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Protein

RRP12-like protein

Gene

Rrp12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RRP12-like protein
Gene namesi
Name:Rrp12
Synonyms:Kiaa0690
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147437 Rrp12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei904 – 924HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507691 – 1295RRP12-like proteinAdd BLAST1295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineBy similarity1
Cross-linki71Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei72PhosphoserineBy similarity1
Modified residuei77PhosphothreonineBy similarity1
Modified residuei88PhosphothreonineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei1050PhosphoserineBy similarity1
Modified residuei1073PhosphoserineBy similarity1
Modified residuei1081PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6P5B0
MaxQBiQ6P5B0
PaxDbiQ6P5B0
PRIDEiQ6P5B0

PTM databases

iPTMnetiQ6P5B0
PhosphoSitePlusiQ6P5B0
SwissPalmiQ6P5B0

Expressioni

Gene expression databases

BgeeiENSMUSG00000035049 Expressed in 255 organ(s), highest expression level in ear
ExpressionAtlasiQ6P5B0 baseline and differential
GenevisibleiQ6P5B0 MM

Interactioni

Protein-protein interaction databases

BioGridi223201, 4 interactors
IntActiQ6P5B0, 1 interactor
STRINGi10090.ENSMUSP00000039853

Structurei

3D structure databases

ProteinModelPortaliQ6P5B0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1055 – 1089Glu-richAdd BLAST35

Sequence similaritiesi

Belongs to the RRP12 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1248 Eukaryota
ENOG410XQ3D LUCA
GeneTreeiENSGT00390000013106
HOGENOMiHOG000006643
HOVERGENiHBG080767
InParanoidiQ6P5B0
KOiK14794
OMAiMRRHFRM
OrthoDBiEOG091G00MA
PhylomeDBiQ6P5B0
TreeFamiTF300780

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR012978 Uncharacterised_NUC173
PfamiView protein in Pfam
PF08161 NUC173, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

Sequencei

Sequence statusi: Complete.

Q6P5B0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRSGKLPSG VSAKLKRWKK GHSSDSNPAT CRHRQAARSR FFSRPSGKSD
60 70 80 90 100
LTVDAVKLHN ELQSGTLSLG KSQAPETTMD QDPEVAFTEK SSGTFLSGLS
110 120 130 140 150
DCTNVTFSKV QRFWESNSAA HKEICAVLAA VTEVIRSQGG KETETEYFAA
160 170 180 190 200
LMTTMEAVES PESLAAVAYL LNLVLKRVPS PVLMKKFSDT SKAFMDIMSA
210 220 230 240 250
QASSGSTSAL RWVLSCLAIL LRKQDLEAWG YPITLQVYHG LLSFTVHAKP
260 270 280 290 300
KIRKAAQHGV CSVLKGSDFM FGEKAPAHHP AAVSTAKFCI QEIEKSGGSK
310 320 330 340 350
EATTTLHMLT LLKDMLPCFP EGLVKSCSET LLRVMTLNHV LVTACAMQAF
360 370 380 390 400
HNLFHAKPSP STLSAELNAQ IVTALYDYVP SENDLQPLLA WLKVMEKAHI
410 420 430 440 450
NLVRLQRDLG LGHLARFFGT AVTCLLSPHS QVAAAATQTL KEILKECVAP
460 470 480 490 500
HIADIGSVTS SASGPPQYIT KMFRAVEEGL TYKFHAAWSS VLQLLGVFFE
510 520 530 540 550
ACGKQAHPVM KKCLQSLCDL RLSPHFPHTA ALDQAVGAAV TSMGPEVVLQ
560 570 580 590 600
AVPLEIDGSE ETLDFPRSWL LPVIRDHVRE TRLGFFTTYF LPLATTLKRK
610 620 630 640 650
AMDLAQAGST VESKIYDTLQ WQIWTLLPGF CTRPTDVAAS FKGLARTLGT
660 670 680 690 700
AINERPDLRV TVCQALRTLI TKGCEAEADR AEVSRFAKNF LPILFNLYGQ
710 720 730 740 750
PVAAGEAAAP RRAVLETIKT YLTITEAQLV NSFLEKATEK VLDPASSDFT
760 770 780 790 800
RLSVLDLVVA LAPYSDEAAI SKLYSTIRPY LESKVHGVQK KAYRVLEEVC
810 820 830 840 850
ASSQGPAARF VQSHLDDLKK TLLDSLRTTS SPAKRPRLKC LIHIVKTLSA
860 870 880 890 900
EHEEFIAALI PEVILCTKEV SVGARKSAFT LLVEMGHAFL RFGSNQEDAL
910 920 930 940 950
QRYLVLIYPG LLGAVTTVSC SILALTHLLF EFKGLMGTST VEQLLENVCL
960 970 980 990 1000
LLASRTRDVV KSALGFIKVA VVVMDVVHLA KHVQLVMEAI GKLSDDMRRH
1010 1020 1030 1040 1050
FRMKLRNLFI KFTRKFGFEL VKGLLPAEYH KVLINIRKAE TRAKKHRALS
1060 1070 1080 1090 1100
QAAVEEEEEE EEEEEPVQSK GDSIEEILAD SEDEDEEEER GRGKEQRKLA
1110 1120 1130 1140 1150
RQRSRAWLKE GGGDEPLNFL DPKVAHRVLA TQPGPGRGKK RDHGFKLSAD
1160 1170 1180 1190 1200
GRLIIREEED GNKVEEEDGT KGEDEDMTDA MEDASVRSKK KLKRQREDEE
1210 1220 1230 1240 1250
DELEIPPRYQ AGGSGIHRPV AKKAAPGAEY KAKKAKGDVK KKGRLDPYAY
1260 1270 1280 1290
VPLNRSKLNR RKKVKLQGQF KGLVKATQRG SQAGHKLRRK DRRRP
Length:1,295
Mass (Da):143,131
Last modified:July 5, 2004 - v1
Checksum:iE662BD4432B43C50
GO

