Cep135

Functionⁱ

Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity).By similarity

GO - Molecular functionⁱ

protein C-terminus binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

centriole-centriole cohesion Source: MGI
centriole replication Source: MGI
positive regulation of establishment of protein localization Source: UniProtKB
positive regulation of non-motile cilium assembly Source: UniProtKB

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition R-MMU-380259 Loss of Nlp from mitotic centrosomes R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes R-MMU-380320 Recruitment of NuMA to mitotic centrosomes R-MMU-5620912 Anchoring of the basal body to the plasma membrane R-MMU-8854518 AURKA Activation by TPX2

Reactomeⁱ

R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Centrosomal protein of 135 kDa Short name: Cep135 Alternative name(s): Centrosomal protein 4
Gene namesⁱ	Name:Cep135 Synonyms:Cep4, Kiaa0635
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:2681869 Cep135

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000089492	1 – 1140	Centrosomal protein of 135 kDaAdd BLAST		1140

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	439	PhosphoserineBy similarity	1
Modified residueⁱ	688	PhosphoserineBy similarity	1
Modified residueⁱ	1121	PhosphothreonineBy similarity	1
Modified residueⁱ	1130	PhosphoserineCombined sources	1
Modified residueⁱ	1134	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q6P5D4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P5D4
PaxDbⁱ	Q6P5D4
PRIDEⁱ	Q6P5D4

PTM databases

iPTMnetⁱ	Q6P5D4
PhosphoSitePlusⁱ	Q6P5D4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000036403 Expressed in 110 organ(s), highest expression level in secondary oocyte
CleanExⁱ	MM_CEP135
Genevisibleⁱ	Q6P5D4 MM

Interactionⁱ

Subunit structureⁱ

Interacts with CEP250 (By similarity). Interacts with DCTN2.By similarity1 Publication

GO - Molecular functionⁱ

protein C-terminus binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	238025, 65 interactors
IntActⁱ	Q6P5D4, 68 interactors
STRINGⁱ	10090.ENSMUSP00000038674

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6P5D4
SMRⁱ	Q6P5D4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	125 – 153	Sequence analysisAdd BLAST	29
Coiled coilⁱ	194 – 420	Sequence analysisAdd BLAST	227
Coiled coilⁱ	447 – 647	Sequence analysisAdd BLAST	201
Coiled coilⁱ	674 – 1117	Sequence analysisAdd BLAST	444

Sequence similaritiesⁱ

Belongs to the CEP135/TSGA10 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IGCA Eukaryota ENOG410XRIP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063949
HOGENOMⁱ	HOG000060077
HOVERGENⁱ	HBG081318
InParanoidⁱ	Q6P5D4
KEGG Orthology (KO) More...KOⁱ	K16461
OMAⁱ	QHIIQRR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G032W
PhylomeDBⁱ	Q6P5D4
TreeFamⁱ	TF326518

Family and domain databases

InterProⁱ	View protein in InterPro IPR026732 Cep135
PANTHERⁱ	PTHR23159:SF18 PTHR23159:SF18, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6P5D4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTTAAERKYI NIRKRLDQLG YRQTLSVDSL PLVEKLFSDL VHTTESLRQC 
        60         70         80         90        100
RLSSGKAEKE SANLDFVLEP YKLENTRLNK ENNELYLELM KLRECSDKHI 
       110        120        130        140        150
KDLKTTLKKC SRETADLKFL NNQYVHKVKV LEKESKAKDE KIQQLQEKNL 
       160        170        180        190        200
RAVVQTPGGR KRNIAFRRQR MQIDEPAPPS EVSAYPVPQP EDPYIADLLQ 
       210        220        230        240        250
VADNRIQELQ EEVQQLQEKL AQMEKGVLDY SKQIELRERE IQRLSLALDG 
       260        270        280        290        300
GCSPDVLSLE TRNKTNEKLI AHLNVQVDFL QQANKELEKH IQELMETKET 
       310        320        330        340        350
VTTEVVNLSN RNEKLCQELT EIDQLAQRLE RHKEQVLETA DKELGEAKKE 
       360        370        380        390        400
IKRNLCEMRN LEEKMSKLQW ELDLSHKEKE RLNSELLLKS DLETVVHQLE 
       410        420        430        440        450
QEKQRLSKKL QSFAVTEREL TLEVERMRLE HGIKRRDKSP SRLDTFLKGI 
       460        470        480        490        500
EEERDYYKKE LEKLQHLIQR RSCAINYSAR EKPPVVKCSE KGDCSTDVHL 
       510        520        530        540        550
ITRERDELQR MLERFEKYME DIQSNVKLLT AERDKLNVLY KEAKEELSTL 
       560        570        580        590        600
RKESTNSTSP NHLVSCVEKE KERALSELRR ITAEKEALRE KLKNIQERNA 
       610        620        630        640        650
VGKSDLEKTI EHLTYINHQL ENEKYELQSK MLMMKETVES LENKSKLQAQ 
       660        670        680        690        700
KLSHVTGDSS HQKTEMTSLR IVSEQLQRSL DDCQHRLSIK RGELESAQEQ 
       710        720        730        740        750
IKMLEQKLEN LSHRMTVQSE ETHAMKKTIG VMDKEKDFLQ ETVDEKTEKI 
       760        770        780        790        800
ANLQESLLSK EKVIAQLKVT VAEYETSLNQ LQETLTTRDR EINSLRRQLD 
       810        820        830        840        850
ASHKELDDVG KSREISFKEN RRLQDDLATM ARENQEISLE LEAAVQEKEE 
       860        870        880        890        900
MKSRVHKYIT EVSRWESLMA AKEKENKDLL DRFQMLHSRA EDWEVKAQQA 
       910        920        930        940        950
EGENSSVRLE LLSIDTERRH LRERVDLLEK EIQEHINAHH AYESQISSMA 
       960        970        980        990       1000
KAMSQLEEEL RRHESEKATM LGDVSSLREL CIKLDSGKDV MTQQLNSKSL 
      1010       1020       1030       1040       1050
ELERAVAELE NVKSESELLK KQLTNERQTI KNLESLLATN RDKEFQSHLT 
      1060       1070       1080       1090       1100
SHEKDTEIQL LKEKLNLSES KLTTQSRETS MLRTKVTQLQ TDYDNLKRQM 
      1110       1120       1130       1140
SNEKYERERA IQEMRRLGLP TSPLSSTLKS PVQTPDHINA

