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Protein

Kinesin light chain 3

Gene

KLC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin light chain 3
Alternative name(s):
KLC2-like
kinesin light chain 2
Gene namesi
Name:KLC3
Synonyms:KLC2, KLC2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104892.16
HGNCiHGNC:20717 KLC3
MIMi601334 gene
neXtProtiNX_Q6P597

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi147700
OpenTargetsiENSG00000104892
PharmGKBiPA142671588

Polymorphism and mutation databases

BioMutaiKLC3
DMDMi91207086

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002307851 – 504Kinesin light chain 3Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173PhosphoserineBy similarity1
Modified residuei466PhosphoserineCombined sources1
Modified residuei498PhosphothreonineCombined sources1
Modified residuei502PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P597
MaxQBiQ6P597
PaxDbiQ6P597
PeptideAtlasiQ6P597
PRIDEiQ6P597
ProteomicsDBi66995
66996 [Q6P597-2]
66997 [Q6P597-3]
TopDownProteomicsiQ6P597-1 [Q6P597-1]
Q6P597-2 [Q6P597-2]

PTM databases

iPTMnetiQ6P597
PhosphoSitePlusiQ6P597

Expressioni

Gene expression databases

BgeeiENSG00000104892 Expressed in 159 organ(s), highest expression level in skin of abdomen
CleanExiHS_KLC2
HS_KLC3
ExpressionAtlasiQ6P597 baseline and differential
GenevisibleiQ6P597 HS

Organism-specific databases

HPAiHPA052797
HPA056508

Interactioni

Subunit structurei

Oligomer composed of two heavy chains and two light chains. Associates with microtubulin in an ATP-dependent manner. Interacts with KIF5C. Interacts with ODF1 (By similarity). Interacts with LRGUK (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127078, 78 interactors
ELMiQ6P597
IntActiQ6P597, 72 interactors
MINTiQ6P597
STRINGi9606.ENSP00000375810

Structurei

3D structure databases

ProteinModelPortaliQ6P597
SMRiQ6P597
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati207 – 240TPR 1Add BLAST34
Repeati249 – 282TPR 2Add BLAST34
Repeati291 – 324TPR 3Add BLAST34
Repeati333 – 366TPR 4Add BLAST34
Repeati375 – 408TPR 5Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili90 – 150Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 184Poly-Glu4
Compositional biasi190 – 196Poly-Ala7

Domaini

The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity).By similarity

Sequence similaritiesi

Belongs to the kinesin light chain family.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000006393
HOGENOMiHOG000261663
HOVERGENiHBG006217
InParanoidiQ6P597
KOiK10407
OMAiQHYARAL
OrthoDBiEOG091G05DM
PhylomeDBiQ6P597
TreeFamiTF314010

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR002151 Kinesin_light
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PRINTSiPR00381 KINESINLIGHT
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P597-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVQVAAPGS AGLGPERLSP EELVRQTRQV VQGLEALRAE HHGLAGHLAE
60 70 80 90 100
ALAGQGPAAG LEMLEEKQQV VSHSLEAIEL GLGEAQVLLA LSAHVGALEA
110 120 130 140 150
EKQRLRSQAR RLAQENVWLR EELEETQRRL RASEESVAQL EEEKRHLEFL
160 170 180 190 200
GQLRQYDPPA ESQQSESPPR RDSLASLFPS EEEERKGPEA AGAAAAQQGG
210 220 230 240 250
YEIPARLRTL HNLVIQYAGQ GRYEVAVPLC RQALEDLERS SGHCHPDVAT
260 270 280 290 300
MLNILALVYR DQNKYKEATD LLHDALQIRE QTLGPEHPAV AATLNNLAVL
310 320 330 340 350
YGKRGRYREA EPLCQRALEI REKVLGADHP DVAKQLNNLA LLCQNQGKFE
360 370 380 390 400
DVERHYARAL SIYEALGGPH DPNVAKTKNN LASAYLKQNK YQQAEELYKE
410 420 430 440 450
ILHKEDLPAP LGAPNTGTAG DAEQALRRSS SLSKIRESIR RGSEKLVSRL
460 470 480 490 500
RGEAAAGAAG MKRAMSLNTL NVDAPRAPGT QFPSWHLDKA PRTLSASTQD

LSPH
Length:504
Mass (Da):55,364
Last modified:April 4, 2006 - v2
Checksum:i3767D66C79EA3D49
GO
Isoform 2 (identifier: Q6P597-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-163: Missing.