Sequence cautioni

The sequence BAC65628 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti706E → G in AAH56232 (PubMed:15489334).Curated1
Sequence conflicti732S → G in BAC65628 (PubMed:12693553).Curated1
Sequence conflicti732S → G in AAH56232 (PubMed:15489334).Curated1
Sequence conflicti1050S → N in AAH56232 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122346 mRNA Translation: BAC65628.3 Sequence problems.
BC056232 mRNA Translation: AAH56232.1
BC062977 mRNA Translation: AAH62977.1
CCDSiCCDS29814.1
RefSeqiNP_955518.1, NM_199447.2
UniGeneiMm.276044

Genome annotation databases

EnsembliENSMUST00000038677; ENSMUSP00000039853; ENSMUSG00000035049
GeneIDi107094
KEGGimmu:107094
UCSCiuc008hmk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122346 mRNA Translation: BAC65628.3 Sequence problems.
BC056232 mRNA Translation: AAH56232.1
BC062977 mRNA Translation: AAH62977.1
CCDSiCCDS29814.1
RefSeqiNP_955518.1, NM_199447.2
UniGeneiMm.276044

3D structure databases

ProteinModelPortaliQ6P5B0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223201, 4 interactors
IntActiQ6P5B0, 1 interactor
STRINGi10090.ENSMUSP00000039853

PTM databases

iPTMnetiQ6P5B0
PhosphoSitePlusiQ6P5B0
SwissPalmiQ6P5B0

Proteomic databases

EPDiQ6P5B0
MaxQBiQ6P5B0
PaxDbiQ6P5B0
PRIDEiQ6P5B0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038677; ENSMUSP00000039853; ENSMUSG00000035049
GeneIDi107094
KEGGimmu:107094
UCSCiuc008hmk.1 mouse

Organism-specific databases

CTDi23223
MGIiMGI:2147437 Rrp12
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1248 Eukaryota
ENOG410XQ3D LUCA
GeneTreeiENSGT00390000013106
HOGENOMiHOG000006643
HOVERGENiHBG080767
InParanoidiQ6P5B0
KOiK14794
OMAiMRRHFRM
OrthoDBiEOG091G00MA
PhylomeDBiQ6P5B0
TreeFamiTF300780

Miscellaneous databases

PROiPR:Q6P5B0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035049 Expressed in 255 organ(s), highest expression level in ear
ExpressionAtlasiQ6P5B0 baseline and differential
GenevisibleiQ6P5B0 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR012978 Uncharacterised_NUC173
PfamiView protein in Pfam
PF08161 NUC173, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRRP12_MOUSE
AccessioniPrimary (citable) accession number: Q6P5B0
Secondary accession number(s): Q7TMI5, Q80TU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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