequence analysisAdd BLAST71
Regioni1094 – 1119DisorderedSequence analysisAdd BLAST26
Regioni1265 – 1291DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 41PolyampholyteSequence analysisAdd BLAST24
Compositional biasi97 – 127PolyampholyteSequence analysisAdd BLAST31
Compositional biasi584 – 601PolarSequence analysisAdd BLAST18
Compositional biasi630 – 652PolarSequence analysisAdd BLAST23
Compositional biasi808 – 822PolyampholyteSequence analysisAdd BLAST15
Compositional biasi840 – 855PolarSequence analysisAdd BLAST16
Compositional biasi891 – 938PolarSequence analysisAdd BLAST48
Compositional biasi1098 – 1119PolarSequence analysisAdd BLAST22
Compositional biasi1265 – 1285PolarSequence analysisAdd BLAST21

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1074 Eukaryota
ENOG410ZE3Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155938

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231986

KEGG Orthology (KO)

More...
KOi
K19871

Identification of Orthologs from Complete Genome Data

More...
OMAi
TKNKDAH

Database of Orthologous Groups

More...
OrthoDBi
244207at2759

TreeFam database of animal gene trees

More...
TreeFami
TF317003

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6P5E3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRKQAKPQ HFQSDPEVAS LPRRDGDTEK GQPSRPTKSK DAHVCGRCCA
60 70 80 90 100
EFFELSDLLL HKKSCTKNQL VLIVNESPAS PAKAFPPGPS LNDPDDQMKD
110 120 130 140 150
AANKADQEDC SDLSEPKGLD REESMEVEVP VATTTTTTTG GSGGSGGSTL
160 170 180 190 200
SGVTNITTPS CHSGSSTGTS AITTSLPQLG DLTTLGNFSV INSNVIIENL
210 220 230 240 250
QSTKVAVAQF SQEARCGGAS GGKLLISTLM EQLLALQQQQ IHQLQLIEQI
260 270 280 290 300
RHQILLLASQ SADLPAAPSI PSQGTLRTSA NPLTTLSSHL SQQLAVAAGL
310 320 330 340 350
AQSLASQSAN ISGVKQLPHV QLPQSSSGTS IVPPSGGTSP NMSIVTAAVP
360 370 380 390 400
TPSSEKVASN AGASHVSSPA VSASSSPAFA ISSLLSPASN PLLPQPTPAN
410 420 430 440 450
AVFPTPLPNI ATTAEDLNSL SALAQQRKSK PPNVTAFEAK STSDEAFFKH
460 470 480 490 500
KCRFCAKVFG SDSALQIHLR SHTGERPFKC NICGNRFSTK GNLKVHFQRH
510 520 530 540 550
KEKYPHIQMN PYPVPEHLDN VPTSTGIPYG MSIPPEKPVT SWLDTKPVLP
560 570 580 590 600
TLTTSVGLPL PPTLPSLTPF IKTEEPAPIP ISHSAASPQG SVKSDSGAPD
610 620 630 640 650
LATRNPSGVP EEVEGSAVPP FGGKGEESNM ASSAVPTAGN STLNSPVADG
660 670 680 690 700
GPGGTTFTNP LLPLMSEQFK AKFPFGGLLD SAQASETSKL QQLVENIDKK
710 720 730 740 750
ATDPNECIIC HRVLSCQSAL KMHYRTHTGE RPFKCKICGR AFTTKGNLKT
760 770 780 790 800
HYSVHRAMPP LRVQHSCPIC QKKFTNAVVL QQHIRMHMGG QIPNTPVPDN
810 820 830 840 850
YPESMESDTG SFDEKNFDDL DNFSDENMEE CPEGSIPDTP KSADASQDSL
860 870 880 890 900
SSSPLPLEMS SIAALENQMK MINAGLAEQL QASLKSVENG SMEGDVLTND
910 920 930 940 950
SSSVGGDMES QSAGSPAISE STSSMQALSP SNSTQEFHKS PGMEEKPQRV
960 970 980 990 1000
GPGEFANGLS PTPVNGGALD LTSSHAEKII KEDSLGILFP FRDRGKFKNT
1010 1020 1030 1040 1050
ACDICGKTFA CQSALDIHYR SHTKERPFIC TVCNRGFSTK GNLKQHMLTH
1060 1070 1080 1090 1100
QMRDLPSQLF EPSSNLGPNQ NSAVIPANSL SSLIKTEVNG FVHVSPQDSK
1110 1120 1130 1140 1150
DAPTSHVPQG PLSSSATSPV LLPALPRRTP KQHYCNTCGK TFSSSSALQI
1160 1170 1180 1190 1200
HERTHTGEKP FACTICGRAF TTKGNLKVHM GTHMWNSTPA RRGRRLSVDG
1210 1220 1230 1240 1250
PMTFLGGNPV KFPEMFQKDL AARSGSGDPS SFWNQYTAAL SNGLAMKANE
1260 1270 1280 1290 1300
ISVIQNGGIP PIPGSLGSGS SSPISGLTGN VEKLGNSEPS APLAGLEKMA
1310 1320
SSENGTNFRF TRFVEDSKEI VTS
Length:1,323
Mass (Da):140,237
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1F05278BC72E9E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9ER74SALL1_MOUSE
Sal-like protein 1
Sall1 Sal3
1,322Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC147558 Genomic DNA No translation available.
BC062937 mRNA Translation: AAH62937.1

NCBI Reference Sequences

More...
RefSeqi
NP_067365.2, NM_021390.3
XP_006531301.1, XM_006531238.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000034090; ENSMUSP00000034090; ENSMUSG00000031665

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
58198

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:58198

UCSC genome browser

More...
UCSCi
uc009msa.3 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC147558 Genomic DNA No translation available.
BC062937 mRNA Translation: AAH62937.1
RefSeqiNP_067365.2, NM_021390.3
XP_006531301.1, XM_006531238.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034090; ENSMUSP00000034090; ENSMUSG00000031665
GeneIDi58198
KEGGimmu:58198
UCSCiuc009msa.3 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6299
MGIiMGI:1889585 Sall1

Phylogenomic databases

eggNOGiKOG1074 Eukaryota
ENOG410ZE3Z LUCA
GeneTreeiENSGT00940000155938
HOGENOMiHOG000231986
KOiK19871
OMAiTKNKDAH
OrthoDBi244207at2759
TreeFamiTF317003

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031665 Expressed in 318 organ(s), highest expression level in pineal body

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6P5E3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P5E3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 31, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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