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Protein

Mitotic-spindle organizing protein 2A

Gene

MZT2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Mitotic-spindle organizing protein 2A
Alternative name(s):
Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A
Gene namesi
Name:MZT2A
Synonyms:FAM128A, MOZART2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000173272.13
HGNCiHGNC:33187 MZT2A
MIMi613449 gene
neXtProtiNX_Q6P582

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173272
PharmGKBiPA165696923

Polymorphism and mutation databases

BioMutaiMZT2A
DMDMi190359337

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003389871 – 158Mitotic-spindle organizing protein 2AAdd BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineBy similarity1
Modified residuei152PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P582
MaxQBiQ6P582
PaxDbiQ6P582
PeptideAtlasiQ6P582
PRIDEiQ6P582
ProteomicsDBi66991

PTM databases

iPTMnetiQ6P582
PhosphoSitePlusiQ6P582

Expressioni

Gene expression databases

BgeeiENSG00000173272 Expressed in 229 organ(s), highest expression level in heart left ventricle
CleanExiHS_FAM128A
ExpressionAtlasiQ6P582 baseline and differential
GenevisibleiQ6P582 HS

Organism-specific databases

HPAiHPA051758
HPA052623

Interactioni

Subunit structurei

Part of the gamma-tubulin complex.1 Publication

Protein-protein interaction databases

BioGridi576069, 27 interactors
IntActiQ6P582, 23 interactors
STRINGi9606.ENSP00000311500

Structurei

3D structure databases

ProteinModelPortaliQ6P582
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOZART2 family.Curated

Phylogenomic databases

eggNOGiENOG410IZ6M Eukaryota
ENOG410Y69K LUCA
GeneTreeiENSGT00390000014845
HOGENOMiHOG000089967
HOVERGENiHBG107896
InParanoidiQ6P582
KOiK16574
OMAiERSNHEG
OrthoDBiEOG091G15V4
PhylomeDBiQ6P582
TreeFamiTF333013

Family and domain databases

InterProiView protein in InterPro
IPR024332 MOZART2
PANTHERiPTHR28578 PTHR28578, 1 hit
PfamiView protein in Pfam
PF12926 MOZART2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6P582-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQGVGPGP GSAAPPGLEA ARQKLALRRK KVLSTEEMEL YELAQAAGGG
60 70 80 90 100
IDPDVFKILV DLLKLNVAPL AVFQMLKSMC AGQRLASEPQ DPAAVSLPTS
110 120 130 140 150
SVPETRGRDK GSAALGGVLA LAERSNHEGS SQRMPRQPSA TRLPKGGGPG

KSPTQGST
Length:158
Mass (Da):16,221
Last modified:June 10, 2008 - v2
Checksum:iB0B90630AE086B75
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C202H7C202_HUMAN
Mitotic-spindle organizing protein ...
MZT2A
140Annotation score:

Sequence cautioni

The sequence AAX93252 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36 – 57EEMEL…PDVFK → LQGGGRAGRRGLTGPASVPA R in AAI04651 (PubMed:15489334).CuratedAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073869 Genomic DNA Translation: AAX93252.1 Different initiation.
BC018206 mRNA Translation: AAH18206.2
BC063024 mRNA Translation: AAH63024.1
BC104650 mRNA Translation: AAI04651.1
CCDSiCCDS42758.1
RefSeqiNP_001078834.1, NM_001085365.1
UniGeneiHs.655067

Genome annotation databases

EnsembliENST00000309451; ENSP00000311500; ENSG00000173272
GeneIDi653784
KEGGihsa:653784
UCSCiuc002tsw.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073869 Genomic DNA Translation: AAX93252.1 Different initiation.
BC018206 mRNA Translation: AAH18206.2
BC063024 mRNA Translation: AAH63024.1
BC104650 mRNA Translation: AAI04651.1
CCDSiCCDS42758.1
RefSeqiNP_001078834.1, NM_001085365.1
UniGeneiHs.655067

3D structure databases

ProteinModelPortaliQ6P582
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi576069, 27 interactors
IntActiQ6P582, 23 interactors
STRINGi9606.ENSP00000311500

PTM databases

iPTMnetiQ6P582
PhosphoSitePlusiQ6P582

Polymorphism and mutation databases

BioMutaiMZT2A
DMDMi190359337

Proteomic databases

EPDiQ6P582
MaxQBiQ6P582
PaxDbiQ6P582
PeptideAtlasiQ6P582
PRIDEiQ6P582
ProteomicsDBi66991

Protocols and materials databases

DNASUi653784
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309451; ENSP00000311500; ENSG00000173272
GeneIDi653784
KEGGihsa:653784
UCSCiuc002tsw.5 human

Organism-specific databases

CTDi653784
EuPathDBiHostDB:ENSG00000173272.13
GeneCardsiMZT2A
HGNCiHGNC:33187 MZT2A
HPAiHPA051758
HPA052623
MIMi613449 gene
neXtProtiNX_Q6P582
OpenTargetsiENSG00000173272
PharmGKBiPA165696923
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ6M Eukaryota
ENOG410Y69K LUCA
GeneTreeiENSGT00390000014845
HOGENOMiHOG000089967
HOVERGENiHBG107896
InParanoidiQ6P582
KOiK16574
OMAiERSNHEG
OrthoDBiEOG091G15V4
PhylomeDBiQ6P582
TreeFamiTF333013

Enzyme and pathway databases

ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Miscellaneous databases

GenomeRNAii653784
PROiPR:Q6P582
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173272 Expressed in 229 organ(s), highest expression level in heart left ventricle
CleanExiHS_FAM128A
ExpressionAtlasiQ6P582 baseline and differential
GenevisibleiQ6P582 HS

Family and domain databases

InterProiView protein in InterPro
IPR024332 MOZART2
PANTHERiPTHR28578 PTHR28578, 1 hit
PfamiView protein in Pfam
PF12926 MOZART2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMZT2A_HUMAN
AccessioniPrimary (citable) accession number: Q6P582
Secondary accession number(s): Q3SWV8, Q8WVB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: September 12, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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