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UniProtKB - Q6P5D8 (SMHD1_MOUSE)

Entry version 124 (07 Apr 2021)
Sequence version 2 (29 Apr 2008)
Previous versions | rss
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Protein

Structural maintenance of chromosomes flexible hinge domain-containing protein 1

Gene

Smchd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (PubMed:26091879, PubMed:29887375). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (PubMed:23754746, PubMed:23819640, PubMed:26391951, PubMed:28587678, PubMed:29887375). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:18425126, PubMed:22841499, PubMed:26391951, PubMed:29887375). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (PubMed:29887375). Required to facilitate Xist RNA spreading (PubMed:29887375). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23754746, PubMed:23819640, PubMed:28587678). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:26391951, PubMed:27059856). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (By similarity). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (By similarity). Required during preimplantation development, probably acts by regulating chromatin architecture (PubMed:29900695).By similarity10 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Hydrolase, Repressor
Biological processDNA damage, DNA repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Structural maintenance of chromosomes flexible hinge domain-containing protein 11 Publication (EC:3.6.1.-2 Publications)
Short name:
SMC hinge domain-containing protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Smchd11 PublicationImported
Synonyms:Kiaa06501 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1921605, Smchd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Defects in Smchd1 are the cause of the MommeD1 (modifier of murine metastable epialleles) phenotype, a semi-dominant suppressor of variegation (PubMed:18425126, PubMed:21553025). Mice display female-specific mid-gestation lethality and hypomethylation of the X-linked gene Hprt1, due to defects in X inactivation (PubMed:18425126, PubMed:21553025, PubMed:23754746). Mice do not show defects on telomeres length (PubMed:18425126, PubMed:21553025). Male mice are less affected, with some surviving to become fertile adults on the FVB/n genetic background (PubMed:18425126). On other genetic backgrounds, all males lacking die perinatally (PubMed:18425126). A subset of clustered autosomal loci display hypomethylation and derepression (PubMed:23754746, PubMed:23819640, PubMed:28587678).5 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi147E → A: Abolishes ATPase activity. 1 Publication1
Mutagenesisi1867R → G: Abolishes ability to bind DNA without altering the ability of the SMC hinge domain to mediate homodimerization. 2 Publications1
Mutagenesisi1872 – 1876GKFGG → AKFAA: Abolishes homodimerization. 1 Publication5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003321452 – 2007Structural maintenance of chromosomes flexible hinge domain-containing protein 1Add BLAST2006

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei833PhosphoserineCombined sources1
Modified residuei1350N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1375Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1500PhosphothreonineBy similarity1
Modified residuei1803N6-succinyllysineCombined sources1
Modified residuei1975PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated with SUMO1.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6P5D8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6P5D8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6P5D8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6P5D8

PeptideAtlas

More...PeptideAtlasi		Q6P5D8

PRoteomics IDEntifications database

More...PRIDEi		Q6P5D8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		261270

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6P5D8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6P5D8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

During embryogenesis, specifically expressed in immature olfactory sensory neurons.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the nasal placodes and optic vesicles at day 9.5 dpc and in the nasal epithelium at 12.5 dpc (PubMed:28067911). Expressed in the nasal cavity in 14.5 dpc animals (PubMed:28067911).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is repressed by CDX2.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000024054, Expressed in pes and 264 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6P5D8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6P5D8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; homodimerizes via its SMC hinge domain (PubMed:26391951, PubMed:26733688, PubMed:27059856).

Interacts with LRIF1 (PubMed:26391951).