Note: No experimental confirmation available.
Show »
Length:503
Mass (Da):55,236
Checksum:iD8F19BD4CAE6E3AB
GO
Isoform 3 (identifier: Q6P597-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MIPQTPHHCSPGAAM

Show »
Length:518
Mass (Da):56,793
Checksum:iC49FD1AE860CB810
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EL76K7EL76_HUMAN
Kinesin light chain 3
KLC3
396Annotation score:
K7ENJ3K7ENJ3_HUMAN
Kinesin light chain 3
KLC3
297Annotation score:
K7ELP9K7ELP9_HUMAN
Kinesin light chain 3
KLC3
157Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti352V → A in BAC03901 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0178311M → MIPQTPHHCSPGAAM in isoform 3. 1 Publication1
Alternative sequenceiVSP_017832163Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47234 Genomic DNA Translation: AAL48324.1
AK092481 mRNA Translation: BAC03901.1
BC062998 mRNA Translation: AAH62998.2
BC073841 mRNA Translation: AAH73841.1
BC126418 mRNA Translation: AAI26419.1
BC133037 mRNA Translation: AAI33038.1
CCDSiCCDS12660.2 [Q6P597-1]
RefSeqiNP_803136.2, NM_177417.2 [Q6P597-1]
UniGeneiHs.298079

Genome annotation databases

EnsembliENST00000391946; ENSP00000375810; ENSG00000104892 [Q6P597-1]
ENST00000470402; ENSP00000436019; ENSG00000104892 [Q6P597-3]
ENST00000585434; ENSP00000466067; ENSG00000104892 [Q6P597-2]
GeneIDi147700
KEGGihsa:147700
UCSCiuc002pbf.2 human [Q6P597-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47234 Genomic DNA Translation: AAL48324.1
AK092481 mRNA Translation: BAC03901.1
BC062998 mRNA Translation: AAH62998.2
BC073841 mRNA Translation: AAH73841.1
BC126418 mRNA Translation: AAI26419.1
BC133037 mRNA Translation: AAI33038.1
CCDSiCCDS12660.2 [Q6P597-1]
RefSeqiNP_803136.2, NM_177417.2 [Q6P597-1]
UniGeneiHs.298079

3D structure databases

ProteinModelPortaliQ6P597
SMRiQ6P597
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127078, 78 interactors
ELMiQ6P597
IntActiQ6P597, 72 interactors
MINTiQ6P597
STRINGi9606.ENSP00000375810

PTM databases

iPTMnetiQ6P597
PhosphoSitePlusiQ6P597

Polymorphism and mutation databases

BioMutaiKLC3
DMDMi91207086

Proteomic databases

EPDiQ6P597
MaxQBiQ6P597
PaxDbiQ6P597
PeptideAtlasiQ6P597
PRIDEiQ6P597
ProteomicsDBi66995
66996 [Q6P597-2]
66997 [Q6P597-3]
TopDownProteomicsiQ6P597-1 [Q6P597-1]
Q6P597-2 [Q6P597-2]

Protocols and materials databases

DNASUi147700
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391946; ENSP00000375810; ENSG00000104892 [Q6P597-1]
ENST00000470402; ENSP00000436019; ENSG00000104892 [Q6P597-3]
ENST00000585434; ENSP00000466067; ENSG00000104892 [Q6P597-2]
GeneIDi147700
KEGGihsa:147700
UCSCiuc002pbf.2 human [Q6P597-1]

Organism-specific databases

CTDi147700
DisGeNETi147700
EuPathDBiHostDB:ENSG00000104892.16
GeneCardsiKLC3
HGNCiHGNC:20717 KLC3
HPAiHPA052797
HPA056508
MIMi601334 gene
neXtProtiNX_Q6P597
OpenTargetsiENSG00000104892
PharmGKBiPA142671588
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000006393
HOGENOMiHOG000261663
HOVERGENiHBG006217
InParanoidiQ6P597
KOiK10407
OMAiQHYARAL
OrthoDBiEOG091G05DM
PhylomeDBiQ6P597
TreeFamiTF314010

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Miscellaneous databases

GeneWikiiKLC3
GenomeRNAii147700
PROiPR:Q6P597
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104892 Expressed in 159 organ(s), highest expression level in skin of abdomen
CleanExiHS_KLC2
HS_KLC3
ExpressionAtlasiQ6P597 baseline and differential
GenevisibleiQ6P597 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR002151 Kinesin_light
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PRINTSiPR00381 KINESINLIGHT
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLC3_HUMAN
AccessioniPrimary (citable) accession number: Q6P597
Secondary accession number(s): A0AVM3
, A2RUT6, Q6GMU2, Q8NAL1, Q8WWJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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