Rrp12

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RRP12-like protein
Gene namesⁱ	Name:Rrp12 Synonyms:Kiaa0690
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:2147437 Rrp12

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	904 – 924	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050769	1 – 1295	RRP12-like proteinAdd BLAST		1295

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	49	PhosphoserineBy similarity	1
Cross-linkⁱ	71	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residueⁱ	72	PhosphoserineBy similarity	1
Modified residueⁱ	77	PhosphothreonineBy similarity	1
Modified residueⁱ	88	PhosphothreonineBy similarity	1
Modified residueⁱ	97	PhosphoserineBy similarity	1
Modified residueⁱ	1050	PhosphoserineBy similarity	1
Modified residueⁱ	1073	PhosphoserineBy similarity	1
Modified residueⁱ	1081	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q6P5B0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P5B0
PaxDbⁱ	Q6P5B0
PRIDEⁱ	Q6P5B0

PTM databases

iPTMnetⁱ	Q6P5B0
PhosphoSitePlusⁱ	Q6P5B0
SwissPalmⁱ	Q6P5B0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000035049 Expressed in 255 organ(s), highest expression level in ear
ExpressionAtlasⁱ	Q6P5B0 baseline and differential
Genevisibleⁱ	Q6P5B0 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	223201, 4 interactors
IntActⁱ	Q6P5B0, 1 interactor
STRINGⁱ	10090.ENSMUSP00000039853

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6P5B0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	1055 – 1089	Glu-richAdd BLAST		35

Sequence similaritiesⁱ

Belongs to the RRP12 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1248 Eukaryota ENOG410XQ3D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013106
HOGENOMⁱ	HOG000006643
HOVERGENⁱ	HBG080767
InParanoidⁱ	Q6P5B0
KEGG Orthology (KO) More...KOⁱ	K14794
OMAⁱ	MRRHFRM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00MA
PhylomeDBⁱ	Q6P5B0
TreeFamⁱ	TF300780

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR012978 Uncharacterised_NUC173
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08161 NUC173, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6P5B0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGRSGKLPSG VSAKLKRWKK GHSSDSNPAT CRHRQAARSR FFSRPSGKSD 
        60         70         80         90        100
LTVDAVKLHN ELQSGTLSLG KSQAPETTMD QDPEVAFTEK SSGTFLSGLS 
       110        120        130        140        150
DCTNVTFSKV QRFWESNSAA HKEICAVLAA VTEVIRSQGG KETETEYFAA 
       160        170        180        190        200
LMTTMEAVES PESLAAVAYL LNLVLKRVPS PVLMKKFSDT SKAFMDIMSA 
       210        220        230        240        250
QASSGSTSAL RWVLSCLAIL LRKQDLEAWG YPITLQVYHG LLSFTVHAKP 
       260        270        280        290        300
KIRKAAQHGV CSVLKGSDFM FGEKAPAHHP AAVSTAKFCI QEIEKSGGSK 
       310        320        330        340        350
EATTTLHMLT LLKDMLPCFP EGLVKSCSET LLRVMTLNHV LVTACAMQAF 
       360        370        380        390        400
HNLFHAKPSP STLSAELNAQ IVTALYDYVP SENDLQPLLA WLKVMEKAHI 
       410        420        430        440        450
NLVRLQRDLG LGHLARFFGT AVTCLLSPHS QVAAAATQTL KEILKECVAP 
       460        470        480        490        500
HIADIGSVTS SASGPPQYIT KMFRAVEEGL TYKFHAAWSS VLQLLGVFFE 
       510        520        530        540        550
ACGKQAHPVM KKCLQSLCDL RLSPHFPHTA ALDQAVGAAV TSMGPEVVLQ 
       560        570        580        590        600
AVPLEIDGSE ETLDFPRSWL LPVIRDHVRE TRLGFFTTYF LPLATTLKRK 
       610        620        630        640        650
AMDLAQAGST VESKIYDTLQ WQIWTLLPGF CTRPTDVAAS FKGLARTLGT 
       660        670        680        690        700
AINERPDLRV TVCQALRTLI TKGCEAEADR AEVSRFAKNF LPILFNLYGQ 
       710        720        730        740        750
PVAAGEAAAP RRAVLETIKT YLTITEAQLV NSFLEKATEK VLDPASSDFT 
       760        770        780        790        800
RLSVLDLVVA LAPYSDEAAI SKLYSTIRPY LESKVHGVQK KAYRVLEEVC 
       810        820        830        840        850
ASSQGPAARF VQSHLDDLKK TLLDSLRTTS SPAKRPRLKC LIHIVKTLSA 
       860        870        880        890        900
EHEEFIAALI PEVILCTKEV SVGARKSAFT LLVEMGHAFL RFGSNQEDAL 
       910        920        930        940        950
QRYLVLIYPG LLGAVTTVSC SILALTHLLF EFKGLMGTST VEQLLENVCL 
       960        970        980        990       1000
LLASRTRDVV KSALGFIKVA VVVMDVVHLA KHVQLVMEAI GKLSDDMRRH 
      1010       1020       1030       1040       1050
FRMKLRNLFI KFTRKFGFEL VKGLLPAEYH KVLINIRKAE TRAKKHRALS 
      1060       1070       1080       1090       1100
QAAVEEEEEE EEEEEPVQSK GDSIEEILAD SEDEDEEEER GRGKEQRKLA 
      1110       1120       1130       1140       1150
RQRSRAWLKE GGGDEPLNFL DPKVAHRVLA TQPGPGRGKK RDHGFKLSAD 
      1160       1170       1180       1190       1200
GRLIIREEED GNKVEEEDGT KGEDEDMTDA MEDASVRSKK KLKRQREDEE 
      1210       1220       1230       1240       1250
DELEIPPRYQ AGGSGIHRPV AKKAAPGAEY KAKKAKGDVK KKGRLDPYAY 
      1260       1270       1280       1290 
VPLNRSKLNR RKKVKLQGQF KGLVKATQRG SQAGHKLRRK DRRRP

