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Entry version 118 (13 Feb 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Tumor necrosis factor alpha-induced protein 8-like protein 2

Gene

TNFAIP8L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1483255 PI Metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 8-like protein 2
Short name:
TIPE2
Short name:
TNF alpha-induced protein 8-like protein 2
Short name:
TNFAIP8-like protein 2
Alternative name(s):
Inflammation factor protein 20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163154.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26277 TNFAIP8L2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612112 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P589

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79626

Open Targets

More...
OpenTargetsi
ENSG00000163154

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670723

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNFAIP8L2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749120

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002857711 – 184Tumor necrosis factor alpha-induced protein 8-like protein 2Add BLAST184

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P589

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P589

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P589

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P589

PeptideAtlas

More...
PeptideAtlasi
Q6P589

PRoteomics IDEntifications database

More...
PRIDEi
Q6P589

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66994

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P589

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P589

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163154 Expressed in 118 organ(s), highest expression level in leukocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P589 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA062742

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122756, 4 interactors

Database of interacting proteins

More...
DIPi
DIP-60326N

Protein interaction database and analysis system

More...
IntActi
Q6P589, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357906

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F4MX-ray1.70A24-184[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6P589

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P589

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6P589

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGTQ Eukaryota
ENOG4111INB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003488

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007708

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053286

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P589

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSGCFGP

Database of Orthologous Groups

More...
OrthoDBi
1553362at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P589

TreeFam database of animal gene trees

More...
TreeFami
TF323415

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1440.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12757 PTHR12757, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05527 DUF758, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6P589-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESFSSKSLA LQAEKKLLSK MAGRSVAHLF IDETSSEVLD ELYRVSKEYT
60 70 80 90 100
HSRPQAQRVI KDLIKVAIKV AVLHRNGSFG PSELALATRF RQKLRQGAMT
110 120 130 140 150
ALSFGEVDFT FEAAVLAGLL TECRDVLLEL VEHHLTPKSH GRIRHVFDHF
160 170 180
SDPGLLTALY GPDFTQHLGK ICDGLRKLLD EGKL
Length:184
Mass (Da):20,556
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD76EAEF5E24D3895
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG44785 differs from that shown. Reason: Frameshift at position 117.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48E → G in CAG33656 (Ref. 4) Curated1
Sequence conflicti103S → T in BAB15664 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF548003 mRNA Translation: AAQ12262.1
AF271774 mRNA Translation: AAG44785.1 Frameshift.
AK027120 mRNA Translation: BAB15664.1
CR457375 mRNA Translation: CAG33656.1
AL833373 mRNA Translation: CAI46145.1
AL592424 Genomic DNA No translation available.
BC063014 mRNA Translation: AAH63014.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS985.1

NCBI Reference Sequences

More...
RefSeqi
NP_078851.2, NM_024575.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.432360
Hs.744751

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368910; ENSP00000357906; ENSG00000163154

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79626

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79626

UCSC genome browser

More...
UCSCi
uc001ewx.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548003 mRNA Translation: AAQ12262.1
AF271774 mRNA Translation: AAG44785.1 Frameshift.
AK027120 mRNA Translation: BAB15664.1
CR457375 mRNA Translation: CAG33656.1
AL833373 mRNA Translation: CAI46145.1
AL592424 Genomic DNA No translation available.
BC063014 mRNA Translation: AAH63014.1
CCDSiCCDS985.1
RefSeqiNP_078851.2, NM_024575.4
UniGeneiHs.432360
Hs.744751

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F4MX-ray1.70A24-184[»]
ProteinModelPortaliQ6P589
SMRiQ6P589
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122756, 4 interactors
DIPiDIP-60326N
IntActiQ6P589, 2 interactors
STRINGi9606.ENSP00000357906

PTM databases

iPTMnetiQ6P589
PhosphoSitePlusiQ6P589

Polymorphism and mutation databases

BioMutaiTNFAIP8L2
DMDMi74749120

Proteomic databases

EPDiQ6P589
jPOSTiQ6P589
MaxQBiQ6P589
PaxDbiQ6P589
PeptideAtlasiQ6P589
PRIDEiQ6P589
ProteomicsDBi66994

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79626
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368910; ENSP00000357906; ENSG00000163154
GeneIDi79626
KEGGihsa:79626
UCSCiuc001ewx.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79626
DisGeNETi79626
EuPathDBiHostDB:ENSG00000163154.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNFAIP8L2
HGNCiHGNC:26277 TNFAIP8L2
HPAiHPA062742
MIMi612112 gene
neXtProtiNX_Q6P589
OpenTargetsiENSG00000163154
PharmGKBiPA142670723

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGTQ Eukaryota
ENOG4111INB LUCA
GeneTreeiENSGT00390000003488
HOGENOMiHOG000007708
HOVERGENiHBG053286
InParanoidiQ6P589
OMAiRSGCFGP
OrthoDBi1553362at2759
PhylomeDBiQ6P589
TreeFamiTF323415

Enzyme and pathway databases

ReactomeiR-HSA-1483255 PI Metabolism

Miscellaneous databases

EvolutionaryTraceiQ6P589

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79626

Protein Ontology

More...
PROi
PR:Q6P589

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163154 Expressed in 118 organ(s), highest expression level in leukocyte
GenevisibleiQ6P589 HS

Family and domain databases

Gene3Di1.20.1440.160, 1 hit
InterProiView protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf
PANTHERiPTHR12757 PTHR12757, 1 hit
PfamiView protein in Pfam
PF05527 DUF758, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTP8L2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P589
Secondary accession number(s): Q6I9Y0, Q9H2H7, Q9H5G2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: February 13, 2019
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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