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Entry version 124 (31 Jul 2019)
Sequence version 1 (05 Jul 2004)
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Protein

RRP12-like protein

Gene

Rrp12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RRP12-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rrp12
Synonyms:Kiaa0690
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2147437 Rrp12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei904 – 924HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507691 – 1295RRP12-like proteinAdd BLAST1295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei49PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki71Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei72PhosphoserineBy similarity1
Modified residuei77PhosphothreonineBy similarity1
Modified residuei88PhosphothreonineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei1050PhosphoserineBy similarity1
Modified residuei1073PhosphoserineBy similarity1
Modified residuei1081PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P5B0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P5B0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P5B0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P5B0

PRoteomics IDEntifications database

More...
PRIDEi
Q6P5B0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P5B0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P5B0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6P5B0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035049 Expressed in 255 organ(s), highest expression level in ear

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P5B0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P5B0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
223201, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P5B0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000039853

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1055 – 1089Glu-richAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRP12 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1248 Eukaryota
ENOG410XQ3D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013106

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006643

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P5B0

KEGG Orthology (KO)

More...
KOi
K14794

Identification of Orthologs from Complete Genome Data

More...
OMAi
LQWQIWT

Database of Orthologous Groups

More...
OrthoDBi
833555at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P5B0

TreeFam database of animal gene trees

More...
TreeFami
TF300780

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR012978 Uncharacterised_NUC173

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08161 NUC173, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6P5B0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRSGKLPSG VSAKLKRWKK GHSSDSNPAT CRHRQAARSR FFSRPSGKSD
60 70 80 90 100
LTVDAVKLHN ELQSGTLSLG KSQAPETTMD QDPEVAFTEK SSGTFLSGLS
110 120 130 140 150
DCTNVTFSKV QRFWESNSAA HKEICAVLAA VTEVIRSQGG KETETEYFAA
160 170 180 190 200
LMTTMEAVES PESLAAVAYL LNLVLKRVPS PVLMKKFSDT SKAFMDIMSA
210 220 230 240 250
QASSGSTSAL RWVLSCLAIL LRKQDLEAWG YPITLQVYHG LLSFTVHAKP
260 270 280 290 300
KIRKAAQHGV CSVLKGSDFM FGEKAPAHHP AAVSTAKFCI QEIEKSGGSK
310 320 330 340 350
EATTTLHMLT LLKDMLPCFP EGLVKSCSET LLRVMTLNHV LVTACAMQAF
360 370 380 390 400
HNLFHAKPSP STLSAELNAQ IVTALYDYVP SENDLQPLLA WLKVMEKAHI
410 420 430 440 450
NLVRLQRDLG LGHLARFFGT AVTCLLSPHS QVAAAATQTL KEILKECVAP
460 470 480 490 500
HIADIGSVTS SASGPPQYIT KMFRAVEEGL TYKFHAAWSS VLQLLGVFFE
510 520 530 540 550
ACGKQAHPVM KKCLQSLCDL RLSPHFPHTA ALDQAVGAAV TSMGPEVVLQ
560 570 580 590 600
AVPLEIDGSE ETLDFPRSWL LPVIRDHVRE TRLGFFTTYF LPLATTLKRK
610 620 630 640 650
AMDLAQAGST VESKIYDTLQ WQIWTLLPGF CTRPTDVAAS FKGLARTLGT
660 670 680 690 700
AINERPDLRV TVCQALRTLI TKGCEAEADR AEVSRFAKNF LPILFNLYGQ
710 720 730 740 750
PVAAGEAAAP RRAVLETIKT YLTITEAQLV NSFLEKATEK VLDPASSDFT
760 770 780 790 800
RLSVLDLVVA LAPYSDEAAI SKLYSTIRPY LESKVHGVQK KAYRVLEEVC
810 820 830 840 850
ASSQGPAARF VQSHLDDLKK TLLDSLRTTS SPAKRPRLKC LIHIVKTLSA
860 870 880 890 900
EHEEFIAALI PEVILCTKEV SVGARKSAFT LLVEMGHAFL RFGSNQEDAL
910 920 930 940 950
QRYLVLIYPG LLGAVTTVSC SILALTHLLF EFKGLMGTST VEQLLENVCL
960 970 980 990 1000
LLASRTRDVV KSALGFIKVA VVVMDVVHLA KHVQLVMEAI GKLSDDMRRH
1010 1020 1030 1040 1050
FRMKLRNLFI KFTRKFGFEL VKGLLPAEYH KVLINIRKAE TRAKKHRALS
1060 1070 1080 1090 1100
QAAVEEEEEE EEEEEPVQSK GDSIEEILAD SEDEDEEEER GRGKEQRKLA
1110 1120 1130 1140 1150
RQRSRAWLKE GGGDEPLNFL DPKVAHRVLA TQPGPGRGKK RDHGFKLSAD
1160 1170 1180 1190 1200
GRLIIREEED GNKVEEEDGT KGEDEDMTDA MEDASVRSKK KLKRQREDEE
1210 1220 1230 1240 1250
DELEIPPRYQ AGGSGIHRPV AKKAAPGAEY KAKKAKGDVK KKGRLDPYAY
1260 1270 1280 1290
VPLNRSKLNR RKKVKLQGQF KGLVKATQRG SQAGHKLRRK DRRRP
Length:1,295
Mass (Da):143,131
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE662BD4432B43C50
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65628 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti706E → G in AAH56232 (PubMed:15489334).Curated1
Sequence conflicti732S → G in BAC65628 (PubMed:12693553).Curated1
Sequence conflicti732S → G in AAH56232 (PubMed:15489334).Curated1
Sequence conflicti1050S → N in AAH56232 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK122346 mRNA Translation: BAC65628.3 Sequence problems.
BC056232 mRNA Translation: AAH56232.1
BC062977 mRNA Translation: AAH62977.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29814.1

