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Protein

Centrosomal protein of 135 kDa

Gene

Cep135

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 135 kDa
Short name:
Cep135
Alternative name(s):
Centrosomal protein 4
Gene namesi
Name:Cep135
Synonyms:Cep4, Kiaa0635
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2681869 Cep135

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894921 – 1140Centrosomal protein of 135 kDaAdd BLAST1140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei439PhosphoserineBy similarity1
Modified residuei688PhosphoserineBy similarity1
Modified residuei1121PhosphothreonineBy similarity1
Modified residuei1130PhosphoserineCombined sources1
Modified residuei1134PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P5D4
MaxQBiQ6P5D4
PaxDbiQ6P5D4
PRIDEiQ6P5D4

PTM databases

iPTMnetiQ6P5D4
PhosphoSitePlusiQ6P5D4

Expressioni

Gene expression databases

BgeeiENSMUSG00000036403 Expressed in 110 organ(s), highest expression level in secondary oocyte
CleanExiMM_CEP135
GenevisibleiQ6P5D4 MM

Interactioni

Subunit structurei

Interacts with CEP250 (By similarity). Interacts with DCTN2.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi238025, 65 interactors
IntActiQ6P5D4, 68 interactors
STRINGi10090.ENSMUSP00000038674

Structurei

3D structure databases

ProteinModelPortaliQ6P5D4
SMRiQ6P5D4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili125 – 153Sequence analysisAdd BLAST29
Coiled coili194 – 420Sequence analysisAdd BLAST227
Coiled coili447 – 647Sequence analysisAdd BLAST201
Coiled coili674 – 1117Sequence analysisAdd BLAST444

Sequence similaritiesi

Belongs to the CEP135/TSGA10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGCA Eukaryota
ENOG410XRIP LUCA
GeneTreeiENSGT00530000063949
HOGENOMiHOG000060077
HOVERGENiHBG081318
InParanoidiQ6P5D4
KOiK16461
OMAiQHIIQRR
OrthoDBiEOG091G032W
PhylomeDBiQ6P5D4
TreeFamiTF326518

Family and domain databases

InterProiView protein in InterPro
IPR026732 Cep135
PANTHERiPTHR23159:SF18 PTHR23159:SF18, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P5D4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTAAERKYI NIRKRLDQLG YRQTLSVDSL PLVEKLFSDL VHTTESLRQC
60 70 80 90 100
RLSSGKAEKE SANLDFVLEP YKLENTRLNK ENNELYLELM KLRECSDKHI
110 120 130 140 150
KDLKTTLKKC SRETADLKFL NNQYVHKVKV LEKESKAKDE KIQQLQEKNL
160 170 180 190 200
RAVVQTPGGR KRNIAFRRQR MQIDEPAPPS EVSAYPVPQP EDPYIADLLQ
210 220 230 240 250
VADNRIQELQ EEVQQLQEKL AQMEKGVLDY SKQIELRERE IQRLSLALDG
260 270 280 290 300
GCSPDVLSLE TRNKTNEKLI AHLNVQVDFL QQANKELEKH IQELMETKET
310 320 330 340 350
VTTEVVNLSN RNEKLCQELT EIDQLAQRLE RHKEQVLETA DKELGEAKKE
360 370 380 390 400
IKRNLCEMRN LEEKMSKLQW ELDLSHKEKE RLNSELLLKS DLETVVHQLE
410 420 430 440 450
QEKQRLSKKL QSFAVTEREL TLEVERMRLE HGIKRRDKSP SRLDTFLKGI
460 470 480 490 500
EEERDYYKKE LEKLQHLIQR RSCAINYSAR EKPPVVKCSE KGDCSTDVHL
510 520 530 540 550
ITRERDELQR MLERFEKYME DIQSNVKLLT AERDKLNVLY KEAKEELSTL
560 570 580 590 600
RKESTNSTSP NHLVSCVEKE KERALSELRR ITAEKEALRE KLKNIQERNA
610 620 630 640 650
VGKSDLEKTI EHLTYINHQL ENEKYELQSK MLMMKETVES LENKSKLQAQ
660 670 680 690 700
KLSHVTGDSS HQKTEMTSLR IVSEQLQRSL DDCQHRLSIK RGELESAQEQ
710 720 730 740 750
IKMLEQKLEN LSHRMTVQSE ETHAMKKTIG VMDKEKDFLQ ETVDEKTEKI
760 770 780 790 800
ANLQESLLSK EKVIAQLKVT VAEYETSLNQ LQETLTTRDR EINSLRRQLD
810 820 830 840 850
ASHKELDDVG KSREISFKEN RRLQDDLATM ARENQEISLE LEAAVQEKEE
860 870 880 890 900
MKSRVHKYIT EVSRWESLMA AKEKENKDLL DRFQMLHSRA EDWEVKAQQA
910 920 930 940 950
EGENSSVRLE LLSIDTERRH LRERVDLLEK EIQEHINAHH AYESQISSMA
960 970 980 990 1000
KAMSQLEEEL RRHESEKATM LGDVSSLREL CIKLDSGKDV MTQQLNSKSL
1010 1020 1030 1040 1050
ELERAVAELE NVKSESELLK KQLTNERQTI KNLESLLATN RDKEFQSHLT
1060 1070 1080 1090 1100
SHEKDTEIQL LKEKLNLSES KLTTQSRETS MLRTKVTQLQ TDYDNLKRQM
1110 1120 1130 1140
SNEKYERERA IQEMRRLGLP TSPLSSTLKS PVQTPDHINA
Length:1,140
Mass (Da):133,345
Last modified:July 5, 2004 - v1
Checksum:iF04798C298E6C4A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062951 mRNA Translation: AAH62951.1
AK172988 mRNA Translation: BAD32266.1
CCDSiCCDS19365.1
RefSeqiNP_950197.1, NM_199032.2
XP_006535086.1, XM_006535023.3
UniGeneiMm.332452