3 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		216686, 24 interactors

Protein interaction database and analysis system

More...IntActi		Q6P5D8, 21 interactors

Molecular INTeraction database

More...MINTi		Q6P5D8

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000121835

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6P5D8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12007
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6P5D8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1721 – 1848SMC hingeSequence analysisAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni111 – 702ATPase activity domain1 PublicationAdd BLAST592

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Atypical member of the structural maintenance of chromosomes (SMC) protein family (PubMed:26733688, PubMed:27059856). Like other members of the SMC family, has ATPase activity, which is probably necessary for its engagement with chromatin, and a SMC hinge domain (PubMed:26733688, PubMed:27059856). However, the SMC hinge domain adopts an unconventional homodimeric arrangement augmented by an intermolecular coiled coil formed between the two monomers. This suggests that protein may assemble as a head-to-head parallel dimer without adopting a hairpin shape at the hinge domain, unlike the dimeric arrangement conventionally found in other members of the SMC protein family (PubMed:26733688). The SMC hinge domain binds DNA and RNA (PubMed:26091879).3 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMC family. Highly divergent.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QREW, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006950

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002288_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P5D8

Identification of Orthologs from Complete Genome Data

More...OMAi		WPELKEC

Database of Orthologous Groups

More...OrthoDBi		34310at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6P5D8

TreeFam database of animal gene trees

More...TreeFami		TF329426

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036890, HATPase_C_sf
IPR010935, SMC_hinge
IPR036277, SMC_hinge_sf
IPR038892, SMCHD1

