UniProtKB - Q6P582 (MZT2A_HUMAN)
Protein
Mitotic-spindle organizing protein 2A
Gene
MZT2A
Organism
Homo sapiens (Human)
Status
Functioni
Enzyme and pathway databases
PathwayCommonsi | Q6P582 |
Reactomei | R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380320, Recruitment of NuMA to mitotic centrosomes |
Names & Taxonomyi
Protein namesi | Recommended name: Mitotic-spindle organizing protein 2AAlternative name(s): Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A |
Gene namesi | Name:MZT2A Synonyms:FAM128A, MOZART2A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33187, MZT2A |
MIMi | 613449, gene |
neXtProti | NX_Q6P582 |
VEuPathDBi | HostDB:ENSG00000173272.13 |
Subcellular locationi
Cytoskeleton
Cytoskeleton
- centrosome Source: UniProtKB
- gamma-tubulin ring complex Source: UniProtKB
- spindle Source: UniProtKB
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 653784 |
OpenTargetsi | ENSG00000173272 |
PharmGKBi | PA165696923 |
Miscellaneous databases
Pharosi | Q6P582, Tdark |
Genetic variation databases
BioMutai | MZT2A |
DMDMi | 190359337 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000338987 | 1 – 158 | Mitotic-spindle organizing protein 2AAdd BLAST | 158 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 34 | PhosphoserineBy similarity | 1 | |
Modified residuei | 152 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6P582 |
jPOSTi | Q6P582 |
MassIVEi | Q6P582 |
MaxQBi | Q6P582 |
PaxDbi | Q6P582 |
PeptideAtlasi | Q6P582 |
PRIDEi | Q6P582 |
ProteomicsDBi | 66991 |
PTM databases
iPTMneti | Q6P582 |
PhosphoSitePlusi | Q6P582 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173272, Expressed in heart left ventricle and 241 other tissues |
ExpressionAtlasi | Q6P582, baseline and differential |
Genevisiblei | Q6P582, HS |
Organism-specific databases
HPAi | ENSG00000173272, Low tissue specificity |
Interactioni
Subunit structurei
Part of the gamma-tubulin complex.
1 PublicationBinary interactionsi
Q6P582
With | #Exp. | IntAct |
---|---|---|
DDX3X [O00571] | 3 | EBI-2558548,EBI-353779 |
Protein-protein interaction databases
BioGRIDi | 576069, 27 interactors |
IntActi | Q6P582, 28 interactors |
STRINGi | 9606.ENSP00000311500 |
Miscellaneous databases
RNActi | Q6P582, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the MOZART2 family.Curated
Phylogenomic databases
eggNOGi | ENOG502S50R, Eukaryota |
GeneTreei | ENSGT00390000014845 |
HOGENOMi | CLU_105461_0_0_1 |
InParanoidi | Q6P582 |
OMAi | LATENMT |
OrthoDBi | 1453946at2759 |
PhylomeDBi | Q6P582 |
TreeFami | TF333013 |
Family and domain databases
InterProi | View protein in InterPro IPR024332, MOZART2 |
PANTHERi | PTHR28578, PTHR28578, 1 hit |
Pfami | View protein in Pfam PF12926, MOZART2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6P582-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAQGVGPGP GSAAPPGLEA ARQKLALRRK KVLSTEEMEL YELAQAAGGG
60 70 80 90 100
IDPDVFKILV DLLKLNVAPL AVFQMLKSMC AGQRLASEPQ DPAAVSLPTS
110 120 130 140 150
SVPETRGRDK GSAALGGVLA LAERSNHEGS SQRMPRQPSA TRLPKGGGPG
KSPTQGST
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C202 | H7C202_HUMAN | Mitotic-spindle organizing protein ... | MZT2A | 140 | Annotation score: |
Sequence cautioni