NCBI Reference Sequences

More...
RefSeqi
NP_955518.1, NM_199447.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000038677; ENSMUSP00000039853; ENSMUSG00000035049

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
107094

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:107094

UCSC genome browser

More...
UCSCi
uc008hmk.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122346 mRNA Translation: BAC65628.3 Sequence problems.
BC056232 mRNA Translation: AAH56232.1
BC062977 mRNA Translation: AAH62977.1
CCDSiCCDS29814.1
RefSeqiNP_955518.1, NM_199447.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi223201, 5 interactors
IntActiQ6P5B0, 1 interactor
STRINGi10090.ENSMUSP00000039853

PTM databases

iPTMnetiQ6P5B0
PhosphoSitePlusiQ6P5B0
SwissPalmiQ6P5B0

Proteomic databases

EPDiQ6P5B0
jPOSTiQ6P5B0
MaxQBiQ6P5B0
PaxDbiQ6P5B0
PRIDEiQ6P5B0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038677; ENSMUSP00000039853; ENSMUSG00000035049
GeneIDi107094
KEGGimmu:107094
UCSCiuc008hmk.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23223
MGIiMGI:2147437 Rrp12

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1248 Eukaryota
ENOG410XQ3D LUCA
GeneTreeiENSGT00390000013106
HOGENOMiHOG000006643
InParanoidiQ6P5B0
KOiK14794
OMAiLQWQIWT
OrthoDBi833555at2759
PhylomeDBiQ6P5B0
TreeFamiTF300780

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6P5B0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000035049 Expressed in 255 organ(s), highest expression level in ear
ExpressionAtlasiQ6P5B0 baseline and differential
GenevisibleiQ6P5B0 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR012978 Uncharacterised_NUC173
PfamiView protein in Pfam
PF08161 NUC173, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRRP12_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P5B0
Secondary accession number(s): Q7TMI5, Q80TU2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: July 31, 2019
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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