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Protein

Tumor necrosis factor alpha-induced protein 8-like protein 2

Gene

TNFAIP8L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-1483255 PI Metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 8-like protein 2
Short name:
TIPE2
Short name:
TNF alpha-induced protein 8-like protein 2
Short name:
TNFAIP8-like protein 2
Alternative name(s):
Inflammation factor protein 20
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163154.5
HGNCiHGNC:26277 TNFAIP8L2
MIMi612112 gene
neXtProtiNX_Q6P589

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi79626
OpenTargetsiENSG00000163154
PharmGKBiPA142670723

Polymorphism and mutation databases

BioMutaiTNFAIP8L2
DMDMi74749120

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002857711 – 184Tumor necrosis factor alpha-induced protein 8-like protein 2Add BLAST184

Proteomic databases

EPDiQ6P589
MaxQBiQ6P589
PaxDbiQ6P589
PeptideAtlasiQ6P589
PRIDEiQ6P589
ProteomicsDBi66994

PTM databases

iPTMnetiQ6P589
PhosphoSitePlusiQ6P589

Expressioni

Gene expression databases

BgeeiENSG00000163154 Expressed in 118 organ(s), highest expression level in leukocyte
CleanExiHS_TNFAIP8L2
GenevisibleiQ6P589 HS

Organism-specific databases

HPAiHPA062742

Interactioni

Subunit structurei

May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8.

Binary interactionsi

Protein-protein interaction databases

BioGridi122756, 4 interactors
DIPiDIP-60326N
IntActiQ6P589, 2 interactors
STRINGi9606.ENSP00000357906

Structurei

Secondary structure

1184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6P589
SMRiQ6P589
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6P589

Family & Domainsi

Domaini

The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.

Sequence similaritiesi

Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IGTQ Eukaryota
ENOG4111INB LUCA
GeneTreeiENSGT00390000003488
HOGENOMiHOG000007708
HOVERGENiHBG053286
InParanoidiQ6P589
OMAiRSGCFGP
OrthoDBiEOG091G0QQ9
PhylomeDBiQ6P589
TreeFamiTF323415

Family and domain databases

Gene3Di1.20.1440.160, 1 hit
InterProiView protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf
PANTHERiPTHR12757 PTHR12757, 1 hit
PfamiView protein in Pfam
PF05527 DUF758, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P589-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESFSSKSLA LQAEKKLLSK MAGRSVAHLF IDETSSEVLD ELYRVSKEYT
60 70 80 90 100
HSRPQAQRVI KDLIKVAIKV AVLHRNGSFG PSELALATRF RQKLRQGAMT
110 120 130 140 150
ALSFGEVDFT FEAAVLAGLL TECRDVLLEL VEHHLTPKSH GRIRHVFDHF
160 170 180
SDPGLLTALY GPDFTQHLGK ICDGLRKLLD EGKL
Length:184
Mass (Da):20,556
Last modified:July 5, 2004 - v1
Checksum:iD76EAEF5E24D3895
GO

Sequence cautioni

The sequence AAG44785 differs from that shown. Reason: Frameshift at position 117.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48E → G in CAG33656 (Ref. 4) Curated1
Sequence conflicti103S → T in BAB15664 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548003 mRNA Translation: AAQ12262.1
AF271774 mRNA Translation: AAG44785.1 Frameshift.
AK027120 mRNA Translation: BAB15664.1
CR457375 mRNA Translation: CAG33656.1
AL833373 mRNA Translation: CAI46145.1
AL592424 Genomic DNA No translation available.
BC063014 mRNA Translation: AAH63014.1
CCDSiCCDS985.1
RefSeqiNP_078851.2, NM_024575.4
UniGeneiHs.432360
Hs.744751

Genome annotation databases

EnsembliENST00000368910; ENSP00000357906; ENSG00000163154
GeneIDi79626
KEGGihsa:79626
UCSCiuc001ewx.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548003 mRNA Translation: AAQ12262.1
AF271774 mRNA Translation: AAG44785.1 Frameshift.
AK027120 mRNA Translation: BAB15664.1
CR457375 mRNA Translation: CAG33656.1
AL833373 mRNA Translation: CAI46145.1
AL592424 Genomic DNA No translation available.
BC063014 mRNA Translation: AAH63014.1
CCDSiCCDS985.1
RefSeqiNP_078851.2, NM_024575.4
UniGeneiHs.432360
Hs.744751

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F4MX-ray1.70A24-184[»]
ProteinModelPortaliQ6P589
SMRiQ6P589
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122756, 4 interactors
DIPiDIP-60326N
IntActiQ6P589, 2 interactors
STRINGi9606.ENSP00000357906

PTM databases

iPTMnetiQ6P589
PhosphoSitePlusiQ6P589

Polymorphism and mutation databases

BioMutaiTNFAIP8L2
DMDMi74749120

Proteomic databases

EPDiQ6P589
MaxQBiQ6P589
PaxDbiQ6P589
PeptideAtlasiQ6P589
PRIDEiQ6P589
ProteomicsDBi66994

Protocols and materials databases

DNASUi79626
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368910; ENSP00000357906; ENSG00000163154
GeneIDi79626
KEGGihsa:79626
UCSCiuc001ewx.2 human

Organism-specific databases

CTDi79626
DisGeNETi79626
EuPathDBiHostDB:ENSG00000163154.5
GeneCardsiTNFAIP8L2
HGNCiHGNC:26277 TNFAIP8L2
HPAiHPA062742
MIMi612112 gene
neXtProtiNX_Q6P589
OpenTargetsiENSG00000163154
PharmGKBiPA142670723
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGTQ Eukaryota
ENOG4111INB LUCA
GeneTreeiENSGT00390000003488
HOGENOMiHOG000007708
HOVERGENiHBG053286
InParanoidiQ6P589
OMAiRSGCFGP
OrthoDBiEOG091G0QQ9
PhylomeDBiQ6P589
TreeFamiTF323415

Enzyme and pathway databases

ReactomeiR-HSA-1483255 PI Metabolism

Miscellaneous databases

EvolutionaryTraceiQ6P589
GenomeRNAii79626
PROiPR:Q6P589
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163154 Expressed in 118 organ(s), highest expression level in leukocyte
CleanExiHS_TNFAIP8L2
GenevisibleiQ6P589 HS

Family and domain databases

Gene3Di1.20.1440.160, 1 hit
InterProiView protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf
PANTHERiPTHR12757 PTHR12757, 1 hit
PfamiView protein in Pfam
PF05527 DUF758, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTP8L2_HUMAN
AccessioniPrimary (citable) accession number: Q6P589
Secondary accession number(s): Q6I9Y0, Q9H2H7, Q9H5G2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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