The PANTHER Classification System

More...PANTHERi		PTHR22640, PTHR22640, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06470, SMC_hinge, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00968, SMC_hinge, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55874, SSF55874, 1 hit
SSF75553, SSF75553, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6P5D8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEGASDPA GLSEGSGRDG AVDGCRTVYL FDRRGKDSEL GDRALQVSEH 
        60         70         80         90        100
ADYAGFRASV CQTIGISSEE KFVITTTSRK EITCNNFDHT VKDGVTLYLL 
       110        120        130        140        150
QSVDQSLLTA TKERIDFLPH YDTLVKSGMY EYYASEGQNP LPFALAELID 
       160        170        180        190        200
NSLSATSRNN GVRRIQIKLL FDETQGKPAV AVVDNGRGMT SKQLNNWAVY 
       210        220        230        240        250
RLSKFTRQGD FESDHSGYVR PLPVPRSLNS DISYFGVGGK QAVFFVGQSA 
       260        270        280        290        300
RMISKPIDSK DVHELVLSKE DFEKKEKNKE AIYSGYIRNR KPADSAHITN 
       310        320        330        340        350
DDERFLHNLI EEEKEKDSFT AVVITGVQPE HIQYLKNYLH LWTRQLTHIY 
       360        370        380        390        400
HYYIHGPKGN EISTAKAIGP FNNIDIEISL FEKGKTPKII NLREIQDDMQ 
       410        420        430        440        450
TLYINTASDS FEFKAHVEGD GVVEGVIRYH PFLYDRETFP DDPCFPSKLK 
       460        470        480        490        500
DEDDDDDCFI SEKAARGKRP IFECFWNGRL IPYTSVGDFD WCAPPKKRGL 
       510        520        530        540        550
VPIECFNRIS GALFTNDKFQ VSTNKLTFMD LELKLKDKNT LFTRILNGQE 
       560        570        580        590        600
QRMKIDREFA LWLKDCHEKH DKQIKFTLFK GIITRPDLPT KKQGPWATFS 
       610        620        630        640        650
AIEWDGKIYK AGQLVKTIKT LPLCYGSIVR FFLHGDHDGE VYATGGEVQI 
       660        670        680        690        700
AMEPQALYDE IKTVPIAKLD RTVAEKTIRK YVEDEMARLP DRLSVTWPEG 
       710        720        730        740        750
DELLPNEVRP AGTPIGALRI EILNKKGEAM QKLPGTSHGG SKKLLVELKV 
       760        770        780        790        800
ILHTSSGNKE IISHISQHGG KWPYWFKKME NIQKLGNYTL KLQVVLNESN 
       810        820        830        840        850
ADTYAGRSLP SKVIKFSVKE GKPEKFSFGL LDSPFRVGVP FNIPLELQDE 
       860        870        880        890        900
FGHTTQLLSD IEPVLEASGL SLHYEGITKG PNCVIQGVVA KGPVNSCQGK 
       910        920        930        940        950
NFNLKVILPG LKEDSQILKI RLLPGPPHQL KVKPDSEVLV IENGTAFPFQ 
       960        970        980        990       1000
VEVVDESDNI TAQPKLIVHC KFLGAPNLPV YTVDCSSSGT SILTGSPIQV 
      1010       1020       1030       1040       1050
QNIKKDQKTL TARIEIPSCK DVSPVEKTIK LLPSSHAACL QIFSVEEQKA 
      1060       1070       1080       1090       1100
IQIKHQDEVT WVAGDVIRNL IFQMYDEGER EINITPSLAE KIKVNWTPEV 
      1110       1120       1130       1140       1150
NKEHLVQGLL PDVQVPTSVK DVRYCHVSFQ DDHVCLESAF TVRPLPDDPK 
      1160       1170       1180       1190       1200
HLKCELKGGK TVQMGQELQG EIVVIIADQY GNQISSFSPD SLSTLSITGD 
      1210       1220       1230       1240       1250
GLDSSNLKIT LEANSQSVSV QGIRFTPGPP GPKDLCFTWR EFSDFLRVQL 
      1260       1270       1280       1290       1300
VSGPPTKLLL MDWPELKESI PVINGRQLEN PLIVQLCDQW DNPALVPNVK 
      1310       1320       1330       1340       1350
ICLIKASSLR LLPSNQQHKT DDKGRANLGV FTVCAPRGEH TVQVKGVYNK 
      1360       1370       1380       1390       1400
STIEGPTIKL TILPDPEKPI RLNVKYDQDA SFIAGDIFTD FMVSVISESG 
      1410       1420       1430       1440       1450
SVIKNINPTR ISMKMWKLSS GMSRPPANAE TFSCNKIKGN DKEDGCFYFR 
      1460       1470       1480       1490       1500
EKTIPNKVGA YCIQFDFMID KTNILSSQQV IVDVLPNQPM KLVPDSQPAT 
      1510       1520       1530       1540       1550
PAVSNVRSIA SRTLVKDLRL SITDNYGNHT GMDLVGTVVA TIKGFNEEDT 
      1560       1570       1580       1590       1600
DTPLFIGKVR TLEFPFVKGS AEITTLVLAE NSPGRDSTEY FIIFEPRLST 
      1610       1620       1630       1640       1650
VSGTLESYSL PFMFYNDVKK QQQMAALTKE KDELSKSITM YRSLFDANKQ 
      1660       1670       1680       1690       1700
LVDEMKCQAE EAKLKETQLR NELKAYNIDI PATQQTTHIE ALLEKKITEQ 
      1710       1720       1730       1740       1750
NELKKRPRRL CTLPNYTKRS GDILGKIAHL AQIEDDRAAM VISWHLASDM 
      1760       1770       1780       1790       1800
DCVVTLTTDA ARAIYDETQG RQQVLPLDSI YRKTLPDWKR PLPHFRNGKL 
      1810       1820       1830       1840       1850
HFKPFGNPVF ARDLLTFPDN IEHCETVFGM LLGDTIILDN LDAANHYRKE 
      1860       1870       1880       1890       1900
VVKITHCPTL LTRDGDRIRS NGKFGGLQNK APPMDKLRGM VFGAPVPKQC 
      1910       1920       1930       1940       1950
VVLGKQIDLI QQYRTALYRL SSVNEDLDNQ LQYLHTPDMK KKKQELDEQE 
      1960       1970       1980       1990       2000
KSLKRIEQKL GMTPVRRCNE SLCHSPKIEV TECPIPTKRM RRESTRQNRR 

