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UniProtKB - Q6P542 (ABCF1_MOUSE)
Protein
ATP-binding cassette sub-family F member 1
Gene
Abcf1
Organism
Mus musculus (Mouse)
Status
Functioni
Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 328 – 335 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 650 – 657 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- ribosome binding Source: UniProtKB
- translation activator activity Source: UniProtKB
GO - Biological processi
- positive regulation of translation Source: UniProtKB
- translational initiation Source: UniProtKB
Keywordsi
Molecular function | Activator |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-382556, ABC-family proteins mediated transport |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-binding cassette sub-family F member 1 |
Gene namesi | Name:Abcf1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1351658, Abcf1 |
VEuPathDBi | HostDB:ENSMUSG00000038762 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- nucleoplasm By similarity
- Nucleus envelope By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nuclear envelope Source: UniProtKB
- nucleoplasm Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- polysomal ribosome Source: UniProtKB
- ribosome Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093319 | 1 – 837 | ATP-binding cassette sub-family F member 1Add BLAST | 837 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 22 | PhosphoserineBy similarity | 1 | |
Modified residuei | 90 | PhosphoserineCombined sources | 1 | |
Modified residuei | 103 | PhosphoserineCombined sources | 1 | |
Modified residuei | 107 | Phosphoserine; by CK2Combined sources | 1 | |
Modified residuei | 138 | Phosphoserine; by CK2Combined sources | 1 | |
Modified residuei | 194 | PhosphoserineCombined sources | 1 | |
Modified residuei | 225 | PhosphoserineBy similarity | 1 | |
Modified residuei | 587 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated at phosphoserine and phosphothreonine. Phosphorylation on Ser-107 and Ser-138 by CK2; inhibits association of EIF2 with ribosomes (By similarity).By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6P542 |
jPOSTi | Q6P542 |
MaxQBi | Q6P542 |
PaxDbi | Q6P542 |
PeptideAtlasi | Q6P542 |
PRIDEi | Q6P542 |
ProteomicsDBi | 285904 |
PTM databases
iPTMneti | Q6P542 |
PhosphoSitePlusi | Q6P542 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000038762, Expressed in forelimb bud and 303 other tissues |
ExpressionAtlasi | Q6P542, baseline and differential |
Genevisiblei | Q6P542, MM |
Interactioni
Subunit structurei
Interacts (via N-terminus) with EIF2S1; the interaction is independent of its phosphorylated status. Associates (via both ABC transporter domains) with the ribosomes (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 230310, 5 interactors |
IntActi | Q6P542, 54 interactors |
MINTi | Q6P542 |
STRINGi | 10090.ENSMUSP00000036881 |
Miscellaneous databases
RNActi | Q6P542, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 296 – 540 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 245 | |
Domaini | 617 – 832 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 216 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 256 | DisorderedSequence analysisAdd BLAST | 256 | |
Regioni | 551 – 599 | DisorderedSequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 37 – 73 | Basic and acidic residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 81 – 119 | Basic and acidic residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 147 – 193 | Basic and acidic residuesSequence analysisAdd BLAST | 47 | |
Compositional biasi | 205 – 256 | Basic and acidic residuesSequence analysisAdd BLAST | 52 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0066, Eukaryota |
GeneTreei | ENSGT00940000158329 |
HOGENOMi | CLU_000604_36_5_1 |
InParanoidi | Q6P542 |
OMAi | MDKIVDH |
OrthoDBi | 580544at2759 |
PhylomeDBi | Q6P542 |
TreeFami | TF105207 |
Family and domain databases