Length:1,140

Mass (Da):133,345

Last modified:July 5, 2004 - v1

Checksum:ⁱF04798C298E6C4A9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC062951 mRNA Translation: AAH62951.1 AK172988 mRNA Translation: BAD32266.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19365.1
NCBI Reference Sequences More...RefSeqⁱ	NP_950197.1, NM_199032.2 XP_006535086.1, XM_006535023.3
UniGeneⁱ	Mm.332452

Genome annotation databases

Ensemblⁱ	ENSMUST00000049060; ENSMUSP00000038674; ENSMUSG00000036403 ENSMUST00000121979; ENSMUSP00000112602; ENSMUSG00000036403
GeneIDⁱ	381644
KEGGⁱ	mmu:381644
UCSC genome browser More...UCSCⁱ	uc008xvc.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6P5D4	Centrosomal protein 135		RAT		1140	UniRef90_Q6P5D4
Uncharacterized protein		MOUSE		1031
UPI000A30E324		MUSPA		1140
UPI000A31B362		MUSCR		1140
UPI0003D71300		MOUSE		783
+4

Protein	Similar proteins		Species	Score	Length	Source
Q6P5D4	Centrosomal protein of 135 kDa	)	HUMAN		1140	UniRef50_Q66GS9
Centrosomal protein of 135 kDa		DANRE		1164
Centrosomal protein of 135 kDa		PTEAL		1166
centrosomal protein of 135 kDa isoform X1		TURTR		1148
centrosomal protein of 135 kDa isoform X1		PHYCD		1148
+480

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC062951 mRNA Translation: AAH62951.1 AK172988 mRNA Translation: BAD32266.1
CCDSⁱ	CCDS19365.1
RefSeqⁱ	NP_950197.1, NM_199032.2 XP_006535086.1, XM_006535023.3
UniGeneⁱ	Mm.332452

3D structure databases

ProteinModelPortalⁱ	Q6P5D4
SMRⁱ	Q6P5D4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	238025, 65 interactors
IntActⁱ	Q6P5D4, 68 interactors
STRINGⁱ	10090.ENSMUSP00000038674

PTM databases

iPTMnetⁱ	Q6P5D4
PhosphoSitePlusⁱ	Q6P5D4

Proteomic databases

EPDⁱ	Q6P5D4
MaxQBⁱ	Q6P5D4
PaxDbⁱ	Q6P5D4
PRIDEⁱ	Q6P5D4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000049060; ENSMUSP00000038674; ENSMUSG00000036403 ENSMUST00000121979; ENSMUSP00000112602; ENSMUSG00000036403
GeneIDⁱ	381644
KEGGⁱ	mmu:381644
UCSCⁱ	uc008xvc.1 mouse

Organism-specific databases

CTDⁱ	9662
MGIⁱ	MGI:2681869 Cep135
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGCA Eukaryota ENOG410XRIP LUCA
GeneTreeⁱ	ENSGT00530000063949
HOGENOMⁱ	HOG000060077
HOVERGENⁱ	HBG081318
InParanoidⁱ	Q6P5D4
KOⁱ	K16461
OMAⁱ	QHIIQRR
OrthoDBⁱ	EOG091G032W
PhylomeDBⁱ	Q6P5D4
TreeFamⁱ	TF326518

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition R-MMU-380259 Loss of Nlp from mitotic centrosomes R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes R-MMU-380320 Recruitment of NuMA to mitotic centrosomes R-MMU-5620912 Anchoring of the basal body to the plasma membrane R-MMU-8854518 AURKA Activation by TPX2

Reactomeⁱ

R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRSⁱ	Cep135 mouse
Protein Ontology More...PROⁱ	PR:Q6P5D4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000036403 Expressed in 110 organ(s), highest expression level in secondary oocyte
CleanExⁱ	MM_CEP135
Genevisibleⁱ	Q6P5D4 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR026732 Cep135
PANTHERⁱ	PTHR23159:SF18 PTHR23159:SF18, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP135_MOUSE
Accessionⁱ	Q6P5D4Primary (citable) accession number: Q6P5D4 Secondary accession number(s): Q6A030
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6P5D4 (CP135_MOUSE)

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Centrosomal protein of 135 kDa

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