Genome annotation databases

EnsembliENSMUST00000049060; ENSMUSP00000038674; ENSMUSG00000036403
ENSMUST00000121979; ENSMUSP00000112602; ENSMUSG00000036403
GeneIDi381644
KEGGimmu:381644
UCSCiuc008xvc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062951 mRNA Translation: AAH62951.1
AK172988 mRNA Translation: BAD32266.1
CCDSiCCDS19365.1
RefSeqiNP_950197.1, NM_199032.2
XP_006535086.1, XM_006535023.3
UniGeneiMm.332452

3D structure databases

ProteinModelPortaliQ6P5D4
SMRiQ6P5D4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi238025, 65 interactors
IntActiQ6P5D4, 68 interactors
STRINGi10090.ENSMUSP00000038674

PTM databases

iPTMnetiQ6P5D4
PhosphoSitePlusiQ6P5D4

Proteomic databases

EPDiQ6P5D4
MaxQBiQ6P5D4
PaxDbiQ6P5D4
PRIDEiQ6P5D4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049060; ENSMUSP00000038674; ENSMUSG00000036403
ENSMUST00000121979; ENSMUSP00000112602; ENSMUSG00000036403
GeneIDi381644
KEGGimmu:381644
UCSCiuc008xvc.1 mouse

Organism-specific databases

CTDi9662
MGIiMGI:2681869 Cep135
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGCA Eukaryota
ENOG410XRIP LUCA
GeneTreeiENSGT00530000063949
HOGENOMiHOG000060077
HOVERGENiHBG081318
InParanoidiQ6P5D4
KOiK16461
OMAiQHIIQRR
OrthoDBiEOG091G032W
PhylomeDBiQ6P5D4
TreeFamiTF326518

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRSiCep135 mouse
PROiPR:Q6P5D4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036403 Expressed in 110 organ(s), highest expression level in secondary oocyte
CleanExiMM_CEP135
GenevisibleiQ6P5D4 MM

Family and domain databases

InterProiView protein in InterPro
IPR026732 Cep135
PANTHERiPTHR23159:SF18 PTHR23159:SF18, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP135_MOUSE
AccessioniPrimary (citable) accession number: Q6P5D4
Secondary accession number(s): Q6A030
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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