Length:1,295

Mass (Da):143,131

Last modified:July 5, 2004 - v1

Checksum:ⁱE662BD4432B43C50

GO

Sequence cautionⁱ

The sequence BAC65628 differs from that shown. Intron retention.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	706	E → G in AAH56232 (PubMed:15489334).Curated	1
Sequence conflictⁱ	732	S → G in BAC65628 (PubMed:12693553).Curated	1
Sequence conflictⁱ	732	S → G in AAH56232 (PubMed:15489334).Curated	1
Sequence conflictⁱ	1050	S → N in AAH56232 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK122346 mRNA Translation: BAC65628.3 Sequence problems. BC056232 mRNA Translation: AAH56232.1 BC062977 mRNA Translation: AAH62977.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29814.1
NCBI Reference Sequences More...RefSeqⁱ	NP_955518.1, NM_199447.2
UniGeneⁱ	Mm.276044

Genome annotation databases

Ensemblⁱ	ENSMUST00000038677; ENSMUSP00000039853; ENSMUSG00000035049
GeneIDⁱ	107094
KEGGⁱ	mmu:107094
UCSC genome browser More...UCSCⁱ	uc008hmk.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6P5B0	Uncharacterized protein		MOUSE		1295	UniRef100_Q6P5B0

Protein	Similar proteins		Species	Score	Length	Source
Q6P5B0	Uncharacterized protein		MOUSE		1295	UniRef90_Q6P5B0
RRP12-like protein		CRIGR		1390
Uncharacterized protein (Fragment)		NEOLE		103
Ribosomal RNA-processing 12 homolog		RAT		1293
RRP12-like protein		MESAU		1248
+8

Protein	Similar proteins		Species	Score	Length	Source
Q6P5B0	RRP12-like protein		HUMAN		1297	UniRef50_Q5JTH9
RRP12-like protein		CHICK		1294
Uncharacterized protein		PANPA		1302
Ribosomal RNA processing 12 homolog		PANTR		1302
RRP12 isoform 4		PONAB		1298
+466

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK122346 mRNA Translation: BAC65628.3 Sequence problems. BC056232 mRNA Translation: AAH56232.1 BC062977 mRNA Translation: AAH62977.1
CCDSⁱ	CCDS29814.1
RefSeqⁱ	NP_955518.1, NM_199447.2
UniGeneⁱ	Mm.276044

3D structure databases

ProteinModelPortalⁱ	Q6P5B0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	223201, 4 interactors
IntActⁱ	Q6P5B0, 1 interactor
STRINGⁱ	10090.ENSMUSP00000039853

PTM databases

iPTMnetⁱ	Q6P5B0
PhosphoSitePlusⁱ	Q6P5B0
SwissPalmⁱ	Q6P5B0

Proteomic databases

EPDⁱ	Q6P5B0
MaxQBⁱ	Q6P5B0
PaxDbⁱ	Q6P5B0
PRIDEⁱ	Q6P5B0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000038677; ENSMUSP00000039853; ENSMUSG00000035049
GeneIDⁱ	107094
KEGGⁱ	mmu:107094
UCSCⁱ	uc008hmk.1 mouse

Organism-specific databases

CTDⁱ	23223
MGIⁱ	MGI:2147437 Rrp12
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1248 Eukaryota ENOG410XQ3D LUCA
GeneTreeⁱ	ENSGT00390000013106
HOGENOMⁱ	HOG000006643
HOVERGENⁱ	HBG080767
InParanoidⁱ	Q6P5B0
KOⁱ	K14794
OMAⁱ	MRRHFRM
OrthoDBⁱ	EOG091G00MA
PhylomeDBⁱ	Q6P5B0
TreeFamⁱ	TF300780

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6P5B0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000035049 Expressed in 255 organ(s), highest expression level in ear
ExpressionAtlasⁱ	Q6P5B0 baseline and differential
Genevisibleⁱ	Q6P5B0 MM

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR012978 Uncharacterised_NUC173
Pfamⁱ	View protein in Pfam PF08161 NUC173, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RRP12_MOUSE
Accessionⁱ	Q6P5B0Primary (citable) accession number: Q6P5B0 Secondary accession number(s): Q7TMI5, Q80TU2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
	Last sequence update:	July 5, 2004
	Last modified:	October 10, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6P5B0 (RRP12_MOUSE)

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RRP12-like protein

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