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR032781, ABC_tran_Xtn IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits PF12848, ABC_tran_Xtn, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q6P542-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKGPKQQPP EPEWIGDGEG TSPADKVVKK GKKDKKTKKT FFEELAVEDK
60 70 80 90 100
QAGEEEKLQK EKEQQQQQQQ QKKKRDTRKG RRKKDVDDDS DERVLMERLK
110 120 130 140 150
QLSVPASDEE DEVPAPIPRG RKKAKGGNVF EALIQDDSEE EEEEEENRVL
160 170 180 190 200
KPAKPEKNRI NKAVAEEPPG LRSKKGKEEK SKGKAKSKPA AADSEGEEEE
210 220 230 240 250
EDTAKEKEPP QQGKDRDKKE AEQGSGEEKE EKEGDLKAND PYANLSKKEK
260 270 280 290 300
KKLKKQMDYE RQVESLKAAN AAENDFSVSQ AEVSSRQAML ENASDIKLEK
310 320 330 340 350
FSISAHGKEL FVNADLYIVA GRRYGLVGPN GKGKTTLLKH IANRALSIPP
360 370 380 390 400
NIDVLLCEQE VVADETPAVQ AVLRADTKRL RLLEEERRLQ GQLEQGDDTA
410 420 430 440 450
AEKLEKVYEE LRATGAAAAE AKARRILAGL GFDPEMQNRP TQKFSGGWRM
460 470 480 490 500
RVSLARALFM EPTLLMLDEP TNHLDLNAVI WLNNYLQGWR KTLLIVSHDQ
510 520 530 540 550
GFLDDVCTDI IHLDTQRLHY YRGNYMTFKK MYQQKQKELL KQYEKQEKKL
560 570 580 590 600
KELKAGGKST KQAEKQTKEV LTRKQQKCRR KNQDEESQEP PELLKRPKEY
610 620 630 640 650
TVRFTFPDPP PLSPPVLGLH GVTFGYEGQK PLFKNLDFGI DMDSRICIVG
660 670 680 690 700
PNGVGKSTLL LLLTGKLTPT NGEMRKNHRL KIGFFNQQYA EQLHMEETPT
710 720 730 740 750
EYLQRSFNLP YQDARKCLGR FGLESHAHTI QICKLSGGQK ARVVFAELAC
760 770 780 790 800
REPDVLILDE PTNNLDIESI DALGEAINDY KGAVIVVSHD ARLITETNCQ
810 820 830
LWVVEEQGVS QIDGDFDDYK REVLEALGEV MVNRPRD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V012 | G3V012_MOUSE | ATP-binding cassette sub-family F m... | Abcf1 | 43 | Annotation score: | ||
G3UYI0 | G3UYI0_MOUSE | ATP-binding cassette sub-family F m... | Abcf1 | 48 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC063094 mRNA Translation: AAH63094.1 BC068282 mRNA Translation: AAH68282.1 |
CCDSi | CCDS28713.1 |
RefSeqi | NP_038882.1, NM_013854.1 |
Genome annotation databases
Ensembli | ENSMUST00000043757; ENSMUSP00000036881; ENSMUSG00000038762 |
GeneIDi | 224742 |
KEGGi | mmu:224742 |
UCSCi | uc008cjk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC063094 mRNA Translation: AAH63094.1 BC068282 mRNA Translation: AAH68282.1 |
CCDSi | CCDS28713.1 |
RefSeqi | NP_038882.1, NM_013854.1 |
3D structure databases
SMRi | Q6P542 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 230310, 5 interactors |
IntActi | Q6P542, 54 interactors |
MINTi | Q6P542 |
STRINGi | 10090.ENSMUSP00000036881 |
PTM databases
iPTMneti | Q6P542 |
PhosphoSitePlusi | Q6P542 |
Proteomic databases
EPDi | Q6P542 |
jPOSTi | Q6P542 |
MaxQBi | Q6P542 |
PaxDbi | Q6P542 |
PeptideAtlasi | Q6P542 |
PRIDEi | Q6P542 |
ProteomicsDBi | 285904 |
Protocols and materials databases
Antibodypediai | 2796, 301 antibodies from 33 providers |
DNASUi | 224742 |
Genome annotation databases
Ensembli | ENSMUST00000043757; ENSMUSP00000036881; ENSMUSG00000038762 |
GeneIDi | 224742 |
KEGGi | mmu:224742 |
UCSCi | uc008cjk.1, mouse |
Organism-specific databases
CTDi | 23 |
MGIi | MGI:1351658, Abcf1 |
VEuPathDBi | HostDB:ENSMUSG00000038762 |
Phylogenomic databases
eggNOGi | KOG0066, Eukaryota |
GeneTreei | ENSGT00940000158329 |
HOGENOMi | CLU_000604_36_5_1 |
InParanoidi | Q6P542 |
OMAi | MDKIVDH |
OrthoDBi | 580544at2759 |
PhylomeDBi | Q6P542 |
TreeFami | TF105207 |
Enzyme and pathway databases
Reactomei | R-MMU-382556, ABC-family proteins mediated transport |
Miscellaneous databases
BioGRID-ORCSi | 224742, 14 hits in 64 CRISPR screens |
ChiTaRSi | Abcf1, mouse |
PROi | PR:Q6P542 |
RNActi | Q6P542, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038762, Expressed in forelimb bud and 303 other tissues |
ExpressionAtlasi | Q6P542, baseline and differential |
Genevisiblei | Q6P542, MM |
Family and domain databases
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR032781, ABC_tran_Xtn IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 2 hits PF12848, ABC_tran_Xtn, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ABCF1_MOUSE | |
Accessioni | Q6P542Primary (citable) accession number: Q6P542 Secondary accession number(s): Q6NV71 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families