The sequence AAX93252 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 36 – 57 | EEMEL…PDVFK → LQGGGRAGRRGLTGPASVPA R in AAI04651 (PubMed:15489334).CuratedAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073869 Genomic DNA Translation: AAX93252.1 Different initiation. BC018206 mRNA Translation: AAH18206.2 BC063024 mRNA Translation: AAH63024.1 BC104650 mRNA Translation: AAI04651.1 |
CCDSi | CCDS42758.1 |
RefSeqi | NP_001078834.1, NM_001085365.1 |
Genome annotation databases
Ensembli | ENST00000309451; ENSP00000311500; ENSG00000173272 |
GeneIDi | 653784 |
KEGGi | hsa:653784 |
UCSCi | uc002tsw.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073869 Genomic DNA Translation: AAX93252.1 Different initiation. BC018206 mRNA Translation: AAH18206.2 BC063024 mRNA Translation: AAH63024.1 BC104650 mRNA Translation: AAI04651.1 |
CCDSi | CCDS42758.1 |
RefSeqi | NP_001078834.1, NM_001085365.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6X0V | electron microscopy | 4.50 | E | 1-158 | [»] | |
SMRi | Q6P582 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 576069, 27 interactors |
IntActi | Q6P582, 28 interactors |
STRINGi | 9606.ENSP00000311500 |
PTM databases
iPTMneti | Q6P582 |
PhosphoSitePlusi | Q6P582 |
Genetic variation databases
BioMutai | MZT2A |
DMDMi | 190359337 |
Proteomic databases
EPDi | Q6P582 |
jPOSTi | Q6P582 |
MassIVEi | Q6P582 |
MaxQBi | Q6P582 |
PaxDbi | Q6P582 |
PeptideAtlasi | Q6P582 |
PRIDEi | Q6P582 |
ProteomicsDBi | 66991 |
Protocols and materials databases
Antibodypediai | 71848, 4 antibodies |
DNASUi | 653784 |
Genome annotation databases
Ensembli | ENST00000309451; ENSP00000311500; ENSG00000173272 |
GeneIDi | 653784 |
KEGGi | hsa:653784 |
UCSCi | uc002tsw.5, human |
Organism-specific databases
CTDi | 653784 |
DisGeNETi | 653784 |
GeneCardsi | MZT2A |
HGNCi | HGNC:33187, MZT2A |
HPAi | ENSG00000173272, Low tissue specificity |
MIMi | 613449, gene |
neXtProti | NX_Q6P582 |
OpenTargetsi | ENSG00000173272 |
PharmGKBi | PA165696923 |
VEuPathDBi | HostDB:ENSG00000173272.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S50R, Eukaryota |
GeneTreei | ENSGT00390000014845 |
HOGENOMi | CLU_105461_0_0_1 |
InParanoidi | Q6P582 |
OMAi | LATENMT |
OrthoDBi | 1453946at2759 |
PhylomeDBi | Q6P582 |
TreeFami | TF333013 |
Enzyme and pathway databases
PathwayCommonsi | Q6P582 |
Reactomei | R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380320, Recruitment of NuMA to mitotic centrosomes |
Miscellaneous databases
BioGRID-ORCSi | 653784, 34 hits in 847 CRISPR screens |
ChiTaRSi | MZT2A, human |
GenomeRNAii | 653784 |
Pharosi | Q6P582, Tdark |
PROi | PR:Q6P582 |
RNActi | Q6P582, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173272, Expressed in heart left ventricle and 241 other tissues |
ExpressionAtlasi | Q6P582, baseline and differential |
Genevisiblei | Q6P582, HS |
Family and domain databases
InterProi | View protein in InterPro IPR024332, MOZART2 |
PANTHERi | PTHR28578, PTHR28578, 1 hit |
Pfami | View protein in Pfam PF12926, MOZART2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MZT2A_HUMAN | |
Accessioni | Q6P582Primary (citable) accession number: Q6P582 Secondary accession number(s): Q3SWV8, Q8WVB2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | February 10, 2021 | |
This is version 123 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM