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Protein

Zinc finger protein 728

Gene

Znf728

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 103C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri109 – 131C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri137 – 159C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 187C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 607C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri641 – 663C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri669 – 691C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri697 – 719C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri725 – 747C2H2-type 23; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 728
Gene namesi
Name:Znf728
Synonyms:Zfp458
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:3040691 Zfp458

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004210241 – 752Zinc finger protein 728Add BLAST752

Proteomic databases

PaxDbiQ6P5C7
PRIDEiQ6P5C7

PTM databases

PhosphoSitePlusiQ6P5C7

Expressioni

Gene expression databases

BgeeiENSMUSG00000055480 Expressed in 177 organ(s), highest expression level in striatum
ExpressionAtlasiQ6P5C7 baseline and differential
GenevisibleiQ6P5C7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047222

Structurei

3D structure databases

ProteinModelPortaliQ6P5C7
SMRiQ6P5C7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 76KRABPROSITE-ProRule annotationAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri81 – 103C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri109 – 131C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri137 – 159C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 187C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 607C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri641 – 663C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri669 – 691C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri697 – 719C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri725 – 747C2H2-type 23; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6P5C7
KOiK09228
OrthoDBiEOG091G02KC
PhylomeDBiQ6P5C7
TreeFamiTF343410

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 15 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 21 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 20 hits
PS50157 ZINC_FINGER_C2H2_2, 23 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6P5C7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDMLSFWDV AIYFSAEEWE CLGPAQWKLY RDVMLENYSN LVFLGLASSK
60 70 80 90 100
PYLVTFLEQI QEPSDVKRQA AITVHPGGKC YTCKECGKGF EHKKVYQNHR
110 120 130 140 150
RIHLRVKSYK CEECGKSFRF PSLLSAHKRN HTGQKPYNCE ICSKAFHVPS
160 170 180 190 200
LLSVHKRIHR VQKPYKSEDY GKTLHCPSLL SQHKIVHTGE KPYQCEDLGK
210 220 230 240 250
AFRYPSRLSN HKKIHTGEKP HKCEVCGKAF DYPSRLSNHK RIHTGEKPYK
260 270 280 290 300
CEVCGKAFHD PSKLSQHKII HTGEKPYKCE VCGKTFHYPS ILSKHKIIHT
310 320 330 340 350
KENLCKCDIC GKAFHYPLLL SQHKIVHTGE KPYKCEDCGK AFYYPSRLSR
360 370 380 390 400
HKKIHTGEKP YKCEVCGKAF YYLSILSKHM IVHTEENPYK CEVCGKAFDY
410 420 430 440 450
PSRLSNHKKI HTEDKPHKCE VCGNAFCFSS SLRKHKIIHT GEKPYKCDIC
460 470 480 490 500
GKAFGSPSRL SKHNKIHTED KPYKCEVCGK AFHFPSLLLV HKRIHTGEKP
510 520 530 540 550
YKCEVCGKAF YCLSTLSVHK RIHTGEYAYK CEVCGKAFHC LSTLSVHKRI
560 570 580 590 600
HTQEKPYKCE VCGQAFHASS KLSHHKRIHS GEKPHKCEIC GKSFYYPSRL
610 620 630 640 650
SKHKVIHTGE KPYHSQASGK TLDYPSRHSK PKTIKTGEKP NKCEICGKAF
660 670 680 690 700
SFPSLLSIHK RIHIGEKPYN CEVCGKAFRN PSRLSNHKKI HTGEKPYKCE
710 720 730 740 750
ICGKAFDYPS LLSKHKIIHT GEKPYHSEVC GKAFSYSSRI SKDKKICTGE

KP
Length:752
Mass (Da):86,422
Last modified:July 5, 2004 - v1
Checksum:i089C07C95BE43A3A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7M6X6Q7M6X6_MOUSE
Zinc finger protein 458
Zfp458
749Annotation score:
A0A286YDU6A0A286YDU6_MOUSE
Zinc finger protein 458
Zfp458
205Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159264 Genomic DNA No translation available.
AC163667 Genomic DNA No translation available.
BC062958 mRNA Translation: AAH62958.1
CCDSiCCDS36710.1
RefSeqiNP_001001152.1, NM_001001152.2
UniGeneiMm.306358

Genome annotation databases

EnsembliENSMUST00000045969; ENSMUSP00000047222; ENSMUSG00000055480
GeneIDi238690
KEGGimmu:238690
UCSCiuc007ral.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159264 Genomic DNA No translation available.
AC163667 Genomic DNA No translation available.
BC062958 mRNA Translation: AAH62958.1
CCDSiCCDS36710.1
RefSeqiNP_001001152.1, NM_001001152.2
UniGeneiMm.306358

3D structure databases

ProteinModelPortaliQ6P5C7
SMRiQ6P5C7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047222

PTM databases

PhosphoSitePlusiQ6P5C7

Proteomic databases

PaxDbiQ6P5C7
PRIDEiQ6P5C7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045969; ENSMUSP00000047222; ENSMUSG00000055480
GeneIDi238690
KEGGimmu:238690
UCSCiuc007ral.1 mouse

Organism-specific databases

CTDi238690
MGIiMGI:3040691 Zfp458

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6P5C7
KOiK09228
OrthoDBiEOG091G02KC
PhylomeDBiQ6P5C7
TreeFamiTF343410

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

PROiPR:Q6P5C7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055480 Expressed in 177 organ(s), highest expression level in striatum
ExpressionAtlasiQ6P5C7 baseline and differential
GenevisibleiQ6P5C7 MM

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 15 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 21 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 20 hits
PS50157 ZINC_FINGER_C2H2_2, 23 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN728_MOUSE
AccessioniPrimary (citable) accession number: Q6P5C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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