MZT2A

Functionⁱ

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Reactomeⁱ

R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitotic-spindle organizing protein 2A Alternative name(s): Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A
Gene namesⁱ	Name:MZT2A Synonyms:FAM128A, MOZART2A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173272.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:33187 MZT2A
MIMⁱ	613449 gene
neXtProtⁱ	NX_Q6P582

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000173272
PharmGKBⁱ	PA165696923

Polymorphism and mutation databases

BioMutaⁱ	MZT2A
DMDMⁱ	190359337

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000338987	1 – 158	Mitotic-spindle organizing protein 2AAdd BLAST		158

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	34	PhosphoserineBy similarity		1
Modified residueⁱ	152	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q6P582
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P582
PaxDbⁱ	Q6P582
PeptideAtlas More...PeptideAtlasⁱ	Q6P582
PRIDEⁱ	Q6P582
ProteomicsDBⁱ	66991

PTM databases

iPTMnetⁱ	Q6P582
PhosphoSitePlusⁱ	Q6P582

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000173272 Expressed in 229 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_FAM128A
ExpressionAtlasⁱ	Q6P582 baseline and differential
Genevisibleⁱ	Q6P582 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051758 HPA052623

HPAⁱ

HPA051758
HPA052623

Interactionⁱ

Subunit structureⁱ

Part of the gamma-tubulin complex.1 Publication

Protein-protein interaction databases

BioGridⁱ	576069, 27 interactors
IntActⁱ	Q6P582, 23 interactors
STRINGⁱ	9606.ENSP00000311500

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6P582
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the MOZART2 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IZ6M Eukaryota ENOG410Y69K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014845
HOGENOMⁱ	HOG000089967
HOVERGENⁱ	HBG107896
InParanoidⁱ	Q6P582
KEGG Orthology (KO) More...KOⁱ	K16574
OMAⁱ	ERSNHEG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G15V4
PhylomeDBⁱ	Q6P582
TreeFamⁱ	TF333013

Family and domain databases

InterProⁱ	View protein in InterPro IPR024332 MOZART2
PANTHERⁱ	PTHR28578 PTHR28578, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12926 MOZART2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q6P582-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAQGVGPGP GSAAPPGLEA ARQKLALRRK KVLSTEEMEL YELAQAAGGG 
        60         70         80         90        100
IDPDVFKILV DLLKLNVAPL AVFQMLKSMC AGQRLASEPQ DPAAVSLPTS 
       110        120        130        140        150
SVPETRGRDK GSAALGGVLA LAERSNHEGS SQRMPRQPSA TRLPKGGGPG 

KSPTQGST

Length:158

Mass (Da):16,221

Last modified:June 10, 2008 - v2

Checksum:ⁱB0B90630AE086B75

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H7C202	H7C202_HUMAN		Mitotic-spindle organizing protein ... Mitotic-spindle organizing protein 2A	MZT2A	140	Annotation score:

Sequence cautionⁱ

The sequence AAX93252 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	36 – 57	EEMEL…PDVFK → LQGGGRAGRRGLTGPASVPA R in AAI04651 (PubMed:15489334).CuratedAdd BLAST		22

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC073869 Genomic DNA Translation: AAX93252.1 Different initiation. BC018206 mRNA Translation: AAH18206.2 BC063024 mRNA Translation: AAH63024.1 BC104650 mRNA Translation: AAI04651.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42758.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001078834.1, NM_001085365.1
UniGeneⁱ	Hs.655067

Genome annotation databases

Ensemblⁱ	ENST00000309451; ENSP00000311500; ENSG00000173272
GeneIDⁱ	653784
KEGGⁱ	hsa:653784
UCSC genome browser More...UCSCⁱ	uc002tsw.5 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6P582	Uncharacterized protein		PANTR		213	UniRef90_Q6P582
Uncharacterized protein		PONAB		158
UPI00018817C9		HUMAN		209
Mitotic spindle organizing protein 2A		PANTR		212
Mitotic spindle organizing protein 2B		PANTR		158
+5

Protein	Similar proteins		Species	Score	Length	Source
Q6P582	Uncharacterized protein		PANTR		213	UniRef50_Q6P582
Uncharacterized protein		PONAB		158
Uncharacterized protein		ICTTR		217
mitotic-spindle organizing protein 2B isoform X1		Florida manatee		211
Mitotic-spindle organizing protein 2 (Fragment)		wild yak		190
+64

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC073869 Genomic DNA Translation: AAX93252.1 Different initiation. BC018206 mRNA Translation: AAH18206.2 BC063024 mRNA Translation: AAH63024.1 BC104650 mRNA Translation: AAI04651.1
CCDSⁱ	CCDS42758.1
RefSeqⁱ	NP_001078834.1, NM_001085365.1
UniGeneⁱ	Hs.655067

3D structure databases

ProteinModelPortalⁱ	Q6P582
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	576069, 27 interactors
IntActⁱ	Q6P582, 23 interactors
STRINGⁱ	9606.ENSP00000311500

PTM databases

iPTMnetⁱ	Q6P582
PhosphoSitePlusⁱ	Q6P582

Polymorphism and mutation databases

BioMutaⁱ	MZT2A
DMDMⁱ	190359337

Proteomic databases

EPDⁱ	Q6P582
MaxQBⁱ	Q6P582
PaxDbⁱ	Q6P582
PeptideAtlasⁱ	Q6P582
PRIDEⁱ	Q6P582
ProteomicsDBⁱ	66991

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	653784
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000309451; ENSP00000311500; ENSG00000173272
GeneIDⁱ	653784
KEGGⁱ	hsa:653784
UCSCⁱ	uc002tsw.5 human

Organism-specific databases

CTDⁱ	653784
EuPathDBⁱ	HostDB:ENSG00000173272.13
GeneCardsⁱ	MZT2A
HGNCⁱ	HGNC:33187 MZT2A
HPAⁱ	HPA051758 HPA052623
MIMⁱ	613449 gene
neXtProtⁱ	NX_Q6P582
OpenTargetsⁱ	ENSG00000173272
PharmGKBⁱ	PA165696923
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IZ6M Eukaryota ENOG410Y69K LUCA
GeneTreeⁱ	ENSGT00390000014845
HOGENOMⁱ	HOG000089967
HOVERGENⁱ	HBG107896
InParanoidⁱ	Q6P582
KOⁱ	K16574
OMAⁱ	ERSNHEG
OrthoDBⁱ	EOG091G15V4
PhylomeDBⁱ	Q6P582
TreeFamⁱ	TF333013

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Reactomeⁱ

R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Miscellaneous databases

GenomeRNAiⁱ	653784
Protein Ontology More...PROⁱ	PR:Q6P582
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173272 Expressed in 229 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_FAM128A
ExpressionAtlasⁱ	Q6P582 baseline and differential
Genevisibleⁱ	Q6P582 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR024332 MOZART2
PANTHERⁱ	PTHR28578 PTHR28578, 1 hit
Pfamⁱ	View protein in Pfam PF12926 MOZART2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MZT2A_HUMAN
Accessionⁱ	Q6P582Primary (citable) accession number: Q6P582 Secondary accession number(s): Q3SWV8, Q8WVB2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
	Last sequence update:	June 10, 2008
	Last modified:	September 12, 2018
	This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q6P582 (MZT2A_HUMAN)

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Mitotic-spindle organizing protein 2A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Cytosol

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