PKGDVPN
Length:2,007
Mass (Da):225,648
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A41FC47C54B5415
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B2W494A0A3B2W494_MOUSE
Structural maintenance of chromosom...
Smchd1
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WD81A0A3B2WD81_MOUSE
Structural maintenance of chromosom...
Smchd1
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH44905 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB30222 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1120K → E in BAB30222 (PubMed:19468303).Curated1
Sequence conflicti1611P → S in BAC97991 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC107664 Genomic DNA No translation available.
AC126942 Genomic DNA No translation available.
AK016419 mRNA Translation: BAB30222.1 Frameshift.
AK078494 mRNA Translation: BAC37307.1
BC044905 mRNA Translation: AAH44905.1 Different initiation.
BC058205 mRNA Translation: AAH58205.1
BC058618 mRNA Translation: AAH58618.1
BC062946 mRNA Translation: AAH62946.1
AK129181 mRNA Translation: BAC97991.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS28958.2

NCBI Reference Sequences

More...RefSeqi		NP_083163.3, NM_028887.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000127430; ENSMUSP00000121835; ENSMUSG00000024054

Database of genes from NCBI RefSeq genomes

More...GeneIDi		74355

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:74355

UCSC genome browser

More...UCSCi		uc008dmh.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107664 Genomic DNA No translation available.
AC126942 Genomic DNA No translation available.
AK016419 mRNA Translation: BAB30222.1 Frameshift.
AK078494 mRNA Translation: BAC37307.1
BC044905 mRNA Translation: AAH44905.1 Different initiation.
BC058205 mRNA Translation: AAH58205.1
BC058618 mRNA Translation: AAH58618.1
BC062946 mRNA Translation: AAH62946.1
AK129181 mRNA Translation: BAC97991.1
CCDSiCCDS28958.2
RefSeqiNP_083163.3, NM_028887.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6N64X-ray3.30A/B/C/D/E/F1683-1899[»]
SMRiQ6P5D8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi216686, 24 interactors
IntActiQ6P5D8, 21 interactors
MINTiQ6P5D8
STRINGi10090.ENSMUSP00000121835

PTM databases

iPTMnetiQ6P5D8
PhosphoSitePlusiQ6P5D8

Proteomic databases

EPDiQ6P5D8
jPOSTiQ6P5D8
MaxQBiQ6P5D8
PaxDbiQ6P5D8
PeptideAtlasiQ6P5D8
PRIDEiQ6P5D8
ProteomicsDBi261270

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49899, 74 antibodies

Genome annotation databases

EnsembliENSMUST00000127430; ENSMUSP00000121835; ENSMUSG00000024054
GeneIDi74355
KEGGimmu:74355
UCSCiuc008dmh.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23347
MGIiMGI:1921605, Smchd1

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiENOG502QREW, Eukaryota
GeneTreeiENSGT00390000006950
HOGENOMiCLU_002288_1_0_1
InParanoidiQ6P5D8
OMAiWPELKEC
OrthoDBi34310at2759
PhylomeDBiQ6P5D8
TreeFamiTF329426

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		74355, 0 hits in 47 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Smchd1, mouse

Protein Ontology

More...PROi		PR:Q6P5D8
RNActiQ6P5D8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000024054, Expressed in pes and 264 other tissues
ExpressionAtlasiQ6P5D8, baseline and differential
GenevisibleiQ6P5D8, MM

Family and domain databases

Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR036890, HATPase_C_sf
IPR010935, SMC_hinge
IPR036277, SMC_hinge_sf
IPR038892, SMCHD1
PANTHERiPTHR22640, PTHR22640, 1 hit
PfamiView protein in Pfam
PF06470, SMC_hinge, 1 hit
SMARTiView protein in SMART
SM00968, SMC_hinge, 1 hit
SUPFAMiSSF55874, SSF55874, 1 hit
SSF75553, SSF75553, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMHD1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P5D8
Secondary accession number(s): Q6PDM8
, Q6PE93, Q6ZQ78, Q811H3, Q8BP09, Q9D4M7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 7, 2021
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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